Sample detection card box

Abstract

The utility model relates to the technical field of sample detection, and discloses a sample detection card box which comprises a base and a sample adding cover. The base is provided with a clamping hole and a plurality of storage bins, the storage bins are annularly arranged on the periphery of the clamping hole, and the base is sleeved with an outer sealing piece. The sample adding cover is rotatably arranged on the base in a covering manner, a sample adding hole communicated with the outside is formed in the sample adding cover, and the sample adding cover is used for being communicated with the multiple storage bins and enabling a solution in the sample adding cover and sample treatment objects in the storage bins to be subjected to mixing treatment. The sample adding cover is provided with a buckle penetrating through the clamping hole, the buckle is in sealing fit with the clamping hole through an inner sealing piece, and the inner side wall of the sample adding cover is in sealing fit with the base through an outer sealing piece. According to the embodiment of the invention, the inner sealing element and the outer sealing element are arranged, so that the sample is always in the closed sample detection card box in the sample treatment process and is not exposed in the external environment, and the condition that the sample is polluted by the external environment in the sample treatment process can be avoided.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample detection, and particularly relates to a sample detection cartridge. Background Art

[0002] The PCR technology is a molecular biology technology for amplifying a specific deoxyribonucleic acid sequence in vitro. Due to the characteristics of strong specificity, high sensitivity, low purity requirement, simplicity and rapidity of the PCR technology, it is widely used in nucleic acid detection and analysis. In order to achieve rapid nucleic acid detection and improve the detection accuracy, various reagents need to be pre-placed in a reagent kit, and nucleic acid extraction and purification steps are realized by adding samples and sucking the mixed reagents multiple times. During the nucleic acid detection process, various solutions and reagents are involved, and there are many pipetting steps, which are relatively complex. If these operations are carried out in an open environment, nucleic acid leakage will inevitably occur, resulting in aerosol pollution and causing significant interference to the accuracy of experimental results. If not carried out in an open environment, cross-contamination is likely to occur during the reagent transfer process, thereby affecting the detection accuracy. Content of the Utility Model

[0003] The purpose of the utility model is to provide a sample detection cartridge to solve the technical problem that sample processing is easily contaminated.

[0004] To achieve the above purpose, the utility model provides a sample detection cartridge, which includes:

[0005] A base, provided with a card hole and a plurality of storage bins, the plurality of storage bins are arranged on the outer periphery of the card hole, and an outer seal is sleeved outside the base;

[0006] A sample adding cover, rotatably covering the base, a sample adding hole communicating with the outside is formed on the sample adding cover, the sample adding cover is used to communicate with the plurality of storage bins, a buckle penetrating through the card hole is arranged on the sample adding cover, the buckle is in sealing cooperation with the card hole through an inner seal, and the inner side wall of the sample adding cover is in sealing cooperation with the base through the outer seal.

[0007] In an embodiment of the utility model, the sample detection cartridge further includes a sealing gasket, the sealing gasket covers the base and is provided with avoiding notches corresponding to the card hole and the storage bins.

[0008] In an embodiment of the utility model, the sample detection cartridge further includes a sample adding sealing ring arranged on the sample adding cover, the sample adding sealing ring is coaxially arranged with the sample adding hole, a hole cover is further covered on the sample adding hole, and the hole cover extending into the sample adding hole is in sealing cooperation with the sample adding hole through the sample adding sealing ring.

[0009] In an embodiment of the utility model, the outer seal and the inner seal are arranged at different heights on the base.

[0010] In the embodiment of the utility model, a movement slot is provided at the top of the sample adding cover, the movement slot penetrates the sample adding cover radially, and an opening for the sample mixing device to extend into is provided on a side of the movement slot away from the base.

[0011] In an embodiment of the present utility model, the motion card slot includes:

[0012] An insertion section, wherein the opening is arranged at the top end of the insertion section;

[0013] The limiting section is connected to the bottom end of the inserting section, the cross-sectional dimension of the inserting section is smaller than the cross-sectional dimension of the limiting section, and the bottom surface of the inserting section is used to abut against the limiting sample mixing device.

