Cell microinjector with multidirectional adjusting structure

Abstract

The utility model discloses a cell microinjector with a multidirectional adjusting structure, which comprises a mounting seat serving as a mounting carrier, the top of the mounting seat is provided with an operating platform, one side of the top of the mounting seat is provided with a mounting rack, the inner side of the mounting rack is provided with a high-precision linear slide rail, and the inner side of the high-precision linear slide rail is provided with a multi-directional adjusting structure. And a lifting table is mounted on the outer side of a moving part of the high-precision linear sliding rail. The internal thread block is controlled to ascend on the outer side of the first lead screw, the internal thread block drives the two sets of sliding blocks to slide on the sliding rods through the first connecting rod and get close to each other, the square installation bins also move towards the direction of the stereoscopic microscope, and when the two sets of square installation bins are close to the inner wall of the movable groove, the square installation bins are in a vertical state; and then the high-precision linear sliding rail is controlled to drive the lifting table to descend, and the output ends of the cell injector device and the cell holder device are inserted into the two groups of protection slots respectively, so that the output ends of the cell injector device and the cell holder device are not directly exposed in the external environment.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a cell microinjector with a multi-directional adjustment structure. Background Technique

[0002] A microinjector is an analytical instrument used in the fields of biology and basic medicine. The application scope of microinjection is very wide. This technology is required for operations ranging from assisted (in vitro) cell fertilization techniques to the transport of basic components of molecules and cells. Typically, certain substances are injected into cells to manipulate or monitor the basic body biochemical state of a specific living cell. Using this technology, precise delivery (microperfusion) of a relatively small amount (picoliters to milliliters) of reagent or drug for a single cell or a group of cells can also be achieved, such as pharmacological drug testing.

[0003] The cell syringe and cell holder of the existing cell microinjector are usually fixedly installed. When the cell microinjector is not in use, the output ends of the cell syringe and cell holder are often exposed to the external environment, which is likely to cause contamination to the inside of the cell syringe and cell holder, and is more likely to accidentally damage the output ends of the cell syringe and cell holder. At the same time, the tilt angles of the cell syringe and cell holder are often fixed. Under different usage requirements, it is difficult for the existing cell microinjector to freely adjust the tilt angles of the cell syringe and cell holder, thereby reducing the usage range of the cell microinjector. Content of the Utility Model

[0004] The purpose of the utility model is to provide a cell microinjector with a multi-directional adjustment structure to solve the problems raised in the above background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solution: A cell microinjector with a multi-directional adjustment structure includes a mounting base as an installation carrier. An operation table is provided on the top of the mounting base. An installation frame is installed on one side of the top of the mounting base. A high-precision linear slide rail is installed inside the installation frame, and a lifting platform is installed outside the moving part of the high-precision linear slide rail. A stereomicroscope is installed at the middle position of the top of the lifting platform. The lens part of the stereomicroscope extends below the lifting platform. Activity slots are symmetrically opened at both ends of the top of the lifting platform. A culture dish slot is opened at the middle position of the top of the operation table. Protection slots are symmetrically opened at both ends of the top of the operation table on the side away from the installation frame. Electric push rods are symmetrically installed at both ends of the inside of the operation table close to the installation frame, and the output ends of the two groups of electric push rods are fixedly connected to the inside of the installation frame. A retractable and expandable component is jointly arranged inside the two activity slots, and multi-directional adjustment components are symmetrically arranged at the mutually remote ends inside the two activity slots.

[0006] Preferably, the expansion and retraction assembly includes a fixed frame located at the middle position on the top of the lifting platform. A first lead screw is arranged at the middle position inside the fixed frame, and an internally threaded block is threadedly arranged on the outer side of the first lead screw. A servo motor drivingly connected to the bottom end of the first lead screw is installed at the middle position inside the lifting platform. On one side close to the mounting frame in the two sets of movable slots, sliding rods are symmetrically installed. A sliding block is sleeved on the outer side of the sliding rod, and a rotating shaft is arranged on the side of the sliding block away from the mounting frame. An injection assembly is arranged on the side of the rotating shaft away from the sliding block. First connecting rods are symmetrically hinged on the outer side of the internally threaded block, and one end of the first connecting rod away from the internally threaded block is hinged to the top of the adjacent sliding block.

