Filling device for nalbuphine hydrochloride injection

Abstract

The utility model relates to the technical field of medicine processing, in particular to a nalbuphine hydrochloride injection filling device which comprises a base, an integrally-formed top plate is arranged at the upper end of the base, a first cylinder body is arranged above the top plate, and the outer wall face of the first cylinder body is fixedly assembled with the surface of the top plate through a support. A first piston rod used for stretching out and drawing back is arranged in the first cylinder body. Liquid medicine can be conveyed and supplied through the liquid medicine pump, filling of a plastic bottle or a glass bottle can be achieved through the bottle filling connector, and filling of small-size ampoules and other micro-bottle containers can be achieved by additionally arranging the ampoule filling connector at the position of the bottle filling connector. The ampoule filling connector and the bottle filling connector are installed through the threaded column and the threaded cap, rapid splicing can be achieved, rapid operation of workers is facilitated, and the working efficiency during replacement is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medicine processing, in particular to a filling device for nalbuphine hydrochloride injection. Background Art

[0002] Nalbuphine hydrochloride injection is a pharmaceutical preparation containing nalbuphine, which is commonly used for pain management in medical settings. Nalbuphine is an opioid drug that has analgesic effects, but also has anti-androgen and anti-gonadotropin effects.

[0003] The mechanism of action of this drug is mainly through binding to opioid receptors in the central nervous system, inhibiting the transmission of pain signals.

[0004] It has both μ-opioid receptor antagonism and κ-opioid receptor agonism, so its effect is relatively complex. It can relieve pain and has a certain potential to prevent dependence.

[0005] Nalbuphine hydrochloride injection is generally administered by intramuscular injection or intravenous injection. The doctor will decide the dosage and method of administration based on the patient's specific condition.

[0006] During use, medical staff will pay close attention to possible side effects of patients, such as respiratory depression, nausea, vomiting, itching, etc., and take appropriate measures.

[0007] Nalbuphine hydrochloride injection is a pharmaceutical preparation mainly used for analgesic treatment. Its filling device usually involves the filling production line of the pharmaceutical industry. This type of equipment is designed to ensure that the pharmaceutical preparation is accurately and safely dispensed into individual syringes or other containers.

[0008] At present, in some small-scale production lines of nalbuphine hydrochloride solution, since the sizes of containers containing the solution are different and the filling structure of such small-scale production lines is relatively simple, when filling different containers, the filling joints and corresponding infusion pipelines need to be completely disassembled and replaced, which is time-consuming and labor-intensive. Frequent disassembly and assembly can easily cause loss of sealing of joints and pipelines. Utility Model Content

[0009] The purpose of the utility model is to solve the above-mentioned shortcomings in the prior art and to propose a filling device for nalbuphine hydrochloride injection.

[0010] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0011] A filling device for nalbuphine hydrochloride injection is designed, comprising a base, an integrally formed top plate is arranged at the upper end of the base, a first cylinder is arranged above the top plate, and the outer wall surface of the first cylinder is fixedly assembled with the surface of the top plate through a bracket, a first piston rod for extension is arranged inside the first cylinder, and the end of the first piston rod extends outward through the interior of the first cylinder, a support plate is arranged at the end of the first piston rod, and the upper end surface of the support plate is fixedly assembled with the end of the first piston rod through screws, a bottle filling interface is arranged at the lower end surface of the support plate, and the bottle The upper end of the filling interface is fixedly assembled with the surface of the first support plate by screws, the port position of the bottle filling interface is slidably sleeved with an ampoule filling interface, a feeding interface is also penetrated through one side of the bottle filling interface, and the connection position of the feeding interface and the bottle filling interface is fixed by welding, a medicine liquid pump is arranged on the lower end surface of the top plate, and the shell surface of the medicine liquid pump is fixedly assembled with the surface of the top plate by screws, the liquid outlet position of the medicine liquid pump is connected with the feeding interface by a rubber hose, and the two ends of the rubber hose are flange-jointed with the liquid outlet of the medicine liquid pump and the feeding interface respectively.

