Sample loading device with needle cleaning function

Abstract

The utility model relates to the field of biological detection, in particular to a sample loading device with a needle cleaning function, which comprises a sample loading cleaning structure, a horizontal movement structure and a vertical movement structure, the horizontal movement structure drives the sample loading cleaning structure to move horizontally, the sample loading cleaning structure is mounted on a motor support, and the motor support is connected with a horizontal movement slider. The horizontal movement structure is fixed on the horizontal cross beam; a Z-direction motor and a Z-direction linear guide rail are further arranged on the motor support, and the Z-direction motor is connected with a sample loading needle of the sample loading cleaning structure. The sample loading needle is nested in the cleaning swab, the inner wall and the outer wall of the needle and the pipeline can be cleaned at any time, the sample loading needle does not need to specially move to the position of a cleaning pool, space and time are saved, and the instrument sample loading efficiency is greatly improved.

Description

Technical Field

[0001] The utility model relates to the field of biological detection, in particular to a sampling device with a cleaning needle function. Background Technique

[0002] For many in vitro diagnostic instruments, it is necessary to transfer the processed blood samples to be tested to specific detection institutions for further analysis and result output.

[0003] After the sampling needle sucks the blood sample from the blood collection tube or the reaction cup, there will be residues on the inner wall and outer wall of the sampling needle and in the pipeline connected to the sampling needle. To ensure the accuracy of the test results, it is necessary to clean the residual blood sample or impurities on the sampling needle before testing the next sample to avoid affecting the subsequent sample testing.

[0004] The currently commonly used cleaning method is to use a special cleaning pool for cleaning, and the sampling needle is cleaned by repeatedly injecting the cleaning liquid into the cleaning pool. The disadvantages are that the cleaning pool needs to occupy space inside the instrument, and the sampling needle needs to move to a specific cleaning pool position to achieve cleaning.

[0005] As a popular branch of in vitro diagnostic instruments in recent years, POCT has high requirements for the space of the instrument to facilitate users to place and carry. Therefore, it is necessary to compress the instrument space as much as possible and reduce unnecessary structures. If a cleaning pool is used, it will inevitably waste a certain amount of space, which is not conducive to the instrument layout, and the sampling needle needs to move to the position of the cleaning pool every time after sampling to complete the cleaning before starting to suck the next blood sample, wasting travel and time.

[0006] At the same time, the sampling needle generally needs to suck the blood samples of multiple channels to the detection institutions respectively. There are generally two common ways for the sampling needle. One is that the rotating arm drives the sampling needle to move along an arc with a radius of R, and the other is that the linear motion arm drives the sampling needle to move to a specific position along the linear guiding structure. Since the medical device tests the blood samples of patients and the blood samples are very precious, the volume of the reaction cup is relatively small, so the motion accuracy requirements of the sampling needle are relatively high, and extremely small motion deviations need to be achieved.

[0007] The commonly used position control method is to add a flange at the end of the motor shaft and cut corresponding notches, and cooperate with the photoelectric switch to realize the judgment and correction of the motion position. Or two photoelectric switches are set at the origin and the end of the linear motion mechanism respectively to judge and correct the motion deviation of the motor. These two methods will inevitably increase additional structural parts or additional photoelectric switches, increasing the cost, and there are still deviations in position control and real-time correction cannot be achieved. If real-time correction is to be realized, an encoder is often used, generally an encoder with a dividing disk installed at the end of the motor, with a high cost. Summary of the Invention

[0008] To solve the above problems existing in the prior art, a sample loading device with a cleaning needle function applicable to POCT is provided herein.

[0009] To achieve the above technical effects, the present utility model is realized through the following technical solutions:

[0010] A sample loading device with a cleaning needle function includes a sample loading and cleaning structure, a horizontal movement structure for driving the sample loading and cleaning structure to move horizontally, and a vertical movement structure. The sample loading and cleaning structure is installed on a motor bracket, the motor bracket is connected to a horizontal movement slider, and the horizontal movement structure is fixed on a horizontal crossbeam; a Z-direction motor and a Z-direction linear guide are further provided on the motor bracket, and the Z-direction motor is connected to a sample loading needle of the sample loading and cleaning structure.

[0011] Further, the sample loading and cleaning structure includes a sample loading needle bracket, a sample loading needle, and a cleaning swab. The sample loading needle is fixed on the sample loading needle bracket, the bottom of the sample loading needle passes through the cleaning swab, and the cleaning swab is connected with a liquid inlet pipe and a liquid outlet pipe.