[0007] Preferably, the multi-directional adjustment assembly includes two mounting grooves located on the same side of the two ends of the lifting platform away from the mounting frame. A second lead screw is arranged inside the mounting groove, and an internally threaded tube is threadedly arranged on the outer side of the second lead screw. A limiting baffle is hinged to the top of the movable slot at the end away from the stereomicroscope. A second connecting rod is hinged on the outer side of the internally threaded tube, and one end of the second connecting rod away from the internally threaded tube is hinged to one side of the limiting baffle. The bottom end of the second lead screw extends below the lifting platform and is equipped with a handwheel.

[0008] Preferably, the injection assembly includes a square mounting bin fixedly connected to the outer side of the rotating shaft at the middle position of the outer side of the square mounting bin. A cell syringe device and a cell holder device are respectively arranged inside the two square mounting bins.

[0009] Preferably, the cross-section of the sliding rod is square, and a square through hole matching the sliding rod is formed inside the sliding block.

[0010] Preferably, first bearings are respectively installed on the inner top and inner bottom of the fixed frame, and the top and bottom of the outer side of the first lead screw are fixedly connected to the inner rings of the two first bearings respectively.

[0011] Preferably, second bearings are respectively installed on the inner top and inner bottom of the second lead screw, and the top and bottom of the outer side of the second lead screw are fixedly connected to the inner rings of the two second bearings respectively.

[0012] Preferably, a pointer is installed on the outer side of the internally threaded tube, and angle scale lines matching the pointer are respectively arranged at both ends of the outer side of the lifting platform.

[0013] Advantageous Effects

[0014] Compared with the prior art, the present utility model provides a cell microinjector with a multi-directional adjustment structure, having the following advantageous effects:

[0015] 1. When the present utility model is not in use, the servo motor is controlled to drive the first lead screw to rotate. By the action of the thread, the internal thread block is forced to rise outside the first lead screw. The internal thread block drives two sliding blocks to slide on the slide bar and approach each other through the first connecting rod. The sliding block drives the square installation bin to move towards the stereo microscope through the rotating shaft. When the two square installation bins are close to the inner wall of the activity slot, the two square installation bins are in a vertical state. Then, the high-precision linear slide rail is controlled to drive the lifting platform to descend, and the output ends of the cell syringe device and the cell holder device are respectively inserted into the two protection slots, so that the output ends of the cell syringe device and the cell holder device are not directly exposed to the external environment, thereby effectively protecting the output ends of the cell syringe device and the cell holder device and ensuring the subsequent use effect of the entire cell microinjector.

[0016] 2. When the present utility model needs to adjust the tilt angle of the cell syringe device and the cell holder device, the second lead screw is rotated through the handwheel, so that the internal thread tube moves up and down outside the second lead screw. The internal thread tube pulls the limit baffle through the second connecting rod to adjust its tilt angle. Then, the sliding block is controlled to slide on the slide bar in the direction away from the stereo microscope. When one side of the square installation bin abuts against the surface of the limit baffle, the square installation bin will gradually tilt along the surface of the limit baffle. By adjusting the tilt angle of the limit baffle, the tilt angle of the output ends of the cell syringe device and the cell holder device can be freely adjusted in multiple directions, thereby helping to improve the use range of the cell microinjector. Description of the Drawings

[0017] Figure 1 is the first front view of the present utility model;

[0018] Figure 2 is the second front view of the present utility model;

[0019] Figure 3 is the first front view cross-sectional view of the present utility model;

[0020] Figure 4 is the second front view cross-sectional view of the present utility model;

[0021] Figure 5 is the top view schematic diagram of the lifting platform of the present utility model;

[0022] Figure 6 of the present utility model Figure 3 is the enlarged view at A;

[0023] Figure 7 of the present utility model Figure 4 is the enlarged view at B.

