Device for testing drug release performance of bone repair graft material

Abstract

The utility model relates to the technical field of orthopedics, and discloses a device for testing the drug release performance of a bone repair graft material. The bone repair graft material drug release performance test device comprises a mounting box, a guide block, a discharge barrel and a box door, the guide block is fixedly connected in the mounting box, the discharge barrel is placed in the mounting box, the box door is rotatably arranged on the front side of the mounting box, and the guide block is fixedly connected with the box door. The stirring device further comprises a screw, a hand wheel, a guide frame, a second motor and a stirring rod, the screw is rotatably arranged in the guide block, the top of the screw is fixedly connected with the hand wheel, the guide frame is slidably arranged on the guide block, the screw is in threaded connection with the guide frame, the second motor is installed on the guide frame, and an output shaft of the second motor is connected with the stirring rod through a coupler. By starting a second motor, an output shaft of the second motor rotates to drive a stirring rod to rotate to stir the medicine and the water, so that the medicine and the water are fully mixed, and the purpose of automatic stirring is achieved by replacing manual stirring.

Description

Technical Field

[0001] The utility model relates to the technical field of orthopedics, and discloses a test device for the drug release performance of a bone repair and transplantation material. Background Technique

[0002] In the field of orthopedics, bone defects caused by various reasons such as severe trauma, bone tumors, osteomyelitis, etc. are very common. Commonly used bone repair materials include autologous bone and metal prostheses. However, autologous bone increases the trauma and pain of patients, and metal prostheses have problems such as loosening and fracture. Therefore, the transplantation and repair of bone defects with artificial bone substitute materials has become a medical focus, and there are many types of materials for artificial bone, such as hydroxyapatite, calcium sulfate, and coral porcelain.

[0003] When producing a bone repair and transplantation material drug, it is necessary to test the drug release performance of the bone repair and transplantation material drug to ensure the quality of the bone repair and transplantation material drug. In the existing test device, after adding the drug and water into the beaker, the drug and water in the beaker are stirred by holding a stirring rod by hand. The manual stirring speed is slow, so the drug and water cannot be quickly mixed, and it is easy to cause arm soreness after long-term stirring.

[0004] Therefore, a test device for the drug release performance of a bone repair and transplantation material with an automatic stirring function is needed. Content of the Utility Model

[0005] In order to overcome the shortcomings of the existing test device, after adding the drug and water into the beaker, the drug and water in the beaker are stirred by holding a stirring rod by hand. The manual stirring speed is slow, so the drug and water cannot be quickly mixed, and it is easy to cause arm soreness after long-term stirring, the utility model provides a test device for the drug release performance of a bone repair and transplantation material with an automatic stirring function.

[0006] The utility model provides the following technical solution: A test device for the drug release performance of a bone repair and transplantation material, including an installation box, a guide block, a feeding bucket, a box door, a feeding mechanism, and a water adding mechanism. A guide block is fixedly connected inside the installation box, a feeding bucket is placed inside the installation box, a box door is rotatably arranged on the front side of the installation box, a feeding mechanism is arranged on the installation box, and a water adding mechanism is arranged inside the installation box. It also includes a screw rod, a hand wheel, a guide frame, a second motor, and a stirring rod. The screw rod is rotatably arranged inside the guide block, the hand wheel is fixedly connected to the top of the screw rod, the guide frame is slidably arranged on the guide block, the screw rod is in threaded connection with the guide frame, the second motor is installed on the guide frame, and the output shaft of the second motor is connected to the stirring rod through a coupling.

[0007] Preferably, the feeding mechanism includes a feeding port, a material guiding box, a fixing frame, a first motor, a guiding sleeve and a material guiding worm. The feeding port is fixedly connected to the top of the installation box. A material guiding groove is formed inside the installation box. The material guiding box is fixedly connected inside the installation box. The bottom of the material guiding box is connected with a guiding sleeve. The material guiding groove extends into the material guiding box and communicates with the guiding sleeve. A fixing frame is installed on the left side of the material guiding box. A first motor is installed on the fixing frame. The output shaft of the first motor is connected with a material guiding worm through a coupling. The material guiding worm is located inside the guiding sleeve.

[0008] Preferably, the water adding mechanism includes an installation frame, an installation plate, a third motor, a rotating pressing plate, rollers, a diversion pipe, a connecting frame and a water storage tank. The installation frame is installed at the rear side inside the installation box. The installation plate is fixedly connected to the installation frame. The third motor is installed on the installation plate. The rotating pressing plate is rotatably arranged on the installation frame. The output shaft of the third motor is connected to the rotating pressing plate. A plurality of rollers are arranged on the rotating pressing plate. The water storage tank is arranged inside the installation box. The top of the water storage tank is connected and communicated with a diversion pipe. The diversion pipe is wound around the installation frame. The connecting frame is installed on the installation box. The diversion pipe penetrates through the connecting frame.

