Reaction kettle structure for biological pharmacy

Abstract

The utility model provides a biopharmaceutical reaction kettle structure which comprises a mixing drum, the upper surface of the mixing drum is rotatably connected with a circular rotating plate, the outer surface of the mixing drum is fixedly connected with a fixed ring plate, the upper surface of the circular rotating plate is fixedly communicated with a feeding hopper, and the outer surface of the feeding hopper is provided with a first electric valve; and the outer surface of the stirring barrel fixedly communicates with a discharging hopper, a second electric valve is installed on the outer surface of the discharging hopper, and a comprehensive cleaning mechanism is arranged on the outer surface of the stirring barrel. Through the arrangement of the comprehensive cleaning mechanism, efficient cleaning of all corners in the mixing drum is achieved, a first servo motor drives a gear to be meshed with a gear block, a circular rotating plate is made to rotate, and the positions of a water outlet pipe assembly and a water spraying head are adjusted in combination with an electric lifting rod and high-pressure water spraying of a water pump; no cleaning dead angle exists in the stirring barrel, the problem that a traditional reaction kettle is difficult to clean is effectively solved, and the use efficiency of equipment and the product quality are improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of reactor structure design, and particularly relates to a reactor structure for biopharmaceuticals. Background Art

[0002] The production and manufacturing of biopharmaceuticals usually involve putting raw materials into a reactor, fermenting them by microorganisms, and making biopharmaceuticals with pharmacological activity from biological raw materials. Generally speaking, a reactor is a stainless-steel container for physical or chemical reactions, where automated physical and chemical reactions are carried out to obtain the final reaction results.

[0003] The patent with the application number 202321148990.4 discloses a reactor structure for biopharmaceuticals, including a bottom box. The right side of the top of the bottom box is fixedly connected with an outer shell. The bottom of the inner cavity of the outer shell is fixedly connected with a motor. The output end of the motor is fixedly connected with a transmission rod. The bottom of the transmission rod penetrates through the top of the bottom box and extends into the inner cavity of the bottom box. The surface of the transmission rod is fixedly connected with a driving gear. The left side of the inner cavity of the bottom box is movably connected with a threaded rod through a bearing. The left side of the surface of the threaded rod is threadedly connected with a threaded sleeve. The right side of the threaded rod is fixedly connected with a driven gear. The driven gear meshes with the driving gear. The surface of the threaded sleeve is fixedly connected with a connecting block. The top of the connecting block penetrates through the inner cavity of the bottom box and extends to the outside of the bottom box. The top of the connecting block is fixedly connected with a mounting frame. The top of the mounting frame is fixedly connected with a kettle body. Both sides of the top of the kettle body are communicated with a feed pipe.

[0004] The above technical solution solves the problem that in the process of using a traditional reactor, the stirring efficiency of its internal components is relatively low, resulting in insufficient mixing reaction of the drug, thus reducing the production efficiency. However, the above technical solution fails to effectively solve the problem of internal cleaning of the reactor, especially in hard-to-reach corners and complex stirring components. The conventional method of water washing plus stirring still leaves cleaning dead corners, and the cleaning dead corners may lead to the accumulation of residues, which may not only affect the quality and efficiency of subsequent reactions, but even pose a threat to the safety of biopharmaceuticals. Summary of the Utility Model

[0005] The purpose of the utility model is to make up for the deficiencies of the prior art and provide a reactor structure for biopharmaceuticals.

[0006] To achieve the above purpose, the utility model provides the following technical solutions:

[0007] A reactor structure for biopharmaceuticals, including a stirring cylinder, the upper surface of the stirring cylinder is rotatably connected with a circular rotating plate, the outer surface of the stirring cylinder is fixedly connected with a fixed ring plate, the upper surface of the fixed ring plate is fixedly connected with a gear protective cover, the upper surface of the circular rotating plate is fixedly communicated with a feeding hopper, the outer surface of the feeding hopper is equipped with a first electric valve, the outer surface of the stirring cylinder is fixedly communicated with a discharging hopper, the outer surface of the discharging hopper is equipped with a second electric valve, and a comprehensive cleaning mechanism is arranged on the outer surface of the stirring cylinder.

[0008] As a preferred solution of this embodiment, a second servo motor is installed on the upper surface of the stirring cylinder, the output end of the second servo motor is installed with a second rotating shaft, and the second rotating shaft is rotatably connected to the inside of the circular rotating plate.