[0014] In an embodiment of the utility model, guide slopes are provided at both ends of the groove side walls of the insertion section and the limiting section along the length direction. The guide slopes are inclined from the outer side of the sample loading cover toward the groove side walls. The guide slopes are used to guide the sample mixing device into the motion card slot.

[0015] In an embodiment of the utility model, a magnetic attraction member for absorbing magnetic beads is arranged on the sample adding cover, a magnetic attraction hole is arranged on one side of the sample adding cover facing the base, and the magnetic attraction member is sealed in the magnetic attraction hole.

[0016] In an embodiment of the utility model, a pipetting hole is further provided on one side of the sample adding cover facing the base, and one end of the pipetting hole is open and used for receiving the storage bin.

[0017] In an embodiment of the utility model, a clamping block is provided on the side of the buckle away from the sample loading cover. There are multiple clamping blocks which are arranged on the buckle at intervals along the circumferential direction, and an avoidance gap is formed between any two adjacent clamping blocks.

[0018] Through the above technical solution, the sample detection cartridge provided by the embodiment of the utility model has the following beneficial effects:

[0019] The sample detection card box in this embodiment includes a base and a sample loading cover, the sample loading cover can be rotatably covered on the base, the sample loading cover is provided with a sample loading hole, the base is provided with a clamping hole and multiple storage bins, multiple storage bins are provided around the outer periphery of the clamping hole, the sample loading cover rotates relative to the base and docks with the multiple storage bins on the base, and the solution in the sample loading cover is mixed with the sample processing material in the storage bin. The sample loading cover is provided with a buckle that passes through the clamping hole, and the buckle is sealed with the clamping hole through an inner seal. Further, the base jacket is provided with an outer seal, and the inner side wall of the sample loading cover is sealed with the base through an outer seal. This embodiment ensures that the sample is always in a closed sample detection card box during the sample processing process by providing an inner seal and an outer seal, and will not be exposed to the external environment, which can avoid the situation where the sample is contaminated by the external environment during the sample processing process.

[0020] Other features and advantages of the embodiments of the present utility model will be described in detail in the subsequent specific implementation section. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings are used to provide a further understanding of the embodiments of the present utility model, and constitute a part of the specification. Together with the following specific implementation, they are used to explain the embodiments of the present utility model, but do not constitute a limitation to the embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on the structures shown in these drawings. In the drawings:

[0022] Figure 1 is a schematic structural diagram of a sample detection cartridge according to the present utility model;

[0023] Figure 2 is a schematic structural diagram of a sample addition cover from one perspective according to the present utility model;

[0024] Figure 3 is a schematic structural diagram of the sample addition cover from another perspective according to the present utility model;

[0025] Figure 4 is a schematic structural diagram of a base according to the present utility model.

[0026] DESCRIPTION OF THE REFERENCE NUMERALS

[0027] 1 Base 232 Limiting section

[0028] 11 Card hole 233 Guide inclined surface

[0029] 12 Storage bin 24 Magnetic attraction hole

[0030] 13 Placement limiting groove 25 Pipetting hole

[0031] 14 Rotation limiting groove 26 Rotation protrusion

[0032] 15 In-place limiting groove 27 Limiting protrusion

[0033] 2 Sample addition cover 3 Outer seal

[0034] 21 Sample addition hole 4 Inner seal

[0035] 22 Buckle 5 Sealing gasket

[0036] 23 Movement card slot 6 Hole cover

[0037] 231 Insertion section SPECIFIC IMPLEMENTATION

[0038] The following will describe in detail the specific embodiments of the present utility model in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only for explaining and illustrating the present utility model, and are not used to limit the present utility model.

[0039] The following describes a sample detection cartridge according to the present utility model with reference to the accompanying drawings.

