Reaction device for light-driven reaction

Abstract

The utility model discloses a reaction device for light-driven reaction. The reaction device comprises a cover plate, a reaction plate and a bottom plate which are arranged in sequence, the reaction plate is provided with a placement unit and an illumination structure; the plurality of placing units are sequentially arranged on the reaction plate side by side, each placing unit comprises a plurality of placing holes which are sequentially arranged and penetrate through the reaction plate, and reaction bottles are arranged in the placing holes; the illumination structure comprises clamping grooves, light sources and power connection ports, the clamping grooves correspond to the placing units one to one, the clamping grooves communicate with the placing holes in the corresponding placing units, the light sources are arranged in the clamping grooves and used for providing light for the placing holes, and the power connection ports are formed in the reaction plate and electrically connected with the light sources. The reaction device provided by the utility model can provide an illumination condition for a light-driven chemical reaction, and compared with an existing bottom irradiation photochemical device, the reaction device provided by the utility model does not have the defects of unsmooth light path, difficulty in uniformly mixing a reaction system and the like, and is beneficial to promoting the application of a high-flux technology in the light-driven chemical reaction.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical reaction equipment, in particular to a reaction device for light-driven reaction. Background Art

[0002] High-throughput chemistry is a chemical research method that uses automated equipment and high-throughput technology to quickly and efficiently perform large-scale chemical reactions and compound synthesis. The goal of high-throughput chemistry is to accelerate the discovery and optimization of new compounds, as well as the speed of drug screening and material development by processing multiple reaction conditions and compound samples simultaneously. The reaction plate is an important reaction equipment in realizing the high-throughput chemical automation process.

[0003] A reaction plate, also called a spot plate or well plate, is a commonly used tool in laboratories, mainly used for chemical or biochemical experiments. When light-driven chemical reactions are required, a reaction plate with the ability to provide illumination is required. Currently, the most commonly used type is a bottom-illuminated photochemical reaction device, which has disadvantages such as poor light path and difficulty in mixing the reaction system.

[0004] In summary, there is an urgent need for a reaction device for light-driven reaction to solve the problems existing in the related technology. Utility Model Content

[0005] In view of the above problems, the utility model discloses a reaction device for light-driven reaction, comprising a cover plate, a reaction plate and a bottom plate arranged in sequence;

[0006] The reaction plate is provided with a placement unit and an illumination structure; a plurality of placement units are arranged side by side on the reaction plate in sequence, the placement unit comprises a plurality of placement holes which are arranged in sequence and penetrate the reaction plate, and the placement holes are provided with reaction bottles; the illumination structure comprises a card slot, a light source and an electrical connection port, a plurality of card slots are arranged in one-to-one correspondence with the placement units and the card slots are connected with the placement holes in the corresponding placement units, the light source is arranged in the card slot for providing light to the placement holes, and the electrical connection port is arranged on the reaction plate and electrically connected to the light source.

[0007] Preferably, the light source is a lamp board, on which lamp beads are arranged that match the number of placement holes in a single group of placement units, and the lamp beads and the placement holes are arranged in a one-to-one correspondence.

[0008] Preferably, the lamp board is provided with lamp beads with at least two different wavelengths and at least two different light-emitting angles; the lamp beads include one or both of LED lamp beads and laser lamp beads.

[0009] Preferably, the wavelength of the lamp bead includes one or more of 278nm, 365nm, 395nm, 450nm, 520nm, 560nm, 590nm, 630nm, 670nm, 730nm, 808nm and white light; the light emitting angle of the lamp bead includes one or more of 15°, 30°, 45°, 60°, 90° and 120°.

[0010] Preferably, one end of the slot is a through slot, and a notch is provided at the opening of the through slot.

[0011] Preferably, the bottom plate is provided with a fluid channel for communicating with an external fluid.

[0012] Preferably, a flexible layer is further provided between the cover plate and the reaction plate.

[0013] Preferably, the flexible layer is provided with bosses corresponding one to one with the placement holes on the reaction plate, and the height of the bosses is 2-5 mm.

