Device for carrying out drug in-vitro release penetration test by using fingernails
By designing a device including a stage, a pool and a fixing cover, the problem that existing equipment cannot perform penetration tests for nail drug release is solved, and effective fixation of nails and drug penetration ability is achieved.
Patent Information
- Application Number
- CN202422255697.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-14
- Publication Date
- 2025-07-11
- Estimated Expiration
- 2034-09-14
AI Technical Summary
Existing equipment cannot effectively carry out in vitro drug release penetration tests for nails and cannot meet the testing needs.
A device including a stage, a tank body, a fixing cover and a communication hole is designed. The nails are fixed by placing a groove and a fixing cover, and the water inlet and the drug inlet are used to realize the delivery of drugs and water, and the water in the tank body is detected to measure the drug release penetration capacity of the nails.
The detection of effective fixation of nails and drug penetration capacity is achieved, reflecting the true release penetration capacity of nails.
Smart Images
Figure CN223091777U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of drug detection equipment, and more specifically to a device for performing an in vitro drug release and permeation test using nails. Background Art
[0002] During the process of performing a conventional in vitro drug release and permeation test, the common test objects are animal skin or human ex vivo skin. However, with the development of technology, the conventional test objects are insufficient to meet the test requirements. For example, when the test object is a nail, the conventional equipment cannot support the in vitro release and permeation test of the nail. Therefore, there is a need for an in vitro release and permeation device that can meet the test object of nails. Summary of the Utility Model
[0003] In view of this, the utility model provides a device for performing an in vitro drug release and permeation test using nails, which fixes the nails and ensures the smooth progress of the in vitro release and permeation test when the test object is a nail.
[0004] In order to achieve the above object, the utility model adopts the following technical solutions:
[0005] The utility model provides a device for performing an in vitro drug release and permeation test using nails, comprising:
[0006] A stage, on which a placement groove is provided. The placement groove is an arc-shaped groove with a protrusion in the middle. A communication hole is provided at the placement groove, and a water outlet communicating with the communication hole is provided on the side wall of the stage. The placement groove is used for placing nails;
[0007] A cell body, which is arranged at the lower end of the stage. The cell body is communicated with the placement groove through the communication hole, and a water inlet is provided on the cell body;
[0008] A fixing cover, which is connected to the stage. A medicine inlet is provided at the position of the fixing cover corresponding to the communication hole. The fixing cover is used to press the nails into the placement groove.
[0009] Further, the water inlet is arranged at the bottom end of the cell body, and the water outlet is arranged at the top end of the cell body.
[0010] Further, a groove adapted to the placement groove is provided at the bottom of the fixing cover, and the medicine inlet is arranged at the position of the groove.
[0011] Further, the communication hole and the water outlet are communicated through a liquid channel arranged inside the stage.
[0012] Further, a connection groove is provided on the stage, and the fixing cover is placed in the connection groove, so as to realize the sealed connection between the fixing cover and the stage through the connection groove.
[0013] As can be seen from the above technical solutions, compared with the prior art, the present utility model discloses a device for performing an in vitro drug release and permeation test using nails. The nails are fixed on the stage through the placement groove and the fixing cover. Water is passed into the cell body through the water inlet, and drugs are delivered to one side of the nails through the drug inlet, so that water and drugs are respectively on both sides of the nails. By detecting the water in the cell body, the result of the drug release and permeation ability of the nails can be obtained. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.
[0015] Figure 1 It is a schematic structural view of the device for performing an in vitro drug release and permeation test using nails provided by the present utility model;
[0016] Figure 2 It is a schematic structural view of another perspective of the device for performing an in vitro drug release and permeation test using nails provided by the present utility model.
[0017] In the figure: 1, cell body; 2, stage; 3, fixing cover; 4, drug inlet; 5, communication hole; 6, placement groove; 7, water outlet; 8, water inlet; 9, groove. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present utility model.
