Rodent vagus nerve stimulation device

Abstract

The utility model discloses a vagus nerve stimulation device for rodents. The vagus nerve stimulation device comprises a stimulation component and a fixing component, the stimulation part is connected in a clamping mode through a clamping assembly arranged on the fixing part. The clamping assembly slides left and right to control clamping or loosening of the fixing part so as to adjust clamping or releasing of the stimulation part. A side opening is formed in one side of the stimulation front end, the two ends of the side opening are each provided with a movable sleeve, a fixing block is fixedly arranged on the lower side of the front end of the outer wall of each movable sleeve, a buckle is arranged on the section of each movable sleeve, and a clamping groove is formed in the corresponding section of the other movable sleeve. The fixed block controls the matching of the sliding adjusting buckle and the clamping groove of the movable pipe to realize the opening and closing of the movable sleeve; according to the utility model, the vagus nerve of a rodent can be directly stimulated by using the electrode in an animal body, so that the stimulation is more accurate; animals can be effectively prevented from being grabbed and pulled, and it is guaranteed that experiments are conducted accurately and effectively.

Description

Technical Field

[0001] The utility model belongs to the technical field of electrostimulation experimental equipment, and particularly relates to a vagus nerve stimulation device for rodents. Background Art

[0002] In the field of modern medicine, the development of neuromodulation technology has provided new hope for the treatment of various neurological diseases. Among them, vagus nerve stimulation technology, as a cutting-edge treatment method, has received increasing attention and research. The vagus nerve is the main parasympathetic nerve in the human body, responsible for regulating many autonomic nerve functions, including heart rate, blood pressure, respiration, etc. Therefore, stimulating the vagus nerve can produce extensive and positive physiological effects, thus becoming a potential method for treating various diseases. The mechanism of action of vagus nerve stimulation technology is not yet clear, so a large number of basic studies are needed to clarify its mechanism of action. Rodents, as one of the research objects of vagus nerve stimulation technology, are widely used, but there is a lack of accurate and reliable stimulation equipment.

[0003] Currently, there are also corresponding vagus nerve stimulation devices. For example, the patent with the patent number CN219167519U discloses an embedded animal ear concha area electrostimulation device. The protrusion of the ear fixing structure of this device can be embedded in the ear of the animal, in close contact with the ear concha area, and accurately stimulate the vagus nerve in the ear concha area of the animal, ensuring the accuracy of mouse stimulation to a certain extent. However, this device conducts the electrostimulation signal to the vagus nerve through the ear, still having unstable irritation to a certain extent, affecting the accuracy of the experiment. In addition, this device is used outside the animal body, and the animal may scratch, making it difficult to conduct the experiment in real time.

[0004] Therefore, a vagus nerve stimulation device for rodents is needed. This device can directly use electrodes to stimulate the vagus nerve of rodents in the animal body, with more obvious experimental effects, more accurate stimulation, and can be left in the body of the mouse for a long time to conduct electrostimulation at any time, effectively preventing the animal from scratching and ensuring the accurate and long-term effective conduct of the experiment. Summary of the Utility Model

[0005] To solve the above technical problems, the present utility model designs a vagus nerve stimulation device for rodents, which includes a stimulation component and a fixing component; the stimulation component is clamped and connected through a clamping assembly provided on the fixing component; the clamping or releasing of the stimulation component is adjusted by controlling the clamping or loosening of the fixing component through the left-right sliding of the clamping assembly; a side opening is provided on one side of the front end of the stimulation, and a movable sleeve is provided at each end of the side opening. A fixing block is fixedly provided on the lower side of the front end of the outer wall of the movable sleeve, and a buckle is provided on the cross-section of the movable sleeve, and a clamping groove is opened on the corresponding cross-section of the other movable sleeve; the sliding of the movable tube is controlled by the fixing block to adjust the cooperation of the buckle and the clamping groove to realize the opening and closing of the movable sleeve.

[0006] Further, the stimulation component is a hollow tubular structure, with the upper end closed, the lower end open, and a plurality of electrodes are provided in the lumen; the upper ends of the electrodes pass through the side opening and extend outwards by a certain length, and the lower ends are connected to a micro socket, and the extended electrodes can wrap around the vagus nerve.

[0007] Further, a connecting line is fixedly provided between the movable sleeves, and U-shaped grooves are opened on the interfaces of the two movable sleeves corresponding to the connecting line; a fixing clip is provided at the end of the connecting line.

