Subpackaging and sampling device

Abstract

The utility model provides a split charging and sampling device, and relates to the technical field of medical instruments. Comprising a filtering device, a buffer, a pressure generator and a container, a liquid inlet and a gas outlet are formed in the upper part of the buffer, the liquid inlet is connected with a first guide pipe connected with a to-be-sampled container, and a first switch device is arranged on the first guide pipe; the filtering device is arranged outside the buffer, the air outlet communicates with the filtering device through a second guide pipe, and the pressure generator is arranged at the end, away from the air outlet, of the filtering device; a liquid outlet is formed in the bottom of the buffer, the container is arranged below the buffer, and the liquid outlet is communicated with the container through a third guide pipe. By adopting the sampling device, the liquid can be effectively prevented from reaching the position of the filtering equipment during sampling, and the situation that the filtering equipment is blocked and further sampling is influenced is avoided.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to a dispensing and sampling device. Background Art

[0002] Dispensing and sampling devices play a crucial role in the research, production, and quality control of cell-based drugs. Cell-based drugs, such as cytotoxic anticancer drugs, are a class of drugs that directly act on cell growth, division, and death. Therefore, their purity and activity are crucial for therapeutic effects.

[0003] Traditional sampling methods for cell-based drugs may involve complex operation steps and manual intervention, which may not only lead to sample contamination and loss but also affect the quality and efficacy of the drugs. In addition, due to the particularity of cell-based drugs, special attention needs to be paid to maintaining the stability and activity of the samples during the sampling process to avoid changes and inactivation of drug components.

[0004] Therefore, in response to the sampling requirements of cell-based drugs, researchers have been working hard to develop new sampling technologies and devices. These technologies aim to achieve a faster and more accurate sampling process to reduce the risk of human error and contamination and improve the quality and efficacy of drugs.

[0005] At the same time, after the cell preparation is completed, the product will be dispensed for the next process, such as cryopreservation; cryopreservation requires removing the air in the bag to prevent damage to the bag caused by the remaining space after cryopreservation.

[0006] In the utility model patent with the authorized announcement number: CN218444630U disclosed in the Chinese patent literature, it discloses a "cell solution sampler and sampling equipment", and specifically discloses including a first connector, a pipe clamp, a sampling container, a second connector, and a filter. One end of the first connector is used to connect an external cell container, the other end of the first connector communicates with the sampling container, one end of the second connector is connected to the filter, and the other end of the second connector communicates with the end of the sampling container away from the first connector; the end of the filter away from the second connector is for an external aspirator; the pipe clamp is clamped on the pipeline between the first connector and the sampling container. In this utility model, the structure of this cell solution sampler is simple, the manufacturing cost is low, and it is convenient to use.

[0007] However, in the prior art disclosed in this patent, the liquid will reach the filter membrane position during sampling, resulting in filter membrane blockage, which will affect further sampling.

[0008] The above information disclosed in the background art section is only used to enhance the understanding of the background of the present disclosure. Therefore, it may include information that does not constitute the prior art known to those of ordinary skill in the art. Utility Model Content

[0009] The main purpose of the present application is to provide a sub-packaging sampling device, which can effectively prevent the liquid from reaching the position of the filtering device during sampling, avoid clogging of the filtering device, and thus affect further sampling.

[0010] To solve the foregoing technical problems, the present application provides a sub-packaging sampling device, including a filtering device, a buffer, and a container; the upper part of the buffer is provided with a liquid inlet and an air outlet, the liquid inlet is connected with a first conduit for connecting with a container to be sampled, and a first switching device is arranged on the first conduit; the filtering device is arranged outside the buffer, and the air outlet is connected to the filtering device through a second conduit; the bottom of the buffer is provided with a liquid outlet, the container is arranged below the buffer, and the liquid outlet is communicated with the container through a third conduit.

[0011] Optionally, in some embodiments of the present invention, a Luer plug is detachably arranged on one side of the filtering device away from the second conduit.

