Clinical medicine detection smear device

By designing a clinical medical detection smear device, using a combination of elastic membrane and non-Newtonian fluid, the problem of uneven sample spread in traditional smear production is solved, and uniform sample spread and protection of slides are achieved.

CN223021664UActive Publication Date: 2025-06-24CENT SOUTH UNIV
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Patent Information

Application Number
CN202421805919.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-29
Publication Date
2025-06-24
Estimated Expiration
2034-07-29

AI Technical Summary

Technical Problem

In traditional smear production, manual manual operation leads to uneven spread of samples on the slide, affecting subsequent microscopic observation and pathological diagnosis.

Method used

A clinical medical detection smear device is designed to use the extrusion of elastic membrane and non-Newtonian fluid through the power assembly to spread the elastic membrane evenly on the slide to ensure the even spread of the samples.

Benefits of technology

The uniform spread of samples on the slide is achieved, which reduces errors and misjudgments caused by uneven sample samples, and avoids damage to the slides and samples by traditional rigid tools.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a clinical medical detection smear device in the technical field of medical detection. The clinical medical detection smear device comprises a carrier, the carrier is provided with a function box and a supporting assembly used for supporting the function box. A chamber is arranged in the function box; an opening is formed in the bottom of the cavity, and an elastic film is arranged in the opening. A non-Newtonian fluid is filled in the cavity; a power assembly used for extruding the non-Newtonian fluid is further arranged in the cavity. And a carrying assembly for placing a glass slide is arranged right below the opening. According to the scheme, through uniform spreading of the elastic film, it can be ensured that a sample on the glass slide is uniformly coated, and the uniformity of a sample material is improved.
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Description

Technical Field

[0001] The utility model belongs to the technical field of medical detection, and specifically relates to a smear device for clinical medical detection. Background Art

[0002] In clinical medical detection, the smear technique is a commonly used examination method, especially playing an important role in fields such as blood detection and bacteriological examination. The smear method involves evenly smearing a sample on a glass slide, followed by staining and microscopic observation to detect and analyze key information such as pathogens and cell morphology in the sample.

[0003] Traditional smear making mostly relies on manual operation. This method is not only inefficient but also has many technical problems, among which uneven smearing is a particularly prominent issue. When manually holding a glass slide for smearing, due to inaccurate control of the operator's force, the force may be uneven during the smearing process, resulting in uneven thickness of the sample (such as blood, tissue fluid, etc.) on the glass slide.

[0004] Therefore, there is an urgent need for a smear device for clinical medical detection that can improve the uniformity of spreading the smear sample. Summary of the Utility Model

[0005] In order to solve the above problems, the purpose of the utility model is to provide a smear device for clinical medical detection, which can solve the problem of uneven spreading of sample materials in the existing smear operation.

[0006] In order to achieve the above purpose, the technical solution of the utility model is as follows:

[0007] A smear device for clinical medical detection includes a carrier; a function box and a support component for supporting the function box are arranged on the carrier; a chamber is arranged inside the function box; an opening is arranged at the bottom of the chamber, and an elastic membrane is arranged inside the opening; a non-Newtonian fluid is filled in the chamber; a power component for extruding the non-Newtonian fluid is also arranged in the chamber; a carrier component for placing a glass slide is arranged directly below the opening.

[0008] The beneficial effects of adopting the above scheme are as follows:

[0009] 1. In this scheme, when smearing, the power component extrudes the non-Newtonian fluid in the chamber. After being extruded, the non-Newtonian fluid acts on the elastic membrane through transmission, causing it to deform. When it contacts the glass slide directly below, the elastic membrane gradually spreads from the contact point from the center to the periphery of the glass slide in a point-to-surface manner, thereby evenly spreading the sample on the glass slide.

[0010] Compared with the prior art, this solution can ensure that the sample on the glass slide is evenly coated through the uniform spreading of the elastic film. This uniformity is crucial for subsequent steps such as microscopic observation, cell counting, and pathological diagnosis, as it can reduce errors and misjudgments caused by uneven samples.

