Negative-pressure microneedle administration device

Abstract

The utility model relates to a negative-pressure microneedle dosing device which comprises a shell, an injector connector is arranged at the top of the shell, and the injector connector is used for being connected with an external injector; a groove and a protrusion are arranged at the bottom of the shell, and the protrusion is used for being attached to the skin. A medicine storage cavity and a negative pressure cavity are formed in the shell, and the medicine storage cavity is communicated with the injector connector; a negative pressure interface is formed in the surface of the shell; one end of the negative pressure cavity is connected with an external negative pressure pumping device through the negative pressure interface; a through hole is formed in the surface of the groove, and the other end of the negative pressure cavity communicates with the outside through the through hole; the microneedle comprises a needle head and a hollow flow channel, the flow channel is arranged in the needle head, the flow channel is communicated with the medicine storage cavity, the needle head protrudes out of the surface of the groove and extends outwards, and the needle head is used for puncturing the skin. The skin can be effectively attracted to be close to the needle head, the skin can be automatically punctured for administration, and the administration effect and the use experience of a patient are improved.

Description

Technical Field

[0001] The utility model mainly relates to the technical field of microneedle drug delivery devices, and particularly relates to a negative pressure microneedle drug delivery device. Background Art

[0002] As a new and minimally invasive drug delivery method, microneedle drug delivery devices have shown application potential in fields such as injection drug delivery and medical aesthetics. The microneedle drug delivery device achieves subcutaneous injection drug delivery by microneedles piercing the dermis of the skin. Microneedles can avoid the pain and discomfort caused by traditional injection methods and improve patient acceptance.

[0003] In recent years, 3D printing technology (Three Dimensional Printing) has gradually become an important means for preparing microneedle drug delivery devices due to its unique advantages such as high precision, high flexibility, and rapid prototyping. In practical applications, existing 3D printed microneedle drug delivery devices rely on manual operation to pierce the skin and inject drugs. This method not only increases the complexity of the operation but also brings significant discomfort to patients, and may even cause patients' nervousness and resistance. Moreover, due to the softness and elasticity of skin tissue, the skin is prone to sagging when subjected to external forces. Existing 3D printed microneedle drug delivery devices often fail to effectively pierce the dermis due to skin sagging when microneedles penetrate the skin, resulting in the inability to accurately deliver drugs to the target area, thus affecting the drug delivery effect, and further making 3D printed microneedles unable to be practicalized and further put into production. Summary of the Utility Model

[0004] The technical problem to be solved by this application is to provide a negative pressure microneedle drug delivery device, which can effectively attract the skin close to the needle and automatically pierce the skin for drug delivery, can accurately deliver drugs to the target area of the skin, and improves the drug delivery effect and the patient's usage experience.

[0005] The technical solution adopted by this application to solve the above technical problem is a negative pressure microneedle drug delivery device, including: a housing, a syringe interface is provided at the top of the housing, and the syringe interface is used to connect an external syringe; a groove and a protrusion are provided at the bottom of the housing, and the protrusion is used to fit with the skin; a drug storage cavity and a negative pressure cavity are provided inside the housing, and the drug storage cavity is communicated with the syringe interface; a negative pressure interface is provided on the surface of the housing, and one end of the negative pressure cavity is connected to an external negative pressure pumping device through the negative pressure interface; through holes are provided on the surface of the groove, and the other end of the negative pressure cavity is communicated with the outside through the through holes; a microneedle, including a needle tip and a hollow flow channel, the flow channel is arranged inside the needle tip, the flow channel is communicated with the drug storage cavity, the needle tip protrudes outward from the surface of the groove, and the needle tip is used to pierce the skin.

[0006] In an embodiment of the present application, the negative pressure interface is provided on the side of the housing. During the process of the negative pressure extraction device extracting negative pressure through the negative pressure interface, negative pressure is generated in the negative pressure cavity, thereby attracting the skin close to the needle tip.

[0007] In an embodiment of the present application, the negative pressure interface includes a first negative pressure interface and a second negative pressure interface, and the first negative pressure interface and the second negative pressure interface are symmetrically arranged on both sides of the housing; the negative pressure cavity includes a first negative pressure cavity and a second negative pressure cavity that are interconnected, the first negative pressure cavity is connected to the first negative pressure interface, and the second negative pressure cavity is connected to the second negative pressure interface.

