Kit and sample analyzer

Abstract

The utility model relates to a kit and a sample analyzer, relates to the technical field of biological detection devices, and is used for solving the problems that the unsealing operation of the kit is complicated, and the time and energy of a user are wasted. The kit comprises a magnetic bead container used for containing a magnetic bead reagent; the kit main body is provided with a storage cavity and a through hole; the kit upper cover comprises a first upper cover and a second upper cover; the pre-opening structure is arranged on the kit upper cover and respectively corresponds to the storage cavity and the magnetic bead container; the sealing film is arranged on the kit upper cover and corresponds to the pre-opening structure, and the sealing film is used for sealing the storage cavity and the magnetic bead container; the sealing film and the pre-opening structure are arranged at an interval, and the pre-opening structure is separated from the magnetic bead reagent and the reagent through the sealing film. According to the utility model, a puncture part does not need to be independently arranged, and the sealing film can be directly punctured through the reagent obtaining device in a sealed environment for liquid extraction, so that the upper cover of the kit does not need to be operated before liquid extraction so as to drive the puncture part to puncture the sealing film.

Description

Technical Field

[0001] The utility model relates to the technical field of biological detection devices, in particular to a reagent kit and a sample analyzer. Background Art

[0002] The test kit is a carrier for biological sample detection reagents. Its structure needs to match the instrument. The cavity containing the magnetic particle reagent needs to be rotated and mixed with the reagent compartment of the sample analysis device. At the same time, after the test kit is opened, it also needs to have the function of preventing the liquid from volatilizing. In order to ensure the sealing of the test kit during transportation and the anti-evaporation after opening, the existing design usually adopts the following two methods:

[0003] Method 1: The upper cover of the test kit is provided with a cross-shaped anti-volatile puncture film made of silicone or TPE, and a tear-off film is heat-sealed on the puncture film. Before use, the customer tears off the tear-off film and then puts it into the reagent compartment for use. This method requires manual tearing of the sealing film, which is complicated and wastes the user's time and energy.

[0004] Method 2: The opening of the reagent box body is sealed with a sealing film, and the upper cover of the reagent box is provided with a cross-shaped anti-volatile puncture film, and a puncture portion is provided below the cross-shaped opening. Before the customer uses it, when the box cover and the box body are engaged, the puncture portion pierces the sealing film, and then the reagent box is placed in the reagent compartment for use. This method also requires manual unsealing of the reagent box, which also wastes the user's time and energy, and has high requirements for manual operation. The engagement needs to be in place, and the gap between the box cover and the box body is prone to cause the reagent to volatilize.

[0005] In other words, the test kit in the prior art has the problem of complicated unsealing operation, which wastes the user's time and energy. Utility Model Content

[0006] The utility model provides a reagent box and a sample analyzer, which are used to solve the problems of complicated unsealing operation of the reagent box and waste of user's time and energy.

[0007] The utility model provides a test kit, which is at least used for containing a magnetic bead reagent, and comprises:

[0008] The magnetic bead container is used to hold the magnetic bead reagent. The magnetic bead container has a transmission part, which is connected to the driving device of the reagent compartment to drive the magnetic bead container to rotate and mix;

[0009] The reagent kit body has a storage cavity for storing reagents and a through hole for inserting the magnetic bead container;

[0010] The reagent kit cover comprises a first cover and a second cover, wherein the first cover is sealed and connected to the top of the magnetic bead container, and the second cover is sealed and connected to the top of the storage cavity;

[0011] A pre-opening structure, which is arranged on the upper cover of the reagent kit and corresponds to the storage cavity and the magnetic bead container respectively; and

[0012] A sealing film is arranged on the upper cover of the reagent kit and is arranged corresponding to the pre-opening structure. The sealing film is used to seal the storage cavity and the magnetic bead container;

[0013] The sealing film and the pre-opening structure are spaced apart, and the pre-opening structure is separated from the magnetic bead reagent and the reagent by the sealing film.