[0009] As a preferred solution of this embodiment, the second rotating shaft is rotatably connected to the inside of the stirring cylinder, and a group of stirring blades are fixedly connected to the outer surface of the second rotating shaft.

[0010] As a preferred solution of this embodiment, the comprehensive cleaning mechanism includes a first servo motor, a gear block, an electric lifting rod, and a water tank. The first servo motor is installed on the bottom surface of the fixed ring plate, the gear block is fixedly connected to the outer side surface of the circular rotating plate, the electric lifting rod is installed on the upper surface of the fixed ring plate, and the water tank is fixedly connected to the upper surface of the circular rotating plate.

[0011] As a preferred solution of this embodiment, the output end of the first servo motor is installed with a first rotating shaft, the first rotating shaft is rotatably connected to the inside of the fixed ring plate, a gear is fixedly connected to the top end of the first rotating shaft, and the gear meshes with the outer surface of the gear block.

[0012] As a preferred solution of this embodiment, a water supply pipe is fixedly communicated with the upper surface of the water tank, a water pump is installed on the inner wall of the water tank, and the output end of the water pump is installed with a water outlet pipe assembly.

[0013] As a preferred solution of this embodiment, the water outlet pipe assembly is fixedly connected to the inside of the water tank, the water outlet pipe assembly is slidably connected to the inside of the circular rotating plate, and two spray heads are fixedly communicated with the bottom end of the water outlet pipe assembly.

[0014] As a preferred solution of this embodiment, the top end of the electric lifting rod is fixedly connected with a first connecting plate, the bottom surface of the first connecting plate is fixedly connected with a rotating sleeve, and the inside of the rotating sleeve is rotatably connected with a rotating rod.

[0015] As a preferred solution of this embodiment, the bottom end of the rotating rod is fixedly connected with a second connecting plate, and the bottom surface of the second connecting plate is fixedly connected with the water outlet pipe assembly.

[0016] Compared with the prior art, the present utility model has the following beneficial effects:

[0017] (1) The utility model realizes the efficient cleaning of every corner inside the mixing drum through the arranged comprehensive cleaning mechanism. By driving the engagement of the gear and the gear block by the first servo motor, the circular rotating plate rotates. Combining the position adjustment of the water outlet pipe assembly and the water spray head by the electric lifting rod, and the high-pressure water spraying of the water pump, it ensures that there is no cleaning dead angle inside the mixing drum, effectively solves the problem of difficult cleaning of traditional reaction kettles, and improves the use efficiency of the equipment and the product quality.

[0018] (2) The utility model drives the second rotating shaft and a group of stirring blades to carry out efficient stirring inside the mixing drum through the second servo motor, promotes the full mixing and reaction of raw materials, and improves the reaction efficiency of biopharmaceuticals. At the same time, the designs of the feeding hopper and the discharging hopper make the feeding and discharging processes more convenient. The control modes of the first electric valve and the second electric valve further improve the automation degree of operation, reduce the need for manual intervention, thereby saving production costs and time. Description of the Drawings

[0019] Figure 1 is the overall structural schematic diagram of the reaction kettle structure for biopharmaceuticals of the utility model;

[0020] Figure 2 is the overall structural schematic diagram of the comprehensive cleaning mechanism of the utility model;

[0021] Figure 3 is the overall structural schematic diagram of the comprehensive cleaning mechanism from another angle of the utility model;

[0022] Figure 4 is the overall structural schematic diagram of the water spray head of the utility model.

[0023] As shown in the figure: 1, mixing drum; 2, circular rotating plate; 3, fixed ring plate; 4, gear protective cover; 5, feeding hopper; 6, first electric valve; 7, discharging hopper; 8, second electric valve; 9, comprehensive cleaning mechanism; 901, first servo motor; 902, first rotating shaft; 903, gear; 904, gear block; 905, electric lifting rod; 906, first connecting plate; 907, rotating sleeve; 908, rotating rod; 909, second connecting plate; 910, water outlet pipe assembly; 911, water tank; 912, water adding pipe; 913, water pump; 914, water spray head; 10, second servo motor; 11, second rotating shaft; 12, stirring blade. Detailed Embodiments

[0024] The principles and features of the utility model are described below in conjunction with the drawings. The examples given are only used to explain the utility model and are not intended to limit the scope of the utility model.

