Suction nozzle accessory of dry powder inhalation inhaler and dry powder inhalation inhaler

Abstract

The utility model relates to a suction nozzle accessory of a powder inhalation inhaler and the powder inhalation inhaler, the suction nozzle accessory comprises a plurality of collision rod pieces, and the plurality of collision rod pieces are located in a suction nozzle channel of the powder inhalation inhaler. According to the suction nozzle accessory and the dry powder inhalation inhaler, the collision rod pieces are located on the path where the airflow and the medicine powder pass through of the suction nozzle channel, so that the medicine powder passing through the suction nozzle channel is collided to be broken and scattered. Therefore, medicine powder in the dry powder inhalation inhaler is more fully collided and dispersed, the amount of fine particles inhaled by a user is increased, and the effective lung delivery amount of medicine taking is increased.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and particularly to a mouthpiece attachment for a dry powder inhaler and a dry powder inhaler. Background Art

[0002] A dry powder inhaler (DPI) is a device that disperses dry powder of a drug by the patient's active inhalation and then delivers the drug to the lungs. The drug powder is generally mixed with a carrier and stored in a capsule, a reservoir or a blister through precise dosage weighing, and the accuracy and stability of the dosage can be ensured during inhalation.

[0003] For the in vivo delivery of commercially available dry powder inhalers, the proportions of the inhaled aerosol deposited in the upper respiratory tract and the middle respiratory tract respectively account for one-third of the delivered dose, and the effective pulmonary delivery efficiency is about 20% - 40%. Most of the drug powder is wasted and not delivered to the desired pulmonary region. For example, the invention patent with the publication number US8336542B2 discloses an inhaler. The drug powder is stored in the blisters of the inhaler drug strip. When the patient inhales through the mouthpiece, the drug powder moves along with the airflow. The drug powder leaving the blister first passes through the cross-channel at the top of the blister, then enters the upper cylindrical channel, further enters the funnel-shaped mouthpiece channel, and finally enters the respiratory tract through the mouth. The distance of the drug powder delivery channel of the inhaler is relatively short, and during the movement of the drug powder in the channel, the degree of collision and dispersion is limited, the particle size of the drug powder delivered to the body is relatively large, and the amount of fine particles is relatively low. Summary of the Utility Model

[0004] In view of this, the embodiments of the present application are to solve the problems of relatively large drug delivery loss and poor drug administration effect when using the inhaler in the background art, and thus provide a mouthpiece attachment for a dry powder inhaler and a dry powder inhaler.

[0005] In a first aspect, the embodiments of the present application provide a mouthpiece attachment for a dry powder inhaler, including:

[0006] A plurality of collision rods, and the plurality of collision rods are located in the mouthpiece channel of the dry powder inhaler so that the drug powder passing through the mouthpiece channel is impacted and fragmented.

[0007] In an optional embodiment, the collision rods include array rods, and the plurality of array rods are arranged in an array form.

[0008] In an optional embodiment, the plane formed by the arrangement of the plurality of array rods forms an angle with the central axis of the mouthpiece channel, and adjacent two of the array rods are parallel or cross each other.

[0009] In an optional embodiment, along the axial direction of the nozzle channel, several of the array rods are arranged in at least two layers. In adjacent two layers, the array rods in one layer are axially aligned with the gaps between the array rods in the other layer, so that when the medicinal powder flows in the nozzle channel, it is successively impacted by the array rods in the two layers.

[0010] In an optional embodiment, a single array rod includes a first rod body and a second rod body respectively located on both sides of the inner wall of the nozzle channel. The first rod body and the second rod body are on the same straight line and there is a gap between the first rod body and the second rod body.

[0011] In an optional embodiment, the collision rod member includes screen wires, and several of the screen wires intersect with each other to form a screen surface.

[0012] In an optional embodiment, the screen surface is concave towards the airflow direction in the nozzle channel.

[0013] In an optional embodiment, several of the collision rod members are fixed on the inner wall of the nozzle channel or connected to the inner wall of the nozzle channel through a nozzle connecting member.

[0014] In an optional embodiment, the nozzle connecting member includes a nozzle sleeve. The outer wall contour of the nozzle sleeve at least partially matches the inner wall contour of the air outlet end of the nozzle channel, and the nozzle sleeve is installed at the air outlet end of the nozzle channel.

[0015] In an optional embodiment, the nozzle sleeve includes a nozzle sleeve body and a protruding portion.

[0016] The outer wall contour of the nozzle sleeve body matches the inner wall contour of the air outlet end of the nozzle channel, and the outer wall contour of the protruding portion matches the inner wall contour of a part of the air inlet end of the nozzle channel. The protruding portion is embedded and installed at the air inlet end of the nozzle channel.

[0017] In an optional embodiment, the nozzle sleeve includes a main ventilation hole that aligns with the nozzle channel and auxiliary ventilation holes located on both sides of the main ventilation hole. The air outlet direction of the auxiliary ventilation holes intersects with the air outlet direction of the main ventilation hole, so that the airflow discharged from the auxiliary ventilation holes merges into the airflow and the medicinal powder discharged from the main ventilation hole.

[0018] In an optional embodiment, the nozzle connecting member includes an assembly frame, and the assembly frame is embedded and installed at the air inlet end of the nozzle channel.