[0012] Optionally, in some embodiments of the present invention, a pressure generator is detachably arranged at one end of the filtering device away from the air outlet.

[0013] Optionally, in some embodiments of the present invention, the pressure generator includes a syringe, a piston, and a piston core rod; the syringe is communicated with the filtering device; the piston is in sealing cooperation with the syringe and is slidably installed in the syringe; the piston core rod is fixedly connected with the piston and is used to drive the piston to slide along the syringe.

[0014] Optionally, in some embodiments of the present invention, the filtering device and the second conduit are connected by threads.

[0015] Optionally, in some embodiments of the present invention, one end of the first conduit near the liquid inlet is lower than one end of the second conduit near the air outlet in the vertical direction.

[0016] Optionally, in some embodiments of the present invention, the first conduit, the second conduit, and the third conduit are all flexible conduits, and the detachable connection between the first conduit and the buffer, between the second conduit and the buffer, between the third conduit and the container, and between the third conduit and the buffer is achieved through interference fit.

[0017] Optionally, in some embodiments of the present invention, the first switching device is any one of a pipe clamp, an electromagnetic valve, an electric valve, a pneumatic valve, or a hydraulic valve.

[0018] Optionally, in some embodiments of the present invention, the number of the containers is multiple, and the multiple containers are respectively communicated with the liquid outlet of the buffer through the third conduit, and the third conduit is provided with a second switching device.

[0019] Optionally, in some embodiments of the present utility model, the first conduit communicates with one ends of a plurality of fourth conduits, and the other ends of the plurality of fourth conduits are respectively used to communicate with a plurality of sub-packaging bags, and a third switching device is provided on any one of the fourth conduits.

[0020] The beneficial effects that can be achieved by this application.

[0021] A sub-packaging sampling device proposed in an embodiment of this application, through the foregoing technical solutions, by providing an air filtration device to filter out bacteria in the air, so that the filtered air reaches a sterile effect. By providing a buffer to play a transitional role in the process of extracting the liquid to be sampled, the liquid to be sampled entering the buffer will naturally flow together to the bottom of the buffer under the action of gravity, and then flow into the container, while the air is above the buffer; the gas and liquid mixed in the liquid to be sampled are separated, achieving the effect of preventing the gas mixed in the liquid to be sampled from entering the container.

[0022] By providing a pressure generator to extract air into the buffer, a negative pressure is formed in the buffer, so that the liquid to be sampled in the container to be sampled can be pumped into the buffer through the first conduit.

[0023] By providing a container to hold the sampled liquid. Brief Description of the Drawings

[0024] Figure 1 It is a schematic structural diagram of the sub-packaging sampling device provided by the embodiment of the present utility model;

[0025] Figure 2 It is a cross-sectional view of the pressure generator provided by the embodiment of the present utility model;

[0026] Figure 3 It is a schematic structural diagram of the sub-packaging sampling device provided by the embodiment of the present utility model connecting multiple containers;

[0027] Figure 4 It is a schematic structural diagram of the sub-packaging sampling device provided by the embodiment of the present utility model connecting multiple sub-packaging bags;

[0028] Icons: 1 - container, 2 - pressure generator, 21 - syringe barrel, 22 - piston, 23 - piston core rod, 24 - push plate, 3 - buffer, 4 - filtration device, 5 - first conduit, 6 - second conduit, 7 - third conduit, 8 - fourth conduit, 9 - first switching device, 10 - second switching device, 11 - third switching device, 12 - Luer plug, 13 - sub-packaging bag.

[0029] The realization of the purpose, functional characteristics and advantages of this application will be further described with reference to the embodiments and the accompanying drawings. Detailed Description of the Embodiments

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present utility model.

[0031] It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiments of the present utility model are only used to explain the relative position relationship and movement conditions between components in a specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indications will also change accordingly.

[0032] In the present utility model, unless otherwise clearly defined and limited, terms such as "connection" and "fixation" should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0033] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present utility model, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the meaning of "and / or" appearing throughout the text includes three parallel solutions. Taking "A and / or B" as an example, it includes solution A, solution B, or the solution where A and B are satisfied simultaneously. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement it. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present utility model.

