Sterile drying device for microneedle array

Abstract

According to the microneedle array sterile drying device, heating of the upper temperature control plate and the lower temperature control plate enables the temperature in the inner container of the drying box to be high, and evaporation of water in a microneedle array is facilitated; meanwhile, through the position design of an upper exhaust port, an upper-layer air inlet hole, a lower-layer air inlet hole, a purified air outlet, an upper exhaust fan, a rear exhaust fan and the like, ventilation airflow gradually flows upwards through the microneedle array from the lower portions of the left side and the right side of the drying box inner container, the air flow speed is increased, the flatness after drying is improved, the microneedle array can be evenly and rapidly dried, and the drying efficiency is improved. Therefore, the drying efficiency and the drying effect are greatly improved. Meanwhile, impurities such as dust and microorganisms in air can be filtered through the arrangement of the primary air filter and the advanced air filter, and the quality stability of the microneedle array is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices and relates to a micro-needle array aseptic drying device. Background Art

[0002] A micro-needle array is composed of hundreds of micron-sized fine needles connected to a base in an array manner. It can be applied to the skin in a minimally invasive way to achieve targeted transdermal drug delivery, which has special significance in immunotherapy and vaccine delivery.

[0003] When producing a micro-needle array, after injecting the raw material in a solution state into a mold, it is necessary to accelerate the drying and forming of the raw material to obtain the micro-needle array. The existing methods for accelerating the drying of the micro-needle array mainly install heating or ventilation devices in the mold, and achieve drying by heating or ventilation to accelerate air circulation. However, this method usually causes a fast drying speed at the base part of the micro-needle, while the needle part is not completely dried, that is, the drying speed is uneven. When the base part of the micro-needle is dried and the needle part is not completely dried, due to the liquid raw material tension, wrinkles will be generated at the base part of the micro-needle, and the incompletely dried needle part will also break away from the base. If the freeze-drying technology is used to quickly dry the micro-needle, although the appearance can be maintained to the greatest extent, this method will make the inside of the micro-needle have a porous structure like a foam sponge, resulting in insufficient hardness of the needle and the base, and thus it cannot penetrate the epidermis for normal use. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a micro-needle array aseptic drying device to solve the problem that wrinkles are easily generated during the drying of the existing micro-needle array.

[0005] To achieve the above purpose, the utility model adopts the following technical solutions:

[0006] The utility model provides a micro-needle array aseptic drying device, which includes a drying box, a drying box inner container located inside the drying box, a drying box door located on one side of the drying box, and a PLC controller and a control chassis both located on the top of the drying box;

[0007] An upper temperature control plate and a lower temperature control plate are horizontally arranged inside the drying box inner container, and a high-grade air filter is arranged between the lower temperature control plate and the bottom of the drying box inner container;

[0008] An upper exhaust port is arranged at the top of the drying box inner container, and the side wall is respectively provided with an upper layer air inlet hole, a lower layer air inlet hole, and a clean air outlet hole; the upper layer air inlet hole is located between the top of the drying box inner container and the upper temperature control plate, the lower layer air inlet hole is located between the upper temperature control plate and the lower temperature control plate, and the clean air outlet hole is located between the lower temperature control plate and the bottom of the drying box inner container;

[0009] The bottom inside the drying oven is provided with a primary air filter, which is located below the inner liner of the drying oven and is communicated with the high-grade air filter;

[0010] The top of the drying oven is provided with an upper exhaust fan, which is communicated with the upper exhaust port;

[0011] The drying oven door is provided with an external air inlet, and the external air inlet is communicated with the primary air filter.

[0012] Preferably, a rear exhaust fan is provided on the side wall of the drying oven, an air outlet channel is provided in the middle of the upper temperature control plate, an exhaust port is provided at the bottom of the upper temperature control plate, and the exhaust port is communicated with the rear exhaust fan through the air outlet channel.

[0013] Preferably, the control chassis is electrically connected to the upper temperature control plate, the lower temperature control plate, the upper exhaust fan and the rear exhaust fan respectively through the PLC controller.

[0014] Preferably, the primary air filter is communicated with the high-grade air filter through a primary effect channel.

[0015] Preferably, the upper exhaust port is located at the center of the top of the inner liner of the drying oven.

