Biological medicine sterile concentration equipment

Abstract

The utility model relates to the technical field of biological medicine, and discloses a biological medicine sterile concentration device which comprises a concentration bin, a heating assembly is arranged on the outer wall of the concentration bin and used for heating raw materials in the concentration bin, a motor is fixedly connected to the top of the concentration bin, and the motor is used for driving the concentration bin to rotate. The output end of the motor is fixedly connected with a rotating column, the bottom of the concentration bin is fixedly connected with a discharging plate, the bottom of the rotating column is fixedly connected with a U-shaped sliding plate, and the outer wall of the U-shaped sliding plate is fixedly connected with a scraping plate. According to the utility model, the problems that the structure and the activity of biomolecules are influenced and the quality and the consistency of products are reduced due to the fact that the traditional biological medicine sterile concentration equipment does not have enough stirring capacity and heating uniformity are solved; and uniform stirring and heating are achieved, so that all components in the raw materials can react or be converted under the same condition, and the quality and the consistency of a final product are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedicine, in particular to a sterile concentration device for biomedicine. Background Art

[0002] Biomedicine refers to drugs developed by means of biotechnology, including recombinant protein drugs, antibody drugs, gene therapy drugs, etc. These drugs require highly precise and strict quality control during the R & D and production processes to ensure the safety and effectiveness of the products. Among them, the sterile concentration device is an indispensable device in the production of biomedicine. It can effectively remove the moisture in the product without damaging the active ingredients of the product, thereby improving the stability and shelf life of the product. In addition, the sterile concentration device can effectively avoid the contamination of the product during the production process and ensure the purity and quality of the product. Therefore, for the production of biomedicine, the use of a sterile concentration device is very important.

[0003] Traditional sterile concentration devices for biomedicine are mainly used to extract and concentrate specific biomolecules, such as proteins, antibodies, etc. from biological samples under strict sterile conditions. Using such devices usually involves the following steps: First, the biological sample is appropriately pretreated to optimize the subsequent concentration process. Then, the pretreated sample is injected into the sterile concentration device, and the sterile filtration system in the device is used to remove the microorganisms in the sample to ensure the purity of the product. Next, through the concentration function of the device, such as using rotation or centrifugation, etc., the enrichment of the target biomolecule is achieved. Finally, the concentrated biomolecule is transferred out of the device and further purified and processed to meet the requirements of biomedicine R & D and production. The whole process needs to follow strict sterile operating procedures to ensure the safety and effectiveness of the product.

[0004] Traditional sterile concentration devices for biomedicine are usually designed to efficiently perform liquid processing and concentration under sterile conditions, but they do not have sufficient stirring ability and heating uniformity. Especially when processing viscous or temperature-sensitive biological samples, uneven heating will cause the temperature of some parts of the sample to be too high, while the temperature of other parts is insufficient. This will affect the structure and activity of biomolecules, especially heat-sensitive substances such as proteins, and reduce the quality and consistency of the product. Summary of the Utility Model

[0005] In order to make up for the above deficiencies, the utility model provides a sterile concentration device for biomedicine, aiming to improve the problem that traditional sterile concentration devices for biomedicine do not have sufficient stirring ability and heating uniformity, which will affect the structure and activity of biomolecules and reduce the product quality and consistency.

[0006] To achieve the above object, the present utility model provides the following technical solutions: A sterile concentration device for biological medicine, including a concentration chamber, an outer wall of the concentration chamber is provided with a heating component, the heating component is used for heating the raw materials inside the concentration chamber, a motor is fixedly connected to the top of the concentration chamber, an output end of the motor is fixedly connected to a rotating column, a blanking plate is fixedly connected to the bottom of the concentration chamber, a U-shaped slide plate is fixedly connected to the bottom of the rotating column, a scraping plate is fixedly connected to an outer wall of the U-shaped slide plate, the scraping plate is slidably connected to an inner wall of the concentration chamber, a mixing plate is fixedly connected to an outer wall of the rotating column, a driving wheel is fixedly connected to the top of the rotating column, a driven wheel is rotatably connected to the inside of the concentration chamber, the driving wheel is engaged with the driven wheel, a stirring rod is fixedly connected to the inside of the driven wheel, bearings are fixedly connected to outer walls of the rotating column and the stirring rod, the bearings are fixedly connected to the inside of the concentration chamber, an auxiliary plate is rotatably connected to the outer wall of the rotating column, and the auxiliary plate is rotatably connected to the outer wall of the stirring rod.