[0011] 2. In this solution, compared with traditional rigid coating tools, the elastic film will not cause rigid impact or scratching on the glass slide or the sample during the coating process. This gentle coating method helps to protect the integrity of the sample and the surface quality of the glass slide.

[0012] Furthermore, the power component includes a pressing block and a first cylinder; the pressing block is slidably matched with the chamber, and the cross-sectional area of the pressing block is smaller than that of the chamber; the first cylinder is fixedly connected to the top of the chamber, and the output shaft of the first cylinder is fixedly connected to the pressing block.

[0013] Beneficial effects: Through the mutual cooperation of the first cylinder and the pressing block, fine control of the sample coating process on the glass slide is achieved.

[0014] Moreover, non-Newtonian fluids are a class of fluids whose viscosity does not remain constant with the shear rate. Different from Newtonian fluids (such as water or air, whose viscosity remains constant when the shear rate changes), the viscosity of non-Newtonian fluids changes with the change of shear rate or shear stress.

[0015] When the first cylinder drives the pressing plate to squeeze the non-Newtonian fluid in the chamber, the shear rate experienced by the non-Newtonian fluid is relatively low at this time. At low shear rates, the intermolecular or interparticle forces in the non-Newtonian fluid are relatively strong, resulting in the fluid exhibiting a relatively high viscosity, but still remaining in a liquid state. At this time, the non-Newtonian fluid can be squeezed and flow like a traditional liquid;

[0016] When the first cylinder drives the pressing plate to be withdrawn from the non-Newtonian fluid, a strong relative motion will occur between the fluid and the barrel wall. In addition, since the fluid is restricted within the bottom of the chamber, its flow path becomes narrow, which will also increase the velocity gradient and shear rate inside the fluid. At this time, the non-Newtonian fluid will present a solid state.

[0017] Therefore, this solution can adjust the state of the non-Newtonian fluid while driving the pressing block to move, enabling it to switch between a solid state and a liquid state for subsequent trimming of the glass slide.

[0018] Furthermore, the loading component includes a second moving groove provided on the top of the carrier; a stepping motor is arranged in the second moving groove; the output shaft of the stepping motor is axially fixedly connected with a turntable; the turntable is rotatably connected with the carrier, the top of the turntable is slidably matched with the bottom of the function box, and a plurality of limiting grooves are circumferentially arranged on the top of the turntable.

[0019] Beneficial effects: By placing the glass slide in the limiting groove and starting the stepper motor to drive the turntable to rotate, the limiting groove corresponding to the glass slide is moved to the bottom of the chamber, thereby flattening the glass slide and evenly spreading the sample.

[0020] Furthermore, the support assembly includes a number of support columns. One end of the support column is fixedly connected to the carrier, and the other end of the support column is fixedly connected to the functional box.

[0021] Beneficial effects: The carrier and the functional box are firmly connected by the support columns, forming a stable support structure. This structure can effectively disperse and bear the weight from the functional box and its internal equipment, preventing structural deformation or damage caused by concentrated weight.

[0022] Furthermore, an extrusion groove is also communicated with the bottom of the chamber.

[0023] Beneficial effects: Through the design of the extrusion groove, when the elastic membrane undergoes elastic deformation under pressure, it can more effectively expand evenly in all directions with the assistance of non-Newtonian fluid. When the elastic membrane is closely attached to the surface of the glass slide, it can transfer pressure to the sample on the glass slide more evenly, thereby significantly improving the uniformity of sample dispersion and being beneficial for subsequent observation and analysis.