[0012] Still further, the sample loading needle is fixed on the sample loading needle bracket by two guiding screws, and a compression spring is provided between the two guiding screws and the sample loading needle.

[0013] Still further, at the inlet of the sample loading needle, a notch is provided to ensure that the liquid can be normally sucked into the pipeline; a code scanning module is installed on the sample loading needle bracket; the cleaning swab is a cylindrical structure with a hollow center, the sample loading needle passes through the hollow part of the cylindrical structure, and two needle tubes are respectively fixed on the cylindrical structure in the radial direction and communicate with the hollow center of the axis. For the two needle tubes, the lower one is the liquid inlet, and the upper one is the liquid outlet.

[0014] Further, the horizontal movement structure includes a horizontal crossbeam, on which a driving motor, a driving wheel, a driven wheel, a synchronous belt, and an X-direction linear guide are installed. An X-direction movement slider is provided on the X-direction linear guide, the X-direction movement slider is connected to the vertical movement structure, the driving motor is connected to the driving wheel, the driving wheel is connected to the driven wheel through the synchronous belt, a synchronous belt connecting plate is fixed on the synchronous belt, and the synchronous belt connecting plate is connected to the motor bracket.

[0015] Still further, a driving plate is installed at the end of the driving motor, and a radial magnet is fixedly installed at the end of the motor shaft of the driving motor. The radial magnet is opposite to a magnetic angle sensing chip provided on the driving plate.

[0016] Furthermore, the vertical movement structure includes a motor bracket, a Z-axis linear guide rail and a Z-axis motor mounted on the motor bracket. A Z-axis linear guide rail slider is mounted on the Z-axis linear guide rail, and the sample loading needle bracket is fixed to the Z-axis linear guide rail slider by screws. The vertical movement of the sample loading needle is realized by driving the sample loading needle bracket with the Z-axis motor.

[0017] Cleaning process:

[0018] When cleaning the outer wall of the sample loading needle, control the liquid path pump valve to perform the liquid suction function at the liquid outlet to form a negative pressure, and inject the cleaning liquid at the liquid inlet. The flow rate should be less than the flow rate at the liquid outlet. Under the action of the negative pressure, after the cleaning liquid enters from the liquid inlet, it flows through the gap between the sample loading needle and the hollow structure, and the cleaning of the outer wall of the needle can be completed. At the same time, by controlling the vertical movement of the sample loading needle, the cleaning of the entire outer wall of the sample loading needle can be completed.

[0019] The advantages of the present utility model are as follows:

[0020] 1. The sample loading needle of the present application is nested in the cleaning swab, and the inner and outer walls of the needle and the pipeline can be cleaned at any time. There is no need to specifically move to the cleaning pool position, saving space and time, and greatly improving the sample loading efficiency of the instrument.

[0021] 2. The position control of the sample loading needle of the present application adopts a radial magnet and a magnetic angle sensing chip, and is combined with a photoelectric switch for determining the origin position of the module movement, which can realize the real-time correction of the position of the sample loading needle.

[0022] 3. The sample loading needle of the present application is buffered by a spring, which can protect the needle from being deformed by collision. A notch is opened at the tip of the sample loading needle to ensure smooth sample suction and prevent the formation of negative pressure. Description of the drawings

[0023] Figure 1 It is a three-dimensional schematic diagram of the sample loading device.

[0024] Figure 2 It is a sectional view of the sample loading needle module.

[0025] Figure 3 It is a three-dimensional diagram of the sample loading needle.

[0026] Figure 4 It is a bottom notch diagram of the sample loading needle.

[0027] Figure 5 The X-axis position control of the sample loading needle adopts a radial magnet and a magnetic angle sensing chip.

[0028] Figure 6 It is a schematic diagram of the sample loading needle module.

[0029] In the drawings:

[0030] 1 - Motor bracket, 2 - Horizontal movement slider, 3 - Horizontal crossbeam, 4 - Z-axis motor, 5 - Z-axis linear guide, 6 - Sampling needle, 7 - Sampling needle bracket, 8 - Cleaning swab, 9 - Liquid inlet pipe, 10 - Liquid outlet pipe, 11 - Guide screw, 12 - Compression spring, 13 - Scanning code module, 14 - Driving motor, 15 - Driving wheel, 16 - Driven wheel, 17 - Timing belt, 18 - X-axis linear guide, 19 - Timing belt connecting plate, 20 - Driving plate, 21 - Radial magnet, 22 - Magnetic angle sensing chip, 23 - Z-axis linear guide slider. Detailed implementation mode

[0031] The embodiments of the present invention will be described in detail below. These embodiments are implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operation processes are given. However, the protection scope of the present invention is not limited to the following embodiments.