[0014] In one embodiment, a mounting hole is provided on the upper cover of the test kit, and the pre-opening structure is a gasket adapted to the mounting hole. The gasket is arranged in the mounting hole, and its outer peripheral wall is sealedly connected to the inner peripheral wall of the mounting hole. A plurality of linear pre-openings are provided through the gasket along its axial direction, and the gasket material is silicone or injection molded elastomer.

[0015] In one embodiment, a placement cavity with a bottom opening is provided on one side of the reagent kit upper cover close to the reagent kit body, and a sealing film is provided at the bottom opening to seal the reagent in the reagent kit body.

[0016] In one embodiment, there is a vertical distance D between the sealing film and the pre-opening structure, and the vertical distance D enables the pre-opening structure to be expanded in the placement cavity.

[0017] In one embodiment, the vertical spacing D has a value range of 2 mm ≤ D ≤ 5 mm, or the thickness M of the sealing film has a value range of 0.01 mm ≤ M ≤ 0.06 mm, and the thickness N of the pre-opening structure has a value range of 0.6 mm ≤ N ≤ 1.5 mm.

[0018] In one embodiment, the sealing film comprises:

[0019] A heat seal layer, welded and sealed to the bottom opening; and

[0020] The sealing layer is arranged on the heat sealing layer, and is used to prevent the liquid in the storage cavity and the magnetic bead container from volatilizing.

[0021] In one embodiment, a limiting groove is provided on the second upper cover, and the storage cavity of the reagent kit body is plugged into and matched with the limiting groove.

[0022] In one embodiment, the reagent kit upper cover is sealed and welded to the reagent kit body.

[0023] In one embodiment, a plurality of storage cavities are disposed in the reagent kit body, and the second upper cover is simultaneously disposed on the plurality of storage cavities.

[0024] The utility model also provides a sample analyzer, comprising:

[0025] The above-mentioned kit;

[0026] The reagent obtaining device can open the pre-opening structure toward the sealing film and extend into the upper cover of the reagent box to pierce the sealing film, so as to obtain the reagent in the main body of the reagent box.

[0027] Compared with the prior art, the advantage of the utility model is that a pre-opening structure is provided on the upper cover of the reagent box. By utilizing the contraction function of the pre-opening structure, the reagent needle can penetrate and absorb the reagent under the action of a relatively small force, and the sealing of the reagent box for use after opening can be ensured to prevent the volatilization of the reagent. In the present application, there is no need to separately provide a puncture part, and the reagent needle in the sample analysis device can directly puncture the sealing film through the pre-opening structure to take the liquid after opening. In this way, the reagent box does not need to operate the upper cover of the reagent box before being placed in the reagent compartment for use, thereby improving the convenience of the use of the reagent box, thereby avoiding the problem of complicated unsealing operation of the reagent box in the prior art, wasting the user's time and energy, and at the same time simplifying the structure of the reagent box and saving its manufacturing cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The present invention will be described in more detail below based on embodiments and with reference to the accompanying drawings.

[0029] Figure 1 is a cross-sectional view of the reagent kit in Example 1 of the utility model;

[0030] Figure 2 yes Figure 1 A partial magnified view of the test kit;

[0031] Figure 3 yes Figure 1 A schematic diagram of the assembly relationship between the upper cover of one of the reagent kits and the pre-opening structure;

[0032] Figure 4 yes Figure 1 A schematic diagram of the three-dimensional structure of the reagent kit body;

[0033] Figure 5 yes Figure 1 A cross-sectional view of the reagent kit (the reagent kit cover is not shown);

[0034] Figure 6 yes Figure 1 A cross-sectional view of a cover of one of the reagent kits;

[0035] Figure 7 yes Figure 1 A cross-sectional view of another upper cover of a reagent kit;

[0036] Figure 8 yes Figure 1 Schematic diagram of the assembly relationship between a reagent kit cover, a pre-opening structure and a corresponding storage cavity.

[0037] Reference numerals:

[0038] 10. Kit main body; 11. Storage cavity; 12. Through hole; 20. Kit upper cover; 21. First upper cover; 22. Placement cavity; 23. Second upper cover; 30. Sealing film; 40. Pre-opening structure; 50. Magnetic bead container; 60. Limiting groove. Detailed implementation manner

[0039] The present utility model will be further described below in conjunction with the accompanying drawings.