[0024] Furthermore, a vibration assembly and a controller are also provided on the carrier; the vibration assembly includes a first movable groove located directly below the elastic membrane. A servo motor is provided at the bottom of the first movable groove. The output shaft of the servo motor is axially fixedly connected with a cylindrical cam. A curve profile is provided on the cylindrical cam. A roller is slidably engaged with the curve profile. The roller is fixedly connected to a vibration cylinder. The vibration cylinder penetrates through the top of the first movable groove and extends below the elastic membrane. The vibration cylinder is slidably engaged with the first movable groove; the controller is electrically connected to the servo motor, the stepper motor, and the first cylinder respectively.

[0025] Beneficial effects: When the glass slide moves below the elastic membrane, the servo motor drives the cylindrical cam to rotate. The rotation of the cylindrical cam drives the roller to move along the curve profile. The roller drives the vibration cylinder to move vertically back and forth. During the vertical reciprocating movement of the vibration cylinder, it will indirectly impact or disturb the glass slide, so that the glass slide can obtain a certain dynamic adjustment while being squeezed by the elastic membrane. This dynamic adjustment helps the elastic membrane to more evenly cover the surface of the glass slide and better transfer pressure, further improving the uniformity of sample dispersion.

[0026] Furthermore, vibration openings for accommodating the vibration cylinder to pass through are provided at the inner bottom of the limiting groove.

[0027] Beneficial effects: The setting of the vibration port allows the vibration cylinder to directly align with and act on the glass slide within a specific limiting groove, achieving precise positioning and independent adjustment of a single glass slide. This design avoids the problems of energy dispersion and mutual influence that may exist in traditional vibration methods, ensuring that each glass slide can receive just the right vibration treatment without interfering with the glass slides in other positions on the turntable.

[0028] Furthermore, buffer pads are also provided in the limiting grooves.

[0029] Beneficial effects: Since the buffer pads can slow down the vibration speed of the vibration cylinder and reduce its amplitude, the shaking and offset of the glass slide during vibration can be reduced. This stability not only helps to ensure the uniform distribution of the sample on the glass slide but also helps to improve the accuracy and reliability of the entire processing process.

[0030] Furthermore, a bracket is also provided on the carrier; an injection pump for dripping a staining agent onto the glass slide is provided on the bracket, and the injection pump is electrically connected to the controller.

[0031] Beneficial effects: By setting the injection pump, the efficiency of sample processing can be improved. Compared with manual dripping, the injection pump can complete the dripping process of the staining agent more quickly, thus shortening the entire processing cycle.

[0032] Furthermore, a cover glass assembly is also provided on the bracket; the cover glass assembly includes a card slot for placing the cover glass, a guide groove is provided on one side of the bottom of the card slot, the card slot communicates with the guide groove, and the guide groove is located directly above any one of the limiting grooves; a second air cylinder is also provided on the opposite side of the bottom of the card slot to the guide groove, and the second air cylinder is electrically connected to the controller.

[0033] Beneficial effects: The cover glass in the card slot is pushed into the guide groove by the second air cylinder, so that the cover glass slides vertically along the inner wall of the guide groove into the limiting groove and covers the glass slide in the limiting groove. The guide groove ensures that the cover glass can slide accurately into the limiting groove along a predetermined path and angle and precisely cover the glass slide. This precise alignment not only ensures the integrity of the sample but also avoids observation or analysis errors caused by improper positioning of the cover glass. Description of the Drawings

[0034] Figure 1 is a three-dimensional schematic diagram of a smear device for clinical medical detection of the present utility model.

[0035] Figure 2 is Figure 1 the top view of

[0036] Figure 3 is Figure 2 the sectional view taken along line A-A in

[0037] Figure 4 isFigure 2 Cross-section view B-B in [the figure].

[0038] Figure 5 is Figure 3 Partial enlarged schematic view at position M in [the figure].

[0039] Figure 6 is Figure 3 Partial enlarged schematic view at position N in [the figure].

[0040] Figure 7 is Figure 4 Partial enlarged schematic view at position P in [the figure].