[0019] In an alternative embodiment, the outer wall of the assembly frame has an assembly surface and a boss protruding from the assembly surface. The assembly surface matches the inner wall profile of the air inlet end of the nozzle channel. The assembly frame is embedded and installed at the air inlet end of the nozzle channel through the assembly surface, and the boss abuts against the end face of the air inlet end of the nozzle channel to limit the movement of the assembly frame in the air flow direction.

[0020] In an alternative embodiment, the nozzle connector includes a nozzle sleeve and an assembly frame;

[0021] The outer wall profile of the nozzle sleeve matches the inner wall profile of the nozzle channel, and the nozzle sleeve is embedded and installed in the nozzle channel; the air inlet end of the nozzle sleeve is located at the air inlet end of the nozzle channel, and the assembly frame is installed at the air inlet end of the nozzle sleeve.

[0022] In a second aspect, an embodiment of the present application provides a powder inhaler, including the nozzle attachment described in the first aspect.

[0023] In the nozzle attachment and the powder inhaler provided by the present application, several of the collision rods are located on the paths of the air flow and the medicine powder passing through the nozzle channel, so that the medicine powder passing through the nozzle channel is impacted and broken up. In this way, the medicine powder in the powder inhaler is more fully collided and dispersed, the amount of fine particles inhaled by the user is increased, and the effective pulmonary delivery amount of the drug administration is increased.

[0024] Additional aspects and advantages of the present application will be given in part in the following description, will become apparent in part from the following description, or will be understood through the practice of the present application. Description of the Drawings

[0025] The drawings described herein are used to provide a further understanding of the present application, and constitute a part of the present application. The schematic embodiments and descriptions thereof of the present application are used to explain the present application and do not constitute an improper limitation of the present application. In the drawings:

[0026] Figure 1 Schematic diagram of the external structure of the powder inhaler provided in Embodiment 1 of the present application;

[0027] Figure 2 Schematic diagram of the cross-sectional structure of the powder inhaler provided in Embodiment 1 of the present application;

[0028] Figure 3 Schematic diagram of the upper structure of the medicine tape distribution box provided in Embodiment 1 of the present application;

[0029] Figure 4 Schematic diagram of the upper cylindrical screen channel structure of the medicine tape distribution box provided in Embodiment 1 of the present application;

[0030] Figure 5Schematic diagram of the first nozzle attachment structure provided in Embodiment 1 of the present application;

[0031] Figure 6 Side view of the first nozzle attachment structure provided in Embodiment 1 of the present application;

[0032] Figure 7 Schematic diagram of the first array rod arrangement form provided in Embodiment 1 of the present application;

[0033] Figure 8 Schematic diagram of the second array rod arrangement form provided in Embodiment 1 of the present application;

[0034] Figure 9 Schematic diagram of the second nozzle attachment structure provided in Embodiment 1 of the present application;

[0035] Figure 10 Schematic diagram of the closed state of the cap sleeve during the use of the powder inhaler provided in Embodiment 1 of the present application.

[0036] The reference numerals in the figure are:

[0037] 1. Cap sleeve;

[0038] 2. Bottom shell;

[0039] 3. Top shell;

[0040] 4. Dose indicator;

[0041] 5. Nozzle;

[0042] 6. Slide bar;

[0043] 7. Medicine tape distribution box; 7-1. Air flow screen; 7-2. Medicine powder screen; 7-3. Cylindrical screen channel;

[0044] 8. Hollow indexing wheel;

[0045] 9. Medicine powder blister groove;

[0046] 10. Indexing ratchet;

[0047] 11. Screen; 11-1. Screen wire; 11-2. Assembly frame; 11-3. Boss;

[0048] 12. Nozzle sleeve;

[0049] 12-1. Array rod; 12-11. First rod body; 12-12. Second rod body;

[0050] 12-2. Auxiliary ventilation hole; 12-5. Main ventilation hole;

[0051] 12-3. Nozzle sleeve main body; 12-4. Protrusion;

[0052] 13. Suction nozzle channel;

[0053] 14. Auxiliary air outlet. Detailed implementation manner

[0054] The exemplary embodiments disclosed in the present application will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present application are shown in the drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the specific embodiments set forth herein. On the contrary, these embodiments are provided so that the present application can be more thoroughly understood and the scope of the present application can be fully communicated to those skilled in the art.

[0055] In the following description, numerous specific details are given to provide a more thorough understanding of the present application. However, it is obvious to those skilled in the art that the present application can be implemented without one or more of these details. In other examples, in order to avoid confusion with the present application, some well-known technical features are not described; that is, not all features of the actual embodiments are described here, and the well-known functions and structures are not described in detail.

[0056] In the drawings, for clarity, the dimensions of parts, components, and mechanisms, as well as their relative dimensions, may be exaggerated. The same reference numerals denote the same elements throughout.

[0057] It should be understood that when a part or component is referred to as "on...", "adjacent to...", "connected to" or "coupled to" another part or component, it can be directly on, adjacent to, connected or coupled to the other part or component, or there may be intervening parts or components. On the contrary, when an element is referred to as "directly on...", "directly adjacent to...", "directly connected to" or "directly coupled to" another part or component, there are no intervening parts or components. It should be understood that although the terms first, second, third, etc. may be used to describe various elements, components, regions, layers, and / or parts, these elements, components, regions, layers, and / or parts should not be limited by these terms. These terms are only used to distinguish one element, component, region, layer, or part from another element, component, region, layer, or part. Therefore, without departing from the teachings of the present application, the first part, component, and mechanism discussed below may be represented as the second part, component, and mechanism. And when discussing the second part, component, and mechanism, it does not mean that the present application necessarily has the first part, component, and mechanism.