[0034] The following will further elaborate on the present utility model with reference to the accompanying drawings, so that those skilled in the art can implement it according to the description in the specification.

[0035] Due to the characteristics of the production process of cell-based drugs, which involve multiple preparation steps and complex processes, the complex process operations and the in vitro environment of cells have a significant impact on cell biological activity. Therefore, during the production process of cell-based drugs, it is necessary to regularly take cell samples to monitor indicators such as cell activity, loss rate, and density.

[0036] At the same time, after the cell preparation is completed, the product will be sub-packaged for the next process, such as cryopreservation. Cryopreservation requires removing the air inside the bag to prevent damage to the bag caused by the remaining empty space after cryopreservation.

[0037] To achieve the above objectives,

[0038] Referring to Figure 1 , the first embodiment of the present application provides a sub-packaging and sampling device, including a filtering device 4, a buffer 3, and a container 1. The upper part of the buffer 3 is provided with a liquid inlet and an air outlet. The liquid inlet is connected to a first conduit 5 for connecting with the container to be sampled, and a first switching device 9 is arranged on the first conduit 5. The filtering device 4 is arranged outside the buffer 3, and the air outlet is connected to the filtering device 4 through a second conduit 6. The bottom of the buffer 3 is provided with a liquid outlet, and the container 1 is arranged below the buffer 3. The liquid outlet is communicated with the container 1 through a third conduit 7.

[0039] In this embodiment, an air filtering device 4 is provided to filter out bacteria in the air, so that the filtered air reaches a sterile effect. Among them, multiple filtering materials are used inside the filtering device 4, and each layer filters specific-sized particles and bacteria. First, large particles are intercepted by the mechanical filtering layer, and then electrostatic filtering technology is used to capture tiny particles. In addition, an activated carbon layer is used to adsorb harmful gases and odors to ensure fresh air.

[0040] The buffer 3 is used to play a transitional role during the process of extracting the liquid to be sampled. Under the action of gravity, the liquid to be sampled entering the buffer 3 will naturally flow together to the bottom of the buffer 3 and then flow into the container 1, while the air is above the buffer 3. The gas and liquid mixed in the liquid to be sampled are separated, which has the effect of preventing the gas mixed in the liquid to be sampled from entering the container 1.

[0041] The container 1 is used to hold the liquid after sampling.

[0042] At the same time, by using the first conduit 5 to connect the liquid inlet of the buffer 3 and the container to be sampled, the liquid inlet is provided with a first switching device 9, by using the second conduit 6 to connect the air outlet of the buffer 3 and the filtering device 4, and by using the third conduit 7 to connect the liquid outlet of the buffer 3 and the container 1; thus, the opening and closing of the first switching device 9 can be adjusted

[0043] The specific usage method is as follows: Turn on the first switch device 9. By connecting an external device to the side of the second conduit 6 away from the buffer 3, a negative pressure is generated in the closed cavity of the buffer 3. The liquid to be sampled in the sampling container enters the buffer 3 and flows into the container 1 under the action of gravity, completing one sampling process.

[0044] Optionally, the first conduit 5, the second conduit 6, and the third conduit 7 in this embodiment can all be existing medical rubber conduits. The first switch device 9 and the third switch device 11 can each be any one of a pipe clamp, an electromagnetic valve, an electric valve, a pneumatic valve, or a hydraulic valve. The container 1 is made of a transparent flexible material, such as a rubber-made container, and a scale is provided on the outside of the container 1. The buffer 3 is made of transparent medical plastic material.

[0045] It should be noted that the detachable connection between the first conduit 5 and the buffer 3, between the second conduit 6 and the buffer 3, between the third conduit 7 and the container 1, and between the third conduit 7 and the buffer 3 through interference fit is just a preferred connection method in this embodiment. In other embodiments, bonding or threaded connection methods can also be used to show detachable connection.