[0040] It should be noted that the reagent acquisition device in this application uses a reagent needle. Of course, it is not limited thereto, and other reagent acquisition devices with a puncture function can also be used.

[0041] The present utility model provides a kit, which is applied to a sample analyzer and placed in the reagent bin of the sample analyzer for containing various reagents required for immunoassay. When the kit is used for the first time, the reagent needle of the sample analyzer can move above the reagent bin and extend into the kit in the reagent bin to pierce the sealing film 30 and aspirate the reagent. After the kit is used up, it is taken away and discarded by the user, and a new kit is replaced.

[0042] Through research, it is found that in the existing technology, when the mouth of the kit is sealed only by a sealing film, and the customer directly puts the kit into the reagent tray and uses it after the reagent needle pierces the sealing film. In order to prevent liquid volatilization, the puncture action will not cause a large crack in the film, only small holes will exist. This method has the following problems: 1. The small holes are too small, and after the reagent needle passes through, it fits tightly with the film. When aspirating the liquid, there is an air pressure difference inside and outside the kit, which affects the accuracy of liquid aspiration. 2. If the film is manually pierced, or the opening is too large after multiple puncture uses, it will shorten the shelf life of the reagent, accelerate the reagent volatilization, and affect the accuracy of the detection result.

[0043] To solve the above problems, the existing technology uses a volatilization-proof puncture film with a cross opening made of silica gel or TPE on the kit upper cover, and an easy-to-tear film is heat-sealed on the puncture film. Before the customer uses it, the easy-to-tear film is torn off and then put into the reagent bin for use. And the existing reagent bins can place dozens of kits at the same time. Some high-speed sample analyzers can even place more than 50 kits. For a laboratory assembly line, there can be multiple sample analyzers in a laboratory. Many times, users need to replace the kits in batches. This method requires manual tearing of the sealing film, which is complicated in operation and wastes the time and energy of the user. Moreover, the utility model person also found that the magnetic particles in the kit in this way are likely to aggregate and adhere to the cross, star, etc. openings during transportation or pass through the openings and adhere between the easy-to-tear film and the puncture film, affecting the reagent performance and the detection result; the entire transportation process of the kit needs to be placed completely upright, which is difficult. Especially when the kit needs to be transported over a long distance, such as transported overseas, etc., the risk of deterioration of the reagent performance is greater.

[0044] There are also some prior art test kits that have a sealing film sealed at the opening of the box body, a cross-opening anti-volatile puncture film on the upper cover of the test kit, and a puncture portion below the cross opening. Before the customer uses it, when the box cover is engaged with the box body, the puncture portion pierces the sealing film, and then puts it into the reagent compartment for use. This method also requires manual unsealing of the test kit, which also wastes the user's time and energy, and has high requirements for manual operation. The box cover and the box body need to be engaged in place, otherwise the reagent needle is easily wrapped by the cross-opening puncture film and the box cover is lifted, causing instrument failure, and the gap between the box cover and the box body is likely to cause the reagent to volatilize, affecting the accuracy of the test results.

[0045] Embodiment 1

[0046] like Figure 1 and Figure 2 As shown, the utility model provides a reagent kit for containing magnetic bead reagents, which includes a magnetic bead container 50, a reagent kit body 10, a reagent kit cover 20, a pre-opening structure 40 and a sealing film 30. Among them, the magnetic bead container 50 is used to hold the magnetic bead reagent, and the magnetic bead container has a transmission part, which is transmission-connected to the driving device of the reagent compartment to drive the magnetic bead container to rotate and mix; the reagent kit body 10 has a storage cavity 11 for storing reagents and a through hole 12 for inserting the magnetic bead container; the reagent kit cover 20 includes a first cover 21 and a second cover 23, the first cover 21 is sealed and connected to the top of the magnetic bead container 50, and the second cover 23 is sealed and connected to the top of the storage cavity 11; the pre-opening structure 40 is arranged on the reagent kit cover 20, corresponding to the storage cavity 11 and the magnetic bead container 50 respectively; the sealing film 30 is arranged on the reagent kit cover 20, corresponding to the pre-opening structure 40, and the sealing film 30 is used to seal the storage cavity 11 and the magnetic bead container 50; the sealing film 30 is spaced apart from the pre-opening structure 40, and the pre-opening structure 40 is separated from the magnetic bead reagent and the reagent by the sealing film 30.