[0008] In an embodiment of the present application, the number of microneedles is multiple, and the needle tips of the multiple microneedles protrude from the surface of the groove in a single-row or multi-row distribution manner.

[0009] In an embodiment of the present application, the flow channel is cylindrical or conical.

[0010] In an embodiment of the present application, the needle tip protrudes outward from the surface of the protrusion.

[0011] In an embodiment of the present application, a fixing portion is further provided on the surface of the groove, and the fixing portion is used to stabilize the microneedles.

[0012] In an embodiment of the present application, the housing is cylindrical.

[0013] In an embodiment of the present application, an anti-slip portion is provided on the protrusion.

[0014] In an embodiment of the present application, the negative pressure microneedle drug delivery device is made by 3D printing using resin.

[0015] The technical solution of the present application can attract the skin to automatically approach the needle tip and automatically pierce the skin for drug delivery by setting a negative pressure cavity and using an external negative pressure extraction device to generate negative pressure, improving the depth and stability of the microneedles penetrating the skin and enabling accurate delivery of drugs to the target area of the skin; by setting the protrusion at the bottom of the housing, the protrusion can closely fit the skin surface, improving the stability of the entire negative pressure microneedle drug delivery device during the skin piercing and drug delivery processes.

[0016] The negative pressure microneedle drug delivery device of the present application has a compact structure and is easy to operate. There is no need for manual pressing injection. Just fit the protrusion to the skin, connect an external syringe to the syringe interface, and connect an external negative pressure extraction device to the negative pressure interface to extract negative pressure to achieve automatic skin piercing for drug delivery. The present application simplifies the drug delivery process, improves the drug delivery effect and the patient's use experience. In the actual application process, 3D printing technology can be used to prepare the negative pressure microneedle drug delivery device, so that it is easier to form hollow structures such as the drug storage cavity and the negative pressure cavity inside the housing, and thus mass production can be achieved. Description of the Drawings

[0017] To make the above objects, features, and advantages of the present application more obvious and understandable, the following provides a detailed description of the specific embodiments of the present application in conjunction with the accompanying drawings, where:

[0018] Figure 1 is a schematic diagram of the overall structure of a negative pressure microneedle drug delivery device according to an embodiment of the present application from a top view perspective;

[0019] Figure 2 is a schematic diagram of the overall structure of a negative pressure microneedle drug delivery device according to an embodiment of the present application from a bottom view perspective;

[0020] Figure 3 is a bottom view of a negative pressure microneedle drug delivery device according to an embodiment of the present application;

[0021] Figure 4 is a top view of a negative pressure microneedle drug delivery device according to an embodiment of the present application;

[0022] Figure 5 is a side view of a negative pressure microneedle drug delivery device according to an embodiment of the present application;

[0023] Figure 6 is a front view of a negative pressure microneedle drug delivery device according to an embodiment of the present application;

[0024] Figure 7 is Figure 6 a schematic sectional structure diagram of;

[0025] Figure 8 is a schematic diagram of the overall structure of a negative pressure microneedle drug delivery device according to another embodiment of the present application from a bottom view perspective;

[0026] Figure 9 is Figure 8 a bottom view of the negative pressure microneedle drug delivery device shown in the embodiment;

[0027] Figure 10 is Figure 8 a side view of the negative pressure microneedle drug delivery device shown in the embodiment;

[0028] Figure 11 is a schematic diagram of a negative pressure microneedle drug delivery device in contact with the skin according to an embodiment of the present application;

[0029] Figure 12 is a schematic diagram of the needle of a negative pressure microneedle drug delivery device piercing the skin according to an embodiment of the present application.

[0030] Explanation of the reference numerals in the specific embodiments:

[0031] 100. Negative pressure microneedle drug delivery device; 101. Housing; 1011. Syringe interface; 1012. Groove; 10121. Through hole; 10123. Fixed part; 1013. Protrusion; 1014. Drug storage cavity; 1015. Negative pressure cavity; 10151. First negative pressure cavity; 10152. Second negative pressure cavity; 1016. Negative pressure interface; 10161. First negative pressure interface; 10162. Second negative pressure interface; 102. Microneedle; 10211. Flow channel; 1022. Needle tip; 103. Skin. Detailed implementation manners

[0032] To make the above objects, features and advantages of the present application more obvious and understandable, the following detailed description of the specific implementation manners of the present application will be given in conjunction with the accompanying drawings.