[0032] It should be noted that all directional indications (such as both sides, edges, top, bottom, left, right, front, back, middle, top end, bottom end, tail, axial direction, radial direction...) in the embodiments of the present invention are only used to explain the relative position relationship and motion state between components in a certain specific posture (as shown in the drawings). If this specific posture changes, the directional indications will also change accordingly.

[0033] Embodiment 1

[0034] As Figure 1 shown, a sampling device with a cleaning needle function includes a sampling and cleaning structure, a horizontal movement structure that drives the sampling and cleaning structure to move horizontally, and a vertical movement structure. The sampling and cleaning structure is installed on the motor bracket 1, the motor bracket 1 is connected to the horizontal movement slider 2, and the horizontal movement structure is fixed on the horizontal crossbeam 3; a Z-axis motor 4 and a Z-axis linear guide 5 are also provided on the motor bracket 1, and the Z-axis motor 4 is connected to the sampling needle 6 of the sampling and cleaning structure.

[0035] The sampling needle 6 of the present application is nested in the cleaning swab 8, and the inner and outer walls of the needle and the pipeline can be cleaned at any time, without specifically moving to the cleaning pool position, saving space and time, and greatly improving the sampling efficiency of the instrument. The sampling needle 6 of the present application uses a spring for buffering, which can protect the needle from being deformed by collision. A notch is opened at the tip of the sampling needle 6 to ensure smooth sample suction and prevent the formation of negative pressure.

[0036] Embodiment 2

[0037] As Figure 1As shown in the figure, a sample loading device with a cleaning needle function includes a sample loading and cleaning structure, a horizontal movement structure for driving the sample loading and cleaning structure to move horizontally, and a vertical movement structure. The sample loading and cleaning structure is installed on a motor bracket 1, and the motor bracket 1 is connected to a horizontal movement slider 2. The horizontal movement structure is fixed on a horizontal crossbeam 3. A Z-axis motor 4 and a Z-axis linear guide 5 are also arranged on the motor bracket 1, and the Z-axis motor 4 is connected to a sample loading needle 6 of the sample loading and cleaning structure.

[0038] The sample loading and cleaning structure includes a sample loading needle bracket 7, a sample loading needle 6, and a cleaning swab 8. The sample loading needle 6 is fixed on the sample loading needle bracket 7. The bottom of the sample loading needle 6 passes through the cleaning swab 8, and the cleaning swab 8 is connected with a liquid inlet pipe 9 and a liquid outlet pipe 10.

[0039] The sample loading needle 6 is fixed on the sample loading needle bracket 7 by two guiding screws 11. Between the two guiding screws 11 and the sample loading needle 6, a compression spring 12 is arranged. The spring reduces the precision of the position control of the sample loading needle 6 and protects the sample loading needle 6. When there is an overshoot during movement, the sample loading needle 6 is pushed upward, the spring is compressed, and the sample loading needle 6 will not be deformed due to force.

[0040] At the inlet of the sample loading needle 6, there is a notch for ensuring that the liquid can be normally sucked into the pipeline. A code scanning module 13 is installed on the sample loading needle bracket 7 for scanning and reading the two-dimensional code or one-dimensional code information of the sample to be analyzed, which is convenient for information confirmation and traceability. The cleaning swab 8 is a cylindrical structure with a hollow center. The sample loading needle 6 passes through the hollow part of the cylindrical structure. There are two needle tubes in the radial direction, which are fixed on the cylindrical structure and communicate with the hollow center of the axis. For the two needle tubes, the lower one is the liquid inlet, and the upper one is the liquid outlet. The vertical movement structure is used to drive the sample loading needle 6 to move up and down, and the cleaning swab 8 is fixed.

