Sample spreading device for hygroscopicity test of solid medicine

Abstract

The utility model discloses a solid medicine hygroscopicity test sample spreading device which comprises a sample spreading mechanism, the sample spreading mechanism comprises a shell, a hanging rope, a limiting block and a pipe body, an opening is formed in the shell, the shell is in a cylindrical step shape, a protruding part protruding downwards is arranged in the middle of the surface of the shell, a cavity is formed in the protruding part, and the limiting block is arranged in the cavity. A cavity is formed in the shell, the cavity is communicated with the inner space of the shell, the limiting block is arranged in the middle of the cavity, the pipe body is arranged on the limiting block in a sleeving and sliding mode, the inner wall of the pipe body is attached to the outer wall of the limiting block, the lower end of the pipe body is turned outwards to form an annular lower turnup part, and the lower turnup part is attached to and slides in a sliding channel formed between the limiting block and the inner wall of the cavity; the hanging rope is rotatably connected to the shell; a through hole is formed in the supporting bracket, and the size of the through hole is matched with that of the protruding part. Therefore, hanging can be quickly and stably realized, the preparation time before an experiment is reduced, the reading of the balance is quick and stable, and the accuracy of a hygroscopicity result is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of drug testing, in particular to a sample laying device for hygroscopicity testing of solid drugs. Background Art

[0002] Hygroscopicity refers to the ability or degree of a drug to absorb moisture under certain temperature and humidity conditions. This property has an important impact on the quality, stability and efficacy of drugs. For the hygroscopicity of some samples, the environmental humidity is extremely sensitive to it: water absorption and water loss will occur when the humidity is too high or too low. Once the sample starts this water exchange process, it will start immediately. Therefore, the rate of sample weighing and the time to place the sample laying device (such as the balance tray) on the electromagnetic force balance or the electronic lever balance (hereinafter referred to as the balance) in the DVS (Dynamic Vapor Sorption) experiment have a significant impact on the hygroscopic rate. Therefore, the steps of putting the sample into the balance tray and hanging the balance tray stably on the balance should be carried out quickly to ensure the accuracy of the hygroscopicity determination of the sample.

[0003] However, in the DVS test, due to the small volume of the balance tray, the operator usually has to rely on tweezers to pick up the hanging rope on the tray and then hang the hanging rope on the hook of the balance. This process not only takes time, but also is extremely likely to cause the tray to shake, overturn or even shake violently due to unstable operation. And the balance is extremely sensitive, and even a slight vibration will cause a significant change in its reading. This requires waiting until the balance tray stops shaking and the balance reading is stable before starting the DVS test. This not only prolongs the preparation time before the experiment, but also may affect the accuracy of the experimental results due to the change of the sample state during the waiting process.

[0004] In addition, the amounts required for different solid drug samples are different, but since the laying thickness of the samples on the balance tray needs to be kept consistent, it is difficult for the tray to meet the usage requirements of different samples. For samples with a smaller specific gravity, more amounts need to be laid to ensure the accuracy of the quality, while for scarce or costly samples, the usage amount needs to be strictly controlled to reduce waste. Summary of the Utility Model

[0005] The utility model aims to solve at least one of the technical problems in the related art to a certain extent.

[0006] For this reason, an object of the utility model is to provide a sample laying device for hygroscopicity testing of solid drugs, which can achieve hanging quickly and stably, reduce the preparation time before the experiment, make the reading of the balance stable quickly, ensure the accuracy of the hygroscopicity result, and at the same time can meet the usage requirements of different samples and reduce the experimental cost.

[0007] To achieve the above object, the present utility model provides a sample spreading device for testing the hygroscopicity of solid drugs, comprising: a sample spreading mechanism, the sample spreading mechanism including a housing, a hanging rope, a limiting block and a tube body. Among them, the housing has an opening, the housing is in a cylindrical stepped shape, and a convex portion protruding downward is provided at the central position of the surface of the housing. A cavity is formed inside the convex portion, and the cavity is communicated with the internal space of the housing. The limiting block is centrally arranged in the cavity. The tube body is sleeved and slidable on the limiting block, and the inner wall of the tube body fits against the outer wall of the limiting block. The lower end of the tube body is turned outwards to form an annular downward turning edge portion, and the downward turning edge portion fits and slides in the sliding channel formed between the limiting block and the inner wall of the cavity; the hanging rope is rotatably connected to the housing; a support tray, a through hole is provided on the support tray, and the size of the through hole is adapted to that of the convex portion.