[0047] In the above-mentioned setting, a pre-opening structure 40 is provided on the upper cover 20 of the reagent box. By utilizing the contraction function of the pre-opening structure 40, the reagent needle can penetrate and absorb the reagent under the action of a relatively small force, and the sealing of the reagent box for use can be ensured, and the volatilization of the reagent can be prevented. In the present application, there is no need to separately provide a puncture part, and the reagent needle can directly puncture the sealing film 30 through the pre-opening structure to take liquid, so that the reagent box does not need to operate the upper cover 20 of the reagent box before being placed in the reagent compartment for use, thereby improving the convenience of the use of the reagent box, thereby avoiding the problem of complicated unsealing operation of the reagent box in the prior art, wasting the user's time and energy, and also simplifying the structure of the reagent box, saving its manufacturing cost. Moreover, during long-distance transportation, the reagent will only directly contact the sealing film, and will not contact the pre-opening structure. The magnetic particles will not gather and adhere to the pre-opening, and will not pass through the pre-opening structure, so as to avoid affecting the performance of the reagent and the test results.

[0048] It should be noted that a pre-opening structure 40 is provided on the reagent kit upper cover 20, and the contraction function of the pre-opening structure 40 is utilized to realize that when the reagent acquisition device is pulled out from the pre-opening structure 40, the pre-opening structure 40 retracts, so that the pre-opening structure 40 is in a closed state. Since the pre-opening structure 40 is spaced apart from the sealing film 30, it can ensure that the pre-opening structure 40 is fully opened in the gap, and there is no obstruction to the downward movement of the reagent acquisition device, thereby ensuring that the reagent acquisition device can smoothly reach the sealing film 30 and puncture it.

[0049] Specifically, if Figure 3 As shown, in one embodiment, a mounting hole is provided on the upper cover 20 of the reagent box, and the pre-opening structure 40 is a gasket adapted to the mounting hole, the gasket is arranged in the mounting hole, and its outer peripheral wall is sealed and connected to the inner peripheral wall of the mounting hole, and a pre-opening is provided on the gasket along its axial direction, wherein the pre-opening is opened in the direction in which the reagent acquisition device moves, and the pre-opening is retracted in the direction away from the reagent acquisition device. In this way, the elastic contraction function of the pre-opening structure 40 is fully utilized, so that when the reagent acquisition device is pulled out of the pre-opening structure 40, the pre-opening structure 40 retracts, so that the pre-opening structure 40 is in a closed state. This ensures that the reagent will not volatilize and leak from the liquid collection port after and during the liquid collection process, so as to ensure that the reagent in the reagent box body 10 can be used normally within the shelf life.

[0050] Specifically, in one embodiment, a plurality of linear pre-openings are provided on the gasket along its axial direction, and the gasket material is silicone or injection-molded elastomer.

[0051] Specifically, if Figures 1 to 3 , Figure 6 and Figure 7 As shown, in one embodiment, the pre-opening is in a "cross" shape.

[0052] It should be noted that the above-mentioned "cross"-shaped structure is a cutout for the reagent needle to pass through, which plays a role in preventing the liquid in the reagent kit from volatilizing after the reagent kit is opened.

[0053] Specifically, Figure 2 and Figure 6 As shown, in one embodiment, a placement cavity 22 with a bottom opening is provided on one side of the reagent kit upper cover 20 close to the reagent kit body 10, and the reagent kit also includes a sealing film 30, which is provided at the bottom opening in the placement cavity 22 and is used to seal the reagent in the reagent kit body 10, and the reagent acquisition device is sequentially inserted into the pre-opening structure 40 and the sealing film 30 to extract the reagent in the reagent kit body 10.

[0054] It should be noted that the reagent obtaining device is inserted into the pre-opening structure 40 by expanding it, and is inserted into the sealing film 30 by puncturing it.

