Embedding bottom die for preparing pathological quality control product

Abstract

The utility model discloses an embedding bottom die for preparing a pathological quality control product. The embedding bottom die comprises a threaded rod, a bottom die body provided with a tissue groove and a working bag arranged in the tissue groove, and the groove wall of the tissue groove is provided with an adjusting hole parallel to the groove bottom; the outer wall of the working bag is attached to the groove bottom and the groove wall of the tissue groove, the working bag comprises a fixed plate, a movable plate and an elastic bag wall, the fixed plate and the movable plate are perpendicular to the groove bottom of the tissue groove, the elastic bag wall is arranged between the fixed plate and the movable plate, and the fixed plate is fixedly connected with the groove wall of the tissue groove; the threaded rod is in threaded connection with the adjusting hole and penetrates through the adjusting hole, the fixed plate is rotationally connected with the movable plate, and when the threaded rod rotates, the movable plate is driven to move in the tissue groove, so that the size of a groove defined by the groove wall and the groove bottom of the tissue groove and the movable plate is changed, and therefore when the embedded wax block manufactured through the method is sliced, the cutting efficiency is improved. And the area ratio of the paraffin in the section can be in a proper range.

Description

Technical Field

[0001] This application belongs to the technical field of medical devices, and specifically relates to an embedding bottom mold for preparing pathological quality control products. Background Art

[0002] Paraffin embedding is a process of immersing fixed tissue blocks in molten paraffin after dehydration and clearing. The conventional paraffin embedding process includes five steps, namely fixation, dehydration, clearing, infiltration, and embedding. The final embedding is to take the tissue blocks that have been fixed, dehydrated, cleared, and infiltrated out of the wax bath and place them into an embedding frame filled with molten paraffin to form blocks, so that the tissue and the embedding agent are fused together and quickly cooled. After the embedding agent solidifies, it further enhances the hardness and toughness of the tissue and facilitates sectioning. The paraffin embedding method is a conventional method for making optical microscope sections. The uses of sections are diverse. For example, cells or tissues cultured under certain standards can be made into paraffin embedding blocks using the paraffin embedding method, and then sectioning operations can be performed to make them into reference sections. During clinical pathological examinations, the section samples of the person to be examined are compared with the reference section samples for diagnosis. In this process, the quality of the sections directly affects the judgment and treatment of diseases, and the quality of the paraffin embedding blocks directly affects the quality of the sections.

[0003] During paraffin embedding, a small amount of paraffin needs to be injected into the tissue groove of the embedding bottom mold first, then the sample is placed into the tissue groove of the embedding bottom mold, and then the tissue embedding box is placed. If the width of the tissue groove is too large, then during sectioning, the paraffin will occupy a large area of the section. When producing quality control wax blocks, if the proportion of paraffin is large, during subsequent sectioning operations, the paraffin will occupy the area of the glass slide, affecting the placement of the section of the sample to be examined on this glass slide. Utility Model Content

[0004] In order to reduce the proportion of paraffin during paraffin embedding and study the optimal size of the tissue groove that should be selected when placing multiple quality control cell line columns during paraffin embedding, this application provides an embedding bottom mold for preparing pathological quality control products.

[0005] An embedding bottom mold for preparing pathological quality control products includes a threaded rod, a bottom mold main body provided with a tissue groove, and a working capsule arranged in the tissue groove. The groove wall of the tissue groove is provided with adjustment holes parallel to the groove bottom; the outer wall of the working capsule fits the groove bottom and the groove wall of the tissue groove. The working capsule includes a fixed plate and a movable plate perpendicular to the groove bottom of the tissue groove, and an elastic capsule wall arranged between the fixed plate and the movable plate. The fixed plate is fixedly connected to the groove wall of the tissue groove; the threaded rod is threadedly connected to the adjustment hole and passes through the adjustment hole, the fixed plate and is rotatably connected to the movable plate. When the threaded rod rotates, it drives the movable plate to move in the tissue groove to change the size of the groove formed by the groove wall and the groove bottom of the tissue groove and the movable plate.

[0006] In an embodiment of the present application, the tissue groove is a square groove, and its cross-section has a long side and a short side. The axial direction of the adjustment hole is parallel to the long side direction of the tissue groove, and the movable plate can move along the long side direction of the tissue groove.

[0007] In an embodiment of the present application, along the long side direction of the tissue groove, a scale is provided at the notch of the tissue groove.