[0040] As Figure 1 shown, in this embodiment, a sample detection cartridge is proposed. The sample detection cartridge includes a base 1 and a sampling cover 2. A card hole 11 and a plurality of storage bins 12 are provided on the base 1. The plurality of storage bins 12 are arranged around the outer periphery of the card hole 11. An outer seal 3 is sleeved outside the base 1. The sampling cover 2 is rotatably covered on the base 1. A sampling hole 21 communicating with the outside is formed on the sampling cover 2. The sampling cover 2 is used to communicate with the plurality of storage bins 12. A buckle 22 passing through the card hole 11 is provided on the sampling cover 2. The buckle 22 is in sealing cooperation with the card hole 11 through an inner seal 4. The inner side wall of the sampling cover 2 is in sealing cooperation with the base 1 through the outer seal 3.

[0041] It should be noted that the sample detection cartridge in this embodiment can be used for nucleic acid detection, such as a nucleic acid extraction cartridge for magnetic bead extraction of nucleic acid. The plurality of storage bins 12 can be storage spaces containing different reaction solutions or enzymes for reacting with nucleic acids. The sample mixing device can adopt a rotating mechanism and a flipping mechanism in the prior art, which can drive the sampling cover 2 to rotate relative to the base 1 and can also drive the entire sample detection cartridge to flip back and forth in the vertical direction.

[0042] The sample detection cartridge in this embodiment includes a base 1 and a sampling cover 2. The sampling cover 2 is rotatably covered on the base 1. A sampling hole 21 is provided on the sampling cover 2, and a card hole 11 and a plurality of storage bins 12 are provided on the base 1. A plurality of storage bins 12 are arranged in a peripheral ring around the card hole 11. The sampling cover 2 rotates relative to the base 1 and is sequentially docked and communicated with the plurality of storage bins 12 on the base 1, so that the solution in the sampling cover 2 is mixed with the sample treatment substance in the storage bin 12. A buckle 22 penetrating through the card hole 11 is provided on the sampling cover 2, and the buckle 22 is hermetically matched with the card hole 11 through an inner seal 4. Further, an outer seal 3 is sleeved outside the base 1, and the inner side wall of the sampling cover 2 is hermetically matched with the base 1 through the outer seal 3. By providing the inner seal 4 and the outer seal 3 in this embodiment, it is ensured that the sample detection cartridge is always in a closed state during the sample treatment process and will not be exposed to the external environment, and the situation that the sample is contaminated by the external environment during the sample treatment process can be avoided. Among them, an inner seal groove for placing the inner seal 4 is provided on the base 1, and an outer seal groove for placing the outer seal 3 is also provided, which can effectively limit the movement range of the inner seal 4 and the outer seal 3 and prevent the sampling cover 2 from driving the inner seal 4 and the outer seal 3 to roll and affecting the sealing effect between the sampling cover 2 and the base 1. Among them, driven by the sample mixing device, the sampling cover 2 and the base 1 can be turned over together and switched between the normal state and the turned-over state. In the normal state, the sampling cover 2 is located above the base 1, and in the turned-over state, the sampling cover 2 is located below the base 1, which improves the matching effect between the hole position on the sampling cover 2 and the storage bin 12 on the base 1 and facilitates the tight docking of the hole position and the storage bin 12.

[0043] As Figure 4 shown, in this embodiment, the sample detection cartridge further includes a gasket 5. The gasket 5 is covered on the base 1 and is provided with avoidance notches corresponding to the card hole 11 and the storage bins 12. Preferably, the gasket 5 can be integrally formed with the base 1, and the connection effect is good. The gasket 5 is made of rubber or silica gel and has a certain deformation ability, so that the docking seal effect between the pipetting hole 25 and the storage bin 12 is better, and the overflow of the sample treatment substance caused by the loose docking between the pipetting hole 25 and the storage bin 12 is avoided.

