Automatic nuclide processing device
Through the nuclide automated processing device, the solution flow is controlled by using a syringe pump and a multi-channel solenoid valve, which solves the problems of solution waste and cross-contamination in radiochemical separation, and improves the recovery rate and production efficiency of radionuclides.
Patent Information
- Application Number
- CN202422302835.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-20
- Publication Date
- 2025-07-22
- Estimated Expiration
- 2034-09-20
AI Technical Summary
The dissolving material solution contains a variety of impurities during the existing radiochemical separation process, which leads to quality control problems, high artificial participation and the reaction solution is prone to adhere to the pipeline, causing waste and reducing the production efficiency of radionuclides.
Nuclide automated processing devices are adopted, including syringe pumps, multi-channel solenoid valves and chromatography columns, to accurately control the solution flow rate and flow rate, separate the pipelines of product liquid, waste liquid and recycling liquid, and reduce cross-contamination and solution waste.
It improves the recovery rate and production efficiency of radionuclides, reduces solution waste, avoids solution cross-contamination, and improves production efficiency.
Smart Images
Figure CN223140399U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of radionuclide separation, and particularly relates to a radionuclide automatic processing device. Background Art
[0002] With the improvement of people's living standards and the enhancement of health awareness, the radioactive drug market is growing at an alarming rate.
[0003] At present, Ac-225, Pb-212 and Cu-67 are produced on a large scale by the photosynthetic reaction method of a high-energy electron accelerator. The bremsstrahlung photons generated by the electron accelerator are used to irradiate the Ra-226 or Zn-68 target, and then the generated Ac-225, Pb-212 and Cu-67 are subjected to radiochemical separation from a large amount of unreacted target materials Ra-226 or Zn-68 to obtain carrier-free Ac-225, Pb-212 and Cu-67, meeting the requirements of nuclear drug labeling.
[0004] In the existing radiochemical separation process, the dissolved feed liquid contains various impurities, which will bring a series of quality control problems. The high degree of manual participation will also bring many safety problems. When some reaction solutions flow in the pipeline, they will adhere to the pipeline, resulting in waste of the reaction solution and reducing the production efficiency of radioactive nuclides. Content of the Utility Model
[0005] In order to overcome the deficiencies of the prior art, the purpose of the utility model is to provide a radionuclide automatic processing device to improve the production efficiency of radioactive nuclides.
[0006] The technical solution adopted by the utility model is as follows:
[0007] A radionuclide automatic processing device includes an injection pump, a first multi-channel solenoid valve, an upper column liquid bottle connected to the inlet end of the injection pump, a first eluent bottle, a second eluent bottle and a desorbing solution bottle;
[0008] A first chromatographic column is connected between the outlet end of the injection pump and the inlet end of the first multi-channel solenoid valve. A recovery liquid bottle, a waste liquid bottle and a second multi-channel solenoid valve are arranged at the outlet end of the first multi-channel solenoid valve. The inlet end and the outlet end of the second multi-channel solenoid valve are respectively connected to the injection pump and a third multi-channel solenoid valve. A second chromatographic column is connected between the outlet end of the second multi-channel solenoid valve and the inlet end of the third multi-channel solenoid valve. A product liquid bottle is arranged at the outlet end of the third multi-channel solenoid valve. The outlet end of the first multi-channel solenoid valve is connected to the product liquid bottle, and the outlet end of the third multi-channel solenoid valve is connected to the waste liquid bottle.
[0009] The injection pump can accurately control the flow rate and velocity of the solution containing radionuclide, the loading solution, the eluent, and the desorption solution. The solution containing radionuclide passes through the first chromatographic column and the second chromatographic column, which improves the recovery rate of radionuclide. The product liquid, waste liquid, and recovery liquid pipelines are separated by the first multi-channel solenoid valve, the second multi-channel solenoid valve, and the third multi-channel solenoid valve, reducing the adhesion of the reaction solution to the pipeline, avoiding cross-contamination between different solutions, reducing the waste of each reaction solution, and improving the production efficiency of radionuclide.
[0010] Optionally, the injection pump drives the solution containing radionuclide to pass through the first chromatographic column and the first multi-channel solenoid valve and enter the recovery bottle.
[0011] Optionally, the loading solution passes through the first chromatographic column and the first multi-channel solenoid valve and enters the recovery liquid bottle.
[0012] The liquid in the recovery liquid bottle can be reused, reducing the waste of the solution.