[0041] The horizontal movement structure includes a horizontal crossbeam 3 (for supporting and fixing), a driving motor 14, a driving wheel 15, a driven wheel 16, a synchronous belt 17, and an X-axis linear guide 18 (for horizontal guiding) are installed on the horizontal crossbeam 3. A horizontal movement slider 2 is arranged on the X-axis linear guide 18. The horizontal movement slider 2 is connected with the vertical movement structure. The driving motor 14 is connected with the driving wheel 15. The driving wheel 15 is connected with the driven wheel 16 through the synchronous belt 17. A synchronous belt connecting plate 19 is fixed on the synchronous belt 17. The synchronous belt connecting plate 19 is connected with the motor bracket 1. The motor bracket 1 and the synchronous belt 17 are connected together through the synchronous belt connecting plate 19. Then, the driving motor 14 drives the synchronous belt 17 to move, so that the synchronous belt 17 drives the motor bracket 1, enabling the motor bracket 1 to move horizontally along the X-axis guide.

[0042] A drive plate 20 is installed at the end of the drive motor 14. A radial magnet 21 is fixedly installed at the end of the motor shaft of the drive motor 14. A magnetic angle sensing chip 22 is arranged on the drive plate 20 opposite to the radial magnet 21. Since the magnetic angle sensor chip has the characteristics of high resolution and high sensitivity, and the cost of the chip is very low compared with the scheme of using a dial-type encoder or the scheme of using a notched flange plate in cooperation with an optoelectronic switch, and the fixed welding of the chip adopts a mature welding process and the assembly cost is very low, the control accuracy is significantly improved while the cost is reduced. There is a radial magnet 21 at the end of the motor shaft. As shown in the figure, the drive plate 20 is installed at the end of the motor. The magnet is basically coaxial with the chip, and there is a small gap as shown in the figure between the two, about 0.5 - 1 mm. Because the chip is very small and the size of the drive plate 20 is the same as that of the motor, and it is directly installed at the end of the motor, the chip can be aligned with the magnet at the end of the motor shaft. The magnetic angle sensing chip 22 is an encoder based on the magnetoelectric principle, and uses a Hall sensor to detect the magnetic field change to determine the rotation position. When an electric current passes through a conductor located in a magnetic field, the magnetic field will generate a force on the electrons in the conductor perpendicular to the direction of electron movement, thereby generating a potential difference in the direction perpendicular to the conductor and the magnetic induction line. Let the magnetic field applied to this conductor rotate around the axis of the current flow path in a certain direction, then this Hall potential difference will change due to the change of the angle between the magnetic field and the conductor, and the change trend of this potential difference is a sine curve. Therefore, based on the voltage on both sides of this energized conductor, the rotation angle of the magnetic field can be inversely calculated.

[0043] The vertical movement structure includes a motor bracket 1, a Z-axis linear guide 5 installed on the motor bracket 1, and a Z-axis motor 4. A Z-axis linear guide slider 23 is installed on the Z-axis linear guide 5. The sample loading needle bracket 7 is fixed to the Z-axis linear guide slider 23 by screws, and the vertical movement of the sample loading needle 6 is realized by driving the sample loading needle bracket 7 by the Z-axis motor 4. The sample loading and cleaning structure is fixed to the motor bracket 1 by screws. The sample loading needle 6 loads the liquid to be measured in different holes. The liquid to be measured is on a module at other positions, which is a row of parallel holes. Therefore, the sample loading and cleaning structure needs to move horizontally above different holes to achieve liquid suction.

[0044] The specific steps are as follows:

[0045] When the liquid in the hole to be measured needs to be loaded and transmitted for detection, the sample loading needle 6 moves along the X-axis guide to above the hole to be measured under the action of the drive motor 14.

[0046] Subsequently, the sample loading needle 6 moves downward along the Z-axis linear guide 5 under the drive of the Z-axis motor 4 and moves into the hole to be measured.

[0047] When the sample loading needle 6 is in the hole, due to the negative pressure provided by the pipeline connected to the sample loading needle 6, the liquid to be measured in the hole is transmitted to the detection structure for result detection and reading.

[0048] After sample loading is completed, the sample loading needle 6 is reset under the action of the Z-axis motor 4. Then, the inner and outer walls of the needle are cleaned to avoid cross-contamination when aspirating other test solutions.

[0049] Cleaning: When cleaning the inner wall of the sample needle, the sample loading needle 6 moves upward under the action of the Z-axis motor 4, and the needle tip moves to the liquid outlet of the cleaning swab 8. Liquid is injected outward from the needle to flush the inner wall of the needle. For the flowing liquid, at the liquid outlet of the cleaning swab 8, a pump is used to suck the liquid outward to form a negative pressure, and the liquid inlet is in a closed state. Thus, the liquid flowing out of the sample needle is sucked away by the liquid outlet and discharged.