[0033] In the following description, many specific details are set forth to facilitate a thorough understanding of the present application. However, the present application may be implemented in other ways different from those described herein. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0034] As shown in the present application and the claims, unless the context clearly indicates otherwise, words such as "a", "an", "one" and / or "the" are not specifically singular and may also include plural. Generally speaking, the terms "comprising" and "including" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0035] In the description of the present application, it should be understood that the orientation or positional relationships indicated by orientation words such as "front, back, up, down, left, right", "horizontal, vertical, perpendicular, horizontal" and "top, bottom" are usually based on the orientation or positional relationships shown in the drawings. This is only for the convenience of describing the present application and simplifying the description. Without contrary instructions, these orientation words do not indicate and imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation on the protection scope of the present application; the orientation words "inside, outside" refer to the inside and outside relative to the contour of each component itself.

[0036] For ease of description, spatial relative terms such as "above", "over", "on the upper surface", "upper", etc. may be used herein to describe the spatial positional relationship of one device or feature to other devices or features as shown in the figures. It should be understood that the spatial relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is inverted, a device described as "above" or "over" other devices or structures will then be positioned "below" or "under" the other devices or structures. Thus, the exemplary term "above" can include both the orientations of "above" and "below". The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the corresponding explanations for the spatial relative descriptions used herein will be made accordingly.

[0037] In addition, it should be noted that the use of terms such as "first", "second", etc. to limit components is only for the convenience of distinguishing the corresponding components. Without further statement, the above terms have no special meaning, and thus should not be construed as limiting the scope of protection of the present application. In addition, although the terms used in the present application are selected from well-known and commonly used terms, some of the terms mentioned in the description of the present application may be selected by the applicant according to his or her judgment, and their detailed meanings are described in the relevant parts of the present description. In addition, it is required to understand the present application not only through the actual terms used, but also through the meaning implied by each term.

[0038] Hereinafter, embodiments of the present application will be described based on the drawings. However, the embodiments shown below are examples of a negative pressure microneedle drug delivery device for embodying the technical idea of the present application, and the negative pressure microneedle drug delivery device of the present application is not specifically limited to the following content. Furthermore, this specification assigns the numbers corresponding to the components shown in the embodiments to the components shown in the "claims" and "application content" columns in order to easily understand the scope of the claims. However, by no means does it specify the components shown in the claims as the components of the embodiments. In particular, the dimensions, materials, shapes, and relative configurations, etc. of the constituent components described in the embodiments, without specific description, are not intended to limit the scope of the present application only thereto, but are only illustrative examples.

[0039] However, the dimensions or positional relationships of the components shown in the respective drawings are sometimes exaggerated for the purpose of clear illustration. Further, in the following description, for the same names and symbols, the same or homogeneous components are appropriately described in detail. Further, each element constituting the present application may be configured such that a plurality of elements are constituted by the same component, so that one component is used in place of a plurality of elements. Conversely, the function of one component may be shared by a plurality of components. In addition, the content described in a part of the embodiments and implementation manners can also be applied to other embodiments, implementation manners, etc. In addition, in this specification, "upper" is not limited to the case where it is formed in contact with the upper surface, but also includes the case where it is formed separately above, and is also used in the meaning that an intervening layer exists between layers.

[0040] The present application provides a negative pressure microneedle drug delivery device, which can be applied to scenarios such as injection drug treatment and medical beauty.