[0046] Specifically, one end of the first conduit 5 near the liquid inlet is lower than one end of the second conduit 6 near the air outlet in the vertical direction. Thus, when the external device makes a negative pressure generated in the buffer 3 through the second conduit 6, the accumulated liquid in the buffer 3 can first contact the first conduit 5 and seal the first conduit 5, which can prevent the liquid from entering the filtering device 4.

[0047] Among them, the length of the first conduit 5 and the second conduit 6 extending into the buffer 3 can be adjusted, or the positions where the first conduit 5 and the second conduit 6 are respectively connected to the buffer 3 can be set, so that one end of the first conduit 5 near the liquid inlet is lower than one end of the second conduit 6 near the air outlet in the vertical direction.

[0048] As an optional implementation manner, a Luer plug 12 is detachably provided on the side of the filtering device 4 away from the second conduit 6 for connecting to other components through a standard Luer interface.

[0049] As an optional implementation manner, the pressure generator 2 in this embodiment is used to extract air from the buffer 3 to form a negative pressure in the buffer 3, so that the liquid to be sampled in the sampling container can be pumped into the buffer 3 through the first conduit 5.

[0050] After sampling is completed, the pressure generator 2 is driven in reverse to make the liquid in the first conduit 5 return to the sampling container.

[0051] Specifically, refer to Figure 2, the pressure generator 2 of this embodiment includes a syringe barrel 21, a piston 22 and a piston core rod 23; the syringe barrel 21 is communicated with the filtering device 4; the piston 22 is in sealing fit with the syringe barrel 21 and is slidably installed in the syringe barrel 21; the piston core rod 23 is fixedly connected to the piston 22 and is used to drive the piston 22 to slide along the syringe barrel 21.

[0052] Thus, by moving the piston core rod 23 relative to the syringe barrel 21, the piston 22 can move inside the syringe barrel 21. When it is necessary to generate negative pressure in the buffer 3, the piston core rod 23 is driven to move away from the syringe barrel 21, so as to generate negative pressure inside the syringe barrel 21. The inside of the syringe barrel 21 is communicated with the buffer 3, so that negative pressure is generated in the buffer 3.

[0053] Wherein, a push plate 24 can be provided at one end of the piston core rod 23 away from the piston 22 to facilitate pulling the piston core rod 23. The filtering device 4 and the second conduit are detachably connected by threads.

[0054] Optionally, the outer surface of the syringe barrel 21 of this embodiment is provided with scales to facilitate the adjustment of the intensity of the generated negative pressure.

[0055] As an alternative embodiment, referring to Figure 3 , the second embodiment of the present application provides a specific structure of a dispensing and sampling device. The difference from the first embodiment is that the number of containers 1 is multiple, and the multiple containers 1 are respectively communicated with the liquid outlet of the buffer 1 through the third conduits 7, and the third conduits 7 are provided with second switching devices 10.

[0056] Wherein, a plurality of third conduits 7 are provided at the bottom of the buffer 3 and are respectively connected corresponding to the plurality of containers 1. By adjusting the second switching devices 10 located in different third conduits 7, the liquid in the buffer 3 can be introduced into different containers 1 in batches to realize the dispensing of the liquid.

[0057] As an alternative embodiment, referring to Figure 4 , the third embodiment of the present application provides a specific structure of a dispensing and sampling device. The difference from the first embodiment is that the first conduit 5 is communicated with a plurality of fourth conduits 8, and the other ends of the plurality of fourth conduits 8 are used to communicate with the dispensing bag 13, and any one of the fourth conduits 8 is provided with a third switching device 11.

[0058] Among them, through the first conduit 1, a multi-way joint can be used to connect multiple fourth conduits 8, and the multiple fourth conduits 8 are respectively connected to multiple sub-packaging bags 13. By adjusting the third switching device 11, the buffer 3 is controlled to communicate with the sub-packaging bags 13, so as to facilitate the extrusion of each sub-packaging bag to discharge the residual air inside the sub-packaging bag. When the residual air inside the sub-packaging bag 13 passes through the buffer 3 and is discharged from the filtering device 4, some liquid will also be carried during the gas discharge process. The liquid will remain in the buffer 3 or accumulate in the container 1, and will not wet the filtering device 4, avoiding the failure or blockage of the filtering device 4.