[0024] In the figure:

[0025] 10. Mounting base; 11. Operating table; 12. Mounting frame; 13. High-precision linear slide rail; 14. Lifting table; 15. Stereomicroscope; 16. Movable groove; 17. Petri dish groove; 18. Protection slot; 19. Electric push rod;

[0026] 20. Folding and unfolding assembly; 21. Fixed frame; 22. Servo motor; 23. First lead screw; 24. Internal thread block; 25. First connecting rod; 26. Slide bar; 27. Sliding block; 28. Rotating shaft; 29. Injection assembly; 291. Square mounting bin; 292. Cell syringe device; 293. Cell holder device;

[0027] 30. Multi-directional adjustment assembly; 31. Mounting groove; 32. Second lead screw; 33. Internal thread tube; 34. Limit baffle; 35. Second connecting rod; 36. Handwheel. Detailed implementation manner

[0028] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0029] As Figures 1-7 shown, a cell microinjector with a multi-directional adjustment structure includes a mounting base 10 as a mounting carrier. An operating table 11 is provided on the top of the mounting base 10. A mounting frame 12 is installed on one side of the top of the mounting base 10. A high-precision linear slide rail 13 is installed inside the mounting frame 12. And a lifting table 14 is installed on the outside of the moving member of the high-precision linear slide rail 13. A stereomicroscope 15 is installed at the middle position on the top of the lifting table 14. The lens part of the stereomicroscope 15 extends below the lifting table 14. Movable grooves 16 are symmetrically opened at both ends on the top of the lifting table 14. A petri dish groove 17 is opened at the middle position on the top of the operating table 11. Protection slots 18 are symmetrically opened at both ends on the side of the top of the operating table 11 away from the mounting frame 12. Electric push rods 19 are symmetrically installed at both ends on the side of the inside of the operating table 11 close to the mounting frame 12. And the output ends of the two groups of electric push rods 19 are fixedly connected to the inside of the mounting frame 12. A folding and unfolding assembly 20 is jointly arranged inside the two groups of movable grooves 16. Multi-directional adjustment assemblies 30 are symmetrically arranged at the mutually remote ends inside the two groups of movable grooves 16.

[0030] In this embodiment, the collection and deployment assembly 20 includes a fixed frame 21. The fixed frame 21 is located at the middle position on the top of the lifting platform 14. A first lead screw 23 is arranged at the middle position inside the fixed frame 21, and an internally threaded block 24 is arranged on the outer side of the first lead screw 23. A servo motor 22 drivingly connected to the bottom end of the first lead screw 23 is installed at the middle position inside the lifting platform 14. On one side close to the mounting frame 12 in the two sets of movable slots 16, sliding rods 26 are symmetrically installed. A sliding block 27 is sleeved on the outer side of the sliding rod 26, and a rotating shaft 28 is arranged on the side of the sliding block 27 away from the mounting frame 12. An injection assembly 29 is arranged on the side of the rotating shaft 28 away from the sliding block 27. On the outer side of the internally threaded block 24, first connecting rods 25 are symmetrically hinged, and one end of the first connecting rod 25 away from the internally threaded block 24 is hinged to the top of the adjacent set of sliding blocks 27.

[0031] In this embodiment, the multi-directional adjustment assembly 30 includes mounting grooves 31. There are two sets of mounting grooves 31, and the two sets of mounting grooves 31 are located on the same side of the two ends of the lifting platform 14 away from the mounting frame 12. A second lead screw 32 is arranged inside the mounting groove 31, and an internally threaded tube 33 is arranged on the outer side of the second lead screw 32. A limit baffle 34 is hinged to the top of the inner side of the movable slot 16 away from the stereo microscope 15. A second connecting rod 35 is hinged to the outer side of the internally threaded tube 33, and one end of the second connecting rod 35 away from the internally threaded tube 33 is hinged to one side of the limit baffle 34. The bottom end of the second lead screw 32 extends below the lifting platform 14 and is provided with a handwheel 36.

[0032] In this embodiment, the injection assembly 29 includes a square mounting bin 291. The middle position on the outer side of the square mounting bin 291 is fixedly connected to the outer side of the rotating shaft 28. A cell syringe device 292 and a cell holder device 293 are respectively arranged inside the two square mounting bins 291. The cell holder device 293 adsorbs the cells to be injected, and then the cell syringe device 292 injects the adsorbed cells.