[0055] Specifically, Figure 1 As shown, in one embodiment, there is a vertical distance D between the sealing film 30 and the pre-opening structure 40 , and the vertical distance D enables the pre-opening structure 40 to be expanded in the placement cavity 22 so that the reagent acquisition device can be inserted into the reagent kit body 10 .

[0056] In the above setting, a vertical spacing D is set to ensure that the linear pre-opening structure 40 can be smoothly opened, so that the reagent needle can pierce the sealing film 30 at one time to achieve the purpose of opening the reagent kit. After opening, the sealing film 30 no longer plays a sealing role and will not hinder the movement of the reagent needle. The sealing of the reagent is guaranteed by the pre-opening structure 40.

[0057] Specifically, in one embodiment, the vertical distance D is in the range of 2 mm ≤ D ≤ 5 mm, so that the linear pre-opening structure 40 can be smoothly expanded.

[0058] Specifically, in one embodiment, the thickness M of the sealing film 30 is in the range of 0.01 mm ≤ M ≤ 0.06 mm.

[0059] Furthermore, the sealing film 30 is an easy-to-tear film, so that the sealing film can be torn open to a larger opening after a single puncture by the reagent needle, thereby no longer hindering the sampling of the reagent needle.

[0060] Specifically, in one embodiment, the thickness N of the pre-opening structure 40 is in the range of 0.6 mm ≤ N ≤ 1.5 mm, so that the reagent needle can pass through more easily and the airtightness can be ensured for multiple punctures.

[0061] Specifically, in one embodiment, the sealing film 30 includes a heat-sealing layer and a sealing layer. The heat-sealing layer is sealed and welded (i.e., the gap between the welded objects is filled with solder to seal the connection gap to ensure sealing) in the placement cavity 22; the sealing layer is arranged on the heat-sealing layer, and the sealing layer is used to prevent the liquid from volatilizing and seal the reagent in the reagent box body 10.

[0062] Specifically, Figure 1 As shown, in one embodiment, a limiting groove 60 is provided on the second upper cover 23, and the storage cavity opening end of the reagent box body 10 is plugged into and matched with the limiting groove 60. This facilitates the sealing welding of the second upper cover 23 and the reagent box body 10.

[0063] Furthermore, if Figure 1 As shown, a limiting groove 60 is provided at the open end of the magnetic bead container 50 , which is plugged into and matched with the first upper cover 21 .

[0064] Specifically, in one embodiment, the reagent box upper cover 20 is connected to the reagent box body 10 by sealing welding (ie, the connection gap between the objects to be welded is filled with solder to seal the connection gap to ensure sealing).

[0065] Specifically, Figure 1 , Figure 4 and Figure 5 As shown, in one embodiment, a plurality of storage cavities 11 are disposed in the reagent box body 10 , and the reagent box includes a plurality of reagent box upper covers 20 , and the plurality of reagent box upper covers 20 are disposed on the plurality of storage cavities 11 .

[0066] Specifically, Figure 1 As shown, in one embodiment, two storage cavities 11 are disposed in the reagent box body 10 , and the second upper cover 23 is simultaneously disposed on the two storage cavities 11 .

[0067] Furthermore, the present application provides a kit comprising:

[0068] The reagent box body 10 is made of PP injection molding. The reagent box body 10 is made of PP and is injection molded.

[0069] The reagent box upper cover 20 is made of PP injection molding. The reagent box upper cover 20 is made of PP and is injection molded. It is ultrasonically welded to the reagent box body 10 .

[0070] Among them, the pre-opened soft rubber gasket (pre-opening structure 40) plays the role of isolating the external environment after opening, ensuring the sealing of the test kit. The material can be silicone or injection molded elastomer. The injection molded elastomer can be dissolved together with the upper cover of the test kit by two-color injection molding. The injection molded elastomer can also be ultrasonically welded to the upper cover of the test kit. The silicone can be fixed to the upper cover of the test kit by snaps or other physical limiting methods.