[0025] Please refer to Figures 1 to 4As shown in the figure, an embodiment of the present utility model provides a reactor structure for biopharmaceuticals, which specifically includes a stirring cylinder 1. A circular rotating plate 2 is rotatably connected to the upper surface of the stirring cylinder 1. A fixed ring plate 3 is fixedly connected to the outer surface of the stirring cylinder 1. A gear protection cover 4 is fixedly connected to the upper surface of the fixed ring plate 3. A feeding hopper 5 is fixedly communicated with the upper surface of the circular rotating plate 2. A first electric valve 6 is installed on the outer surface of the feeding hopper 5. A discharging hopper 7 is fixedly communicated with the outer surface of the stirring cylinder 1. A second electric valve 8 is installed on the outer surface of the discharging hopper 7. A comprehensive cleaning mechanism 9 is arranged on the outer surface of the stirring cylinder 1. A second servo motor 10 is installed on the upper surface of the stirring cylinder 1. The output end of the second servo motor 10 is provided with a second rotating shaft 11. The second rotating shaft 11 is rotatably connected to the inside of the circular rotating plate 2 and the inside of the stirring cylinder 1. A group of stirring blades 12 are fixedly connected to the outer surface of the second rotating shaft 11. In this embodiment, when using the reactor for biopharmaceutical reactions, first, reaction raw materials are added into the stirring cylinder 1 through the feeding hopper 5. This process can be achieved by controlling the first electric valve 6 to open and close the feeding hopper 5. After the feeding is completed, the second servo motor 10 is started, and a group of stirring blades 12 are driven by the second rotating shaft 11 to stir inside the stirring cylinder 1 to promote the full mixing and reaction of the raw materials. After the reaction is completed, the discharging hopper 7 can be opened by controlling the second electric valve 8 to discharge the reaction products. By starting the second servo motor 10, a group of stirring blades 12 are driven by the second rotating shaft 11 to stir inside the stirring cylinder 1 to promote the full mixing and reaction of the raw materials.

[0026] Please refer to Figures 2 to 4As shown in the figure, the comprehensive cleaning mechanism 9 specifically includes a first servo motor 901, a gear block 904, an electric lifting rod 905, and a water tank 911. The first servo motor 901 is installed on the bottom surface of the fixed ring plate 3. The gear block 904 is fixedly connected to the outer side surface of the circular rotating plate 2. The electric lifting rod 905 is installed on the upper surface of the fixed ring plate 3. The water tank 911 is fixedly connected to the upper surface of the circular rotating plate 2. A first rotating shaft 902 is installed at the output end of the first servo motor 901. The first rotating shaft 902 is rotatably connected to the inside of the fixed ring plate 3. The top end of the first rotating shaft 902 is fixedly connected to a gear 903. The gear 903 meshes with the outer surface of the gear block 904. A water supply pipe 912 is fixedly connected to the upper surface of the water tank 911. A water pump 913 is installed on the inner wall of the water tank 911. The output end of the water pump 913 is installed with a water outlet pipe assembly 910. The water outlet pipe assembly 910 is fixedly connected to the inside of the water tank 911. The water outlet pipe assembly 910 is slidably connected to the inside of the circular rotating plate 2. The bottom end of the water outlet pipe assembly 910 is fixedly connected to two spray nozzles 914. The top end of the electric lifting rod 905 is fixedly connected to a first connecting plate 906. The bottom surface of the first connecting plate 906 is fixedly connected to a rotating sleeve 907. A rotating rod 908 is rotatably connected to the inside of the rotating sleeve 907. The bottom end of the rotating rod 908 is fixedly connected to a second connecting plate 909. The bottom surface of the second connecting plate 909 is fixedly connected to the water outlet pipe assembly 910. A set of gear blocks 904 is arranged on the outer surface of the circular rotating plate 2. The gear blocks 904 mesh with the gear 903.