[0058] Spatial relationship terms such as "under", "below", "lower", "beneath", "above", "upper", etc. may be used herein for convenience of description to describe the relationship of one element or feature shown in the figure with other elements or features. It should be understood that, in addition to the orientation shown in the figure, spatial relationship terms are also intended to include different orientations of the device during use and operation. For example, if the device in the drawing is flipped, then an element or feature described as "under other elements" or "beneath it" or "under it" will be oriented "above" the other elements or features. Thus, the exemplary terms "under" and "beneath" can include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or other orientations) and the spatial descriptors used herein are to be interpreted accordingly.

[0059] The purpose of the terms used herein is only to describe specific embodiments and is not a limitation of the present application. As used herein, the singular forms "a", "an" and "the" are also intended to include the plural forms unless the context clearly dictates otherwise. It should also be understood that the terms "comprising" and / or "including", when used in this specification, identify the presence of the stated features, steps, parts, components and / or mechanisms, but do not preclude the presence or addition of one or more other features, steps, operations, parts, components and / or mechanisms. As used herein, the term "and / or" includes any and all combinations of the related listed items.

[0060] To fully understand the present application, detailed steps and detailed structures will be presented in the following description to illustrate the technical solution of the present application. The preferred embodiments of the present application are described in detail below. However, in addition to these detailed descriptions, the present application may have other embodiments.

[0061] Embodiment 1

[0062] This embodiment provides a powder inhaler, as Figure 1 , Figure 2 shown, the powder inhaler includes: a cover sleeve 1, a bottom shell 2, a top shell 3, a dose indicator 4, a mouthpiece 5, a sliding rod 6, a medicine strip distribution box 7, a hollow indexing wheel 8, a powder vesicle groove 9, an indexing ratchet 10, a mouthpiece channel 13, and a mouthpiece accessory.

[0063] The structural relationship and principle of each component of the powder inhaler:

[0064] As Figure 1 , Figure 2 shown, the top shell 3 and the bottom shell 2 are assembled to form an internal cavity, the mouthpiece 5 is fixed at the top connection, and the rotatable cover sleeve 1 is assembled externally, and the cover sleeve 1 can completely cover the mouthpiece 5. Both the inner walls of the top shell 3 and the bottom shell 2 have shafts corresponding to the internal parts for rotatably mounting the sliding rod 6, the hollow indexing wheel 8, and the indexing ratchet 10.

[0065] The dose indicator 4 can indicate the remaining amount of the available medicine strip inside the powder inhaler.

[0066] The inner wall of the mouthpiece 5 forms a mouthpiece channel 13. When the user holds the mouthpiece 5 and inhales, the airflow in the mouthpiece channel 13 carries the medicine powder and flows from the intake end to the outlet end of the mouthpiece channel 13. The outlet end of the mouthpiece channel 13 is the end for the user to inhale, the intake end is the opposite end of the outlet end, and is also the end extending towards the inside of the powder inhaler. As Figure 2 shown, the inner wall of the intake end of the mouthpiece channel 13 is cylindrical, and the inner wall of the outlet end is funnel-shaped.

[0067] The medicine strip distribution box 7 is used to fix the dry powder medicine strip. The dry powder medicine strip is provided with rows of vesicles, and the vesicles store the medicine powder. As Figure 3 shown, there are two circular cross-shaped sieves on the medicine strip distribution box 7, namely an air flow sieve 7-1 for external air flow to enter and a medicine powder sieve 7-2 for air flow and medicine powder to be delivered. As Figure 4 shown, the upper end of the medicine strip distribution box 7 has a cylindrical sieve channel 7-3 communicating with the medicine powder sieve 7-2. The medicine powder can enter the mouthpiece channel 13 along with the air flow through the cylindrical sieve channel 7-3.

[0068] The sliding rod 6 and the indexing ratchet 10 are placed in the cavity and are respectively connected to the corresponding shafts on the bottom shell 2 and / or the top shell 3, and can rotate around the shafts. The teeth are distributed on one side of the lower end of the indexing ratchet 10 and are engaged with the teeth of the fixed end of the sliding rod 6, and can cooperate to rotate. The hollow indexing wheel 8 is sleeved outside the indexing ratchet 10 and shares the same shaft with it. The medicine powder vesicle grooves 9 are evenly distributed on the circumference of the hollow indexing wheel 8, and the shapes and sizes of the medicine powder vesicle grooves 9 match the vesicles storing the medicine powder on the dry powder medicine strip. When the sliding rod 6 rotates, the indexing ratchet 10 cooperating with it rotates accordingly, driving the hollow indexing wheel 8 to rotate, and further driving the dry powder medicine strip placed inside the medicine strip distribution box 7 to rotate, realizing the use of the vesicles one by one.

[0069] This embodiment provides a mouthpiece accessory for a powder inhaler. As Figure 5 shown, it includes: a plurality of array rods 12-1. The plurality of array rods 12-1 are located on the path of the air flow and medicine powder passing through the mouthpiece channel 13, so that the medicine powder passing through the mouthpiece channel 13 is impacted and broken up.

[0070] The nozzle attachment provided in this embodiment uses the array rods 12-1 as the collision rods. A number of array rods 12-1 are located on the path of the airflow and powder passing through the nozzle channel 13, so that the powder passing through the nozzle channel 13 is impacted and broken up. In this way, the powder in the powder inhaler is more fully collided and dispersed, improving the amount of fine particles inhaled by the user and the effective pulmonary delivery amount of the medicine taken. It can be understood that in other embodiments, the collision rods used are not limited to the array rods 12-1.