[0008] Further, the fixing clip includes a fixing clip body and a support block; rotating shafts are provided on both sides of the upper end of the fixing clip body, the support block is fixedly provided on both sides of the fixing clip body, the support block extends inwards to form an extension block, and a round hole is opened at the upper end of the extension block.

[0009] Further, a clamping hole is opened in the middle of the fixing block; the diameter of the clamping hole is between 2 mm and 5 mm.

[0010] Further, fixing belts are fixedly connected to both sides of the fixing component, and magic tapes are connected to the ends of the fixing belts.

[0011] Further, the clamping assembly includes a fixing sleeve and clamping petals, the clamping petals are a bifurcated petal structure with a linearly changing diameter, and there are at least 3 clamping petals; the fixing sleeve is sleeved outside the clamping petals.

[0012] Further, the stimulation component is made of polyethylene material, the electrodes are made of multi-strand spiral platinum wires, and the surfaces of the electrodes are wrapped with polyethylene tubes.

[0013] The beneficial effects of the present utility model are:

[0014] The utility model controls the clamping or relaxation of the fixing component through the left - right sliding of the clamping component to adjust the clamping or disengagement of the stimulating component, so that the stimulating component can be fixed during use to prevent it from falling off due to the activities of animals. Secondly, by placing the stimulating component in the body of the animal, the utility model can effectively prevent the animal from scratching and pulling it during the experiment, ensuring the smooth progress of the experiment. In addition, a fixing block is fixedly arranged on the lower side of the front end of the outer wall of the moving sleeve of the utility model. A buckle is arranged on the cross - section of the moving sleeve, and a clamping groove is opened on the corresponding cross - section of another moving sleeve. The sliding of the moving tube is controlled through the fixing block, and the cooperation of the buckle and the clamping groove is adjusted to realize the opening and closing of the moving sleeve, which can reinforce the side opening, ensure that the electrode will not be pulled, and increase its stability. At the same time, in the utility model, the exposed plug is further protected and fixed through the fixing component outside, which can provide double - layer protection and fixation. And through this device, the vagus nerve of rodents can be directly stimulated by using electrodes in the animal body, and the experimental effect is more obvious and the stimulation is more accurate. Brief Description of the Drawings

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for describing the embodiments will be briefly introduced below.

[0016] Figure 1 It is an overall structural schematic diagram of a vagus nerve stimulation device for rodents;

[0017] Figure 2 It is a rear - view overall structural schematic diagram of a vagus nerve stimulation device for rodents;

[0018] Figure 3 It is an overall schematic diagram of the stimulating component of a vagus nerve stimulation device for rodents;

[0019] Figure 4 It is a partial schematic diagram of the moving sleeve of the stimulating component of a vagus nerve stimulation device for rodents;

[0020] Figure 5 It is a structural schematic diagram of the fixing component of a vagus nerve stimulation device for rodents;

[0021] Figure 6 It is a structural schematic diagram of the fixing clip of a vagus nerve stimulation device for rodents;

[0022] Figure 7 It is an internal cross - sectional schematic diagram of the stimulating device of a vagus nerve stimulation device for rodents;

[0023] Figure 8 It is a cross - sectional structural schematic diagram of the clamping - groove part of a vagus nerve stimulation device for rodents;

[0024] Figure 9 It is a schematic cross-sectional view of the fixing sleeve part of a vagus nerve stimulation device for rodents.

[0025] In the accompanying drawings, the list of components represented by each reference numeral is as follows:

[0026] 1 - Stimulation component, 101 - Moving sleeve, 1011 - Fixing block, 10111 - Clamping hole, 1012 - U-shaped groove, 102 - Connecting wire, 1021 - Fixing clip, 10211 - Rotating shaft, 10212 - Supporting block, 10213 - Through hole, 10214 - Extension block, 103 - Side opening, 104 - Socket, 105 - Electrode, 106 - Snap, 107 - Card slot, 2 - Fixing component, 201 - Fixing belt, 2011 - Velcro, 202 - Fixing sleeve, 203 - Clamping flap. Specific implementation mode

[0027] The utility model discloses a vagus nerve stimulation device for rodents, including: a stimulation component 1 and a fixing component 2; the stimulation component 1 is clamped and connected through a clamping component arranged on the fixing component 2; the clamping or releasing of the stimulation component 1 is adjusted by controlling the clamping or loosening of the fixing component 2 through the left-right sliding of the clamping component; a side opening 103 is provided on one side of the front end of the stimulation, and a moving sleeve 101 is arranged at each end of the side opening 103. A fixing block 1011 is fixedly arranged on the lower side of the front end of the outer wall of the moving sleeve 101. A snap 106 is arranged on the cross-section of the moving sleeve 101, and a card slot 107 is opened on the corresponding cross-section of the other moving sleeve 101; the cooperation of the snap 106 and the card slot 107 is realized by controlling the sliding of the moving tube through the fixing block 1011 to achieve the opening and closing of the moving sleeve 101. Embodiment 1