[0041] Figure 1 FIG. 7 is a schematic diagram of the overall structure of a negative pressure microneedle drug delivery device according to an embodiment of the present application from a top view. Figure 2 FIG. 9 is a schematic diagram of the overall structure of a negative pressure microneedle drug delivery device according to an embodiment of the present application from a bottom view. Figure 6 FIG. 11 is a front view of a negative pressure microneedle drug delivery device according to an embodiment of the present application. Figure 7 is Figure 6 a schematic cross-sectional structure diagram of

[0042] Referring to Figure 1 、 Figure 2 、 Figure 6 and Figure 7 As shown in FIGS. 26, the negative pressure microneedle drug delivery device 100 of the present application includes: a housing 101, a syringe interface 1011 is provided at the top of the housing 101, and the syringe interface 1011 is used to connect an external syringe (not shown); a groove 1012 and a protrusion 1013 are provided at the bottom of the housing 101, and the protrusion 1013 is used to fit with the skin; a drug storage cavity 1014 and a negative pressure cavity 1015 are provided inside the housing 101, and the drug storage cavity 1014 is communicated with the syringe interface 1011; a negative pressure interface 1016 is provided on the surface of the housing 101, and one end of the negative pressure cavity 1015 is connected to an external negative pressure pumping device (not shown) through the negative pressure interface 1016; a through hole 10121 is provided on the surface of the groove 1012, and the other end of the negative pressure cavity 1015 is communicated with the outside through the through hole 10121.

[0043] Continuing to refer to Figure 7As shown, the negative pressure microneedle drug delivery device 100 further includes microneedles 102. The microneedles 102 include needle tips 1022 and hollow channels 10211. The channels 10211 are disposed inside the needle tips 1022 and are in communication with the drug storage cavity 1014. The needle tips 1022 protrude from the surface of the groove 1012 (as shown by the arrow X in Figure 7 ) and extend outward for puncturing the skin. Exemplarily, in practical applications, the needle tips 1022 can be set to protrude only from the surface of the groove 1012 (as shown by the arrow X in Figure 7 ) and not from the surface of the protrusion 1013 (as shown by the arrow Y in Figure 7 ); or the needle tips 1022 can be directly set to protrude from the surface of the protrusion 1013. The present application does not make any restrictions.

[0044] Figure 4 is a top view of the negative pressure microneedle drug delivery device according to an embodiment of the present application. Referring to Figure 4 and Figure 7 shown, exemplarily, a circular syringe interface 1011 is provided at the top of the housing 101 in the present application. By connecting the syringe interface 1011 to an external syringe, the drug in the syringe can be transferred into the drug storage cavity 1014, thereby realizing the supply of the drug. In other embodiments, multiple syringe interfaces can be provided to realize the simultaneous injection and supply of different drugs, and the syringe interface can also be set in other shapes such as a rectangle. The present application does not make any restrictions on the number and shape of the syringe interface 1011.

[0045] Figure 3 is a bottom view of the negative pressure microneedle drug delivery device according to an embodiment of the present application. Referring to Figure 3 shown, exemplarily, 3 microneedles 102 are provided in this embodiment, and the skin can be punctured through the needle tips 1022 of the 3 microneedles 102. In practical applications, only 1 microneedle or more microneedles can be provided. The present application does not make any restrictions on the number of the microneedles 102. Referring to Figure 7 shown, the microneedles 102 are vertically disposed below the drug storage cavity 1014, and the needle tips 1022 are in communication with the drug storage cavity 1014 through the internal channels 10211.

[0046] Figure 5 is a side view of the negative pressure microneedle drug delivery device according to an embodiment of the present application. Referring to Figure 5 shown, exemplarily, the negative pressure interface 1016 in this embodiment is circular. In other embodiments, the negative pressure interface can be set in other shapes such as a rectangle. The present application does not make any restrictions on the shape of the negative pressure interface 1016.

[0047] Figure 11 is a schematic diagram when the negative pressure microneedle drug delivery device according to an embodiment of the present application is in contact with the skin. Figure 12This is a schematic diagram when the needle of the negative pressure microneedle drug delivery device in an embodiment of the present application pierces the skin. Refer to Figure 11 As shown, exemplarily, when using the negative pressure microneedle drug delivery device 100, a staff member can gently press the protrusion 1013 against the surface of the patient's skin 103. At this time, the needle 1022 can just contact the skin 103, or there is a certain distance between the needle 1022 and the skin 103.