[0012] In detail, an integrally formed workbench is arranged on the front of the base, and a plurality of groups of roller supports are arranged on the upper end of the workbench. The outer ring wall of the roller support is fixedly assembled with the surface of the workbench by screws.

[0013] In detail, a conveyor belt roller is arranged between the roller shaft brackets located in the same group, the shaft core of the conveyor belt roller is rotatably arranged with the shaft groove of the roller shaft bracket, the roller shaft bracket is divided into a single driving roller shaft bracket and several groups of linked roller shaft brackets, the conveyor belt roller is divided into a single driving conveyor belt roller and several linked conveyor belt rollers, the linked shaft core of the linked conveyor belt roller is rotatably arranged with the linked shaft groove of the corresponding linked roller shaft bracket, the driving shaft core of the driving conveyor belt roller is rotatably arranged with the driving shaft groove of the driving roller shaft bracket, and the surfaces of the single driving conveyor belt roller and several linked conveyor belt rollers pass through the conveyor belt body.

[0014] In detail, a motor is provided at one end of the workbench, and the outer wall surface of the motor is fixedly assembled with the surface of the workbench through a bracket, and a rotating shaft for driving is provided inside the motor, and the end of the rotating shaft passes through the interior of the motor and extends outward, and the driving shaft core of the driving conveyor belt roller passes through the inner wall of the driving shaft groove of the driving roller shaft bracket distributed on one side and extends outward, and its extended end is fixedly assembled with the rotating shaft of the motor through a coupling.

[0015] In detail, extension plates are welded on both sides of the bottle filling interface, and threaded columns are welded and fixed on the lower ends of the extension plates. Rings are welded on both sides of the ampoule filling interface, and the surface of the threaded column passes through the interior of the ring and extends downward.

[0016] In detail, the lower end of the threaded column is covered with a threaded cap, the end face of the threaded cap is tightly arranged with the end face of the collar, and the internal threaded surface of the threaded cap and the external threaded surface of the threaded column are threadedly connected with each other.

[0017] In detail, a plate frame is fixedly assembled on one side of the workbench by screws, a second cylinder body is distributed on one side surface of the plate frame and a side surface symmetrical to the workbench and the plate frame, and one end of the second cylinder body is fixedly assembled to the corresponding workbench surface and plate frame surface by screws.

[0018] In detail, a second piston rod for extension and retraction is arranged inside the second cylinder body, and the end of the second piston rod extends outward through the interior of the second cylinder body. A limiting plate is arranged at the other end of the second piston rod. The surface of the limiting plate is fixedly assembled with the end of the second piston rod by screws, and the limiting plates are arranged in parallel on both sides.

[0019] The design scheme proposed by the utility model has the following beneficial effects during application:

[0020] 1. The liquid medicine can be delivered and supplied through the liquid medicine pump, and the filling of plastic bottles or glass bottles can be realized through the bottle filling interface. By adding an ampoule filling interface at the position of the bottle filling interface, small-volume ampoules and other micro-bottle containers can be filled. The ampoule filling interface and the bottle filling interface adopt the installation method of threaded column and threaded cap, which can realize quick splicing, facilitate workers' quick operation, and improve work efficiency during replacement.

[0021] 2. The conveyor belt can be driven by the motor to transport the filled containers normally. The limit plates set at the front and rear can stabilize the front and rear positions of the containers during movement. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0023] Figure 2 It is a schematic diagram of the overall structure of the utility model in an oblique top view;

[0024] Figure 3 It is an enlarged schematic diagram of point a of the utility model;

[0025] Figure 4 It is an enlarged schematic diagram of point b of the utility model;

[0026] Figure 5 It is a front structural schematic diagram of the utility model.