[0071] In an alternative embodiment, as Figures 5 - 8 shown, the nozzle attachment provided in the embodiment of the present application is a nozzle attachment with a nozzle connector, hereinafter referred to as an array rod nozzle sleeve, which includes a nozzle sleeve 12 and a number of array rods 12-1. The nozzle sleeve 12 serves as the nozzle connector for connecting the inner wall of the nozzle channel 13, and a number of array rods 12-1 are fixed on the nozzle sleeve 12. In this embodiment, the nozzle sleeve 12 can be disassembled and cleaned, bringing convenience in use. Unless otherwise specified, the axial direction of the nozzle channel 13 in this embodiment is the same as the axial direction of the nozzle sleeve 12.

[0072] In an alternative embodiment, as Figure 5 、 Figure 7 、 Figure 8 shown, a number of array rods 12-1 are arranged in an array. In this embodiment, the array formed by the arrangement of the array rods 12-1 can ensure the uniformity of the distribution of the array rods 12-1, avoiding the situation where some powder is overly collided and some powder is insufficiently collided when the powder passes through the nozzle channel 13.

[0073] In an alternative embodiment, as Figure 5 、 Figure 7 、 Figure 8 shown, the plane formed by the arrangement of a number of array rods 12-1 forms an angle with the central axis of the nozzle channel 13. In this embodiment, the plane formed by the arrangement refers to that a number of array rods 12-1 are arranged in sequence along a certain path and are on the same plane, and this plane is the plane formed by the arrangement. There can be one or more planes formed by the arrangement of a number of array rods 12-1. As Figure 5 shown, adjacent two array rods 12-1 cross each other and can be arranged alternately and obliquely. It can be seen that in this arrangement form, there are multiple planes formed by the arrangement of a number of array rods 12-1. In this embodiment, the inclination angle of the array rods 12-1 relative to the radial direction of the nozzle channel 13 is between 0° and 30°. In other embodiments, the inclination angle of the array rods 12-1 relative to the radial direction of the nozzle channel 13 can be in other angular ranges. As Figure 7 、 Figure 8As shown, two adjacent array rods 12-1 can also be arranged parallel to each other. It can be understood that whether the two adjacent array rods 12-1 are arranged in a crosswise manner or a parallel manner, it is for the convenience of arranging to form an array and making full use of the space of the nozzle channel 13.

[0074] It can be understood that in order to ensure the basic ventilation volume of the nozzle channel 13, the arrangement of the array rods 12-1 should not be too dense, and there should be a reasonable interval between adjacent array rods 12-1 and between the array rods 12-1 and the wall surface of the nozzle channel 13. In order to provide an arrangement interval for the array rods 12-1, it can be understood that the array rods 12-1 are preferentially arranged at the wider position of the funnel-shaped nozzle sleeve 12, that is Figure 6 the upper part of the nozzle sleeve 12 shown. In order to make the airflow in the nozzle sleeve 12 flow more evenly, the array rods 12-1 are preferably arranged evenly.

[0075] In an alternative embodiment, as Figure 7 、 Figure 8 shown, along the axial direction of the nozzle sleeve 12, several array rods 12-1 are arranged in multiple layers. In two adjacent layers, along the axial direction of the nozzle sleeve 12, the array rods 12-1 in one layer are aligned with the gaps between the array rods 12-1 in the other layer, so that when the medicament powder flows in the nozzle channel 13, it is successively impacted by the array rods 12-1 in the two layers. In this embodiment, by the way of staggering the array rods 12-1 between different layers, on the one hand, it provides a greater collision probability when the medicament powder flows, and on the other hand, it avoids the array rods 12-1 being too close to each other and affecting the airflow. In other embodiments, the array rods 12-1 can be arranged in only one layer.

[0076] In an alternative embodiment, as Figure 7 、 Figure 8 shown, a single array rod 12-1 includes a first rod body 12-11 and a second rod body 12-12 respectively fixed on both sides of the inner wall of the nozzle sleeve 12. The first rod body 12-11 and the second rod body 12-12 are on the same straight line and there is a gap between the first rod body 12-11 and the second rod body 12-12. The disconnection between the first rod body 12-11 and the second rod body 12-12 can improve the processing convenience.

[0077] In an alternative embodiment, as Figure 7 shown, between adjacent array rods 12-1, the gaps between the first rod body 12-11 and the second rod body 12-12 are arranged staggeredly, which can prevent larger-sized medicament powder particles from passing through the gaps. As Figure 8 shown, between adjacent array rods 12-1, the gaps between the first rod body 12-11 and the second rod body 12-12 can also be arranged in alignment, and the processing of the array rods 12-1 is relatively easy in this scheme.

[0078] In an alternative embodiment, as Figure 7 , Figure 8 shown, the gap between the first rod 12-11 and the second rod 12-12 may be located on the axis of symmetry of the nozzle sleeve 12, or may be evenly distributed on both sides of the axis of symmetry of the nozzle sleeve 12.

[0079] In an alternative embodiment, as Figure 7 , Figure 8 shown, the cross-sectional shape of the nozzle sleeve 12 perpendicular to the axis is oval, and the array rods 12-1 extend along the short axis direction of the cross-section. In this embodiment, the array rods 12-1 extend along the short axis direction of the oval, and the required length is shorter and it is easy to arrange. On the other hand, the array rods 12-1 extend along the short axis direction, and the arrangement of the plurality of array rods 12-1 can be along the long axis direction of the oval, which is convenient for arranging more array rods 12-1. In other embodiments, the array rods 12-1 may also extend along the long axis direction of the oval, and the plurality of array rods 12-1 may also be arranged along the short axis direction of the oval.