[0008] For the sample spreading device for testing the hygroscopicity of solid drugs of the present utility model, by using the support tray in cooperation with the sample spreading mechanism, it can ensure that the sample spreading mechanism is fast and stable during the hanging process, reduce the preparation time before the experiment, make the reading of the balance quickly stable, and ensure the accuracy of the hygroscopicity result.

[0009] For samples with a relatively small specific gravity, the sample amount is increased to improve the accuracy of the test. The user can choose to press the tube body downward until it is flush with the bottom wall of the inner wall of the housing, and use the capacity of the entire housing to increase the capacity of the sample to be loaded. This operation not only expands the loading diameter of the sample, but also improves the accuracy of the test result.

[0010] For samples with a relatively large specific gravity or high cost, in order to save resources and reduce the experimental cost, the user can place the sample in the specific space formed between the exposed part of the tube body and the limiting block, enabling the user to make an adaptable choice according to the characteristics of the sample and the test requirements, which not only meets the test requirements of different samples, but also can effectively control the experimental cost.

[0011] In addition, according to the above application, the following additional technical features may also be provided:

[0012] Specifically, a groove is formed inside the housing; the upper end of the tube body is turned outwards to form an annular upward turning edge portion, the size of the upward turning edge portion is adapted to that of the groove, and the thickness of the upward turning edge portion is equal to the depth of the groove. When the upward turning edge portion is embedded in the groove, the upper surface of the tube body is flush with the inner bottom wall of the housing.

[0013] Specifically, the present utility model further includes a ferrule, the ferrule is fixed in the sliding channel, the outer diameter of the ferrule is equal to the outer diameter of the downward turning edge portion, and the inner diameter of the ferrule is larger than the outer diameter of the tube body.

[0014] Specifically, the ferrule is a magnet, and the ferrule and the downward flanging portion are magnetically connectable.

[0015] Specifically, the present utility model further includes a rubber ring, the rubber ring is fixed in the sliding channel, and the inner wall of the rubber ring fits on the outer wall of the tube body; the rubber ring is arranged above the ferrule, and the rubber ring is arranged near the opening of the cavity.

[0016] Specifically, when the downward flanging portion fits with the ferrule, the height by which the tube body exceeds the limiting block is equal to the depth of the housing.

[0017] Specifically, the depth of the housing is 1 mm.

[0018] Specifically, the present utility model further includes a grip, and the grip is fixed on the support bracket. Description of the Drawings

[0019] The drawings here are incorporated into the specification and form a part of this specification, showing embodiments consistent with the present utility model and used together with the specification to explain the principles of the present utility model.

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0021] Figure 1 is a schematic structural diagram of a solid drug hygroscopicity test sample laying device according to an embodiment of the present utility model;

[0022] Figure 2 is a schematic cross-sectional structural diagram of a housing according to an embodiment of the present utility model;

[0023] Figure 3 is a schematic structural diagram of a sample laying mechanism placed on a support bracket according to an embodiment of the present utility model;

[0024] Figure 4 is a schematic structural diagram of a tube body retracted in a housing according to an embodiment of the present utility model;

[0025] Figure 5 is according to an embodiment of the present utility model Figure 2 The enlarged structural diagram of area A in.

[0026] As shown in the figure: 1. Sampling mechanism; 2. Support tray; 10. Housing; 11. Protrusion; 12. Limit block; 13. Tube body; 14. Ferrule; 15. Rubber ring; 16. Hanging rope; 20. Grip; 21. Through hole; 100. Sliding channel; 101. Groove; 130. Upper flanging part; 131. Lower flanging part. Detailed implementation manners

[0027] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the solutions of the present invention will be further described below. It should be noted that, without conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0028] In the following description, many specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described herein; obviously, the embodiments in the specification are only a part of the embodiments of the present invention, rather than all the embodiments.

[0029] The following describes the solid drug hygroscopicity test sampling device according to the embodiments of the present invention with reference to the accompanying drawings.