[0016] Preferably, a sealing strip is provided on the drying oven door, and the sealing strip seals the inner liner of the drying oven.

[0017] Preferably, the external air inlet and the primary air filter are on the same horizontal plane.

[0018] The utility model has the following beneficial effects:

[0019] (1) The heating of the upper temperature control plate and the lower temperature control plate makes the temperature inside the inner liner of the drying oven relatively high, which is convenient for the evaporation of moisture in the micro-needle array; at the same time, the position design of the upper exhaust port, the upper layer air inlet hole, the lower layer air inlet hole, the clean air outlet, the upper exhaust fan, the rear exhaust fan, etc. makes the ventilation air flow gradually flow upward from the lower sides of the left and right sides of the inner liner of the drying oven through the micro-needle array. This not only increases the air flow rate, but also improves the flatness after drying, enabling the micro-needle array to be dried evenly and quickly without wrinkles, greatly improving the drying efficiency and drying effect.

[0020] (2) The setting of the primary air filter and the high-grade air filter can filter out impurities such as dust and microorganisms in the air, improving the quality stability of the micro-needle array. Description of the Drawings

[0021] Figure 1 is a three-dimensional structural schematic diagram of the micro-needle array sterile drying device provided by the embodiment of the present application;

[0022] Figure 2 Exploded perspective view of the three-dimensional structure of the micro-needle array aseptic drying device provided by the embodiment of the present application;

[0023] Figure 3 Schematic perspective view of the three-dimensional structure of the micro-needle array aseptic drying device provided by the embodiment of the present application when the drying chamber door is opened;

[0024] Figure 4 Side cross-sectional view of the micro-needle array aseptic drying device provided by the embodiment of the present application;

[0025] Figure 5 Partial rear view of the micro-needle array aseptic drying device provided by the embodiment of the present application;

[0026] Symbol representation:

[0027] 1 - Drying chamber, 2 - Inner liner of drying chamber, 3 - Drying chamber door, 4 - PLC controller, 5 - Control chassis, 6 - Upper temperature control plate, 7 - Lower temperature control plate, 8 - High-efficiency air filter, 9 - Upper exhaust port, 10 - Upper layer air intake hole, 11 - Lower layer air intake hole, 12 - Clean air outlet, 13 - Primary air filter, 14 - Upper exhaust fan, 15 - External air intake port, 16 - Rear exhaust fan, 17 - Air outlet channel, 18 - Exhaust port, 19 - Primary effect channel, 20 - Sealing strip. Detailed implementation manners

[0028] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0029] The embodiment of the present application provides a micro-needle array aseptic drying device, which includes a drying chamber 1, an inner liner 2 of the drying chamber, a PLC controller 4, a control chassis 5, etc., as shown in the attached Figures 1-3 figure. The drying chamber 1 is the outermost component of the micro-needle array aseptic drying device, and an inner liner 2 of the drying chamber is arranged inside it for placing the micro-needle array to be dried. A drying chamber door 3 is provided on one side of the drying chamber 1 for placing the micro-needle array to be dried after opening the drying chamber 1. A PLC controller 4 and a control chassis 5 are provided on the top of the drying chamber 1. The control chassis 5 is electrically connected to the upper temperature control plate 6, the lower temperature control plate 7, the upper exhaust fan 14, and the rear exhaust fan 16 inside the inner liner 2 of the drying chamber through the PLC controller 4 respectively, so as to control the temperature adjustment of the upper temperature control plate 6 and the lower temperature control plate 7, and control the rotation speeds of the upper exhaust fan 14 and the rear exhaust fan 16 through the PLC controller 4.

[0030] The inner liner 2 of the drying oven is located inside the drying oven 1 and has a certain gap with the inner wall of the drying oven 1 to facilitate gas flow. A primary air filter 13 is provided between the bottom of the inner liner 2 of the drying oven and the bottom of the drying oven 1 for preliminary air filtration. To allow external air to enter the primary air filter 13, an external air inlet 15 is provided on the drying oven door 3, and the external air inlet 15 is connected to the primary air filter 13. Thus, when the drying oven door 3 is closed, external air enters the primary air filter 13 through the external air inlet 15 and is then filtered through the primary air filter 13. Further, to reduce pipeline installation, the external air inlet 15 and the primary air filter 13 are located on the same horizontal plane. In the embodiment of the present application, the primary air filter 13 is rectangular strip-shaped.