[0048] Refer to Figure 12 As shown, when the external negative pressure pumping device starts to pump negative pressure, the gas between the groove 1012 and the protrusion 1013 is gradually pumped out to the outside along the through hole 10121, the negative pressure cavity 1015, and the negative pressure interface 1016. Thus, negative pressure is generated in the negative pressure cavity 1015, and the skin 103 located in the groove 1012 is continuously attracted to approach the needle 1022 and is finally pierced by the needle 1022. Furthermore, the drug in the drug storage cavity 1014 can enter the skin 103 from the needle 1022 along the flow channel 10211, realizing drug delivery.

[0049] The technical solution of the present application can attract the skin 103 to automatically approach the needle 1022 and automatically pierce the skin 103 for drug delivery by setting the negative pressure cavity 1015 and using the external negative pressure pumping device to generate negative pressure, improving the penetration depth and stability of the microneedle 102 into the skin 103, and being able to accurately deliver the drug to the target area of the skin 103; by setting the protrusion 1013 at the bottom of the housing 101, the protrusion 1013 can be closely attached to the surface of the skin 103, improving the stability of the entire negative pressure microneedle drug delivery device 100 during the process of piercing the skin 103 and drug delivery.

[0050] The negative pressure microneedle drug delivery device 100 of the present application has a compact structure and is easy to operate. There is no need for manual pressing injection. Just attach the protrusion 1013 to the skin 103, connect an external syringe to the syringe interface 1011, and connect an external negative pressure pumping device through the negative pressure interface 1016 to pump negative pressure to achieve automatic piercing of the skin 103 for drug delivery. The present application simplifies the drug delivery process, improves the drug delivery effect and the user experience of patients. In the actual application process, 3D printing technology can be used to prepare the negative pressure microneedle drug delivery device 100, so that it is easier to form hollow structures such as the drug storage cavity 1014 and the negative pressure cavity 1015 inside the housing 101, and thus large-scale production can be realized.

[0051] Refer to Figure 1 As shown, in some embodiments, the housing 101 is cylindrical. Exemplarily, such a setting can facilitate the user to hold the entire negative pressure microneedle drug delivery device 100.

[0052] In some embodiments, the flow channel 10211 is cylindrical or conical. Exemplarily, refer to Figure 7As shown, the flow channel 10211 shown in this embodiment is cylindrical, and the cylindrical flow channel 10211 is not easily blocked by drugs. In other embodiments, the flow channel can be set to a conical shape. The present application does not limit the shape of the flow channel 10211.

[0053] Reference Figure 11 and Figure 12 As shown, in some embodiments, the negative pressure interface 1016 is disposed on the side surface of the housing 101. During the process of the negative pressure pumping device pumping negative pressure through the negative pressure interface 1016, negative pressure is generated in the negative pressure cavity 1015 to attract the skin 103 close to the needle 1022. Exemplarily, disposing the negative pressure interface 1016 on the side surface of the housing 101 facilitates connecting to an external negative pressure pumping device and does not affect the syringe interface 1011 and syringe connection at the top of the housing 101.

[0054] Reference Figure 4 and Figure 7 As shown, in some embodiments, the negative pressure interface 1016 includes a first negative pressure interface 10161 and a second negative pressure interface 10162. The first negative pressure interface 10161 and the second negative pressure interface 10162 are symmetrically disposed on both sides of the housing 101; the negative pressure cavity 1015 includes a first negative pressure cavity 10151 and a second negative pressure cavity 10152 that communicate with each other. The first negative pressure cavity 10151 is connected to the first negative pressure interface 10161, and the second negative pressure cavity 10152 is connected to the second negative pressure interface 10162.

[0055] Exemplarily, by providing the symmetric first negative pressure interface 10161 and second negative pressure interface 10162, the stability of the connection to an external negative pressure pumping device can be improved. In practical applications, only one negative pressure interface can be provided. The present application does not limit the number of the negative pressure interfaces 1016. Figure 7 The cross-section of the negative pressure cavity 1015 shown in is L-shaped. Such a setting can appropriately increase the internal space of the negative pressure cavity 1015 and reduce the material used for the housing 101, thereby reducing the weight of the entire negative pressure microneedle drug delivery device 100 while ensuring the negative pressure effect.