[0041] The reference numerals in the accompanying drawings of the specification include: carrier 1, function box 2, support column 3, turntable 4, bracket 5, stepper motor 101, first movable slot 102, second movable slot 103, servo motor 1021, vibration cylinder 1022, cylindrical cam 1023, curve profile 1024, roller 1025, chamber 201, first cylinder 202, extrusion block 203, elastic membrane 204, extrusion groove 205, limiting groove 401, buffer pad 402, vibration port 403, injection pump 501, card slot 502, second cylinder 503, guiding groove 504. Detailed implementation manners

[0042] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0043] In the description of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "longitudinal", "transverse", "vertical", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. are based on the orientation or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.

[0044] In the description of the present invention, unless otherwise specified and limited, it should be noted that the terms "installation", "connection", and "coupling" should be understood in a broad sense. For example, it may be a mechanical connection or an electrical connection, or it may be the communication inside two elements. It may be directly connected, or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms can be understood according to specific situations.

[0045] The following is a further detailed description through specific embodiments:

[0046] The embodiment is basically as shown in the appendix Figures 1 - 7 as follows:

[0047] A smear device for clinical medical detection includes a carrier 1; a function box 2 and a support assembly for supporting the function box 2 are provided on the carrier 1. Specifically, the support assembly includes a plurality of support columns 3. As shown in the appendix Figure 1 as follows, in this embodiment, there are three support columns 3. One end of the support column 3 is fixedly welded to the carrier 1, and the other end of the support column 3 is fixedly welded to the function box 2.

[0048] A chamber 201 is opened in the function box 2; an opening is opened at the bottom of the chamber 201, and an elastic membrane 204 is adhesively fixed in the opening; a non-Newtonian fluid is contained in the chamber 201. In this embodiment, the non-Newtonian fluid is a shear-thickening fluid, that is, the viscosity of the fluid increases significantly with the increase of the shear rate or shear stress; a power assembly for extruding the non-Newtonian fluid is also provided in the chamber 201; a carrier assembly for placing a glass slide is provided directly below the opening. An extrusion groove 205 is also communicated with the bottom of the chamber 201. As shown in the appendix Figure 3 as follows, the side wall of the extrusion groove 205 is a concave curved surface, so as to improve the extrusion effect when the elastic mold extrudes the glass slide.

[0049] Specifically, the power assembly includes an extrusion block 203 and a first cylinder 202; the extrusion block 203 is slidably matched with the chamber 201, and the cross-sectional area of the extrusion block 203 is smaller than the cross-sectional area of the chamber 201. In this embodiment, the shapes of the extrusion block 203 and the chamber 201 are both cylindrical; as shown in the appendix Figure 3 as follows, the first cylinder 202 is bolted and fixed to the top of the chamber 201, and the output shaft of the first cylinder 202 is fixedly welded to the top of the extrusion block 203.

[0050] Specifically, the carrier assembly includes a second movable groove 103 opened at the top of the carrier 1; a stepping motor 101 is bolted and fixed in the second movable groove 103; a turntable 4 is fixedly welded axially to the output shaft of the stepping motor 101; the turntable 4 is rotatably connected to the carrier 1, the top of the turntable 4 is slidably matched with the bottom of the function box 2, and a plurality of limiting grooves 401 are circumferentially opened at the top of the turntable 4. In this embodiment, there are 4 limiting grooves 401 in total. Buffer pads 402 are also placed in the limiting grooves 401.

[0051] A vibration component and a controller are also provided on the carrier 1; the vibration component includes a first movable slot 102 opened directly below the elastic mold. A servo motor 1021 is fixedly connected to the bottom of the first movable slot 102 by bolts. A cylindrical cam 1023 is fixedly welded to the output shaft of the servo motor 1021 in the axial direction. A curve profile 1024 is provided on the cylindrical cam 1023. A roller 1025 is slidably engaged with the curve profile 1024. The roller 1025 is fixedly welded with a vibration cylinder 1022. The vibration cylinder 1022 passes through the top of the first movable slot 102 and extends below the elastic membrane 204. The vibration cylinder 1022 is slidably engaged with the first movable slot 102; the controller is electrically connected to the servo motor 1021, the stepper motor 101, and the first cylinder 202 respectively.