[0028] As Figure 5 shown, in this embodiment, the stimulation component 1 is a hollow tubular structure, closed at the upper end, open at the lower end, and a plurality of electrodes 105 are arranged in the tube cavity; the upper ends of the electrodes 105 pass through the side opening 103 and extend outwards by a certain length, and the lower ends are connected with a micro socket 104. The extended electrodes 105 can wrap around the vagus nerve; the plurality of electrodes 105 in the tube cavity are multi-strand spiral platinum wires, and the platinum wires are insulated by being wrapped with polyethylene materials. The tube body of the stimulation component 1 is made of polyethylene materials, which can effectively prevent damage and mis-stimulation to the tissues around the vagus nerve; the micro socket 104 arranged at the lower end connects the stimulation signal of the external stimulator with the fixed micro plug at the head end through the micro plug when stimulation is needed, so as to exert a stimulating effect on the vagus nerve. The micro plug can be stimulated at any time as needed. Embodiment 2

[0029] In this embodiment, a connecting line 102 is fixedly arranged between the movable sleeves 101, and U-shaped grooves 1012 are formed on the interfaces of the two movable sleeves 101 corresponding to the connecting line 102; a fixing clip 1021 is arranged at the end of the connecting line 102; the U-shaped grooves 1012 can be used for storing the connecting line 102, ensuring that when the movable sleeves 101 are in use, the problem that the movable sleeves 101 cannot be tightened due to the existence of the storage line does not occur;

[0030] In this embodiment, a fixing clip 1021 is arranged at the end of the connection. The fixing clip 1021 includes a fixing clip 1021 main body and a support block 10212; fixing clip 10211s are arranged on both sides of the upper end of the fixing clip 1021 main body, the support block 10212 is fixedly arranged on both sides of the fixing clip 1021 main body, the support block 10212 extends inward to form an extension block 10214, and a round hole is formed at the upper end of the extension block 10214. The using process is as follows: Pass the front end of the surgical forceps through the through hole 10213, and then pinch the surgical forceps inward. At this time, driven by the support block 10212, the plates on both sides of the fixing clip 1021 rotate around the fixing clip 10211 to both sides to achieve the opening effect. After aligning and surrounding the nerve, release the surgical forceps. Under the action of the scroll spring arranged on the fixing clip 10211, the fixing clip 1021 returns to its original state to form a clamping effect, and then use a surgical thread to fix the fixing clip 1021 on the muscle around the vagus nerve. Embodiment 3

[0031] As Figure 4 、 Figure 8 shown, in this embodiment, a clamping hole 10111 is formed in the middle of the fixing block 1011; the diameter of the clamping hole 10111 is between 2 mm and 5 mm; the clamping hole 10111 on the fixing block 1011 is adapted to the diameter of the front-end forceps arm of the surgical forceps, facilitating the penetration of the surgical forceps, thereby driving the movable sleeve 101 to move through, and then fastening it through the buckle 106. The specific principle is as follows: First, pass the surgical forceps through the clamping hole 10111, and then gently pinch the forceps. Driven by the surgical forceps, the fixing block 1011 drives the two movable sleeves 101 to move towards each other; at this time, the buckle 106 moves towards the card slot 107 until the buckle 106 is buckled into the card slot 107 to complete the locking, that is, to complete the reinforcement of the side opening 103. Embodiment 4

[0032] In this embodiment, fixing straps 201 are fixedly connected to both sides of the fixing member 2, and a magic tape 2011 is connected to the end of the fixing strap 201; the fixing member 2 is fixed to the skull of the experimental animal through the fixing strap 201, and adhesion is performed through the magic tape 2011, which is convenient for disassembly; in addition, in this embodiment, in order to ensure the stability of the entire device, the device can be first fixed to the skull of the experimental animal using dental cement, and then the fixing member 2 can be used for secondary reinforcement. Embodiment 5

[0033] In this embodiment, the clamping assembly includes a fixing sleeve 202 and clamping flaps 203. The clamping flaps 203 are a bifurcated flap structure with a linearly changing diameter, and there are at least 3 clamping flaps 203; the fixing sleeve 202 is sleeved outside the clamping flaps 203; the clamping flaps 203 are a structure with a gradually decreasing diameter. As Figure 5 , Figure 9 shown, when the fixing sleeve 202 is slid to the right, the clamping flaps 203 are squeezed by the fixing sleeve 202 and will move inward to clamp the stimulating member 1, and the tighter it gets as it is slid further to the right; when the fixing sleeve 202 is slid to the left, the clamping flaps 203 will no longer be squeezed by the fixing sleeve 202, and the clamping flaps 203 will return to their original positions, and the looser it gets as it is slid further to the left.