[0071] Among them, the film (sealing film 30) is a composite film with at least 2 layers, the inner layer is a heat-sealing layer, and the heat-sealing layer can be welded to the upper cover of the reagent box by heat welding or ultrasonic welding. The outer layer is a sealing layer, which can effectively prevent the liquid in the reagent bottle from volatilizing and seal the liquid. The reagent is sealed before opening the bottle and is under the gasket. When the user uses it, the film can be punctured first and then the reagent tray can be placed in the reagent acquisition device to absorb the reagent, or the reagent tray can be directly placed in the reagent acquisition device, and the reagent can be absorbed after the film is punctured.

[0072] It should be noted that in the present application, there is no compatibility risk between the film and the reagent, and an easy-to-puncture film can be used. After the reagent acquisition device punctures, there will be a larger hole, which will not affect the air pressure. The pre-opening structure 40 isolates the air and ensures the sealing of the reagent kit and the performance of the reagent.

[0073] Embodiment 2

[0074] refer to Figures 1 to 8 As shown, the utility model provides a test kit.

[0075] The reagent kit comprises a magnetic bead container 50, a reagent kit body 10, a reagent kit cover, a pre-opening structure 40 and a sealing film 30. The magnetic bead container 50 is used to hold magnetic bead reagents, and the magnetic bead container has a transmission part, which is transmission-connected with the driving device of the reagent compartment to drive the magnetic bead container to rotate and mix; the reagent kit body 10 has a storage cavity 11 for storing reagents and a through hole 12 for inserting the magnetic bead container; the reagent kit cover comprises a first cover 21 and a second cover, the first cover 21 is sealedly connected to the top of the magnetic bead container 50, and the second cover is sealedly connected to the top of the storage cavity 11; the pre-opening structure 40 is arranged on the reagent kit cover, corresponding to the storage cavity 11 and the magnetic bead container 50 respectively; the sealing film 30 is arranged on the reagent kit cover, corresponding to the pre-opening structure 40, and the sealing film 30 is used to seal the storage cavity 11 and the magnetic bead container 50; the sealing film 30 is spaced apart from the pre-opening structure 40, and the pre-opening structure 40 is separated from the magnetic bead reagent and the reagent by the sealing film 30.

[0076] A pre-opening structure 40 is provided on the upper cover of the reagent box. By utilizing the contraction function of the pre-opening structure 40, the reagent needle can penetrate and absorb the reagent under the action of a relatively small force, and the sealing of the reagent box for use can be ensured, and the volatilization of the reagent can be prevented. In the present application, there is no need to separately provide a puncture part, and the reagent needle can directly puncture the sealing film 30 through the pre-opening structure to take liquid, so that the reagent box does not need to operate the upper cover of the reagent box before being placed in the reagent compartment for use, thereby improving the convenience of the use of the reagent box, thereby avoiding the problem of complicated unsealing operation of the reagent box in the prior art, wasting the user's time and energy, and also simplifying the structure of the reagent box, saving its manufacturing cost. Moreover, during long-distance transportation, the reagent will only directly contact the sealing film, and will not contact the pre-opening structure. The magnetic particles will not gather and adhere to the pre-opening, and will not pass through the pre-opening structure, so as to avoid affecting the reagent performance and the test results.

[0077] Specifically, in one embodiment, a mounting hole is provided on the upper cover of the reagent box, and the pre-opening structure 40 is a gasket adapted to the mounting hole, the gasket is arranged in the mounting hole, and its outer peripheral wall is sealed and connected to the inner peripheral wall of the mounting hole, and a pre-opening is provided on the gasket along its axial direction, wherein the pre-opening is opened in the direction in which the reagent acquisition device moves, and the pre-opening is retracted in the direction away from the reagent acquisition device. In this way, the elastic contraction function of the pre-opening structure 40 is fully utilized, so that when the reagent acquisition device is pulled out of the pre-opening structure 40, the pre-opening structure 40 retracts, so that the pre-opening structure 40 is in a closed state. This ensures that the reagent will not volatilize and leak from the liquid collection port after or during the liquid collection process, so as to ensure that the reagent in the reagent box body 10 can be used normally within the shelf life.

[0078] Specifically, in one embodiment, the pre-opening is in a "M"-shaped configuration.

[0079] Of course, other structures can be adopted according to actual conditions, such as a "Y"-shaped structure or an "X"-shaped structure.