[0033] In this embodiment, the cross-section of the sliding rod 26 is square, and a square through hole matching the sliding rod 26 is opened inside the sliding block 27, which helps the sliding block 27 to slide stably on the sliding rod 26 and the sliding block 27 will not rotate.

[0034] In this embodiment, first bearings are respectively installed on the inner top and inner bottom of the fixed frame 21, and the top and bottom of the outer side of the first lead screw 23 are respectively fixedly connected to the inner rings of the two first bearings, which helps to improve the rotation stability of the first lead screw 23.

[0035] In this embodiment, second bearings are symmetrically installed on the inner top and inner bottom of the second lead screw 32, and the top and bottom of the outer side of the second lead screw 32 are respectively fixedly connected to the inner rings of the two second bearings, which helps to improve the rotation stability of the second lead screw 32.

[0036] In this embodiment, a pointer is installed on the outer side of the internally threaded tube 33, and angle scale lines that cooperate with the pointer are provided at both ends of the outer side of the lifting platform 14, which helps to accurately adjust the inclination angle of the limiting baffle 34.

[0037] Working principle: Connect the power supply before use. During use, control the high-precision linear slide rail 13 to drive the lifting platform 14 to rise, and then adjust the inclination angles of the two groups of limiting baffles 34 according to the inclination angle required for cell injection. Rotate the second lead screw 32 through the hand wheel 36 to move the internally threaded tube 33 up and down on the outer side of the second lead screw 32. The internally threaded tube 33 then pulls the limiting baffle 34 through the second connecting rod 35 to adjust its inclination angle. Then control the servo motor 22 to drive the first lead screw 23 to rotate, and use the thread action to force the internally threaded block 24 to descend on the outer side of the first lead screw 23. The internally threaded block 24 drives the two sliding blocks 27 to slide on the slide rod 26 and move away from each other through the first connecting rod 25. The sliding block 27 drives the square mounting bin 291 to move towards the limiting baffle 34 through the rotating shaft 28. When one side of the square mounting bin 291 abuts against the surface of the limiting baffle 34, the square mounting bin 291 will gradually tilt along the surface of the limiting baffle 34 and finally reach the same inclination angle as the limiting baffle 34. When the cell micro-injector is not in use, control the internally threaded block 24 to rise on the outer side of the first lead screw 23. The internally threaded block 24 drives the two sliding blocks 27 to slide on the slide rod 26 and move closer to each other through the first connecting rod 25. The sliding block 27 drives the square mounting bin 291 to move towards the stereomicroscope 15 through the rotating shaft 28. When the two square mounting bins 291 are close to the inner wall of the movable slot 16, the two square mounting bins 291 are in a vertical state. Then control the electric push rod 19 to shorten, so that the operating table 11 moves closer to the mounting frame 12 until the two protection slots 18 on the operating table 11 move to directly below the cell syringe device 292 and the cell suction device 293 at this time. Then control the high-precision linear slide rail 13 to drive the lifting platform 14 to descend, and insert the output ends of the cell syringe device 292 and the cell suction device 293 into the two protection slots 18 respectively, so that the output ends of the cell syringe device 292 and the cell suction device 293 are not directly exposed to the external environment.

[0038] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or device comprising said element.

[0039] Although embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A cell microinjection instrument with a multi-directional adjustment structure, comprising a mounting seat (10) as a mounting carrier, characterized in that: An operating table (11) is arranged on the top of the mounting seat (10), a mounting frame (12) is installed on one side of the top of the mounting seat (10), a high-precision linear slide rail (13) is installed on the inner side of the mounting frame (12), and a lifting platform (14) is installed on the outer side of the moving part of the high-precision linear slide rail (13), a stereo microscope (15) is installed at the middle position of the top of the lifting platform (14), the lens part of the stereo microscope (15) extends to the bottom of the lifting platform (14), and movable grooves (16) are symmetrically opened at both ends of the top of the lifting platform (14), and the operating table (11) is provided with a plurality of movable grooves (16) on the top of the lifting platform (14). A culture dish slot (17) is provided at the middle position of the top of the operating table (11), and protective slots (18) are symmetrically provided at both ends of the top of the operating table (11) away from the mounting frame (12). Electric push rods (19) are symmetrically installed at both ends of the inside of the operating table (11) close to the mounting frame (12), and the output ends of the two groups of electric push rods (19) are fixedly connected to the inner side of the mounting frame (12). The inside of the two groups of movable slots (16) are jointly provided with a retracting and extending component (20), and the ends of the two groups of movable slots (16) away from each other are symmetrically provided with a multi-directional adjustment component (30).