[0052] Among them, vibration ports 403 for accommodating the vibration cylinder 1022 to pass through are provided at the inner bottoms of the limiting slots 401.

[0053] A bracket 5 is also fixedly welded on the carrier 1; an injection pump 501 for dripping a staining agent onto the glass slide is fixedly connected to the bracket 5 by bolts. As shown in the appendix Figure 2 and Figure 3 shown, the injection pump 501 is directly above the center of the limiting slot 401, so as to accurately drip the staining agent onto the sample on the glass slide. The injection pump 501 is electrically connected to the controller.

[0054] A cover glass component is also provided on the bracket 5; the cover glass component includes a card slot 502 for placing the cover glass. As shown in the appendix Figure 2 and Figure 4 shown, the card slot 502 is opened directly above one of the limiting slots 401. As shown in the appendix Figure 7 shown, a guiding slot 504 is provided at one side of the bottom of the card slot 502. The card slot 502 communicates with the guiding slot 504. The guiding slot 504 is directly above any one of the limiting slots 401; a second cylinder 503 is also fixedly connected to the opposite side of the bottom of the card slot 502 relative to the guiding slot 504 by bolts. The second cylinder 503 is electrically connected to the controller.

[0055] The specific implementation process is as follows:

[0056] When performing the smearing operation, place the sample at the exact center of the glass slide, and then place the glass slide in the unobstructed limiting slot 401 (as shown in the appendix Figure 2As shown, for ease of understanding, it is hereinafter referred to as the limit slot 401A), and then the controller is started. The controller will control the stepper motor 101 to operate. The output shaft of the stepper motor 101 rotates to drive the turntable 4 to rotate, so that the limit slot 401A rotates counterclockwise to the bottom of the injection pump 501. The controller controls the injection pump 501 to drip dye into it, and then drives the stepper motor 101 to continue to rotate, so that the limit slot 401A moves to the bottom of the guide slot 504, and then controls the second cylinder 503 to work. The output shaft of the second cylinder 503 pushes the bottom cover glass in the card slot 502 horizontally into the guide slot 504. After the cover glass enters the guide slot 504, it slides vertically along the inner wall of the guide slot 504 by its own gravity to the slide in the limit slot 401A, and the cover glass is completed. Then the controller continues to drive the stepper motor 101 to operate, so that the limit slot 401A moves to the bottom of the elastic membrane 204, as shown in the attached Figure 3 As shown, the first cylinder 202 is driven to operate. The first cylinder 202 pushes the extrusion block 203 downward into the non-Newtonian fluid, so that the non-Newtonian fluid squeezes the elastic membrane 204. The elastic membrane 204 generates elastic deformation after being squeezed, which is similar to the expansion of a balloon. During the expansion process, the center of the elastic membrane 204 contacts the cover glass placed on the limiting groove 401A, and then gradually diffuses to the surroundings, spreading the sample on the slide evenly from point to surface.

[0057] Then the controller controls the first cylinder 202 to retract the output shaft at the same speed and lift the extrusion plate. At the same time, the controller starts the servo motor 1021. The output shaft of the servo motor 1021 drives the cylindrical cam 1023 to rotate. Since the roller 1025 slides with the curved profile 1024, the cylindrical cam 1023 can drive the roller 1025 to move back and forth in the vertical direction when it rotates, thereby driving the vibration cylinder 1022 to reciprocate up and down. During the upward movement of the vibration cylinder 1022, it passes through the vibration port 403 and then contacts the buffer pad 402. After absorbing the force transmitted by the vibration cylinder 1022, the buffer pad 402 transmits part of the force to the slide, causing it to vibrate slightly, thereby expelling bubbles that may exist between the slide and the cover glass.