[0007] Further, the heating component includes a power supply, the power supply is fixedly connected to the outer wall of the concentration chamber, a heating coil is fixedly connected to the inside of the power supply, and the heating coil is fixedly connected to the inside of the concentration chamber.

[0008] Further, a delivery pipe is fixedly connected to the inside of the concentration chamber, one end of the delivery pipe is fixedly connected to a filtering chamber, the filtering chamber is fixedly connected to the outer wall of the concentration chamber, a feeding pipe is fixedly connected to the top of the filtering chamber, and a filter plate is slidably connected to the inside of the filtering chamber.

[0009] Further, a sealing slide plate is fixedly connected to the outer wall of the filter plate, and the sealing slide plate is slidably connected to the inside of the filtering chamber.

[0010] Further, a baffle is attached to the outer wall of the filter plate, fixing bolts are provided inside the baffle, and the outer wall of the baffle is threadedly connected to the inside of the filter plate.

[0011] Further, a sealing gasket is sleeved on the outer wall of the fixing bolt, and the sealing gasket is arranged between the filter plate and the baffle.

[0012] Further, a rotating shaft is rotatably connected to the inside of the baffle, a handle is fixedly connected to one end of the rotating shaft, and a torsion spring is sleeved on the outer wall of the rotating shaft.

[0013] Further, one end of the torsion spring is fixedly connected to the inside of the baffle, the other end of the torsion spring is fixedly connected to the inside of the handle, and a clamping block is fixedly connected to the outer wall of the filtering chamber.

[0014] The utility model has the following beneficial effects:

[0015] 1. In the utility model, first, start the motor to drive the rotating column, the driving wheel, the mixing plate and the U-shaped sliding plate to rotate. Then, scrape the inside of the concentration bin through the scraping plate. Next, drive the stirring rod to uniformly stir the raw materials inside the concentration bin by means of the driven wheel, the auxiliary plate and the bearing. Finally, heat the raw materials inside the concentration bin by means of the power supply and the heating coil, solving the problem that the traditional sterile concentration equipment for biological medicine does not have sufficient stirring ability and heating uniformity, which will affect the structure and activity of biological molecules and reduce the product quality and consistency, and achieving that uniform stirring and heating helps to ensure that all components in the raw materials can react or transform under the same conditions, thereby improving the quality and consistency of the final product.

[0016] 2. In the utility model, first, convey the raw materials through the feeding pipe and the conveying pipe. During this process, filter the raw materials through the filter bin and the filter plate to achieve aseptic treatment. Then, drive the handle to cooperate with the clamping block, the torsion spring, the baffle plate, the fixing bolt, the sealing gasket and the sealing sliding plate to facilitate the disassembly, assembly and cleaning of the filter plate, improving the treatment efficiency, achieving efficient aseptic filtration treatment, ensuring the purity and aseptic state of the final product, and thus guaranteeing the quality and safety of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic three-dimensional structure diagram of a sterile concentration equipment for biological medicine proposed by the utility model;

[0018] Figure 2 is a schematic diagram of the internal structure of the concentration bin of a sterile concentration equipment for biological medicine proposed by the utility model;

[0019] Figure 3 is a schematic diagram of the structure on one side of the rotating column of a sterile concentration equipment for biological medicine proposed by the utility model;

[0020] Figure 4 is a schematic diagram of the internal structure of the filter bin of a sterile concentration equipment for biological medicine proposed by the utility model;

[0021] Figure 5 is a schematic diagram of the structure on one side of the sealing sliding plate of a sterile concentration equipment for biological medicine proposed by the utility model.