[0080] In an alternative embodiment, as Figure 1 , Figure 2 shown, the outer wall contour of the nozzle sleeve 12 matches the inner wall contour of the air outlet end of the nozzle channel 13, and the nozzle sleeve 12 is embedded and installed at the air outlet end of the nozzle channel 13. In this embodiment, by designing the contour of the nozzle sleeve 12 to correspond to the nozzle 5, it is possible to not change the actual air flow situation of the nozzle 5 as much as possible, and to ensure the basic use effect of the nozzle 5. At the same time, the matching of the two contours is also beneficial to the stability of the nozzle sleeve 12 fixed on the nozzle 5.

[0081] In an alternative embodiment, as Figure 6 shown, the nozzle sleeve 12 includes a nozzle sleeve main body 12-3 and a protruding portion 12-4. The outer wall contour of the nozzle sleeve main body 12-3 matches the inner wall contour of the air outlet end of the nozzle channel 13, and the outer wall contour of the protruding portion 12-4 matches the inner wall contour of a part of the air inlet end of the nozzle channel 13. The protruding portion 12-4 is embedded and installed at the air inlet end of the nozzle channel 13. If the air inlet end of the nozzle channel 13 is square, the outer wall width of the protruding portion 12-4 is the same as the inner wall width of the air inlet end of the nozzle channel 13. If the air inlet end of the nozzle channel 13 is cylindrical, the inner diameter of the protruding portion 12-4 is the same as the inner diameter of the air inlet end of the nozzle channel 13. In this embodiment, the nozzle sleeve 12 is attached to the inner wall of the air outlet end of the nozzle channel 13 through its nozzle sleeve main body 12-3, and the protruding portion 12-4 is embedded in the air inlet end of the nozzle channel 13 to improve the stability of the connection with the inner wall of the nozzle 5 and prevent it from loosening and falling off from the nozzle 5.

[0082] In an optional embodiment, the outer wall of the protrusion 12-4 is frosted to form a frosted surface, which can increase the friction of the contact surface, reduce the probability of the suction nozzle accessory loosening during use, and improve the stability of the suction nozzle accessory installation.

[0083] In an optional embodiment, if Figure 5 As shown, the nozzle cover 12 has a main vent hole 12-5 aligned with the nozzle channel 13 and auxiliary vent holes 12-2 located on both sides of the main vent hole 12-5, and the air outlet direction of the auxiliary vent holes 12-2 intersects with the air outlet direction of the main vent hole 12-5, so that the airflow discharged from the auxiliary vent holes 12-2 merges into the airflow discharged from the main vent hole 12-5 and the powder. Figure 2 As shown, the powder inhaler of this embodiment is further provided with auxiliary air outlet holes 14 on both sides of the nozzle channel 13. The auxiliary air outlet holes 14 are used to promote the air outlet of the nozzle channel 13. The air in the assembly gap of the powder inhaler housing and other positions is used to discharge the airflow from the auxiliary air outlet holes 14 and merge into the air outlet end of the nozzle channel 13, thereby increasing the airflow and the probability of drug powder collision. The auxiliary air holes 12-2 are provided to avoid blocking the auxiliary air outlet holes 14.

[0084] In an optional embodiment, the bottom shell 2 and the top shell 3 have corresponding semicircular notches on their opposite side edges, and the nozzle channel 13 and the auxiliary air outlet 14 are both channels formed by splicing the corresponding notches after the bottom shell 2 and the top shell 3 are assembled.

[0085] In an optional embodiment, the cross section of the array bar 12-1 may be a circle with a constant diameter for ease of processing. In other embodiments, the cross section of the array bar 12-1 may be a circle, triangle, or polygon with varying diameters.

[0086] In an optional embodiment, the array rod nozzle is mainly made of plastic to facilitate manufacturing and reduce costs.

[0087] This embodiment provides a nozzle attachment for a powder inhaler, such as Figure 9 As shown, it includes a plurality of screen wires 11-1. The plurality of screen wires 11-1 are located in the suction nozzle channel 13 so that the medicine powder passing through the suction nozzle channel 13 is impacted and broken.

[0088] In the nozzle attachment provided in this embodiment, the mesh wire 11-1 is used as a collision rod, and a plurality of mesh wires 11-1 are located on the airflow of the nozzle channel 13 and the path through which the powder passes, so that the powder passing through the nozzle channel 13 is impacted and broken up. In this way, the powder in the powder inhaler is more fully collided and dispersed, the amount of fine particles inhaled by the user is increased, and the effective lung delivery amount of the medicine is increased. It can be understood that in other embodiments, the collision rod used is not limited to the mesh wire 11-1 and the above-mentioned array rod 12-1.

[0089] In an alternative embodiment, as Figure 9 shown, a plurality of the screen wires 11-1 cross each other to form a screen surface. In this embodiment, the screen wires 11-1 cross each other to form a screen surface. Airflow can pass through the holes of the screen surface, while the screen wires 11-1 increase the probability of powder collision. This mesh structure has better air permeability on the one hand, and on the other hand, the sizes of the formed holes are relatively controllable and uniform, and it is not easy for the powder with too large particles to pass through, which is beneficial to reducing the particle size of the powder.