[0027] In the figure: 10, base; 11, top plate; 12, first cylinder; 13, first piston rod; 14, support plate; 15, bottle filling interface; 16, ampoule filling interface; 17, feeding interface; 18, rubber hose; 19, liquid medicine pump; 20, workbench; 21, roller bracket; 22, conveyor belt roller; 23, conveyor belt body; 24, motor; 30, threaded column; 31, collar; 32, threaded cap; 40, plate frame; 41, second cylinder; 42, second piston rod; 43, limit plate. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0029] Reference Figure 1-Figure 5 A filling device for nalbuphine hydrochloride injection includes a base 10, an upper end of the base 10 is provided with an integrally formed top plate 11, a first cylinder 12 is provided above the top plate 11, and the outer wall surface of the first cylinder 12 is fixedly assembled with the surface of the top plate 11 through a bracket, a first piston rod 13 for telescopic operation is provided inside the first cylinder 12, and the end of the first piston rod 13 extends outward through the inside of the first cylinder 12, a support plate 14 is provided at the end of the first piston rod 13, and the upper end surface of the support plate 14 is fixedly assembled with the end of the first piston rod 13 through screws, a bottle filling interface 15 is provided at the lower end surface of the support plate 14, and the bottle filling interface 15 is provided at the lower end surface of the support plate 14. The upper end of the interface 15 is fixedly assembled with the surface of the first support plate 14 by screws, the port position of the bottle filling interface 15 is slidably sleeved with an ampoule filling interface 16, and a feeding interface 17 is also penetrated through one side of the bottle filling interface 15, and the connection position of the feeding interface 17 and the bottle filling interface 15 is fixed by welding, and a liquid medicine pump 19 is provided on the lower end surface of the top plate 11, and the shell surface of the liquid medicine pump 19 is fixedly assembled with the surface of the top plate 11 by screws, and the liquid outlet position of the liquid medicine pump 19 is connected with the feeding interface 17 through a rubber hose 18, and the two ends of the rubber hose 18 are flange-jointed with the liquid outlet of the liquid medicine pump 19 and the feeding interface 17 respectively.

[0030] It should be further explained that an integrally formed workbench 20 is disposed on the front of the base 10 , and a plurality of roller brackets 21 are disposed on the upper end of the workbench 20 . The outer ring wall of the roller bracket 21 is fixedly assembled with the surface of the workbench 20 by screws.

[0031] It should be further explained that a conveyor belt roller 22 is arranged between the roller bracket 21 in the same group, the axis core of the conveyor belt roller 22 is rotatably arranged with the axis groove of the roller bracket 21, the roller bracket 21 is divided into a single driving roller bracket and several groups of linked roller brackets, the conveyor belt roller 22 is divided into a single driving conveyor belt roller and several linked conveyor belt rollers, the linked axis core of the linked conveyor belt roller is rotatably arranged with the linked axis groove of the corresponding linked roller bracket, the driving axis core of the driving conveyor belt roller is rotatably arranged with the driving axis groove of the driving roller bracket, and the surfaces of the single driving conveyor belt roller and several linked conveyor belt rollers pass through a conveyor belt body 23.

[0032] It should be further explained that a motor 24 is provided at one end of the workbench 20, and the outer wall surface of the motor 24 is fixedly assembled with the surface of the workbench 20 through a bracket, and a rotating shaft for driving is provided inside the motor 24, and the end of the rotating shaft passes through the interior of the motor 24 and extends outward, and the driving shaft core of the driving conveyor roller passes through the inner wall of the driving shaft groove of the driving roller shaft bracket distributed on one side and extends outward, and its extended end is fixedly assembled with the rotating shaft of the motor 24 through a coupling. The motor 24 is a servo motor, which is the same as the two cylinders, and the numerical control coordination of PLC programming is realized through the controller, so that the medicine can be stably filled into the container during filling.

[0033] It should be further explained that extension plates are welded on both sides of the bottle filling interface 15, and a threaded column 30 is welded and fixed on the lower end of the extension plate. Rings 31 are welded on both sides of the ampoule filling interface 16, and the surface of the threaded column 30 passes through the interior of the ring 31 and extends downward.