[0019] See Figure 1-2 , the embodiments of the present utility model disclose a device for performing an in vitro drug release and permeation test using nails, including:
[0020] The stage 2 is provided with a placement groove 6. The placement groove 6 is an arc-shaped groove with a protrusion in the middle. A communication hole 5 is provided at the placement groove 6. An outlet 7 communicating with the communication hole 5 is provided on the side wall of the stage 2. The placement groove 6 is used for placing nails.
[0021] The pool body 1 is arranged at the lower end of the stage 2. The pool body 1 is communicated with the placement groove 6 through the communication hole 5. An inlet 8 is provided on the pool body 1.
[0022] The fixed cover 3 is connected to the stage 2. A medicine inlet 4 is provided at the position of the fixed cover 3 corresponding to the communication hole 5. The fixed cover 3 is used for pressing the nail in the placement groove 6.
[0023] Place the nail in the placement groove 6, fix the nail on the placement groove 6 through the fixed cover 3, inject water into the pool body 1 through the inlet 8 until the water surface reaches the lower end of the communication hole 5, and convey medicine into the communication hole 5 through the medicine inlet 4, so that the medicine and water contact the nail, and detect the water in the pool body 1 to complete the detection of the drug release and penetration ability of the nail.
[0024] In some embodiments, the inlet 8 is arranged at the bottom end of the pool body 1, and the outlet 7 is arranged at the top end of the pool body 1.
[0025] In some embodiments, a groove 9 adapted to the placement groove 6 is provided at the bottom of the fixed cover 3, and the medicine inlet 4 is arranged at the position of the groove 9.
[0026] The groove 9 on the fixed cover 3 prevents the nail from moving and deforming in the placement groove 6, enabling the nail to be tested in a natural state and effectively reflecting the true drug release and penetration ability of the nail.
[0027] In some embodiments, the communication hole 5 and the outlet 7 are communicated through a liquid channel arranged inside the stage 2.
[0028] Continuously inject water into the pool body 1 through the inlet 8. The water surface in the pool body 1 continuously rises. The uppermost layer of water contacts the nail and then flows out through the outlet 7 via the liquid channel. By detecting the drug content in the water flowing out of the liquid channel, the ability of the nail to release and penetrate drugs in vitro is detected.
[0029] In some embodiments, a connection groove is provided on the stage 2. The fixed cover 3 is placed in the connection groove, and the fixed cover 3 is hermetically connected to the stage 2 through the connection groove.
[0030] In this specification, each embodiment is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other. For the device disclosed in the embodiments, since it corresponds to the method disclosed in the embodiments, the description is relatively simple, and the relevant parts can be referred to the description of the method part.
[0031] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present utility model. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present utility model. Therefore, the present utility model will not be limited to the embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.
Claims
1. An apparatus for performing an in vitro drug release and permeation test using nails, characterized in that, Comprising: A stage, on which a placement groove is provided. The placement groove is an arc-shaped groove with a protrusion in the middle. A communication hole is provided at the placement groove, and a water outlet communicating with the communication hole is provided on the side wall of the stage. The placement groove is used for placing nails; A pool body, which is arranged at the lower end of the stage. The pool body is communicated with the placement groove through the communication hole, and a water inlet is provided on the pool body; A fixed cover, which is connected to the stage. A medicine inlet is provided at the position of the fixed cover corresponding to the communication hole. The fixed cover is used for pressing the nails in the placement groove.
2. The device for performing an in vitro drug release and permeation test using nails according to claim 1, characterized in that, The water inlet is arranged at the bottom end of the pool body, and the water outlet is arranged at the top end of the pool body.
3. The device for performing an in vitro drug release and permeation test using nails according to claim 1, characterized in that, A groove adapted to the placement groove is provided at the bottom of the fixed cover, and the medicine inlet is arranged at the position of the groove.
4. The device for in vitro drug release and permeation test using nails according to claim 2, characterized in that, The communication hole and the water outlet are communicated through a liquid channel arranged inside the stage.
5. The device for in vitro drug release and penetration test using nails according to claim 1, characterized in that, A connection groove is provided on the stage. The fixed cover is placed in the connection groove, and the sealed connection between the fixed cover and the stage is realized through the connection groove.