[0022] LEGEND DESCRIPTION:

[0023] 1. Concentrating bin; 2. Power supply; 3. Heating coil; 4. Motor; 5. Rotating column; 6. Feeding plate; 7. U-shaped slide plate; 8. Scraping plate; 9. Mixing plate; 10. Driving wheel; 11. Driven wheel; 12. Stirring rod; 13. Bearing; 14. Auxiliary plate; 15. Delivery pipe; 16. Filtering bin; 17. Feeding pipe; 18. Filter plate; 19. Sealing slide plate; 20. Baffle; 21. Fixed bolt; 22. Sealing gasket; 23. Rotating shaft; 24. Torsion spring; 25. Handle; 26. Clamping block. Detailed implementation manner

[0024] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0025] Refer to Figure 1 - Figure 3 As shown in the figure, an embodiment provided by the present invention: a biomedical aseptic concentration device, including a concentrating bin 1, a heating component is arranged on the outer wall of the concentrating bin 1, and the heating component is used to heat the raw materials inside the concentrating bin 1. A motor 4 is fixedly connected to the top of the concentrating bin 1, the output end of the motor 4 is fixedly connected to a rotating column 5, a feeding plate 6 is fixedly connected to the bottom of the concentrating bin 1, the bottom of the rotating column 5 is fixedly connected to a U-shaped slide plate 7, a scraping plate 8 is fixedly connected to the outer wall of the U-shaped slide plate 7, and the outer wall of the scraping plate 8 is slidably connected to the inner wall of the concentrating bin 1. A mixing plate 9 is fixedly connected to the outer wall of the rotating column 5, a driving wheel 10 is fixedly connected to the top of the rotating column 5, a driven wheel 11 is rotatably connected to the inside of the concentrating bin 1, the driving wheel 10 is engaged with the driven wheel 11, a stirring rod 12 is fixedly connected to the inside of the driven wheel 11, bearings 13 are fixedly connected to the outer walls of the rotating column 5 and the stirring rod 12, and the outer walls of the bearings 13 are fixedly connected to the inside of the concentrating bin 1. An auxiliary plate 14 is rotatably connected to the outer wall of the rotating column 5, and the inside of the auxiliary plate 14 is rotatably connected to the outer wall of the stirring rod 12. The heating component includes a power supply 2, the outer wall of the power supply 2 is fixedly connected to the outer wall of the concentrating bin 1, and a heating coil 3 is fixedly connected to the inside of the power supply 2. The outer wall of the heating coil 3 is fixedly connected to the inside of the concentrating bin 1.

[0026] Specifically, the starting motor 4 drives the rotating column 5 to rotate inside the concentration bin 1. Then, the rotation of the rotating column 5 drives the U-shaped slide plate 7 and the mixing plate 9 to rotate inside the concentration bin 1. The rotation of the U-shaped slide plate 7 drives the scraping plate 8 to slide on the inner wall of the concentration bin 1, thereby preventing the raw materials from sticking to the inside of the concentration bin 1 and affecting concentration. Then, the rotation of the rotating column 5 can also drive the driving wheel 10 to rotate. Due to the meshing relationship between the driving wheel 10 and the driven wheels 11, the driven wheels 11 on both sides are driven to rotate synchronously, and then the stirring rods 12 on both sides are driven to rotate to cooperate with the mixing plate 9 to uniformly stir the raw materials. At the same time, the cooperation between the stirring rods 12 and the auxiliary plate 14 can stably rotate the rotating column 5 and the stirring rods 12 to achieve efficient stirring. Then, the heating coil 3 is started by the power supply 2 to heat the raw materials inside the concentration bin 1, and with stirring, uniform heating is achieved to improve the concentration efficiency.