[0044] In this embodiment, the sample detection cartridge further includes a sampling sealing ring provided on the sampling cover 2. The sampling sealing ring is coaxially arranged with the sampling hole 21. A hole cover 6 is also covered on the sampling hole 21. The hole cover 6 extending into the sampling hole 21 is hermetically matched with the sampling hole 21 through the sampling sealing ring, further improving the sealing performance of the sample detection cartridge and ensuring that during the nucleic acid detection process, external contaminants will not enter the interior of the sample detection cartridge from the sampling hole 21. Among them, the inner seal 4, the outer seal 3 and the sampling sealing ring are all rubber sealing rings in the prior art.

[0045] In this embodiment, the outer seal 3 and the inner seal 4 are disposed at different heights on the base 1, so as to avoid excessive resistance when the sample adding cover 2 is assembled with the base 1 due to the same height settings of the outer seal 3 and the inner seal 4, which may cause difficulties in the snap connection between the sample adding cover 2 and the base 1, and the snap 22 is difficult to be closely and smoothly fitted with the snap hole 11, affecting the assembly efficiency of the sample adding cover 2 and the base 1 and the sealing effect of the sample detection cartridge.

[0046] As Figure 2 and Figure 3 shown, in one embodiment, a movement slot 23 is formed at the top of the sample adding cover 2. The movement slot 23 penetrates the sample adding cover 2 along the radial direction of the sample adding cover 2. An opening for the sample mixing device to extend into is formed on the side of the movement slot 23 facing away from the base 1, and the opening of the movement slot 23 also extends along the radial direction of the sample adding cover 2. This setting method can increase the length for the sample mixing device to extend into, enhancing the adaptability to the sample mixing device. Among them, the movement slot 23 extends along the radial direction, with a large contact area, facilitating the full contact between the sample mixing device and the movement slot 23 after the sample mixing device enters the movement slot 23, improving the stability of the fitting and snap connection between the sample mixing device and the movement slot 23. Moreover, the movement slot 23 is located at the top of the sample adding cover 2, facilitating the connection operation of the sample mixing device and effectively improving the operation efficiency of reagent mixing.

[0047] In another embodiment, the opening on the side of the movement slot 23 facing away from the base 1 does not extend along the radial direction of the sample adding cover 2. The sample mixing device can be inserted into the movement slot 23 through the open ends at both radial ends of the movement slot 23, and then a locking member is inserted through the opening to fix the sample mixing device, enhancing the stability of the fitting and snap connection between the sample mixing device and the movement slot 23.

[0048] As Figure 2 and Figure 3As shown, in this embodiment, the movement card slot 23 includes an insertion section 231 and a limiting section 232. The opening of the insertion section 231 is provided at the top end of the insertion section 231. The limiting section 232 communicates with the bottom end of the insertion section 231. The cross-sectional dimension of the insertion section 231 is smaller than that of the limiting section 232, and the bottom surface of the insertion section 231 is used to abut against the limiting sample mixing device. Among them, the sample mixing device can switch between a normal state and an expanded state. The width of the sample mixing device in the expanded state is greater than that in the normal state. During the process of the sample mixing device being adaptively clamped with the movement card, first, the sample mixing device in the normal state enters the limiting section 232 through the insertion section 231. At this time, the sample mixing device will switch from the normal state to the expanded state. Since the cross-sectional dimension of the insertion section 231 is smaller than that of the limiting section 232, the sample mixing device will be clamped in the limiting section 232 at this time, and the protrusions formed on the two sample adding covers 2 on both sides of the insertion section 231 cooperate to realize the limitation of the sample mixing device, ensuring the stability of the adaptive clamping of the sample mixing device and the movement card slot 23.

[0049] As Figure 2 and Figure 3 shown, in this embodiment, guiding inclined surfaces 233 are provided at both ends of the groove side walls of the insertion section 231 and the limiting section 232 along the length direction. The guiding inclined surfaces 233 are inclined from the outer side surface of the sample adding cover 2 towards the groove side wall. The guiding inclined surfaces 233 are used to guide the sample mixing device into the movement card slot 23. The guiding inclined surfaces 233 are used to guide the sample mixing device into the movement card slot 23. Among them, the sample mixing device can enter the movement card slot 23 either through the opening of the movement card slot 23 or through the open ends at both radial ends of the movement card slot 23. At this time, the guiding inclined surfaces 233 formed on the groove side walls of the insertion section 231 and the limiting section 232 can assist the sample mixing device to be efficiently positioned and inserted, which is beneficial to the sample mixing device smoothly entering the movement card slot 23.