[0013] Optionally, the first eluent bottle and the second eluent bottle contain eluent, and the eluent is used to elute the first chromatographic column and the second chromatographic column and flow into the waste liquid bottle.
[0014] The solution in the first eluent bottle elutes the first chromatographic column and the first multi-channel solenoid valve and flows into the waste liquid bottle. The solution in the second eluent bottle elutes the first chromatographic column, the first multi-channel solenoid valve, the second multi-channel solenoid valve, the second chromatographic column, and the third multi-channel solenoid valve and flows into the waste liquid bottle. By using the two bottles of eluent to elute the treatment device respectively, the amount of waste liquid is reduced.
[0015] Optionally, the desorption solution passes through the second multi-channel solenoid valve, the second chromatographic column, and the third multi-channel solenoid valve and enters the product liquid bottle.
[0016] Optionally, the desorption solution in the desorption solution bottle passes through the first chromatographic column and the first multi-channel solenoid valve and enters the product liquid bottle.
[0017] Optionally, a washing solution bottle is connected to the inlet end of the injection pump, and a washing solution for pipeline cleaning is provided in the washing solution bottle.
[0018] The beneficial effects of the present utility model are as follows: The injection pump can accurately control the flow rate and velocity of the solution containing radionuclides, the loading solution, the eluent, and the desorption solution. The solution containing radionuclides passes through the first chromatography column and the second chromatography column, which improves the recovery rate of radionuclides. The pipelines of the product solution, waste solution, and recovery solution are separated by the first multi-channel solenoid valve, the second multi-channel solenoid valve, and the third multi-channel solenoid valve, reducing the phenomenon of the reaction solution adhering to the pipeline, avoiding cross-contamination between different solutions, reducing the waste of each reaction solution, and improving the production efficiency of radionuclides. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a schematic diagram of the overall structure of the present utility model.
[0020] The reference numerals in the figure correspond to the names as follows: 1. Injection pump; 21. First multi-channel solenoid valve; 22. Second multi-channel solenoid valve; 23. Third multi-channel solenoid valve; 3. Loading solution bottle; 41. First eluent bottle; 42. Second eluent bottle; 43. Washing solution bottle; 5. Desorption solution bottle; 61. First chromatography column; 62. Second chromatography column; 7. Recovery solution bottle; 8. Waste solution bottle; 9. Product solution bottle. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0021] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.
[0022] Please refer to Figure 1 , the present utility model provides a technical solution:
[0023] A nuclide automatic processing device includes an injection pump 1, a first multi-channel solenoid valve 21, a loading solution bottle 3, a loading solution bottle 3 connected to the inlet end of the injection pump 1, a first eluent bottle 41, a second eluent bottle 42, and a desorption solution bottle 5. The outlet end of the injection pump 1 is connected to the inlet end of the first multi-channel solenoid valve 21 through the first chromatography column 61. The outlet end of the first multi-channel solenoid valve 21 is provided with a recovery solution bottle 7, a waste solution bottle 8, and a second multi-channel solenoid valve 22. The injection pump 1 drives the solution containing radionuclides to enter the recovery bottle through the first chromatography column 61 and the first multi-channel solenoid valve 21. The injection pump 1 drives the loading solution to enter the recovery solution bottle 7 through the first chromatography column 61 and the first multi-channel solenoid valve 21. The loading solution bottle 3 contains a loading solution, and the loading solution is one of a nitric acid solution of Ra-226, a hydrochloric acid solution of Ra-226, a nitric acid solution of Zn-68, and a hydrochloric acid solution of Zn-68.
[0024] The filling materials of the first layer chromatography column 61 and the second layer chromatography column 62 are one of LN resin, DGA resin, Pb resin, Cu resin, Sr resin and ion exchange resin, and the volumes of the first layer chromatography column 61 and the second layer chromatography column 62 are 2 - 25 ml.
[0025] The inlet end and the outlet end of the second multi-channel solenoid valve 22 are respectively connected to the injection pump 1 and the third multi-channel solenoid valve 23. The outlet end of the second multi-channel solenoid valve 22 is connected to the inlet end of the third multi-channel solenoid valve 23 through the second layer chromatography column 62. A product liquid bottle 9 is arranged at the outlet end of the third multi-channel solenoid valve 23. The outlet end of the first multi-channel solenoid valve 21 is connected to the product liquid bottle 9, and the outlet end of the third multi-channel solenoid valve 23 is connected to the waste liquid bottle 8.