[0034] It should be further explained that the lower end of the threaded column 30 is covered with a threaded cap 32, the end face of the threaded cap 32 is tightly set with the end face of the ring 31, and the internal thread surface of the threaded cap 32 and the external thread surface of the threaded column 30 are threadedly connected with each other, which can facilitate the quick assembly and disassembly of the two filling interfaces when the container size is changed.

[0035] It should be further explained that a plate frame 40 is fixedly assembled on one side of the workbench 20 by screws, and a second cylinder body 41 is distributed on one side surface of the plate frame 40 and a side surface symmetrical to the workbench 20 and the plate frame 40. One end of the second cylinder body 41 is fixedly assembled to the corresponding surface of the workbench 20 and the surface of the plate frame 40 by screws. The first cylinder body 12 and the second cylinder body 41 are both servo electric cylinders. The servo electric cylinder is usually used in conjunction with a servo motor to achieve high-precision position control, speed control and torque control, and is widely used in the field of industrial automation. The servo electric cylinder can achieve very precise displacement control and is suitable for applications that require precise positioning. Due to the fast response characteristics of the servo motor, the servo electric cylinder also has the ability to respond quickly. The servo electric cylinder can easily achieve forward and reverse motion and has good reversibility.

[0036] It should be further explained that a second piston rod 42 for extension and retraction is provided inside the second cylinder body 41, and the end of the second piston rod 42 extends outward through the interior of the second cylinder body 41, and a limiting plate 43 is provided at the other end of the second piston rod 42. The surface of the limiting plate 43 is fixedly assembled with the end of the second piston rod 42 by screws, and the limiting plates 43 are arranged in parallel on both sides. The limiting plates 43 distributed front and back can protect the front and back positions when the container is transported to prevent it from falling from the conveying mechanism.

[0037] Working method: When it is necessary to fill various containers of nalbuphine hydrochloride, firstly, based on the traditional production line, the two ends of the conveyor belt body 23 will be connected to another set of conveyor belts, so that the long-distance transportation of the filled containers can be realized. The second piston rod 42 of the second cylinder body 41 is extended and retracted, so that the two limit plates 43 can move in opposite directions, so that they can be positioned and slid forward and backward when passing through the conveyor belt body 23 (in the traditional filling production line, the containers are closely connected to each other and wait for filling, so there is no need to consider the stability of the front and rear positions). Through the drive of the motor 24, the motor 24 can move the conveyor belt body 23 to realize the transportation of the containers.

[0038] Under the setting of PLC programming, the container moves to the bottom of the bottle filling interface 15 or the ampoule filling interface 16 at a fixed point in the container interval, and the upper and lower heights of the filling interface can be adjusted by retracting the first piston rod 13 of the first cylinder body 12. The drug liquid can be transported by the drug liquid pump 19, and can be delivered into the filling interface with the rubber hose 18.

[0039] When the ampoule filling interface 16 needs to be disassembled, the threaded cap 32 is rotated to separate the threaded cap 32 from the threaded column 30, so that the collar 31 and the threaded column 30 can be disengaged, thereby quickly assembling and disassembling the two filling interfaces.

[0040] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A filling device for nalbuphine hydrochloride injection, comprising a base (10), characterized in that: An integrally formed top plate (11) is provided at the upper end of the base (10), a first cylinder (12) is provided above the top plate (11), and an outer wall surface of the first cylinder (12) is fixedly assembled with a surface of the top plate (11) via a bracket, a first piston rod (13) for telescopic movement is provided inside the first cylinder (12), and an end of the first piston rod (13) extends outward through the interior of the first cylinder (12), a support plate (14) is provided at the end of the first piston rod (13), and an upper end surface of the support plate (14) is fixedly assembled with the end of the first piston rod (13) via screws, a bottle filling interface (15) is provided at the lower end surface of the support plate (14), and an upper end of the bottle filling interface (15) is connected to the first support plate (14). The surface of the support plate (14) is fixedly assembled by screws, the port position of the bottle filling interface (15) is slidably sleeved with an ampoule filling interface (16), a feeding interface (17) is also provided through one side of the bottle filling interface (15), and the connection position of the feeding interface (17) and the bottle filling interface (15) is fixed by welding, the lower end surface of the top plate (11) is provided with a liquid medicine pump (19), and the shell surface of the liquid medicine pump (19) is fixedly assembled with the surface of the top plate (11) by screws, the liquid outlet position of the liquid medicine pump (19) is connected to the feeding interface (17) by a rubber hose (18), and the two ends of the rubber hose (18) are flange-jointed with the liquid outlet of the liquid medicine pump (19) and the feeding interface (17) respectively.