[0050] In this embodiment, a magnetic attracting member for adsorbing magnetic beads is provided on the sample adding cover 2. A magnetic attracting hole 24 is provided on the side of the sample adding cover 2 facing the base 1. The magnetic attracting member is sealed in the magnetic attracting hole 24. Among them, a magnetic bead hole for accommodating magnetic beads is also provided on the base 1. First, by rotating the sample adding cover 2, the sample adding hole 21 is aligned with the magnetic bead hole, and nucleic acid substances are injected. Then, the sample adding cover 2 is rotated to adsorb magnetic beads through the magnetic attracting member, and the nucleic acid substances are attached to the magnetic beads. Then, the sample adding cover 2 is driven to rotate axially, so that the sample adding hole 21 is aligned with the storage bin 12. By using the magnetic attracting member to adsorb magnetic beads, and then continuing to rotate the sample adding cover 2 to realize the transfer of nucleic acid substances, so that the nucleic acid substances are transported through the magnetic attracting member and react with the reagents in multiple storage bins 12 on the base 1 in sequence, and finally the detection of nucleic acid substances is completed. Among them, the magnetic attracting member is a magnet in the prior art.

[0051] In another embodiment, a magnetic attraction hole 24 is provided on the side of the sampling cover 2 facing the base 1. A magnetic attraction member is sealed in the magnetic attraction hole 24, and the magnetic attraction hole 24 does not penetrate through the sampling cover 2. Preferably, the diameter of the magnetic attraction member is slightly smaller than the aperture of the magnetic attraction hole 24, and a filling gap is left between the magnetic attraction member and the magnetic attraction hole 24, and sealant can be injected into the filling gap. Thus, the magnetic attraction member is fixed in the magnetic attraction hole 24 by the sealant, ensuring the connection stability of the magnetic attraction member. Of course, the magnetic attraction member can also be fixed in the magnetic attraction hole 24 by interference fit, and any other method capable of fixing the magnetic attraction member can be used. Among them, the diameter of the magnetic attraction member matches the diameter of the storage bin 12.

[0052] As Figure 3 shown, in this embodiment, a pipetting hole 25 is also formed on the side of the sampling cover 2 facing the base 1. One end of the pipetting hole 25 is open and used to receive the storage bin 12. Similarly, the pipetting hole 25 does not penetrate through the sampling cover 2. The pipetting hole 25 is used to transfer the liquid in the storage bin 12. After the pipetting hole 25 is docked with the storage bin 12, the sample detection cartridge is flipped by the sample mixing device. At this time, the base 1 is above the sampling cover 2, so that the liquid in the storage bin 12 flows into the pipetting hole 25. At this time, the sample mixing device drives the sampling cover 2 to rotate relative to the cartridge until it is docked with another storage bin 12. After the liquids in all the storage bins 12 are mixed in sequence, the sample detection cartridge is flipped by the sample mixing device again. At this time, the sampling cover 2 is above the base 1. Of course, the sample detection cartridge can be flipped multiple times during the mixing process of the liquid in the storage bin 12 and the pipetting hole 25 to ensure that the liquids in the storage bin 12 and the pipetting hole 25 can be fully mixed.