[0090] In an alternative embodiment, as Figure 2 , Figure 9 shown, the screen surface is recessed in the direction of the airflow in the nozzle channel 13. This recessed structure can conform to the directions of the airflow and the powder flow in the nozzle channel 13, facilitating the passage of the powder. In other embodiments, the screen wires 11-1 can also be arranged parallel to the end face of the nozzle channel 13.

[0091] In an alternative embodiment, the screen 11 is used as a nozzle accessory, as Figure 9 shown, the screen 11 includes: a mounting frame 11-2 and a plurality of screen wires 11-1.

[0092] The mounting frame 11-2 serves as a nozzle connecting piece for connecting the nozzle 5. A plurality of screen wires 11-1 are fixed on the mounting frame 11-2, and a plurality of screen wires 11-1 are located on the paths of the airflow and the powder passing through the nozzle channel 13, so that the powder passing through the nozzle channel 13 is impacted and broken up.

[0093] For the nozzle accessory provided in this embodiment, the mounting frame 11-2 serves as a nozzle connecting piece, and the screen wires 11-1 serve as collision rods. A plurality of screen wires 11-1 are located on the paths of the airflow and the powder passing through the nozzle channel 13, so that the powder passing through the nozzle channel 13 is impacted and broken up. In this way, the powder in the powder inhaler is more fully collided and dispersed, the amount of fine particles inhaled by the user is increased, and the effective pulmonary delivery amount of the medicine is increased. At the same time, this nozzle accessory can be disassembled and cleaned, bringing convenience in use.

[0094] In an alternative embodiment, as Figure 9 shown, the mounting frame 11-2 is embedded and installed at the air inlet end of the nozzle channel 13. In this embodiment, the mounting frame 11-2 is installed through the space at the air inlet end of the nozzle channel 13, facilitating the disassembly of the nozzle connecting piece.

[0095] In an alternative embodiment, as Figure 9As shown in the figure, the outer wall of the assembly frame 11-2 has an assembly surface and a boss 11-3 protruding from the assembly surface. The assembly surface matches the inner wall contour of the air inlet end of the nozzle channel 13. The assembly frame 11-2 is embedded and installed at the air inlet end of the nozzle channel 13 through the assembly surface. The boss 11-3 abuts against the end surface of the air inlet end of the nozzle channel 13 to limit the movement of the assembly frame 11-2 along the air flow direction, preventing the screen 11 from falling into the nozzle channel 13. The outer diameter of the assembly surface can be set to be the same as the inner diameter of the nozzle channel 13 to achieve a tight fit during assembly. Correspondingly, the outer diameter of the boss 11-3 is larger than the inner diameter of the nozzle channel 13. During assembly, it is located at the lower part of the channel and can limit the upward movement of the screen 11 in the inhalation state. At the same time, it also facilitates the assembly and disassembly of the screen 11.

[0096] In an alternative embodiment, the cross-section of the screen wire 11-1 can be circular, rectangular, polygonal, or irregular. The material of the screen wire 11-1 can be metal or plastic.

[0097] In an alternative embodiment, for the nozzle attachment of the powder inhaler in this embodiment, the nozzle connector includes a nozzle sleeve 12 and an assembly frame 11-2. The outer wall contour of the nozzle sleeve 12 matches the inner wall contour of the nozzle channel 13. The nozzle sleeve 12 is embedded and installed in the nozzle channel 13. The air inlet end of the nozzle sleeve 12 is located at the air inlet end of the nozzle channel 13, and the assembly frame 11-2 is installed at the air inlet end of the nozzle sleeve 12.

[0098] In this embodiment, the outer wall contour of the nozzle sleeve 12 is designed to match the inner wall contour of the nozzle 5 so that it can completely fill the nozzle channel 13. The assembly frame 11-2 is embedded and installed at the air inlet end of the nozzle sleeve 12 through the assembly surface, and the two are connected as a whole for easy disassembly and use. In the solution of this embodiment, since the assembly frame 11-2 is installed at the air inlet end of the nozzle sleeve 12, as Figure 2 shown, the nozzle sleeve 12 is exposed outside the powder inhaler at the nozzle 5. Therefore, the nozzle sleeve 12 can be disassembled and assembled relatively easily, and when the nozzle sleeve 12 is removed, the assembly frame 11-2 is also taken out of the nozzle 5 accordingly. The assembly frame 11-2 only needs to be unsealed with the nozzle sleeve 12 once to complete the removal. This solution has certain advantages in terms of the disassembly and assembly convenience of the assembly frame 11-2.

[0099] The nozzle connector provided in this embodiment can be directly installed at the nozzle 5 without changing the original air flow channel structure of the existing powder inhaler, which can effectively increase the collision between the powder particles and the screen wire 11-1 and / or the array rod 12-1 when moving with the air flow, generate more fine particles, improve the pulmonary delivery dose, and ensure the administration effect.

[0100] The nozzle connector provided in this embodiment ensures the functionality of the nozzle accessory while facilitating installation, disassembly, and cleaning, thus guaranteeing the safety of drug administration.

[0101] This embodiment provides a method of using a powder inhaler, including the following usage states:

[0102] ① Initial state

[0103] As Figure 10 shown, when the inhaler is in the initial state, the cover sleeve 1 completely covers the nozzle 5. As Figure 2 shown, the sliding rod 6 is on the side close to the nozzle 5, and the empty powder blister slot 9 is directly above the nozzle channel 13.