[0059] It should be noted that the first conduit 1 of this embodiment can be connected to multiple fourth conduits 8 through a multi-way joint, so as to be able to connect multiple different sub-packaging bags 13. This is only a preferred implementation mode of this embodiment. In other embodiments, several fourth conduits 8 can also be directly connected to the top of the buffer 3 and other ways to realize the connection between the buffer 3 and multiple sub-packaging bags 13.

[0060] Optionally, the fourth conduit 8 and the sub-packaging bag 13 of this embodiment can be detachably connected by threads.

[0061] Furthermore, after the cell preparation is completed, the product will be sub-packaged for the next process, such as cryopreservation; cryopreservation requires the exclusion of air in the bag body to prevent damage to the bag body caused by the remaining space after cryopreservation.

[0062] After the sampling is completed, because the original air in the system pipeline will remain in the sub-packaging bag 13, the sub-packaging bag 13 can be manually squeezed to enable the gas to be discharged from the filtering device 4. Some liquid will also be carried during the gas discharge process. The liquid will remain in the buffer 3 or accumulate in the container 1, and will not wet the filtering device, causing the filtering device 4 to fail or be blocked.

[0063] The above are only the preferred embodiments of the present invention and are not used to limit the present invention. For those skilled in the art, it is obvious that this application is not limited to the details of the above exemplary embodiments, and can be implemented in other specific forms without departing from the spirit or basic characteristics of this application.

Claims

1. A packaging sampling device, characterized in that: including a filter device, a buffer and a container; The buffer is provided with a liquid inlet and an air outlet at the upper part, the liquid inlet is connected to a first conduit for connecting to a container to be sampled, and the first conduit is provided with a first switch device; the filter device is arranged outside the buffer, and the air outlet is connected to the filter device through a second conduit; The bottom of the buffer is provided with a liquid outlet, the container is arranged below the buffer, and the liquid outlet is communicated with the container through a third conduit.

2. The packaging and sampling device according to claim 1, characterized in that: A Luer plug is detachably provided on one side of the filter device away from the second conduit.

3. The packaging and sampling device according to claim 1, characterized in that: A pressure generator is detachably provided at one end of the filter device away from the air outlet.

4. The packaging and sampling device according to claim 3, characterized in that: The pressure generator includes a syringe, a piston and a piston core rod; the syringe is connected to the filtering device; the piston is sealed and matched with the syringe and can be slidably installed in the syringe; the piston core rod is fixedly connected to the piston and is used to drive the piston to slide along the syringe.

5. The packaging and sampling device according to claim 1, characterized in that: The filtering device is connected to the second conduit via threads.

6. The packaging and sampling device according to claim 1, characterized in that: An end of the first conduit close to the liquid inlet is lower than an end of the second conduit close to the gas outlet in a vertical direction.

7. The packaging and sampling device according to claim 1, characterized in that: The first conduit, the second conduit and the third conduit are all flexible conduits, and the first conduit and the buffer, the second conduit and the buffer, the third conduit and the container, and the third conduit and the buffer are all detachably connected by interference fit.

8. The packaging and sampling device according to claim 1, characterized in that: The first switch device is any one of a pipe clamp, a solenoid valve, an electric valve, a pneumatic valve or a hydraulic valve.

9. The packaging and sampling device according to claim 1, characterized in that: There are multiple containers, and the multiple containers are connected to the liquid outlet of the buffer through a third conduit respectively. The third conduit is provided with a second switch device.

10. The packaging and sampling device according to claim 1, characterized in that: The first conduit is connected to one end of a plurality of fourth conduits, and the other ends of the plurality of fourth conduits are respectively used to connect to a plurality of packaging bags, and any of the fourth conduits is provided with a third switch device.

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