[0053] As Figure 2 and Figure 3 shown, in this embodiment, the centers of the pipetting hole 25, the sampling hole 21, and the magnetic attraction hole 24 on the sampling cover 2 are located on the same radius arc. The pipetting hole 25, the sampling hole 21, and the magnetic attraction hole 24 are arranged circumferentially on the sampling cover 2 and are arranged around the outer periphery of the buckle 22. The sampling hole 21 is arranged between the magnetic attraction hole 24 and the pipetting hole 25. The docking of the pipetting hole 25, the sampling hole 21, and the magnetic attraction hole 24 with the storage bin 12 on the base 1 can be achieved only by rotation operation. Other arrangement methods of the pipetting hole 25, the sampling hole 21, and the magnetic attraction hole 24 can also be adjusted accordingly according to the arrangement of the magnetic bead holes and the storage bins 12 on the base 1. Moreover, the distance between the magnetic attraction hole 24 and the pipetting hole 25 is set corresponding to the distance between different storage bins 12 on the base 1, and the distance between the sampling hole 21 and the magnetic attraction hole 24 can also be adjusted according to the distance between the magnetic bead holes and the storage bins 12 on the base 1.

[0054] Among them, a limiting protrusion 27 is also formed on the side wall surface of the sample cover 2, and the limiting protrusion 27 is arranged corresponding to the magnetic hole 24. The limiting protrusion 27, the magnetic hole 24 and the center of the sample cover 2 are located on the same straight line. The limiting protrusion 27 is used to slide and cooperate with the rotating rail provided on the side wall of the base 1, so that the sample cover 2 can rotate more stably relative to the base 1 under the drive of the sample mixing device. The base 1 is also provided with a positioning limit groove 15, which can effectively determine the positioning of the sample detection cartridge on the external adjustment instrument. Furthermore, the bottom of the base 1 is also provided with a placement limit groove 13, which extends radially along the base 1 and the placement openings arranged radially at both ends of the placement limit groove 13 are of different sizes, which can assist in determining whether the placement position of the sample detection cartridge is correct.

[0055] like Figure 1 and Figure 2 As shown, in this embodiment, the moving card slot is arranged in the middle of the sample loading cover 2 and the sample loading cover 2 is divided into two top cover parts of the same shape. The pipetting hole 25, the sample loading hole 21 and the magnetic suction hole 24 are all arranged on the top cover part on either side of the moving card slot 23. The layout is compact, which improves the space utilization rate of the sample loading cover 2. Among them, the base 1 is also provided with a rotation limit slot 14, and a rotation protrusion 26 is formed on the side wall of the sample loading cover 2. The rotation protrusion 26 is used to cooperate with the rotation limit slot 14 and a notch is arranged above the rotation protrusion 26. The notch allows the rotation protrusion 26 to deform elastically so as to better cooperate with the rotation limit slot 14, so that the rotation protrusion 26 is not easy to slide after being engaged with the rotation limit slot 14, which can effectively limit the technical problem that the sample loading cover 2 of the sample detection cartridge is easy to rotate relative to the base 1 after leaving the factory.

[0056] like Figure 3 As shown, in this embodiment, a clamping block is provided on the side of the buckle 22 away from the sample loading cover 2, and the number of the clamping blocks is multiple and arranged on the buckle 22 at intervals along the circumferential direction, and an escape gap is formed between any two adjacent clamping blocks. When the buckle 22 is inserted into the clamping hole 11, the clamping block is squeezed and deformed by the wall of the clamping hole 11, so that the escape gap between the clamping blocks is compressed and reduced. At this time, the tension generated by the deformation of the clamping block can make the buckle 22 better seal with the clamping hole 11, thereby improving the locking effect of the sample loading cover 2 and the base 1. Among them, a protrusion is also provided on the side of the clamping block away from the sample loading cover 2, which can further improve the locking effect of the buckle 22 and the clamping hole 11, and a guide surface is provided on the protrusion, and the guide surface is gradually set from the side close to the sample loading cover 2 to the side away from the sample loading cover 2, so as to improve the sealing effect of the buckle 22 and the clamping hole 11.

[0057] In the description of the present utility model, it should be understood that the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present utility model, the meaning of "a plurality" is at least two, such as two, three, etc., unless otherwise specifically defined.