[0027] Refer to Figure 1 、 Figure 4 and Figure 5 , a conveying pipe 15 is fixedly connected inside the concentration bin 1. One end of the conveying pipe 15 is fixedly connected to a filtering bin 16. The outer wall of the filtering bin 16 is fixedly connected to the outer wall of the concentration bin 1. The top of the filtering bin 16 is fixedly connected to a feeding pipe 17. A filter plate 18 is slidably connected inside the filtering bin 16. A sealing slide plate 19 is fixedly connected to the outer wall of the filter plate 18. The outer wall of the sealing slide plate 19 is slidably connected inside the filtering bin 16. A baffle 20 is attached to the outer wall of the filter plate 18. A fixing bolt 21 is arranged inside the baffle 20. The outer wall of the baffle 20 is threadedly connected inside the filter plate 18. A sealing gasket 22 is sleeved on the outer wall of the fixing bolt 21. The sealing gasket 22 is arranged between the filter plate 18 and the baffle 20. A rotating shaft 23 is rotatably connected inside the baffle 20. One end of the rotating shaft 23 is fixedly connected to a handle 25. A torsion spring 24 is sleeved on the outer wall of the rotating shaft 23. One end of the torsion spring 24 is fixedly connected inside the baffle 20, and the other end of the torsion spring 24 is fixedly connected inside the handle 25. A clamping block 26 is fixedly connected to the outer wall of the filtering bin 16;

[0028] Specifically, first, the raw materials are transported into the interior of the filtration chamber 16 through the feed pipe 17. Then, the raw materials are filtered by the filter plate 18 inside the filtration chamber 16 to remove large particulate matter, suspended substances, as well as bacteria and microorganisms in the raw materials, ensuring a sterile environment for the pharmaceutical process. Next, they are transported into the interior of the concentration chamber 1 through the conveying pipe 15 for concentration. After long-term use, the handle 25 can be rotated, so that the protrusion at one end of the handle 25 slides on the inner wall of the clamping block 26, and at the same time, the torsion spring 24 is twisted. When the handle 25 is completely removed from the interior of the clamping block 26, the handle 25 can be pulled, thereby driving the baffle 20 and the filter plate 18 to be removed from the interior of the filtration chamber 16. Then, the filter plate 18 is cleaned. The filter plate 18 can also be removed and replaced by driving the fixing bolt 21. After cleaning, the filter plate 18 is positioned inside the filtration chamber 16 through the guiding and sealing of the sealing slide plate 19. Then, the handle 25 is released. At this time, the torsion spring 24 is no longer stressed and rotates back, thereby driving the protrusion of the handle 25 to return to the inner wall of the clamping block 26 for fixation, achieving the effect of facilitating the cleaning and replacement of the filter plate 18.

[0029] Working principle: When the biomedical sterile concentration equipment needs to be used, first, the raw materials are transported into the filtration chamber 16 through the feed pipe 17, and the raw materials are filtered by the built-in filter plate 18 to remove large particles, suspended substances, as well as bacteria and microorganisms, ensuring the sterility of the pharmaceutical process. The filtered raw materials are sent into the concentration chamber 1 through the conveying pipe 15 for concentration treatment. After long-term use, the handle 25 can be rotated, so that its protrusion slides on the inner wall of the clamping block 26, and the torsion spring 24 rotates. When the handle 25 is completely separated from the clamping block 26, the handle 25 can be pulled out, thereby removing the baffle 20 and the filter plate 18 for cleaning or replacement. After cleaning, the filter plate 18 is repositioned into the filtration chamber 16 by using the guiding and sealing functions of the sealing slide plate 19. The handle 25 is released, and the torsion spring 24 rotates back, fixing the protrusion of the handle 25 to the clamping block 26 again;

[0030] In addition, the motor 4 is started to drive the rotating column 5 to rotate, so that the U-shaped slide plate 7 and the mixing plate 9 rotate, and then drive the scraping plate 8 to slide on the inner wall of the concentration chamber 1 to prevent the raw materials from adhering. The rotation of the rotating column 5 also drives the driving wheel 10 to realize the synchronous rotation of the driven wheel 11, and then drives the stirring rod 12 to stir the raw materials. The auxiliary plate 14 ensures the stability of the stirring process. At the same time, the power supply 2 starts the heating coil 3 to heat the raw materials in the concentration chamber 1 to improve the concentration efficiency. This series of operations ensures the efficient operation of the equipment and the uniform concentration of the raw materials.