[0014] Preferably, the material of the flexible layer includes one of silicone, rubber, fluororubber and latex.

[0015] Preferably, the cover plate, reaction plate and bottom plate are made of aluminum alloy, magnesium alloy or copper.

[0016] Preferably, it also includes a thermocouple arranged on the reaction plate.

[0017] Preferably, a clamping groove is also provided on the reaction plate.

[0018] Compared with the prior art, the present invention has the following advantages:

[0019] (1) The reaction device obtained by the technical solution of the utility model has an illumination structure, which can provide illumination conditions for light-driven chemical reactions. Compared with the existing transparent reaction plate, the reaction device provided by the utility model does not have the disadvantages of poor light path and difficulty in mixing the reaction system. In the reaction device, the reaction bottle is a separate component, and the appropriate material can be replaced according to the different reaction types to resist chemical corrosion. When the reaction bottle is damaged, only the damaged reaction bottle can be replaced, which is conducive to reducing the waste of experimental consumables and reducing the cost required for the experiment, thereby better solving the technical problems existing in the prior art and promoting the application of high-throughput chemistry in light-driven chemical reactions.

[0020] (2) Through the technical solution of the utility model, the temperature of the bottom plate can be changed by controlling the temperature of the external fluid so that the fluid flows through the bottom plate through the fluid channel. In addition, since the cover plate, the reaction plate and the bottom plate are all made of metal (such as aluminum alloy, magnesium alloy or copper, etc.), they have good thermal conductivity. When the temperature of the bottom plate changes, the temperature of the reaction plate and other components can also be changed at the same time, so that the reaction bottle can be placed in a relatively stable temperature environment, avoiding the temperature change caused by light affecting the ongoing chemical reaction in the reaction bottle, ensuring the consistency of the experimental conditions, and improving the accuracy and reliability of the experimental results.

[0021] (3) Through the technical solution of the utility model, when the reaction bottle is loaded into the reaction plate, the mouth of the reaction bottle is sealed by pressing the cover plate and the flexible layer tightly against the reaction plate, thereby forming a separate sealed reaction environment in each reaction bottle, avoiding the risk of cross-contamination or the problem of deviation in experimental results and reaction data caused by sample evaporation and edge effect; on this basis, bosses corresponding to the placement holes on the reaction plate can be provided on the flexible layer to further enhance the sealing performance of the reaction bottle.

[0022] (4) Through the technical solution of the utility model, the material of the flexible layer is selected from elastic materials such as silicone, rubber and latex, which can adapt to the large pressure of the cover plate or the bottom plate, and can also adapt to the deformation of the shape of the mouth of the reaction bottle to avoid crushing the reaction bottle; on this basis, chemical corrosion-resistant materials such as fluororubber can be further used.

[0023] (5) Through the technical solution of the utility model, by using metals or alloys such as aluminum alloy, magnesium alloy or copper as materials for making the cover plate, the reaction plate body and the bottom plate, the good thermal conductivity of these materials can be used to improve the uniformity of the overall temperature when the temperature of the reaction plate is controlled by the fluid, thereby avoiding local temperatures that are too high or too low.

[0024] The following is a more detailed description of the best embodiment of the present application in conjunction with the accompanying drawings so that the features and advantages of the present application can be easily understood. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0026] Figure 1 This is a schematic diagram of an explosion of a reaction device according to an embodiment of the present application.

[0027] Figure 2Schematic diagram of the structure of the reaction plate in the reaction device of the embodiment of the present application.

[0028] Figure 3 for Figure 2 Schematic diagram of the structure of the reaction plate from another angle.

[0029] Figure 4 Schematic diagram of the structure of the bottom plate in the reaction device of the embodiment of the present application.

[0030] Figure 5 for Figure 4 Schematic diagram of the structure of the midsole plate from another angle.