[0104] ② Startup state

[0105] Rotate the cover sleeve 1. As Figure 1 shown, the nozzle 5 is completely exposed, and the sliding rod 6 is toggled to the side away from the nozzle 5.

[0106] During the process of toggling the sliding rod 6, the indexing ratchet 10 engaged with the rotating teeth of the sliding rod 6 rotates accordingly, driving the hollow indexing wheel 8 assembled with it to rotate. The powder strip fixed in the surface groove of the hollow indexing wheel 8 rotates accordingly. After toggling the sliding rod 6 once, the hollow indexing wheel 8 rotates clockwise, and the powder blister slot 11 with powder rotates to the highest position, directly above the nozzle channel 13. At this time, the patient holds the nozzle 5 and inhales. The powder in the powder blister slot 11 passes through the cross powder sieve 7-2 above the powder distribution box, then sequentially passes through the sieve 11 and the array rod nozzle sleeve assembled on the nozzle channel 13, and the fully dispersed powder enters the oral cavity accordingly, completing the drug administration process.

[0107] ③ Reset state

[0108] After completing the inhalation step, the inhaler needs to be reset to the initial state.

[0109] Rotate the cover sleeve 1 in the opposite direction until the cover sleeve 1 completely covers the nozzle 5 and a clear "click" sound is heard.

[0110] When the cover sleeve 1 rotates back to the initial state, the slider in the cover sleeve 1 will drive the indexing ratchet 10 to rotate in the reverse direction, which will drive the rotating teeth of the sliding rod 6 engaged with the teeth of the indexing ratchet 10, and the sliding rod 6 will move in the reverse direction and return to the side close to the nozzle 5. At the same time, the hollow indexing wheel 8 located outside the indexing ratchet 10 remains stationary. At this time, the position of the powder blister slot 11 on the powder strip remains unchanged.

[0111] This embodiment provides a test on the usage effect after adding a nozzle accessory to a powder inhaler.

[0112] ① Test method

[0113] The fine particle dose is an important parameter for evaluating the quality of inhaled preparations. In this experiment, the test was carried out with reference to the general rules for inhaled preparations in Part IV of the Pharmacopoeia 2020 Edition and the method for determining the aerodynamic characteristics of fine particles in inhaled preparations in 0951.

[0114] The test is divided into two parts:

[0115] Part 1: Powder inhaler + preparation, measure the inhalation flow rate Q and the inhalation time t.

[0116] Part 2: Powder inhaler + mouthpiece attachment + preparation, measure the inhalation flow rate Q and the inhalation time t.

[0117] For the tests in the above two parts, except for the difference in the mouthpiece attachment, the preparations used in the test, the test flow rate and time, the detection method, etc. are all the same.

[0118] ② Test results

[0119] The fine particle dose is mainly the amount of drug powder particles smaller than 5 μm atomized and delivered by the inhalation device, FPD; the delivered dose is the dose of drug powder particles released from outside the device, DD. The definition of the evaluation index of the fine particle proportion FPF in this experiment is as follows:

[0120] Fine particle proportion FPF = fine particle dose FPD / delivered dose DD;

[0121] The experimental test data are shown in the following table:

[0122]

[0123] As can be seen from the data in the above table, compared with the fine particle data of Test Part 1, the solution of this embodiment, that is, adding additional screen wires 11-1 and array rods 12-1 in the mouthpiece channel 13 of the powder inhaler, can improve the atomization and dispersion effect of the drug powder in the device. After the drug powder continuously collides with the screen wires 11-1 and the array rods 12-1, more fine particles are dispersed. The average FPF increments of Sample 1 and Sample 2 reach 108.7% and 107.0% respectively.

[0124] ③ Test conclusion

[0125] The solution of this embodiment, adding additional screen wires 11-1 and array rods 12-1 in the mouthpiece channel 13 of the powder inhaler, can effectively increase the collision of drug powder particles with the screen wall and the array rods when moving with the airflow, generate more fine particles, improve the pulmonary delivery dose, and ensure the administration effect.

[0126] Example 2

[0127] This embodiment provides a powder inhaler, including: a mouthpiece 5 and a number of collision rods.

[0128] The nozzle 5 has a nozzle passage 13 through which air flow and medicament powder pass; several of the collision rods are integrally formed on the inner wall of the nozzle 5, and several of the collision rods are located in the nozzle passage 13 so that the medicament powder passing through the nozzle passage 13 is impacted and broken up.

[0129] Different from the solution of Embodiment 1, in the powder inhaler of this embodiment, several of the collision rods are directly integrally formed on the inner wall of the nozzle 5, and the solution of setting a nozzle connector in Embodiment 1 is not adopted. It can be understood that in this embodiment, the collision rods being integrally formed and fixed on the inner wall of the nozzle 5 is a form of fixing the collision rods on the inner wall of the nozzle 5. In other embodiments, the form of fixing the collision rods on the inner wall of the nozzle 5 can be fixing with glue, fixing with a clamping groove and a buckle, interference fit fixing, etc.

[0130] In the powder inhaler provided in this embodiment, several of the collision rods are located on the path of the air flow and the medicament powder passing through the nozzle passage 13 so that the medicament powder passing through the nozzle passage 13 is impacted and broken up. In this way, the medicament powder in the powder inhaler is more fully collided and dispersed, the amount of fine particles inhaled by the user is increased, and the effective pulmonary delivery amount of taking medicine is increased.