[0080] Specifically, in one embodiment, a placement cavity 22 with a bottom opening is provided on one side of the upper cover of the reagent kit close to the reagent kit body 10, and the reagent kit also includes a sealing film 30, which is provided at the bottom opening in the placement cavity 22 and is used to seal the reagent in the reagent kit body 10, and the reagent acquisition device is sequentially inserted into the pre-opening structure 40 and the sealing film 30 to extract the reagent in the reagent kit body 10.

[0081] It should be noted that the reagent obtaining device is inserted into the pre-opening structure 40 by expanding it, and is inserted into the sealing film 30 by puncturing it.

[0082] Specifically, in one embodiment, there is a vertical distance D between the sealing film 30 and the pre-opening structure 40 , so that the pre-opening structure 40 can be expanded in the placement cavity 22 , so that the reagent acquisition device can be inserted into the reagent kit body 10 .

[0083] In the above setting, a vertical spacing D is set to ensure that the linear pre-opening structure 40 can be smoothly opened, so that the reagent needle can pierce the sealing film 30 at one time to achieve the purpose of opening the reagent kit. After opening, the sealing film 30 no longer plays a sealing role and will not hinder the movement of the reagent needle. The sealing of the reagent is guaranteed by the pre-opening structure 40.

[0084] Specifically, in one embodiment, the vertical distance D is in the range of 2 mm ≤ D ≤ 5 mm, so that the linear pre-opening structure 40 can be smoothly expanded.

[0085] Specifically, in one embodiment, the thickness M of the sealing film 30 has a value range of: 0.01 mm ≤ M ≤ 0.06 mm

[0086] Furthermore, the sealing film 30 is an easy-to-tear film, so that the sealing film can be torn open to a larger opening after a single puncture by the reagent needle, thereby no longer hindering the sampling of the reagent needle.

[0087] Specifically, in one embodiment, the thickness N of the pre-opening structure 40 is in the range of 0.6 mm ≤ N ≤ 1.5 mm, so that the reagent needle can pass through more easily and the airtightness can be ensured for multiple punctures.

[0088] Specifically, in one embodiment, the sealing film 30 includes a heat sealing layer and a sealing layer, wherein the heat sealing layer is sealed and welded in the placement cavity 22 ; and the sealing layer is arranged on the heat sealing layer, and the sealing layer is used to prevent the liquid from volatilizing and seal the reagent in the reagent box body 10 .

[0089] Specifically, in one embodiment, a limiting groove 60 is provided on the upper cover of the reagent kit, and the opening end of the reagent kit body 10 is plugged into and matched with the limiting groove 60 .

[0090] Specifically, in one embodiment, a limiting groove 60 is provided on the first upper cover 21 , and the opening end of the reagent box body 10 is plugged into and matched with the limiting groove 60 .

[0091] Specifically, in one embodiment, the reagent box upper cover is connected to the reagent box body 10 by sealing welding.

[0092] Specifically, in one embodiment, a plurality of storage cavities 11 are disposed in the reagent box body 10 , and the reagent box includes a plurality of second upper covers, and the plurality of second upper covers are covered on the plurality of storage cavities 11 in a one-to-one correspondence.

[0093] Specifically, in one embodiment, two storage cavities 11 are disposed in the reagent box body 10 , and the reagent box includes two second upper covers, wherein the two second upper covers are covered on the two storage cavities 11 in a one-to-one correspondence.

[0094] It should be noted that in the present application, there is no compatibility risk between the film and the reagent, and an easy-to-puncture film can be used. After the reagent acquisition device punctures, there will be a larger hole, which will not affect the air pressure. The pre-opening structure 40 isolates the air and ensures the sealing of the reagent kit and the performance of the reagent.

[0095] It should be noted that the compatibility of the sealing film itself with the reagent is better than that of the soft glue, and this film adopts an easy-to-tear film.