2. The cell microinjection device with a multi-directional adjustment structure according to claim 1, characterized in that: The retracting and unfolding assembly (20) comprises a fixing frame (21), the fixing frame (21) being located at the middle position of the top of the lifting platform (14), a first screw rod (23) being arranged at the middle position inside the fixing frame (21), and an inner thread block (24) being arranged on the outer thread of the first screw rod (23), a servo motor (22) being transmission-connected to the bottom end of the first screw rod (23) being installed at the middle position inside the lifting platform (14), the inside of the two sets of movable grooves (16) being close to the mounting frame (12) A sliding rod (26) is symmetrically installed on one side, a sliding block (27) is sleeved on the outer side of the sliding rod (26), and a rotating shaft (28) is provided on the side of the sliding block (27) away from the mounting frame (12), and an injection assembly (29) is provided on the side of the rotating shaft (28) away from the sliding block (27), and a first connecting rod (25) is symmetrically hinged on the outer side of the internal thread block (24), and one end of the first connecting rod (25) away from the internal thread block (24) is hinged to the top of an adjacent group of sliding blocks (27).

3. The cell microinjection instrument with a multi-directional adjustment structure according to claim 1, characterized in that: The multi-directional adjustment component (30) comprises a mounting groove (31), wherein the mounting groove (31) is provided with two groups, and the two groups of mounting grooves (31) are located on the same side of the two ends of the lifting platform (14) away from the mounting frame (12), a second screw rod (32) is provided inside the mounting groove (31), and the outer thread of the second screw rod (32) is provided with an internal threaded tube (33), the top of the movable groove (16) away from one end of the stereomicroscope (15) is hingedly connected to a limit baffle (34), the outer side of the internal threaded tube (33) is hingedly connected to a second connecting rod (35), and the end of the second connecting rod (35) away from the internal threaded tube (33) is hingedly connected to one side of the limit baffle (34), and the bottom end of the second screw rod (32) extends to the bottom of the lifting platform (14) and is provided with a hand wheel (36).

4. The cell microinjection device with a multi-directional adjustment structure according to claim 2, characterized in that: The injection assembly (29) comprises a square mounting chamber (291), the middle position of the outer side of the square mounting chamber (291) is fixedly connected to the outer side of the rotating shaft (28), and the interiors of the two groups of square mounting chambers (291) are respectively provided with a cell injector device (292) and a cell holder device (293).

5. The cell microinjection device with a multi-directional adjustment structure according to claim 2, characterized in that: The cross section of the sliding rod (26) is square, and a square through hole cooperating with the sliding rod (26) is provided inside the sliding block (27).

6. The cell microinjection device with a multi-directional adjustment structure according to claim 2, characterized in that: The inner top and the inner bottom of the fixing frame (21) are provided with first bearings, and the outer top and the outer bottom of the first screw rod (23) are fixedly connected to the inner rings of the two sets of first bearings respectively.

7. The cell microinjection device with a multi-directional adjustment structure according to claim 3, characterized in that: Second bearings are installed on the inner top and inner bottom of the second screw rod (32), and the outer top and bottom of the second screw rod (32) are fixedly connected to the inner rings of the two sets of second bearings respectively.

8. The cell microinjection device with a multi-directional adjustment structure according to claim 3, characterized in that: A pointer is installed on the outside of the internally threaded tube (33), and angle scale lines cooperating with the pointer are arranged at both ends of the outside of the lifting platform (14).

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