[0030] As Figure 1 , Figure 2 , Figure 3 and Figure 4 shown, the solid drug hygroscopicity test sampling device according to the embodiments of the present invention may include a sampling mechanism 1, and the sampling mechanism 1 includes a housing 10, a hanging rope 16, a limit block 12 and a tube body 13.

[0031] Among them, the housing 10 has an opening, the housing 10 is in a cylindrical stepped shape, and a downwardly protruding protrusion 11 is provided at the central position of the surface of the housing 10. A cavity (not marked in the figure) is provided inside the protrusion 11, and the cavity is communicated with the internal space of the housing 10.

[0032] Among them, it can be understood that by designing the housing 10 in a cylindrical shape, the drug samples can be evenly smeared in the housing 10, and the thickness of the samples can be made uniform. Different from the conical design of the balance tray in the prior art, the samples will not all accumulate at the bottom and the thickness will not be the same. Therefore, the accuracy of the sample hygroscopicity test can be further improved, and the central arrangement of the protrusion 11 can ensure the stability of the center of gravity.

[0033] The limit block 12 is centrally arranged in the cavity, the tube body 13 is sleeved and slid on the limit block 12, and the inner wall of the tube body 13 is in contact with the outer wall of the limit block 12. The lower end of the tube body 13 is turned outwards with an annular lower flanging part 131, and the lower flanging part 131 is in sliding contact between the limit block 12 and the inner wall of the cavity to form a sliding channel 100.

[0034] The lanyard 16 is rotatably connected to the housing 10.

[0035] It should be noted that the lanyard 16 described in this embodiment can be a steel wire rope or an arc-shaped iron rod, which has a certain hardness. The lanyard 16 with high hardness can provide better support, reduce the shaking caused by its own deformation, and at the same time, the lanyard 16 with high hardness has less elasticity. This means that when subjected to an external force, the lanyard 16 with high hardness can return to its original state faster, reduce the shaking caused by elastic deformation, further reduce the probability of shaking when the housing 10 is hung on the balance, make the reading of the balance fast and stable, shorten the preparation time before the experiment, and thus improve the accuracy of the hygroscopicity test.

[0036] The support tray 2 is provided with a through hole 21, and the size of the through hole 21 is adapted to that of the protrusion 11.

[0037] It can be understood that by using the cooperation of the protrusion 11 and the through hole 21, the housing 10 can be limited, so that the stability of the housing 10 on the support tray 2 can be improved during the process of transporting the housing 10 by using the support tray 2. At the same time, the support tray 2 can be used to stably transfer the housing 10. Compared with the traditional technology of using tweezers for transfer, this design effectively reduces the shaking caused by hanging during the transfer process, further improves the stability of efficiently transporting to the balance after loading the sample, effectively reduces the shaking of the housing 10, makes the reading of the balance fast and stable, and shortens the preparation time before the experiment.

[0038] Specifically, Figure 4 For the initial state of the sample spreading mechanism 1, during the actual operation, the sample spreading mechanism 1 needs to be placed on the support tray 2 first. Due to the restriction of the through hole 21 on the protrusion 11, the housing 10 will be stuck, effectively avoiding the risk of the housing 10 being overturned during the operation.

[0039] Next, the operator presses the sample of the solid drug to be tested into powder, uniformly pours the powder sample into the housing 10 from above, and then spreads the sample evenly in the housing 10 with a sample spoon to form a sample spread, ensuring that the thickness of the sample is uniform.

[0040] After the sample laying is completed, the operator will pick up the support bracket 2 to lift the entire sample laying mechanism 1, and skillfully hang the hanging rope 16 on the balance. At this time, the support bracket 2 can be pulled out downward from the sample laying mechanism 1, so that the support bracket 2 is separated from the sample laying mechanism 1. During the hanging process, the vibration of the balance is small, and the hanging can be achieved quickly and smoothly, enabling the reading of the balance to be quickly stable and quickly enter the test. The entire hanging process is not only fast but also stable, greatly reducing the preparation time before the experiment and improving the test efficiency. At the same time, due to the stable maintenance of the initial state of the experiment, the accuracy of the hygroscopicity test results has also been significantly improved.