[0031] An upper temperature control plate 6 and a lower temperature control plate 7 are horizontally provided inside the inner liner 2 of the drying oven. The upper temperature control plate 6 and the lower temperature control plate 7 are used to place the micro-needle array to be dried and control the heating and drying of the micro-needle array under the control of the chassis 5. A high-level air filter 8 is provided between the lower temperature control plate 7 and the inner bottom of the inner liner 2 of the drying oven. The high-level air filter 8 is connected to the primary air filter 13 through a primary effect channel 19 for further filtering the gas filtered by the primary air filter 13 to achieve gas sterility.

[0032] An upper layer air inlet hole 10, a lower layer air inlet hole 11, and a clean air outlet 12 are respectively provided on the side wall of the inner liner 2 of the drying oven. The upper layer air inlet hole 10 is located between the top of the inner liner 2 of the drying oven and the upper temperature control plate 6, the lower layer air inlet hole 11 is located between the upper temperature control plate 6 and the lower temperature control plate 7, and the clean air outlet 12 is located between the lower temperature control plate 7 and the bottom of the inner liner 2 of the drying oven. Thus, the sterile gas filtered by the high-level air filter 8 enters between the inner liner 2 of the drying oven and the drying oven 1 through the clean air outlet 12, and then enters between the top of the inner liner 2 of the drying oven and the upper temperature control plate 6 and between the upper temperature control plate 6 and the lower temperature control plate 7 respectively through the upper layer air inlet hole 10 and the lower layer air inlet hole 11, thereby realizing the circulation of sterile gas.

[0033] After the sterile air entering between the upper temperature control plate 6 and the lower temperature control plate 7 dries the micro-needle array, it gradually flows upward under the heating action of the lower temperature control plate 7. To facilitate the discharge of the sterile air, an exhaust port 18 is provided at the bottom of the upper temperature control plate 6, and an air outlet channel 17 is provided in the middle, as shown in the appendix. Figure 4 Thus, the sterile air enters the air outlet channel 17 through the exhaust port 18 and is then discharged through the air outlet channel 17. In addition, a rear exhaust fan 16 is provided on the side wall of the drying oven 1, and the air outlet channel 17 is connected to the rear exhaust fan 16. Thus, the sterile air discharged into the air outlet channel 17 is discharged to the outside of the drying oven 1 through the rear exhaust fan 16, as shown in the appendix. Figure 5As shown in the figure. More preferably, two rear exhaust fans 16 are provided on the side wall of the drying oven 1. In the embodiment of the present application, the exhaust port 18 is provided at the center of the bottom of the upper temperature control plate 6 and is provided with 9 holes.

[0034] In order to realize the discharge of the sterile air between the top of the drying oven inner tank 2 and the upper temperature control plate 6 after drying the micro-needle array, an upper exhaust port 9 is provided at the top of the drying oven inner tank 2, and an upper exhaust fan 14 is provided at the top of the drying oven 1, and the upper exhaust fan 14 is communicated with the upper exhaust port 9, so as to realize the air above the upper temperature control plate 6 to be discharged to the outside of the drying oven 1 through the upper exhaust port 9 and the upper exhaust fan 14 in sequence. More preferably, the upper exhaust port 9 in the embodiment of the present application is provided at the center of the top of the drying oven inner tank 2.

[0035] In the embodiment of the present application, a sealing strip 20 is provided on the drying oven door 3, and the sealing strip 20 seals the drying oven inner tank 2 to prevent external air from entering the inside of the drying oven inner tank 2 between the drying oven door 3 and the drying oven 1.