[0056] In some embodiments, the number of microneedles 102 is multiple, and the needles 1022 of the multiple microneedles 102 protrude from the surface of the groove 1012 in a single-row or multi-row distribution manner (as shown by the arrow X in Figure 7 ). Reference Figure 2 and Figure 3 As shown, in this embodiment, the needles 1022 of 3 microneedles 102 protrude from the surface of the groove 1012 in a single-row distribution manner. Figure 8 is a schematic diagram of the overall structure of another embodiment of the negative pressure microneedle drug delivery device of the present application from a bottom view perspective. Figure 9 is Figure 8Bottom view of the negative pressure microneedle drug delivery device of the illustrated embodiment Figure 10 is Figure 8 a side view of the negative pressure microneedle drug delivery device of the illustrated embodiment. Exemplarily, referring to Figures 8 to 10 as shown, in this embodiment, the needle tips 1022 of 9 microneedles 102 protrude from the surface of the groove 1012 in a multi-row (specifically 3 rows) distribution manner. In practical applications, the number and distribution manner of the microneedles can be selected according to the size of the target drug delivery skin area, and this application does not make any restrictions

[0057] Referring to Figure 7 、 Figure 11 and Figure 12 as shown, in some embodiments, the needle tip 1022 protrudes from the surface of the protrusion 1013 (as shown by the arrow Y in Figure 7 ) and extends outwards. Exemplarily, such a setting can enable the needle tip of the needle 1022 to pierce the skin 103 faster and reduce the pain of the patient

[0058] In practical applications, the needle 1022 can be set to be conical or cylindrical. Exemplarily, Figure 7 shows a conical needle 1022, and the needle tip of this needle 1022 is located in the middle of the cone. In other embodiments, the needle tip of the needle can be set to be located on the side (for example, the left or right side) of the cone. After the needle pierces the skin, the flow channel is not easily blocked by skin tissue. This application does not make any restrictions on the shape of the needle 1022

[0059] Referring to Figure 2 and Figure 7 as shown, in some embodiments, a fixing portion 10123 is further provided on the surface of the groove 1012, and the fixing portion 10123 is used to stabilize the microneedle 102. Exemplarily, such a setting can enable the microneedle 102 to be perpendicular to the bottom surface of the drug storage cavity 1014, which is beneficial to the smooth output of the drug from the flow channel 10211, and can also prevent the microneedle 102 from bending or deviating in direction during the process of piercing the skin 103

[0060] In some embodiments, an anti-slip portion (not shown) is provided on the protrusion 1013. Exemplarily, referring to Figure 3 as shown, a silicone anti-slip portion can be provided on the surface of the protrusion 1013, or an anti-slip coating can be applied on the protrusion 1013. Such a setting can strengthen the fitting effect between the protrusion 1013 and the skin 103 and improve the stability of the negative pressure microneedle drug delivery device 100 during use

[0061] In some embodiments, the negative pressure microneedle drug delivery device 100 is made by 3D printing using resin. Exemplarily, the negative pressure microneedle drug delivery device 100 is fabricated by 3D printing technology, and it is easier to form hollow structures such as the drug storage cavity 1014 and the negative pressure cavity 1015 inside the housing 101, thereby enabling mass production. Transparent resin materials or the like can be used to print the negative pressure microneedle drug delivery device 100, so that during the use of the negative pressure microneedle drug delivery device 100, it is convenient to observe the degree to which the skin 103 is punctured by the microneedles 102, and thus better control the timing of starting or stopping the negative pressure pumping by the negative pressure pumping device.

[0062] The following combines Figure 11 and Figure 12 to introduce the usage process of the negative pressure microneedle drug delivery device 100 of the present application.

[0063] Step 1: Use an external syringe to aspirate the liquid medicine and insert the syringe into the syringe interface 1011. Step 2: Connect an external negative pressure pumping device to the negative pressure interface 1016. Step 3: Align the microneedles 102 with the target injection area of the skin 103 and then press the protrusion 1013 against the surface of the skin 103, and use the negative pressure pumping device to start pumping negative pressure. Step 4: When the negative pressure is pumped to a certain value, the skin 103 is adsorbed and punctured by the needle tips 1022, and stop pumping negative pressure. Step 5: Start pushing the medicine for injection, and the medicine is output to the skin 103 through the flow channel 10211. Step 6: After the drug administration is completed, remove the negative pressure microneedle drug delivery device 100. During the removal process, the positive pressure can be output by the negative pressure pumping device, so that the needle tips 1022 and the protrusion 1013 automatically separate from the skin 103, or the staff can hold the housing 101 to pull out the needle tips 1022.