[0058] At this time, the non-Newtonian fluid will exhibit solid-like properties during the lifting of the squeezing block 203, and the contact surface between the cover glass and the elastic membrane 204 will become hard, so that when the slide glass vibrates, it will press against the cover glass and assist the cover glass in squeezing out the bubbles.

[0059] The above are only embodiments of the present utility model, and common general knowledge of specific structures and / or characteristics in the solution is not described in detail herein. It should be noted that for those skilled in the art, without departing from the structure of the present utility model, several modifications and improvements can be made, which should also be regarded as the protection scope of the present utility model, and these will not affect the implementation effect of the present utility model and the practicality of the patent. The protection scope claimed in this application shall be subject to the content of its claims, and the specific implementation manners and the like recorded in the specification can be used to interpret the content of the claims.

Claims

1. A clinical medical detection smear device, characterized in that: It comprises a carrier; a function box and a support component for supporting the function box are arranged on the carrier; a chamber is arranged in the function box; an opening is arranged at the bottom of the chamber, and an elastic membrane is arranged in the opening; a non-Newtonian fluid is filled in the chamber; a power component for squeezing the non-Newtonian fluid is also arranged in the chamber; and a loading component for placing a slide is arranged directly below the opening.

2. The clinical medical detection smear device according to claim 1, characterized in that: The power assembly includes an extrusion block and a first cylinder; the extrusion block is slidably matched with the chamber, and the cross-sectional area of ​​the extrusion block is smaller than the cross-sectional area of ​​the chamber; the first cylinder is fixedly connected to the top of the chamber, and the output shaft of the first cylinder is fixedly connected to the extrusion block.

3. The clinical medical detection smear device according to claim 2, characterized in that: The object-carrying assembly includes a second movable groove arranged on the top of the carrier; a stepper motor is arranged in the second movable groove; the output shaft of the stepper motor is axially fixedly connected with a turntable; the turntable is rotatably connected to the carrier, the top of the turntable is slidably matched with the bottom of the function box, and a plurality of limit grooves are circumferentially arranged on the top of the turntable.

4. The clinical medical detection smear device according to claim 3, characterized in that: The supporting assembly comprises a plurality of supporting columns, one end of each supporting column is fixedly connected to the carrier, and the other end of each supporting column is fixedly connected to the function box.

5. The clinical medical detection smear device according to claim 4, characterized in that: The bottom of the chamber is also connected with an extrusion groove.

6. The clinical medical detection smear device according to claim 5, characterized in that: A vibration component and a controller are also provided on the carrier; the vibration component includes a first movable groove located directly below the elastic mold, a servo motor is provided at the bottom of the first movable groove, the output shaft of the servo motor is axially fixedly connected to a cylindrical cam, a curved profile is provided on the cylindrical cam, the curved profile is slidably matched with a roller, the roller is fixedly connected to a vibration cylinder, the vibration cylinder passes through the top of the first movable groove and extends to the bottom of the elastic membrane, and the vibration cylinder is slidably matched with the first movable groove; the controller is electrically connected to the servo motor, the stepper motor and the first cylinder respectively.

7. The clinical medical detection smear device according to claim 6, characterized in that: The bottom of the limiting groove is provided with a vibration opening for accommodating the passage of the vibration cylinder.

8. The clinical medical detection smear device according to claim 7, characterized in that: Buffer pads are also arranged in the limiting grooves.

9. The clinical medical detection smear device according to claim 8, characterized in that: The carrier is also provided with a bracket; the bracket is provided with an injection pump for dripping a dye onto the glass slide, and the injection pump is electrically connected to the controller.

10. The clinical medical detection smear device according to claim 9, characterized in that: A cover assembly is also provided on the bracket; the cover assembly includes a card slot for placing a cover glass, a guide groove is provided on one side of the bottom of the card slot, the card slot is connected to the guide groove, and the guide groove is located directly above any limit groove; a second cylinder is also provided on the side of the bottom of the card slot opposite to the guide groove, and the second cylinder is electrically connected to the controller.