[0034] The working principle of the present utility model is as follows: First, separate the stimulating member 1 and the fixing member 2, then place the stimulating device at the incision position of the experimental animal, then wind the extended electrode 105 around the vagus nerve of the experimental animal, then align the surgical forceps with the clamping hole 10111 of the fixing block 1011 and insert it, then gently engage the surgical forceps to clamp the movable sleeve 101, completing the reinforcement of the side opening 103; then fix the wrapped vagus nerve through the fixing clip 1021, and then use surgical sutures to fix the metal clip to the muscle tissue around the vagus nerve to prevent it from falling off; then pass the remaining stimulating member 1 through the subcutaneous tunnel and open it at the animal's head. At this time, clamp and fix the stimulating member 1 through the fixing component by the fixing member 2, and then fix it to the skull of the experimental animal through the fixing straps 201 and the magic tape 2011 at both ends of the fixing member 2; then when stimulation is needed, connect the external stimulation signal to the fixed micro-plug at the head end to exert a stimulating effect on the vagus nerve.

[0035] The above-disclosed preferred embodiments of the present utility model are only used to help illustrate the present utility model. The preferred embodiments do not elaborate on all details and do not limit the utility model to the specific embodiments described.

Claims

1. A rodent vagus nerve stimulation device, characterized in that: include: Stimulation components and fixation components; The stimulation component is connected by clamping through a clamping assembly arranged on the fixed component; the clamping or release of the stimulation component is adjusted by controlling the clamping or loosening of the fixed component by sliding left and right of the clamping assembly; a side opening is opened on one side of the front end of the stimulation, and a movable sleeve is respectively arranged at both ends of the side opening, a fixed block is fixedly arranged on the lower side of the front end of the outer wall of the movable sleeve, a buckle is arranged on the cross section of the movable sleeve, and a slot is opened on the corresponding cross section of the other movable sleeve; the sliding of the movable sleeve is controlled by the fixed block to adjust the cooperation of the buckle and the slot to realize the opening and closing of the movable sleeve.

2. A rodent vagus nerve stimulation device according to claim 1, characterized in that: The stimulation component is a hollow tubular structure with a closed upper end, an open lower end and a plurality of electrodes arranged in the lumen; the upper end of the electrode passes through the side opening and extends outward for a certain length, and the lower end is connected to a micro socket, and the extended electrode can wrap around the vagus nerve.

3. A rodent vagus nerve stimulation device according to claim 1, characterized in that: A connecting line is fixedly arranged between the movable sleeves, and a U-shaped groove is opened on the interface of the movable sleeves on both sides corresponding to the connecting line; and a fixing clamp is arranged at the end of the connecting line.

4. A rodent vagus nerve stimulation device according to claim 3, characterized in that: The fixing clamp comprises a fixing clamp body and a support block; a rotating shaft is arranged on both sides of the upper end of the fixing clamp body, the support blocks are fixedly arranged on both sides of the fixing clamp body, and the support blocks extend inwardly to form extension blocks, and a round hole is opened on the upper end of the extension blocks.

5. The rodent vagus nerve stimulation device according to claim 1, characterized in that: A clamping hole is opened in the middle of the fixing block; the diameter of the clamping hole is between 2mm and 5mm.

6. A rodent vagus nerve stimulation device according to claim 1, characterized in that: The two sides of the fixing component are fixedly connected with fixing belts, and the ends of the fixing belts are connected with Velcro.

7. A rodent vagus nerve stimulation device according to claim 1, characterized in that: The clamping assembly comprises a fixing sleeve and a clamping petal, wherein the clamping petal is a bifurcated petal structure with a linearly changing diameter and the clamping petal has at least three petals; the fixing sleeve is provided with the outside of the clamping petal.

8. A rodent vagus nerve stimulation device according to claim 2, characterized in that: The stimulation component is made of polyethylene material, the electrode is made of multiple spiral platinum wires, and the surface of the electrode is wrapped with a polyethylene tube.

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