[0131] It should be understood that the above embodiments are all exemplary and do not cover all possible implementation manners included in the claims. Without departing from the scope of the present disclosure, various deformations and changes can also be made on the basis of the above embodiments. Similarly, the various technical features of the above embodiments can also be arbitrarily combined to form other embodiments of the present application that may not be clearly described. Therefore, the above embodiments only represent several implementation manners of the present application and do not limit the protection scope of the patent of the present application.

Claims

1. A nozzle accessory for a powder inhaler, characterized in that: include: A plurality of collision rods are provided, wherein the collision rods are located in a nozzle channel (13) of a nozzle (5) of the powder inhaler, so that the medicine powder passing through the nozzle channel (13) is impacted and broken into pieces.

2. The nozzle attachment of the powder inhaler according to claim 1, characterized in that: The collision rod member comprises an array rod (12-1), and a plurality of the array rods (12-1) are arranged in an array.

3. The nozzle attachment of the powder inhaler according to claim 2, characterized in that: A surface formed by the arrangement of the plurality of array bars (12-1) forms an angle with the central axis of the nozzle channel (13), and two adjacent array bars (12-1) are parallel to or cross each other.

4. The nozzle attachment of the powder inhaler according to claim 2, characterized in that: Along the axial direction of the suction nozzle channel (13), a plurality of the array rods (12-1) are arranged in at least two layers, and in two adjacent layers, the array rods (12-1) of one layer are aligned with the gaps between the array rods (12-1) of the other layer along the axial direction of the suction nozzle channel (13), so that when the medicine powder flows in the suction nozzle channel (13), it is hit by the two layers of array rods (12-1) in sequence.

5. The nozzle attachment of the powder inhaler according to claim 2, characterized in that: A single array rod (12-1) comprises a first rod body (12-11) and a second rod body (12-12) respectively located on both sides of the inner wall of the suction nozzle channel (13); the first rod body (12-11) and the second rod body (12-12) are located on the same straight line and there is a gap between the first rod body (12-11) and the second rod body (12-12).

6. The nozzle attachment of the powder inhaler according to claim 1, characterized in that: The collision rod comprises screen wires (11-1), and a plurality of the screen wires (11-1) are intertwined to form a screen surface.

7. The nozzle attachment of the powder inhaler according to claim 6, characterized in that: The screen is recessed towards the direction of airflow in the suction nozzle channel (13).

8. The nozzle attachment of the powder inhaler according to any one of claims 1 to 7, characterized in that: A plurality of collision rods are fixed to the inner wall of the suction nozzle channel (13) or connected to the inner wall of the suction nozzle channel (13) via a suction nozzle connecting piece.

9. The nozzle attachment of the powder inhaler according to claim 8, characterized in that: The suction nozzle connecting piece comprises a suction nozzle sleeve (12), the outer wall profile of the suction nozzle sleeve (12) at least partially matches the inner wall profile of the air outlet end of the suction nozzle channel (13), and the suction nozzle sleeve (12) is installed at the air outlet end of the suction nozzle channel (13).

10. The mouthpiece attachment of the powder inhaler according to claim 9, characterized in that: The nozzle cover (12) comprises a nozzle cover body (12-3) and a protruding portion (12-4). The outer wall profile of the nozzle cover body (12-3) matches the inner wall profile of the air outlet end of the nozzle channel (13), the outer wall profile of the protrusion (12-4) matches the inner wall profile of the air inlet end portion of the nozzle channel (13), and the protrusion (12-4) is embedded and installed in the air inlet end of the nozzle channel (13).

11. The mouthpiece attachment of the powder inhaler according to claim 9, characterized in that: The nozzle cover (12) comprises a main air vent (12-5) aligned with the nozzle channel (13) and auxiliary air vents (12-2) located on both sides of the main air vent (12-5), wherein the air outlet direction of the auxiliary air vent (12-2) intersects with the air outlet direction of the main air vent (12-5), so that the airflow discharged from the auxiliary air vent (12-2) merges into the airflow and medicine powder discharged from the main air vent (12-5).

12. The mouthpiece attachment of the powder inhaler according to claim 8, characterized in that: The suction nozzle connecting piece comprises an assembly frame (11-2), and the assembly frame (11-2) is embedded and installed at the air inlet end of the suction nozzle channel (13).

13. The mouthpiece attachment of the powder inhaler according to claim 12, characterized in that: The outer wall of the assembly frame (11-2) comprises an assembly surface and a boss (11-3) protruding from the assembly surface, the assembly surface matches the inner wall profile of the air inlet end of the suction nozzle channel (13), the assembly frame (11-2) is embedded and installed in the air inlet end of the suction nozzle channel (13) through the assembly surface, and the boss (11-3) abuts against the end surface of the air inlet end of the suction nozzle channel (13) to limit the movement of the assembly frame (11-2) along the air flow direction.

14. The mouthpiece attachment of the powder inhaler according to claim 8, characterized in that: The nozzle connector comprises a nozzle sleeve (12) and an assembly frame (11-2); The outer wall profile of the nozzle sleeve (12) matches the inner wall profile of the nozzle channel (13), and the nozzle sleeve (12) is embedded and installed in the nozzle channel (13); the air inlet end of the nozzle sleeve (12) is located at the air inlet end of the nozzle channel (13), and the assembly frame (11-2) is installed at the air inlet end of the nozzle sleeve (12).

15. A powder inhaler, characterized in that: Comprising a nozzle attachment as described in any one of claims 1-14.

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