[0096] It should be noted that the utility model forms the first step of sealing the reagent by heat welding the reagent box upper cover and the reagent box body 10, forms the second step of sealing the reagent by heat welding the sealing film 30 and the reagent box upper cover with the pre-opening puncture film (pre-opening structure 40), and then limits the size of the gap between the sealing film 30 and the pre-opening puncture film to ensure that the reagent needle can directly pierce the sealing film 30. The reagent box of the utility model can directly use the reagent needle to pierce the sealing film 30, avoiding the steps of manually covering and then piercing the sealing film when the user obtains the reagent, saving the user time and energy.

[0097] The utility model also provides a sample analyzer, which includes a reagent box and a reagent obtaining device, wherein the reagent obtaining device can open the pre-opening structure toward the sealing film and extend into the upper cover of the reagent box to pierce the sealing film to obtain the reagent in the main body of the reagent box.

[0098] Specifically, in one embodiment, the reagent obtaining device adopts a reagent needle.

[0099] Although the present invention has been described with reference to preferred embodiments, various modifications may be made thereto and parts thereof may be replaced with equivalents without departing from the scope of the present invention. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there is no structural conflict. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A kit, at least for containing a magnetic bead reagent, characterized in that: include: A magnetic bead container is used to hold magnetic bead reagents, and the magnetic bead container has a transmission part, which is in transmission connection with a driving device of the reagent compartment to drive the magnetic bead container to rotate and mix; The reagent kit body has a storage cavity for storing reagents and a through hole for inserting the magnetic bead container; The reagent kit upper cover comprises a first upper cover and a second upper cover, wherein the first upper cover is sealed and connected to the top of the magnetic bead container, and the second upper cover is sealed and connected to the top of the storage cavity; A pre-opening structure, which is arranged on the upper cover of the reagent kit and corresponds to the storage cavity and the magnetic bead container respectively; as well as A sealing film, which is arranged on the upper cover of the reagent kit and is arranged corresponding to the pre-opening structure, and the sealing film is used to seal the storage cavity and the magnetic bead container; Wherein, the sealing film and the pre-opening structure are spaced apart, and the pre-opening structure is separated from the magnetic bead reagent and the reagent by the sealing film.

2. The kit according to claim 1, characterized in that A mounting hole is provided on the upper cover of the test kit, and the pre-opening structure is a gasket adapted to the mounting hole. The gasket is arranged in the mounting hole, and its outer peripheral wall is sealedly connected to the inner peripheral wall of the mounting hole. A plurality of linear pre-openings are provided through the gasket along its axial direction, and the gasket material is silicone or injection molded elastomer.

3. The kit according to claim 1 or 2, characterized in that A placement cavity with a bottom opening is arranged on one side of the reagent kit upper cover close to the reagent kit body, and the sealing film is arranged at the bottom opening to seal the reagent in the reagent kit body.

4. The kit according to claim 3, characterized in that There is a vertical distance D between the sealing film and the pre-opening structure, and the vertical distance D enables the pre-opening structure to be expanded in the placement cavity.

5. The kit according to claim 4, characterized in that The vertical spacing D has a value range of 2 mm ≤ D ≤ 5 mm, or the thickness M of the sealing film has a value range of 0.01 mm ≤ M ≤ 0.06 mm, and the thickness N of the pre-opening structure has a value range of 0.6 mm ≤ N ≤ 1.5 mm.

6. The kit according to claim 3, characterized in that The sealing film comprises: A heat sealing layer, welded and sealed with the bottom opening; and A sealing layer is arranged on the heat sealing layer, and is used to prevent the liquid in the storage cavity and the magnetic bead container from volatilizing.

7. The kit according to claim 3, characterized in that The second upper cover is provided with a limiting groove, and the storage cavity of the reagent box body is plugged and matched with the limiting groove.

8. The kit according to claim 3, characterized in that The reagent kit upper cover is sealed and welded to the reagent kit body.

9. The kit according to claim 3, characterized in that A plurality of storage cavities are arranged in the reagent box body, and the second upper cover is simultaneously arranged on the plurality of storage cavities.

10. A sample analyzer, characterized in that: include: The kit according to any one of claims 1 to 9; The reagent obtaining device can open the pre-opening structure toward the sealing film and extend into the upper cover of the reagent box to pierce the sealing film, so as to obtain the reagent in the main body of the reagent box.

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