[0009] Preferably, it further includes a first guiding cylinder, a first buffer plate, a first elastic member, a second guiding cylinder, a second buffer plate and a second elastic member. A plurality of first guiding cylinders are fixedly connected to the right side of the installation box. A first buffer plate is slidably arranged on the plurality of first guiding cylinders together. The first elastic member is sleeved on the first guiding cylinder. A plurality of second guiding cylinders are fixedly connected to the left side of the installation box. A second buffer plate is slidably arranged on the plurality of second guiding cylinders together. The second elastic member is sleeved on the second guiding cylinder.

[0010] Preferably, it further includes a controller and a heating pipe. The controller is installed on the installation box. The heating pipe is connected to the controller. The heating pipe is wound around the discharging barrel.

[0011] Preferably, it further includes a filter screen. The filter screen is slidably arranged at the end of the diversion pipe.

[0012] Compared with the prior art, the utility model provides a feed processing and pulverizing device for preventing splashing, which has the following beneficial effects: 1. By starting the second motor, the output shaft of the second motor rotates to drive the stirring rod to rotate, thereby stirring the medicine and water, making the medicine and water fully mixed, so as to achieve the purpose of automatic stirring instead of manual stirring, and then quickly mixing the medicine and water.

[0013] 2. When the second buffer plate is no longer squeezed, the second elastic member returns to its original state to make the second buffer plate move to the left to buffer the impact force generated by the impact, thereby preventing the installation box from being dented due to the impact.

[0014] 3. Adjust the temperature of the heating tube through the controller, so that the temperature of the heating tube can quickly meet the temperature required for the drug release performance, thus facilitating the control of the heating temperature and improving the accuracy of the experiment. Description of the Drawings

[0015] Figure 1 It is a three-dimensional structural schematic diagram of the present utility model.

[0016] Figure 2 It is a three-dimensional structural schematic diagram of the installation box, guide block and feed inlet of the present utility model.

[0017] Figure 3 It is a three-dimensional sectional structural schematic diagram of the fixing frame, first motor and guide sleeve of the present utility model.

[0018] Figure 4 It is a three-dimensional sectional structural schematic diagram of the guide frame, second motor and stirring rod of the present utility model.

[0019] Figure 5 It is a three-dimensional sectional structural schematic diagram of the screw rod and installation frame of the present utility model.

[0020] Figure 6 It is a three-dimensional sectional structural schematic diagram of the diversion pipe and filter screen of the present utility model.

[0021] Figure 7 It is a three-dimensional sectional structural schematic diagram of the installation plate, third motor and rotating pressing plate of the present utility model.

[0022] Figure 8 It is a three-dimensional structural schematic diagram of the discharging barrel, controller and heating tube of the present utility model.

[0023] Figure 9 It is a three-dimensional sectional structural schematic diagram of the first guide cylinder, first buffer plate and second guide cylinder of the present utility model.

[0024] Reference numerals in the drawings: 1. Installation box, 101. Guide block, 102. Discharging barrel, 2. Box door, 3. Feed inlet, 4. Guide trough, 5. Guide box, 6. Fixing frame, 7. First motor, 8. Guide sleeve, 9. Guide worm, 10. Screw rod, 1001. Hand wheel, 11. Guide frame, 12. Second motor, 13. Stirring rod, 14. Installation frame, 15. Installation plate, 16. Third motor, 17. Rotating pressing plate, 18. Roller, 19. Diversion pipe, 20. Connecting frame, 21. Water storage tank, 22. Controller, 23. Heating tube, 24. First guide cylinder, 25. First buffer plate, 26. First elastic member, 27. Second guide cylinder, 28. Second buffer plate, 29. Second elastic member, 30. Filter screen. Detailed Description of the Invention