[0064] Although various examples are discussed in the above disclosure to illustrate some currently useful utility model embodiments, it should be understood that such details are only for illustrative purposes. The appended claims are not limited to the disclosed embodiments. On the contrary, the claims are intended to cover all modifications and equivalent combinations that conform to the essence and scope of the embodiments of the present application. For example, although the system components described above can be implemented by hardware devices, they can also be implemented only through software solutions, such as installing the described system on existing servers or mobile devices.

[0065] Similarly, it should be noted that, in order to simplify the description of the present application disclosure and thus help the understanding of one or more utility model embodiments, in the foregoing description of the embodiments of the present application, sometimes multiple features are merged into one embodiment, drawing, or description thereof. However, this disclosure method does not mean that the features required by the object of the present application are more than those mentioned in the claims. In fact, the features of the embodiments are less than all the features of the above-disclosed single embodiment.

[0066] In some embodiments, numbers are used to describe components and the quantity of attributes. It should be understood that such numbers used in the description of embodiments are, in some examples, modified by the modifiers "about", "approximately" or "substantially". Unless otherwise stated, "about", "approximately" or "substantially" indicate that the said numbers allow a variation of ±20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, which may vary according to the characteristics required by individual embodiments. In some embodiments, the numerical parameters should take into account the specified significant digits and adopt the method of retaining the general number of digits. Although the numerical ranges and parameters used in some embodiments of the present application to confirm the breadth of their scope are approximate values, in specific embodiments, such numerical settings are made as precise as possible within the feasible range.

[0067] Although the present application has been described with reference to the current specific embodiments, those of ordinary skill in the art should recognize that the above embodiments are only used to illustrate the present application, and various equivalent changes or substitutions can be made without departing from the spirit of the present application. Therefore, as long as the changes and modifications to the above embodiments are within the scope of the spirit of the present application, they will fall within the scope of the claims of the present application.

Claims

1. A negative pressure microneedle drug delivery device, characterized in that: include: A shell, wherein a syringe interface is provided on the top of the shell, and the syringe interface is used to connect an external syringe; a groove and a protrusion are provided on the bottom of the shell, and the protrusion is used to fit the skin; a drug storage cavity and a negative pressure cavity are provided inside the shell, and the drug storage cavity is connected to the syringe interface; a negative pressure interface is provided on the surface of the shell, and one end of the negative pressure cavity is connected to an external negative pressure extraction device through the negative pressure interface; a through hole is provided on the surface of the groove, and the other end of the negative pressure cavity is connected to the outside through the through hole; The microneedle comprises a needle and a hollow flow channel, wherein the flow channel is arranged inside the needle and is connected to the drug storage cavity. The needle protrudes from the surface of the groove and extends outward, and the needle is used to pierce the skin.

2. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The negative pressure interface is arranged on the side of the shell, and during the process of the negative pressure extraction device extracting negative pressure through the negative pressure interface, negative pressure is generated in the negative pressure cavity to attract the skin to approach the needle.

3. The negative pressure microneedle drug delivery device according to claim 2, characterized in that: The negative pressure interface includes a first negative pressure interface and a second negative pressure interface, and the first negative pressure interface and the second negative pressure interface are symmetrically arranged on both sides of the shell; the negative pressure cavity includes a first negative pressure cavity and a second negative pressure cavity that are interconnected, the first negative pressure cavity is connected to the first negative pressure interface, and the second negative pressure cavity is connected to the second negative pressure interface.

4. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The number of the microneedles is multiple, and the needles of the multiple microneedles protrude from the surface of the groove in a single row or multiple rows.

5. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The flow channel is cylindrical or conical.

6. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The needle protrudes from the surface of the protrusion and extends outward.

7. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: A fixing portion is also provided on the surface of the groove, and the fixing portion is used to stabilize the microneedle.

8. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The shell is cylindrical.

9. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The protrusion is provided with an anti-slip portion.

10. The negative pressure microneedle drug delivery device according to claim 1, characterized in that: The negative pressure microneedle drug delivery device is made of resin through 3D printing.

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