[0036] When the micro-needle array sterile drying device provided by the embodiment of the present application is in use, the drying oven door 3 is opened, the micro-needle array to be dried is placed on the upper temperature control plate 6 and the lower temperature control plate 7, and the drying oven door 3 is closed. The upper temperature control plate 6 and the lower temperature control plate 7 are controlled by the PLC controller 4 to heat, and at the same time, the upper exhaust fan 14 and the rear exhaust fan 16 are controlled to start, so as to form a negative pressure inside the drying oven 1. When the drying oven door 3 is closed, the sealing strip 20 seals the drying oven door 3 and the drying oven inner tank 2. Under the negative pressure condition, external air enters the inside of the drying oven 1 through the external air inlet 15 on the drying oven door 3, and then enters the primary air filter 13 to realize the preliminary filtration of the air. The preliminarily filtered air enters the high-efficiency air filter 8 through the primary effect channel 19 to realize gas sterility. The sterile gas is discharged from the clean air outlet 12 to between the drying oven inner tank 2 and the drying oven 1, and then enters above the upper temperature control plate 6 and the lower temperature control plate 7 through the upper layer air inlet hole 10 and the lower layer air inlet hole 11 respectively, and flows through the micro-needle array to be dried. During the heating process of the upper temperature control plate 6 and the lower temperature control plate 7, the micro-needle array is heated, the moisture in the micro-needle array evaporates, and then is discharged to the rear exhaust fan 16 through the exhaust port 18 and the air outlet channel 17 along with the sterile gas flowing through the upper temperature control plate 6; at the same time, the sterile gas of the lower temperature control plate 7 is discharged to the upper exhaust fan 14 through the upper exhaust port 9, realizing the external discharge of the moisture in the micro-needle array and preventing wrinkles from appearing during the drying process.

[0037] The above are only the preferred embodiments of the present application and are not used to limit the present application. For those skilled in the art, the present application can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A microneedle array sterile drying device, characterized in that: It comprises a drying box (1), a drying box liner (2) located inside the drying box (1), a drying box door (3) located on one side of the drying box (1), and a PLC controller (4) and a control cabinet (5) both located on the top of the drying box (1); An upper temperature control plate (6) and a lower temperature control plate (7) are horizontally arranged inside the drying box inner liner (2), and a high-grade air filter (8) is arranged between the lower temperature control plate (7) and the bottom of the drying box inner liner (2); The top of the drying box liner (2) is provided with an upper exhaust port (9), and the side walls are respectively provided with an upper air inlet hole (10), a lower air inlet hole (11) and a clean air outlet (12); the upper air inlet hole (10) is located between the top of the drying box liner (2) and the upper temperature control plate (6), the lower air inlet hole (11) is located between the upper temperature control plate (6) and the lower temperature control plate (7), and the clean air outlet (12) is located between the lower temperature control plate (7) and the bottom of the drying box liner (2); A primary air filter (13) is provided at the bottom of the drying box (1), wherein the primary air filter (13) is located below the drying box liner (2) and is connected to the high-level air filter (8); An upper exhaust fan (14) is provided on the top of the drying box (1), and the upper exhaust fan (14) is connected to the upper exhaust port (9); The drying box door (3) is provided with an external air inlet (15), and the external air inlet (15) is in communication with the primary air filter (13).

2. The microneedle array sterile drying device according to claim 1, characterized in that: A rear exhaust fan (16) is provided on the side wall of the drying box (1), an air outlet channel (17) is provided in the middle of the upper temperature control plate (6), an exhaust port (18) is provided at the bottom of the upper temperature control plate (6), and the exhaust port (18) is connected to the rear exhaust fan (16) through the air outlet channel (17).

3. The microneedle array sterile drying device according to claim 2, characterized in that: The control chassis (5) is electrically connected to the upper temperature control board (6), the lower temperature control board (7), the upper exhaust fan (14) and the rear exhaust fan (16) respectively through the PLC controller (4).

4. The microneedle array sterile drying device according to claim 1, characterized in that: The primary air filter (13) is connected to the high-grade air filter (8) via a primary-effect channel (19).

5. The microneedle array sterile drying device according to claim 1, characterized in that: The upper exhaust port (9) is located at the top center of the drying box inner container (2).

6. The microneedle array sterile drying device according to claim 1, characterized in that: The drying box door (3) is provided with a sealing strip (20), and the sealing strip (20) seals the drying box liner (2).

7. The microneedle array sterile drying device according to claim 1, characterized in that: The external air inlet (15) and the primary air filter (13) are located on the same horizontal plane.

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