[0026] The injection pump 1 drives the desorbing liquid in the desorbing liquid bottle 5 to enter the product liquid bottle 9 through the second multi-channel solenoid valve 22, the second layer chromatography column 62, and the third multi-channel solenoid valve 23. The injection pump 1 drives the desorbing liquid in the desorbing liquid bottle 5 to enter the product liquid bottle 9 through the first layer chromatography column 61 and the first multi-channel solenoid valve 21. The desorbing liquid is a nitric acid or hydrochloric acid solution with a concentration of 0.001 - 0.1 mol / L. The injection pump 1 drives the eluent in the first eluent bottle 41 and the second eluent bottle 42 to wash the first layer chromatography column 61 and the second layer chromatography column 62 and flow into the waste liquid bottle 8. The eluent in the first eluent bottle 41 flows into the waste liquid bottle 8 through the first layer chromatography column 61 and the first multi-channel solenoid valve 21; the eluent in the second eluent bottle 42 flows into the waste liquid bottle 8 through the first layer chromatography column 61, the first multi-channel solenoid valve 21, the second multi-channel solenoid valve 22, the second layer chromatography column 62, and the third multi-channel solenoid valve 23. The eluent is a nitric acid or hydrochloric acid solution with a concentration of 0.01 - 6 mol / L.
[0027] The inlet end of the injection pump 1 is connected to a washing liquid bottle 43. The washing liquid bottle 43 is provided with a washing liquid for pipeline cleaning. The washing liquid is a nitric acid or hydrochloric acid solution with a concentration of 0.5 - 3.0 mol / L. For the radiochemical preparation of different radionuclides, it is possible to replace the filling materials of the first layer chromatography column 61 and the second layer chromatography column 62, or replace the loading liquid, eluent or desorbing liquid.
[0028] Finally, it should be noted that the above are only the preferred examples of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.
Claims
1. An automated nuclide processing device, characterized in that, It includes an injection pump (1), a first multi-channel solenoid valve (21), an upper column liquid bottle (3) connected to the inlet end of the injection pump (1), a first eluent bottle (41), a second eluent bottle (42), and a desorbing solution bottle (5); A first chromatographic column (61) is connected between the outlet end of the injection pump (1) and the inlet end of the first multi-channel solenoid valve (21). A recovery liquid bottle (7), a waste liquid bottle (8), and a second multi-channel solenoid valve (22) are provided at the outlet end of the first multi-channel solenoid valve (21). The inlet end and the outlet end of the second multi-channel solenoid valve (22) are respectively connected to the injection pump (1) and a third multi-channel solenoid valve (23). A second chromatographic column (62) is connected between the outlet end of the second multi-channel solenoid valve (22) and the inlet end of the third multi-channel solenoid valve (23). A product liquid bottle (9) is provided at the outlet end of the third multi-channel solenoid valve (23). The outlet end of the first multi-channel solenoid valve (21) is connected to the product liquid bottle (9). The outlet end of the third multi-channel solenoid valve (23) is connected to the waste liquid bottle (8).
2. The nuclide automatic processing device according to claim 1, wherein The injection pump (1) drives a solution containing a radionuclide to enter the recovery bottle through the first chromatographic column (61) and the first multi-channel solenoid valve (21).
3. The nuclide automatic processing device according to claim 2, wherein The upper column liquid enters the recovery liquid bottle (7) through the first chromatographic column (61) and the first multi-channel solenoid valve (21).
4. The nuclide automatic processing device according to claim 1, wherein The first eluent bottle (41) and the second eluent bottle (42) contain eluent, and the eluent is used to elute the first chromatographic column (61) and the second chromatographic column (62) and flow into the waste liquid bottle (8).
5. The nuclide automatic processing device according to claim 1, characterized in that, The desorbing solution in the desorbing solution bottle (5) enters the product liquid bottle (9) through the second multi-channel solenoid valve (22), the second chromatographic column (62), and the third multi-channel solenoid valve (23).
6. The nuclide automatic processing device according to claim 1, characterized in that, The desorbing solution in the desorbing solution bottle (5) enters the product liquid bottle (9) through the first chromatographic column (61) and the first multi-channel solenoid valve (21).
7. The nuclide automatic processing device according to claim 1, characterized in that A washing liquid bottle (43) is connected to the inlet end of the injection pump (1), and a washing liquid for pipeline cleaning is provided in the washing liquid bottle (43).