[0025] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0026] Embodiment 1: A device for testing the drug release performance of a bone repair and transplantation material. Please refer to Figures 1-9 , which includes an installation box 1, a guide block 101, a feeding bucket 102, a box door 2, a feeding mechanism, and a water adding mechanism. A guide block 101 is fixedly connected inside the installation box 1, a feeding bucket 102 is placed inside the installation box 1, a box door 2 is rotatably arranged on the front side of the installation box 1, a feeding mechanism is arranged on the installation box 1, a feeding port 3 is fixedly connected to the top of the installation box 1, a material guiding groove 4 is opened inside the installation box 1, a material guiding box 5 is fixedly connected inside the installation box 1, the bottom of the material guiding box 5 is connected with a guiding sleeve 8, the material guiding groove 4 extends into the material guiding box 5 and communicates with the guiding sleeve 8, a fixing frame 6 is arranged on the left side of the material guiding box 5 by means of bolt connection, a first motor 7 is arranged on the fixing frame 6 by means of bolt connection, a material guiding worm 9 is connected to the output shaft of the first motor 7 through a coupling, the material guiding worm 9 is located inside the guiding sleeve 8, a water adding mechanism is arranged inside the installation box 1, an installation frame 14 is arranged on the rear side inside the installation box 1 by means of bolt connection, an installation plate 15 is fixedly connected to the installation frame 14, a third motor 16 is arranged on the installation plate 15 by means of bolt connection, a rotating pressing plate 17 is rotatably arranged on the installation frame 14, the output shaft of the third motor 16 is connected to the rotating pressing plate 17, three rollers 18 are arranged on the rotating pressing plate 17, a water storage tank 21 is arranged inside the installation box 1, a diversion pipe 19 is connected and communicated with the top of the water storage tank 21, the diversion pipe 19 is a flexible pipe, the diversion pipe 19 is wound around the installation frame 14, the rotation of the rollers 18 will squeeze the diversion pipe 19, a connecting frame 20 is arranged on the installation box 1 by means of bolt connection, the diversion pipe 19 penetrates through the connecting frame 20, a screw rod 10 is rotatably arranged inside the guide block 101, a hand wheel 1001 is fixedly connected to the top of the screw rod 10, the hand wheel 1001 increases the contact area between the hand and the screw rod 10, and it is convenient to rotate the screw rod 10 by holding the hand wheel 1001. A guide frame 11 is slidably arranged on the guide block 101, the screw rod 10 is threadedly connected to the guide frame 11, a second motor 12 is arranged on the guide frame 11 by means of bolt connection, rotating the screw rod 10 can make the second motor 12 move up and down, the output shaft of the second motor 12 is connected to a stirring rod 13 through a coupling, a filter screen 30 is slidably arranged at the end of the diversion pipe 19, and the filter screen 30 filters impurities in the water to prevent impurities from entering the feeding bucket 102.

[0027] When the device needs to be used, rotate the box door 2 to open the installation box 1, then pour the medicine from the feed port 3. The medicine enters the inside of the guiding sleeve 8 through the guiding chute 4. Then turn on the first motor 7. The output shaft of the first motor 7 rotates to drive the guiding worm 9 to rotate, thereby adjusting the speed of the medicine flowing into the discharging bucket 102. After adding an appropriate amount of medicine into the discharging bucket 102, turn off the first motor 7, turn on the water pump and the third motor 16. The water pump operates to pump the water in the water storage tank 21 into the diversion pipe 19. The output shaft of the third motor 16 rotates to drive the rotating pressing plate 17 to rotate, so that the roller 18 rotates to squeeze the diversion pipe 19, thereby controlling the flow rate of the water inside the diversion pipe 19, and thus avoiding the excessive addition of water from affecting the test accuracy. After the water addition is completed, turn off the water pump and the third motor 16. Then hold the handwheel 1001 and rotate the screw 10 to move the guiding frame 11 to drive the second motor 12 to move, thereby adjusting the height of the second motor 12 to move, so that the stirring rod 13 contacts the liquid inside the discharging bucket 102. Then turn on the second motor 12. The output shaft of the second motor 12 rotates to drive the stirring rod 13 to rotate, thereby stirring the medicine and water, making the medicine and water fully mixed, so as to replace manual stirring to achieve the purpose of automatic stirring, and thus quickly mix the medicine and water. After the stirring is completed, turn off the second motor 12 and observe the change of the liquid inside the discharging bucket 102.

[0028] Embodiment 2: On the basis of Embodiment 1, please refer to Figure 1 , Figure 8 and Figure 9 , four first guiding cylinders 24 are fixedly connected to the right side of the installation box 1. A first buffer plate 25 is slidably arranged on the four first guiding cylinders 24. A first elastic member 26 is sleeved on the first guiding cylinder 24. Two ends of the first elastic member 26 are respectively connected to the installation box 1 and the first buffer plate 25. Four second guiding cylinders 27 are fixedly connected to the left side of the installation box 1. A second buffer plate 28 is slidably arranged on the four second guiding cylinders 27. A second elastic member 29 is sleeved on the second guiding cylinder 27. Two ends of the second elastic member 29 are respectively connected to the installation box 1 and the second buffer plate 28.

[0029] When the left side of the installation box 1 is impacted, the impact force generated by the impact squeezes the second buffer plate 28 to move to the right, and the second elastic member 29 is compressed accordingly. When the second buffer plate 28 is no longer squeezed, the second elastic member 29 returns to its original state to make the second buffer plate 28 move to the left to buffer the impact force generated by the impact, thereby preventing the installation box 1 from being dented due to the impact. On the contrary, when the left side of the installation box 1 is impacted, the first buffer plate 25 will buffer the impact force generated by the impact.