[0031] Figure 6 for Figure 5 Schematic diagram of the cross section of the midsole along the AA plane

[0032] Among them, 1-cover plate, 2-reaction plate, 3-bottom plate, 4-flexible layer, 5-placement hole, 6-electrical connection port, 7-recess, 8-card slot, 9-fluid channel, 10-thermocouple. DETAILED DESCRIPTION

[0033] It should be noted that, in the absence of conflict, the embodiments in the present application and the features described in the embodiments may be combined with each other. The present application is further described in detail below in conjunction with the drawings and specific embodiments.

[0034] In the embodiments of the present application, if there are directional indications such as up, down, left, right, front, back..., they are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture as shown in the accompanying drawings. If the specific posture changes, the directional indication will also change accordingly.

[0035] In addition, in this application, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" or "second" may explicitly or implicitly include at least one of the features.

[0036] Example 1, see Figure 1 , the embodiment of the present application provides a reaction device for light-driven reaction, comprising a cover plate 1, a reaction plate 2 and a bottom plate 3 arranged in sequence, and the three are connected by bolts;

[0037] See also Figure 2 and Figure 3, the reaction plate 2 is provided with a placement unit and an illumination structure; four groups of placement units are arranged side by side on the reaction plate 2 in sequence, the placement unit includes twelve placement holes 5 arranged in sequence and penetrating the reaction plate, and the placement holes 5 are provided with reaction bottles; the illumination structure includes a card slot 8, a light source and an electrical connection port 6, four card slots are arranged one by one with the four groups of placement units, and the card slots are connected to the placement holes 5 in the corresponding placement units (such as Figure 3 As shown, one card slot corresponds to a group of placement units, and the twelve placement holes in the placement units are respectively connected to the card slots), the light source is arranged in the card slot to provide light to the placement holes (that is, to provide light from the hole wall direction of the placement holes, rather than from the bottom, avoiding the poor light path caused by the need for magnetic stirring of the reaction system or the poor light path caused by precipitation of the reaction system, so magnetic stirring can also be used in the light-driven reaction system, effectively avoiding the problem that it is difficult to mix the reaction system in the prior art), and the electrical port 6 is arranged on the reaction plate 2 and electrically connected to the light source (the electrical port types include Mini USB interface (Mini USB is a USB interface standard, USB is the abbreviation of Universal Serial BUS in English, and the Chinese meaning is "Universal Serial Bus", which is a technology developed for transmitting data between PCs and digital devices), Type-C interface (common fast charging interface), etc.).

[0038] Furthermore, in this embodiment, the light source is a lamp board, and the lamp board is provided with lamp beads matching the number of placement holes 5 in a single group of placement units, and the lamp beads and the placement holes are arranged in a one-to-one correspondence.

[0039] Furthermore, the lamp board is provided with at least two lamp beads with different wavelengths and at least two lamp beads with different light-emitting angles. Furthermore, the lamp beads are LED lamp beads.

[0040] Furthermore, the wavelength of the lamp bead includes 365nm and 520nm; the light emitting angle of the lamp bead includes 45° and 60°.

[0041] Furthermore, one end of the slot 8 is a through slot, and a notch 7 is provided at the opening of the through slot. When the lamp board in the slot needs to be repaired or replaced, the lamp board can be more conveniently taken out of the slot through the notch.

[0042] For further information, see Figure 4 , Figure 5 and Figure 6 The bottom plate 3 is provided with a fluid channel 9 for communicating with an external fluid. Figure 6, the fluid channel includes a group of longitudinal pipelines and two groups of transverse pipelines (of course, multiple groups of longitudinal pipelines and multiple groups of transverse pipelines can also be set in other embodiments), a single group of longitudinal pipelines or a single group of transverse pipelines includes four pipelines, the head and tail ends of the above-mentioned group of longitudinal pipelines are respectively connected to one end of the other two groups of transverse pipelines, and one end of the longitudinal pipeline has a blind hole left by drilling; the ends of the two groups of transverse pipelines away from the longitudinal pipelines have blind holes left by drilling, and the transverse pipelines are also drilled longitudinally to connect the four pipelines of the single group of transverse pipelines and leave blind holes. The blind holes and the two pipeline openings in the two groups of transverse pipelines are sealed by rubber plugs or sealing screws, so that when the cooling medium flows through the fluid channel, it can form the following Figure 6 The flow direction is shown by the arrow. Through the above pipeline design scheme, the heat exchange efficiency when the external cooling medium flows through the bottom plate fluid channel can be effectively improved.