[0041] In addition, the relevant personnel can easily hold the convex portion 11 and gently swing it slightly from top to bottom, so that the tube body 13 slides slightly outward from the cavity, exposing a part of the cavity. At this time, the tube body 13 can be pulled out upward, so that a space for placing another medicine is formed between the exposed part of the tube body 13 and the limiting block 12. The advantage of this design is that for some samples with a small specific gravity, in order to increase the sample amount, the housing 10 can be selected. For some samples with a large specific gravity or expensive samples, in order to reduce the sample amount, it can be selected to be placed in the space for placing another medicine formed between the exposed part of the tube body 13 and the limiting block 12. Through this design, users can make an adaptive selection according to the characteristics of the sample and the test requirements, which not only meets the test requirements of different samples but also effectively reduces the sample test cost and realizes the efficient utilization of resources.

[0042] Furthermore, as Figure 2 shown, a groove 101 is opened inside the housing 10, and an annular upward folding edge portion 130 is turned outward at the upper end of the tube body 13. The upward folding edge portion 130 is adapted to the size of the groove 101, and the thickness of the upward folding edge portion 130 is equal to the depth of the groove 101. When the upward folding edge portion 130 is embedded in the groove 101, the upper surface of the tube body 13 is flush with the inner bottom wall of the housing 10.

[0043] Specifically, by pressing down the tube body 13, the upward folding edge portion 130 can be accurately embedded in the groove 101. At this time, the inside of the housing 10 presents a flat state, which is convenient for ensuring the uniformity of sample laying and the consistency of thickness when laying the sample, and further ensuring the accuracy during the test.

[0044] In an embodiment of the present utility model, as Figure 2 and Figure 5 shown, the solid drug hygroscopicity test sample laying device further includes a ferrule 14. The ferrule 14 is fixed in the sliding channel 100. The outer diameter of the outer ring of the ferrule 14 is equal to the outer diameter of the downward folding edge portion 131, and the inner diameter of the inner ring of the ferrule 14 is greater than the outer diameter of the tube body 13.

[0045] Specifically, by setting the ferrule 14, it can play a role in limiting the downward flanging part 131, thereby avoiding the situation where the tube body 13 detaches from the cavity when the sample laying mechanism 1 is swung.

[0046] Furthermore, as Figure 2 shown, the ferrule 14 is a magnet, and the ferrule 14 and the downward flanging part 131 can be magnetically connected.

[0047] It should be noted that in this embodiment, the material of the downward flanging part 131 is made of iron products, which is convenient for realizing magnetic adsorption with the ferrule 14, further fixing the height of the extracted tube body 13, ensuring the stability during testing. The materials of the tube body 13 and the housing 10 are selected as corrosion-resistant materials (such as platinum, stainless steel, etc.), thereby avoiding the corrosion of the drug on the tube body 13 or the housing 10 and improving the service life of the tube body 13 and the housing 10.

[0048] In an embodiment of the present utility model, as Figure 2 and Figure 5 shown, the solid drug hygroscopicity test sample laying device further includes a rubber ring 15. The rubber ring 15 is fixed in the sliding channel 100, and the inner wall of the rubber ring 15 fits on the outer wall of the tube body 13. The rubber ring 15 is arranged above the ferrule 14 and is arranged near the opening of the cavity.

[0049] It should be noted that in this embodiment, the rubber ring 15 is made of corrosion-resistant materials, such as fluororubber, butyl rubber, etc., so as to improve the service life of the rubber ring 15.

[0050] Furthermore, the setting of the rubber ring 15 not only strengthens the sealing between the tube body 13 and the sliding channel 100, ensures the tight fit between the two, but also plays a role in preventing the drug from penetrating into the sliding channel 100 at the key point, effectively avoiding the potential blockage risk.

[0051] In an embodiment of the present utility model, as Figure 2 shown, when the downward flanging part 131 is in contact with the ferrule 14, the height by which the tube body 13 exceeds the limit block 12 is equal to the depth of the housing 10.