[0027] Specifically in this embodiment, when it is necessary to clean the mixing drum 1, first start the first servo motor 901, drive the gear 903 to rotate through the first rotating shaft 902. Since the gear block 904 meshes with the gear 903, the rotation of the gear 903 will drive the circular rotating plate 2 to rotate on the upper surface of the mixing drum 1. At the same time, start the electric lifting rod 905, and through the linkage of the first connecting plate 906 and the second connecting plate 909, adjust the up and down positions of the water outlet pipe assembly 910 and the spray nozzles 914 to ensure that all corners inside the mixing drum 1 can be effectively cleaned. During the cleaning process, turn on the water pump 913, spray the water in the water tank 911 into the mixing drum 1 through the water outlet pipe assembly 910 and the spray nozzles 914 for high-pressure flushing. The water in the water tank 911 can be supplemented through the water supply pipe 912. By combining rotation and spraying, it can ensure that all corners inside the mixing drum 1, including difficult-to-reach parts and complex mixing components, can be thoroughly cleaned, thus effectively avoiding the problems of cleaning dead corners and accumulation of residues.

[0028] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A reactor structure for biopharmaceuticals, comprising a stirring cylinder (1), characterized in that: The upper surface of the mixing drum (1) is rotatably connected to a circular rotating plate (2). The outer surface of the mixing drum (1) is fixedly connected to a fixed ring plate (3). The upper surface of the fixed ring plate (3) is fixedly connected to a gear protective cover (4). The upper surface of the circular rotating plate (2) is fixedly communicated with a feeding hopper (5). A first electric valve (6) is installed on the outer surface of the feeding hopper (5). The outer surface of the mixing drum (1) is fixedly communicated with a discharging hopper (7). A second electric valve (8) is installed on the outer surface of the discharging hopper (7). A comprehensive cleaning mechanism (9) is arranged on the outer surface of the mixing drum (1).

2. The structure of the reactor for biopharmaceuticals according to claim 1, characterized in that: A second servo motor (10) is installed on the upper surface of the mixing drum (1). The output end of the second servo motor (10) is installed with a second rotating shaft (11). The second rotating shaft (11) is rotatably connected to the inside of the circular rotating plate (2).

3. The structure of the reactor for biopharmaceuticals according to claim 2, wherein: The second rotating shaft (11) is rotatably connected to the inside of the mixing drum (1). A group of stirring blades (12) are fixedly connected to the outer surface of the second rotating shaft (11).

4. The structure of the reactor for biopharmaceuticals according to claim 1, wherein: The comprehensive cleaning mechanism (9) includes a first servo motor (901), a gear block (904), an electric lifting rod (905) and a water tank (911). The first servo motor (901) is installed on the bottom surface of the fixed ring plate (3). The gear block (904) is fixedly connected to the outer side surface of the circular rotating plate (2). The electric lifting rod (905) is installed on the upper surface of the fixed ring plate (3). The water tank (911) is fixedly connected to the upper surface of the circular rotating plate (2).

5. The structure of the reactor for biopharmaceuticals according to claim 4, characterized in that: The output end of the first servo motor (901) is installed with a first rotating shaft (902). The first rotating shaft (902) is rotatably connected to the inside of the fixed ring plate (3). The top end of the first rotating shaft (902) is fixedly connected to a gear (903). The gear (903) meshes with the outer surface of the gear block (904).

6. The structure of the reactor for biopharmaceuticals according to claim 5, characterized in that: A water adding pipe (912) is fixedly communicated with the upper surface of the water tank (911). A water pump (913) is installed on the inner wall of the water tank (911). The output end of the water pump (913) is installed with a water outlet pipe assembly (910).

7. The structure of the reactor for biopharmaceuticals according to claim 6, characterized in that: The water outlet pipe assembly (910) is fixedly connected to the inside of the water tank (911). The water outlet pipe assembly (910) is slidably connected to the inside of the circular rotating plate (2). The bottom end of the water outlet pipe assembly (910) is fixedly communicated with two spray nozzles (914).

8. The structure of the reactor for biopharmaceuticals according to claim 4, wherein: The top end of the electric lifting rod (905) is fixedly connected to a first connecting plate (906). The bottom surface of the first connecting plate (906) is fixedly connected to a rotating sleeve (907). The inside of the rotating sleeve (907) is rotatably connected to a rotating rod (908).

9. The structure of the reactor for biopharmaceuticals according to claim 8, characterized in that: The bottom end of the rotating rod (908) is fixedly connected to a second connecting plate (909). The bottom surface of the second connecting plate (909) is fixedly connected to the water outlet pipe assembly (910).

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