2. A filling device for nalbuphine hydrochloride injection according to claim 1, characterized in that: An integrally formed workbench (20) is arranged on the front side of the base (10), and a plurality of groups of roller supports (21) are arranged on the upper end of the workbench (20). The outer ring wall of the roller supports (21) is fixedly assembled with the surface of the workbench (20) by means of screws.

3. A filling device for nalbuphine hydrochloride injection according to claim 2, characterized in that: The roller shaft bracket (21) is located in the same group and a conveyor belt roller (22) is arranged between the roller shaft bracket (21), the shaft core of the conveyor belt roller (22) is rotatably arranged with the shaft groove of the roller shaft bracket (21), the roller shaft bracket (21) is divided into a single driving roller shaft bracket and a plurality of groups of linkage roller shaft brackets, the conveyor belt roller (22) is divided into a single driving conveyor belt roller and a plurality of linkage conveyor belt rollers, the linkage shaft core of the linkage conveyor belt roller is rotatably arranged with the linkage shaft groove of the corresponding linkage roller shaft bracket, the driving shaft core of the driving conveyor belt roller is rotatably arranged with the driving shaft groove of the driving roller shaft bracket, and the surfaces of the single driving conveyor belt roller and the plurality of linkage conveyor belt rollers pass through a conveyor belt body (23).

4. A filling device for nalbuphine hydrochloride injection according to claim 3, characterized in that: A motor (24) is provided at one end of the workbench (20), the outer wall surface of the motor (24) is fixedly assembled with the surface of the workbench (20) via a bracket, a rotating shaft for driving is provided inside the motor (24), the end of the rotating shaft passes through the inside of the motor (24) and extends outwardly, the driving shaft core of the driving conveyor belt roller passes through the inner wall of the driving shaft groove of the driving roller shaft bracket distributed on one side and extends outwardly, and the extended end is fixedly assembled with the rotating shaft of the motor (24) via a coupling.

5. A filling device for nalbuphine hydrochloride injection according to claim 4, characterized in that: Extension plates are welded on both sides of the bottle filling interface (15), and threaded columns (30) are welded and fixed at the lower ends of the extension plates. Rings (31) are welded on both sides of the ampoule filling interface (16), and the surface of the threaded column (30) penetrates the interior of the ring (31) and extends downward.

6. A filling device for nalbuphine hydrochloride injection according to claim 5, characterized in that: The lower end of the threaded column (30) is covered with a threaded cap (32), the end surface of the threaded cap (32) is tightly arranged with the end surface of the collar (31), and the internal thread surface of the threaded cap (32) and the external thread surface of the threaded column (30) are threadably connected to each other.

7. A filling device for nalbuphine hydrochloride injection according to claim 6, characterized in that: A plate frame (40) is fixedly mounted on one side of the workbench (20) by means of screws, a second cylinder body (41) is distributed on a surface of one side of the plate frame (40) and a surface of one side of the workbench (20) symmetrical to the plate frame (40), and one end of the second cylinder body (41) is fixedly mounted on the corresponding surface of the workbench (20) and the surface of the plate frame (40) by means of screws.

8. A filling device for nalbuphine hydrochloride injection according to claim 7, characterized in that: A second piston rod (42) for extension and retraction is arranged inside the second cylinder body (41), and the end of the second piston rod (42) extends outward through the interior of the second cylinder body (41). A limit plate (43) is arranged at the other end of the second piston rod (42). The surface of the limit plate (43) is fixedly assembled with the end of the second piston rod (42) by screws, and the limit plates (43) are arranged in parallel on both sides.

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