[0058] In the present utility model, unless otherwise clearly specified and defined, terms such as "installed", "connected", "coupled", "fixed", etc. shall be construed in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection, an electrical connection, or communicable with each other; it may be directly connected, or indirectly connected through an intermediate medium, and may be the communication inside two elements or the interaction relationship between two elements, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0059] In the description of this specification, the description with reference to terms such as "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present utility model. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0060] Although the embodiments of the present utility model have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present utility model. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present utility model.

Claims

1. A sample detection cartridge, characterized in that: The sample detection cartridge comprises: A base (1) is provided with a clamping hole (11) and a plurality of storage bins (12), wherein the plurality of storage bins (12) are arranged on the outer periphery of the clamping hole (11), and an outer seal (3) is provided on the outer cover of the base (1); A sample loading cover (2) is rotatably covered on the base (1); a sample loading hole (21) communicating with the outside is formed on the sample loading cover (2); the sample loading cover (2) is used to communicate with a plurality of storage bins (12); a buckle (22) penetrating the buckle hole (11) is provided on the sample loading cover (2); the buckle (22) is sealed with the buckle hole (11) through an inner sealing member (4); and the inner side wall of the sample loading cover (2) is sealed with the base (1) through the outer sealing member (3).

2. The sample detection cartridge according to claim 1, characterized in that: The sample detection card box further comprises a sealing gasket (5), wherein the sealing gasket (5) is covered on the base (1) and is provided with avoidance notches corresponding to the card hole (11) and the storage compartment (12).

3. The sample detection cartridge according to claim 1, characterized in that: The sample detection card box further comprises a sample loading sealing ring arranged on the sample loading cover (2), the sample loading sealing ring being coaxially arranged with the sample loading hole (21), the sample loading hole (21) being also covered with a hole cover (6), the hole cover (6) extending into the sample loading hole (21) being sealed and matched with the sample loading hole (21) through the sample loading sealing ring.

4. The sample detection cartridge according to claim 1, characterized in that: The outer sealing component (3) and the inner sealing component (4) are arranged at different heights on the base (1).

5. The sample detection cartridge according to any one of claims 1 to 4, characterized in that: The top of the sample loading cover (2) is provided with a movement slot (23), the movement slot (23) radially penetrates the sample loading cover (2), and a side of the movement slot (23) facing away from the base (1) is provided with an opening for a sample mixing device to extend into.

6. The sample detection cartridge according to claim 5, characterized in that: The motion card slot (23) comprises: An insertion section (231), wherein the opening is arranged at a top end of the insertion section (231); A limiting section (232), wherein the limiting section (232) is connected to the bottom end of the inserting section (231), the cross-sectional dimension of the inserting section (231) is smaller than the cross-sectional dimension of the limiting section (232), and the bottom surface of the inserting section (231) is used to abut against and limit the sample mixing device.

7. The sample detection cartridge according to claim 6, characterized in that: Both ends of the slot sidewalls of the insertion section (231) and the limiting section (232) along the length direction are provided with guiding inclined surfaces (233), the guiding inclined surfaces (233) being arranged obliquely from the outer side of the sample loading cover (2) toward the slot sidewall, and the guiding inclined surfaces (233) are used to guide the sample mixing device into the moving slot (23).

8. The sample detection cartridge according to any one of claims 1 to 4, characterized in that: The sample loading cover (2) is provided with a magnetic attraction component for absorbing magnetic beads, and a magnetic attraction hole (24) is provided on a side of the sample loading cover (2) facing the base (1), and the magnetic attraction component is sealed in the magnetic attraction hole (24).

9. The sample detection cartridge according to claim 8, characterized in that: The sample loading cover (2) is also provided with a transfer hole (25) on one side facing the base (1), and one end of the transfer hole (25) is open and is used for docking with the storage bin (12).

10. The sample detection cartridge according to any one of claims 1 to 4, characterized in that: A clamping block is provided on one side of the clamp (22) away from the sample loading cover (2); the clamping blocks are multiple and are arranged on the clamp (22) at intervals along the circumferential direction; and an escape gap is formed between any two adjacent clamping blocks.

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