[0030] Please refer to Figure 8 , a controller 22 is arranged on the installation box 1 by means of bolt connection. A heating pipe 23 is connected to the controller 22. The heating pipe 23 is wound around the discharging bucket 102.

[0031] When conducting tests on drugs, turn on the controller 22, and adjust the temperature heated by the heating tube 23 through the controller 22, so that the temperature heated by the heating tube 23 can quickly meet the temperature required for the drug release performance, thereby facilitating the control of the heating temperature and improving the accuracy of the test.

[0032] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug release performance test device for bone repair transplant materials, comprising an installation box (1), a guide block (101), a discharge barrel (102), a box door (2), a loading mechanism and a water adding mechanism, wherein the installation box (1) is fixedly connected with the guide block (101), the discharge barrel (102) is placed inside the installation box (1), the front side of the installation box (1) is rotatably provided with a box door (2), the installation box (1) is provided with a loading mechanism, and the installation box (1) is provided with a water adding mechanism, characterized in that: The invention also comprises a screw (10), a hand wheel (1001), a guide frame (11), a second motor (12) and a stirring rod (13); the screw (10) is rotatably arranged inside the guide block (101); the hand wheel (1001) is fixedly connected to the top of the screw (10); the guide frame (11) is slidably arranged on the guide block (101); the screw (10) and the guide frame (11) are threadedly connected; the second motor (12) is installed on the guide frame (11); and the output shaft of the second motor (12) is connected to the stirring rod (13) via a coupling.

2. A bone repair graft material drug release performance test device according to claim 1, characterized in that: The feeding mechanism comprises a feeding port (3), a material guide box (5), a fixing frame (6), a first motor (7), a guide sleeve (8) and a material guide worm (9); the feeding port (3) is fixedly connected to the top of the installation box (1); a material guide groove (4) is provided inside the installation box (1); the material guide box (5) is fixedly connected inside the installation box (1); the bottom of the material guide box (5) is connected to the guide sleeve (8); the material guide groove (4) extends into the inside of the material guide box (5) and is connected to the guide sleeve (8); a fixing frame (6) is installed on the left side of the material guide box (5); the first motor (7) is installed on the fixing frame (6); the output shaft of the first motor (7) is connected to the material guide worm (9) through a coupling; the material guide worm (9) is located inside the guide sleeve (8).

3. A bone repair graft material drug release performance test device according to claim 1, characterized in that: The water adding mechanism comprises a mounting frame (14), a mounting plate (15), a third motor (16), a rotating pressure plate (17), a roller (18), a guide pipe (19), a connecting frame (20) and a water storage tank (21). The mounting frame (14) is mounted on the rear side of the mounting box (1). The mounting frame (14) is fixedly connected to the mounting frame (14). The third motor (16) is mounted on the mounting plate (15). A rotating pressure plate (17) is rotatably arranged on the mounting frame (14). The output shaft of the third motor (16) is connected to the rotating pressure plate (17). A plurality of rollers (18) are arranged on the rotating pressure plate (17). The mounting box (1) is provided with a water storage tank (21). The top of the water storage tank (21) is connected and communicated with a guide pipe (19). The guide pipe (19) is wound around the mounting frame (14). The connecting frame (20) is mounted on the mounting box (1). The guide pipe (19) passes through the connecting frame (20).

4. A bone repair graft material drug release performance test device according to claim 1, characterized in that: The invention also comprises a first guide cylinder (24), a first buffer plate (25), a first elastic member (26), a second guide cylinder (27), a second buffer plate (28) and a second elastic member (29); the right side of the installation box (1) is fixedly connected to a plurality of first guide cylinders (24); the plurality of first guide cylinders (24) are slidably provided with a first buffer plate (25); the first guide cylinders (24) are sleeved with a first elastic member (26); the left side of the installation box (1) is fixedly connected to a plurality of second guide cylinders (27); the plurality of second guide cylinders (27) are slidably provided with a second buffer plate (28); the second guide cylinders (27) are sleeved with a second elastic member (29).

5. The drug release performance testing device for bone repair graft materials according to claim 1, characterized in that: It also includes a controller (22) and a heating pipe (23). The controller (22) is installed on the installation box (1), the heating pipe (23) is connected to the controller (22), and the heating pipe (23) is wound around the discharge barrel (102).

6. The drug release performance test device for bone repair graft materials according to claim 3, characterized in that: It also includes a filter screen (30), and the filter screen (30) is slidably arranged at the end of the flow guide tube (19).

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