[0052] It can be understood that when the downward flanging part 131 is in contact with the ferrule 14, the height by which the tube body 13 exceeds the limit block 12 is also equal to the height by which the tube body 13 is exposed beyond the limit block 12 when it is pulled out to the extreme position, which is equal to the depth of the housing 10. Thus, it is ensured that whether the sample is in the housing 10 or the sample is laid flat in the tube body 13, the thickness is the same. Due to the standardization of the laying thickness in the experiment, users do not need to make additional adjustments or calibrations when processing the sample, thereby simplifying the operation process and improving work efficiency.

[0053] Furthermore, the depth of the housing 10 is 1 mm.

[0054] It can be understood that according to the "Pharmacopoeia of the People's Republic of China (2020 Edition)", the thickness that meets the detection requirements for hygroscopicity in the standard is 1 mm, so that the spreading thickness of the sample is 1 mm, which can meet the detection requirements, ensure the accuracy and reliability of the test results, and there is no need for separate measurement, providing users with efficient and accurate hygroscopicity tests for drugs.

[0055] In an embodiment of the present utility model, as Figure 3 shown, the spreading device for solid drug hygroscopicity test of the present invention further includes a handle 20, and the handle 20 is fixed on the support tray 2.

[0056] It can be understood that by providing the handle 20, it is convenient for relevant personnel to grasp. The support tray 2 is lifted through the handle 20, and the handle 20 can increase the contact area with the hand surface, thereby improving the stability and controllability when hanging the spreading mechanism 1, ensuring that the spreading mechanism 1 can be stably and accurately hung on the balance during the operation process.

[0057] It should be noted that in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0058] The above are only specific embodiments of the present utility model, enabling those skilled in the art to understand or implement the present utility model. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present utility model. Therefore, the present utility model will not be limited to these embodiments described herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A solid drug hygroscopicity test sample laying device, characterized in that, Comprising: A sample laying mechanism, the sample laying mechanism includes a housing, a hanging rope, a limiting block and a tube body, wherein, The housing has an opening, the housing is in a cylindrical stepped shape, and a convex portion protruding downward is provided at the central position of the surface of the housing. A cavity is provided inside the convex portion, and the cavity is communicated with the internal space of the housing. The limiting block is centrally arranged in the cavity. The tube body is sleeved and slid on the limiting block, and the inner wall of the tube body fits with the outer wall of the limiting block. The lower end of the tube body is turned outward to form an annular downward turning edge portion, and the downward turning edge portion fits and slides in a sliding channel formed between the limiting block and the inner wall of the cavity; The hanging rope is rotatably connected to the housing; A support bracket, a through hole is provided on the support bracket, and the size of the through hole is adapted to the size of the convex portion.

2. The hygroscopicity test sample laying device for solid drugs according to claim 1, characterized in that, A groove is provided inside the housing; The upper end of the tube body is turned outward to form an annular upward turning edge portion, the size of the upward turning edge portion is adapted to the size of the groove, and the thickness of the upward turning edge portion is equal to the depth of the groove. When the upward turning edge portion is embedded in the groove, the upper surface of the tube body is flush with the inner bottom wall of the housing.

3. The solid drug hygroscopicity test sample laying device according to claim 1, characterized in that, It further includes a ferrule, the ferrule is fixed in the sliding channel, the outer diameter of the outer ring of the ferrule is equal to the outer diameter of the downward turning edge portion, and the inner diameter of the inner ring of the ferrule is larger than the outer diameter of the tube body.

4. The solid drug hygroscopicity test sample laying device according to claim 3, characterized in that The ferrule is a magnet, and the ferrule and the downward turning edge portion can be magnetically attracted to each other.

5. The hygroscopicity test sample laying device for solid drugs according to claim 4, characterized in that, It further includes a rubber ring, the rubber ring is fixed in the sliding channel, and the inner wall of the rubber ring fits on the outer wall of the tube body; The rubber ring is arranged above the ferrule, and the rubber ring is arranged near the opening of the cavity.

6. The solid drug hygroscopicity test sample laying device according to claim 4, wherein When the downward turning edge portion is in contact with the ferrule, the height by which the tube body exceeds the limiting block is equal to the depth of the housing.

7. The hygroscopicity test sample laying device for solid drugs according to claim 6, wherein, The depth of the housing is 1 mm.

8. The solid drug hygroscopicity test sample laying device according to claim 1, wherein, It further includes a handle, and the handle is fixed on the support bracket.

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