[0031] Finally, it should be noted that the above are only the preferred embodiments of the present utility model and are not used to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A biopharmaceutical aseptic concentration device, comprising a concentration chamber (1), characterized in that: The outer wall of the concentration bin (1) is provided with a heating component, and the heating component is used to heat the raw materials inside the concentration bin (1); the top of the concentration bin (1) is fixedly connected to a motor (4), and the output end of the motor (4) is fixedly connected to a rotating column (5); the bottom of the concentration bin (1) is fixedly connected to a feed plate (6), and the bottom of the rotating column (5) is fixedly connected to a U-shaped slide plate (7); the outer wall of the U-shaped slide plate (7) is fixedly connected to a scraper plate (8), and the outer wall of the scraper plate (8) is slidably connected to the inner wall of the concentration bin (1); the outer wall of the rotating column (5) is fixedly connected to a mixing plate ( 9), a driving wheel (10) is fixedly connected to the top of the rotating column (5), a driven wheel (11) is rotatably connected to the inside of the concentration bin (1), the driving wheel (10) is meshed with the driven wheel (11), a stirring rod (12) is fixedly connected to the inside of the driven wheel (11), the outer walls of the rotating column (5) and the stirring rod (12) are fixedly connected to bearings (13), the outer wall of the bearing (13) is fixedly connected to the inside of the concentration bin (1), the outer wall of the rotating column (5) is rotatably connected to an auxiliary plate (14), and the inside of the auxiliary plate (14) is rotatably connected to the outer wall of the stirring rod (12).

2. A biopharmaceutical aseptic concentration device according to claim 1, characterized in that: The heating component comprises a power supply (2), the outer wall of the power supply (2) is fixedly connected to the outer wall of the concentration bin (1), the interior of the power supply (2) is fixedly connected with a heating coil (3), and the outer wall of the heating coil (3) is fixedly connected to the interior of the concentration bin (1).

3. The biopharmaceutical aseptic concentration device according to claim 1, characterized in that: The interior of the concentration bin (1) is fixedly connected to a delivery pipe (15), one end of the delivery pipe (15) is fixedly connected to a filter bin (16), an outer wall of the filter bin (16) is fixedly connected to the outer wall of the concentration bin (1), a feed pipe (17) is fixedly connected to the top of the filter bin (16), and a filter plate (18) is slidably connected to the interior of the filter bin (16).

4. The biopharmaceutical aseptic concentration device according to claim 3, characterized in that: The outer wall of the filter plate (18) is fixedly connected to a sealing slide plate (19), and the outer wall of the sealing slide plate (19) is slidably connected to the interior of the filter bin (16).

5. The biopharmaceutical aseptic concentration device according to claim 4, characterized in that: The outer wall of the filter plate (18) is fitted with a baffle (20), a fixing bolt (21) is arranged inside the baffle (20), and the outer wall of the baffle (20) is threadedly connected to the inside of the filter plate (18).

6. The biopharmaceutical aseptic concentration device according to claim 5, characterized in that: The outer wall of the fixing bolt (21) is sleeved with a sealing gasket (22), and the sealing gasket (22) is arranged between the filter plate (18) and the baffle plate (20).

7. The biopharmaceutical aseptic concentration device according to claim 6, characterized in that: A rotating shaft (23) is rotatably connected inside the baffle (20), a handle (25) is fixedly connected to one end of the rotating shaft (23), and a torsion spring (24) is sleeved on the outer wall of the rotating shaft (23).

8. The biopharmaceutical aseptic concentration device according to claim 7, characterized in that: One end of the torsion spring (24) is fixedly connected to the inside of the baffle (20), the other end of the torsion spring (24) is fixedly connected to the inside of the handle (25), and the outer wall of the filter bin (16) is fixedly connected with a clamping block (26).

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