[0050] Cleaning: When cleaning the outer wall of the sample needle, the sample loading needle 6 moves up and down within a certain range under the action of the Z-axis motor 4. The cleaning liquid flows into the liquid inlet of the cleaning swab 8 through a pump, and the liquid outlet of the cleaning swab 8 discharges the liquid through a pump to form a negative pressure, and the flow rate of the liquid outlet is significantly greater than that of the liquid inlet. Since the gap between the outer wall of the sample needle and the cleaning swab 8 is very small, under the negative pressure of the liquid outlet, the cleaning liquid flows through the liquid inlet and flushes the outer wall of the sample needle from bottom to top, and then discharges from the liquid outlet. Since the cleaning swab 8 is fixed and the sample needle can move up and down driven by the Z-axis motor 4, the outer wall of the sample needle can be cleaned more comprehensively.

Claims

1. A sample loading device with a cleaning needle function, characterized in that: The invention comprises a sample loading and cleaning structure, a horizontal motion structure for driving the sample loading and cleaning structure to perform horizontal motion, and a vertical motion structure, wherein the sample loading and cleaning structure is mounted on a motor support (1), the motor support (1) is connected to a horizontal motion slider (2), and the horizontal motion structure is fixed on a horizontal beam (3); a Z-direction motor (4) and a Z-direction linear guide rail (5) are also arranged on the motor support (1), and the Z-direction motor (4) is connected to a sample loading needle (6) of the sample loading and cleaning structure.

2. A sample loading device with a cleaning needle function according to claim 1, characterized in that: The sample loading and cleaning structure comprises a sample loading needle support (7), a sample loading needle (6) and a cleaning swab (8); the sample loading needle (6) is fixed on the sample loading needle support (7); the bottom of the sample loading needle (6) passes through the cleaning swab (8); and the cleaning swab (8) is connected to a liquid inlet tube (9) and a liquid outlet tube (10).

3. A sample loading device with a cleaning needle function according to claim 2, characterized in that: The sample loading needle (6) is fixed to the sample loading needle bracket (7) via two guide screws (11), and a compression spring (12) is provided between the two guide screws (11) and the sample loading needle (6).

4. A sample loading device with a cleaning needle function according to claim 2, characterized in that: A notch is provided at the inlet of the loading needle (6) to ensure that the liquid can be normally sucked into the pipeline.

5. The sample loading device with a cleaning needle function according to claim 2, characterized in that: The sample loading needle support (7) is provided with a code scanning module (13).

6. A sample loading device with a cleaning needle function according to claim 2, characterized in that: The cleaning swab (8) is a cylindrical structure with a hollow axis. The sample loading needle (6) passes through the hollow part of the cylindrical structure. Two needle tubes are fixed on the cylindrical structure in the radial direction and connected to the hollow part of the axis. The lower one of the two needle tubes is the liquid inlet and the upper one is the liquid outlet.

7. The sample loading device with a cleaning needle function according to claim 1, characterized in that: The horizontal motion structure comprises a horizontal crossbeam (3), on which a driving motor (14), a driving wheel (15), a driven wheel (16), a synchronous belt (17) and an X-direction linear guide rail (18) are mounted, and on which a horizontal motion slider (2) is arranged, the X-direction linear guide rail (18), the horizontal motion slider (2) is connected to the vertical motion structure, the driving motor (14) is connected to the driving wheel (15), the driving wheel (15) is connected to the driven wheel (16) via a synchronous belt (17), a synchronous belt connecting plate (19) is fixed to the synchronous belt (17), and the synchronous belt connecting plate (19) is connected to the motor bracket (1).

8. The sample loading device with a needle cleaning function according to claim 7, characterized in that: A driving plate (20) is mounted on the end of the driving motor (14); a radial magnet (21) is fixedly mounted on the end of the motor shaft of the driving motor (14); and a magnetic angle sensor chip (22) is arranged on the driving plate (20) directly opposite the radial magnet (21).

9. The sample loading device with a cleaning needle function according to claim 1, characterized in that: The vertical motion structure comprises a motor support (1), a Z-direction linear guide rail (5) and a Z-direction motor (4) mounted on the motor support (1); a Z-direction linear guide rail slider (23) is mounted on the Z-direction linear guide rail (5); a loading needle support (7) is fixed to the Z-direction linear guide rail slider (23) by means of screws; and the loading needle support (7) is driven by the Z-direction motor (4) to realize vertical motion of the loading needle (6).

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