[0043] Furthermore, a flexible layer 4 is provided between the cover plate 1 and the reaction plate 2 .

[0044] Furthermore, the flexible layer 4 is provided with bosses corresponding one to one with the placement holes on the reaction plate 2, and the height of the bosses is 2 mm.

[0045] Furthermore, the material of the flexible layer 4 includes one of silicone, rubber, fluororubber and latex (silicone is used in this embodiment).

[0046] Furthermore, the cover plate 1 , the reaction plate 2 and the bottom plate 3 are made of aluminum alloy, magnesium alloy or copper (aluminum alloy is used in this embodiment).

[0047] Furthermore, it also includes a thermocouple 10 arranged on the reaction plate. The thermocouple is inserted into the reaction plate through the reserved holes of the cover plate and the flexible layer, and is used to monitor the temperature change of the reaction plate in real time.

[0048] Furthermore, the reaction plate is provided with a clamping groove whose shape matches that of an automated clamping device such as a clamping claw, so as to facilitate clamping by the automated clamping device such as the clamping claw.

[0049] The present application is further described above with the aid of specific embodiments, but it should be understood that the specific description here should not be construed as limiting the essence and scope of the present application, and various modifications made to the above embodiments by ordinary technicians in this field after reading this specification are all within the scope of protection of this application.

Claims

1. A reaction device for light-driven reaction, characterized in that: It comprises a cover plate (1), a reaction plate (2) and a bottom plate (3) which are arranged in sequence; The reaction plate (2) is provided with a placement unit and an illumination structure; a plurality of placement units are arranged in sequence and side by side on the reaction plate, the placement unit comprises a plurality of placement holes (5) arranged in sequence and penetrating the reaction plate, and the placement holes (5) are provided with reaction bottles; the illumination structure comprises a card slot (8), a light source and an electrical connection port (6), the card slot (8) is arranged in one-to-one correspondence with the placement unit and the card slot is connected to the placement hole (5) in the corresponding placement unit, the light source is arranged in the card slot for providing light to the placement hole, and the electrical connection port (6) is arranged on the reaction plate and electrically connected to the light source.

2. The reaction device according to claim 1, characterized in that: The light source is a lamp board, on which lamp beads are arranged whose number matches the number of placement holes in a single group of placement units, and the lamp beads and the placement holes are arranged in a one-to-one correspondence.

3. The reaction device according to claim 2, characterized in that: The lamp board is provided with lamp beads with at least two different wavelengths and at least two different light-emitting angles; the lamp beads include one or both of LED lamp beads and laser lamp beads.

4. The reaction device according to claim 3, characterized in that: The wavelength of the lamp bead includes one or more of 278nm, 365nm, 395nm, 450nm, 520nm, 560nm, 590nm, 630nm, 670nm, 730nm, 808nm and white light; the light emitting angle of the lamp bead includes one or more of 15°, 30°, 45°, 60°, 90° and 120°.

5. The reaction device according to claim 1, characterized in that: One end of the clamping slot is a through slot, and a notch (7) is provided at the opening of the through slot.

6. The reaction device according to claim 1, characterized in that: The bottom plate (3) is provided with a fluid channel (9) for communicating with an external fluid.

7. The reaction device according to claim 1, characterized in that: A flexible layer (4) is also provided between the cover plate (1) and the reaction plate (2).

8. The reaction device according to claim 7, characterized in that: The flexible layer (4) is provided with bosses corresponding one to one with the placement holes on the reaction plate (2), and the height of the bosses is 2-5 mm.

9. The reaction device according to claim 8, characterized in that: The material of the flexible layer (4) includes one of silica gel, rubber, fluororubber and latex.

10. The reaction device according to any one of claims 1 to 9, characterized in that: The cover plate (1), the reaction plate (2) and the bottom plate (3) are made of aluminum alloy, magnesium alloy or copper.

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