[0008] In an embodiment of the present application, the fixing plate is detachably connected to the groove wall of the tissue groove.

[0009] In an embodiment of the present application, a first guide rail is provided on the groove wall of the tissue groove. The extending direction of the first guide rail is the same as the depth direction of the tissue groove. The fixing plate is provided with a sliding part that can be slidably matched with the first guide rail. The working capsule can move along the depth direction of the tissue groove through the sliding part and the first guide rail and fit with the bottom of the tissue groove.

[0010] In an embodiment of the present application, the movable plate is provided with a rotation fitting hole, the rotation fitting hole is arranged inside the working capsule, and one end of the threaded rod can be inserted into the rotation fitting hole.

[0011] In an embodiment of the present application, the fixing plate is provided with a guide cylinder. The rotation fitting hole and the guide cylinder are coaxially arranged, and the threaded rod can pass through the adjustment hole and the guide cylinder and be inserted into the rotation fitting hole.

[0012] In an embodiment of the present application, the working capsule is detachably connected to the tissue groove, and the threaded rod is detachably connected to the working capsule and the bottom die body.

[0013] In an embodiment of the present application, the tissue groove and the movable plate have heat conductivity, and the movable plate abuts against the groove wall and the bottom of the tissue groove.

[0014] In an embodiment of the present application, the elastic capsule wall has high temperature resistance.

[0015] The present application at least has the following beneficial effects:

[0016] 1. By changing the position of the movable plate, the present application can change the occupied space of the working capsule in the tissue groove, thereby changing the size of the groove for paraffin injection. Adjust the position of the movable plate according to the amount of the quality control cell line column or other samples placed in the tissue groove, so as to reduce the proportion of paraffin in the section and facilitate placing the sample to be detected on the glass slide.

[0017] 2. By means of the detachable connection between the working bladder and the tissue groove, and the detachable connection between the threaded rod and the working bladder and the bottom mold body, after the wax block is made, the connection between the working bladder, the bottom mold body and the threaded rod can be disconnected, which is convenient for cleaning the working bladder, the bottom mold body and the threaded rod and convenient for reuse. Description of the Drawings

[0018] Figure 1 is a schematic structural diagram of an exemplary embodiment of the present application;

[0019] Figure 2 is a schematic structural diagram of an exemplary embodiment of the working bladder in the present application;

[0020] Figure 3 is a schematic structural diagram of an exemplary embodiment of the wax injection space in the present application;

[0021] Figure 4 is a schematic structural diagram of an exemplary embodiment of the first guide rail in the present application;

[0022] Figure 5 is a schematic structural diagram of an exemplary embodiment when the working bladder is located in the tissue groove in the present application.

[0023] In the figure:

[0024] 101, bottom mold body; 102, tissue groove; 103, wax injection space; 104, scale; 105, first guide rail; 106, adjustment hole;

[0025] 201, working bladder; 202, movable plate; 203, fixed plate; 204, elastic bladder wall; 205, sliding part; 206, guide cylinder; 301, threaded rod. Detailed Embodiments

[0026] For a clearer understanding of the technical features, objectives and effects of the present application, the specific embodiments of the present application are now described with reference to the accompanying drawings. In the figures, the same reference numerals denote components having the same or similar structures but the same functions.

[0027] In this document, "schematic" means "serving as an example, instance or illustration", and any illustration or embodiment described as "schematic" in this document should not be construed as a more preferred or more advantageous technical solution.

[0028] For the sake of simplicity of the drawings, only the parts related to the present application are schematically shown in each figure, and they do not represent their actual structures as products. In addition, for the sake of simplicity and understanding of the drawings, in some figures, only one of the components with the same structure or function is schematically shown, or only one of them is marked.

[0029] Please refer to Figures 1 to 5 to understand this application.

[0030] Refer to Figure 1 and Figure 2 , an embedding bottom mold for preparing a pathological quality control product, which includes a threaded rod 301, a bottom mold main body 101 provided with a tissue groove 102, and a working capsule 201 arranged in the tissue groove 102. Refer to Figure 4 , the groove wall of the tissue groove 102 is provided with an adjustment hole 106 parallel to the groove bottom; the outer wall of the working capsule 201 fits the groove bottom and the groove wall of the tissue groove 102 to prevent paraffin from invading the gap between the working capsule 201 and the tissue groove 102 when injecting paraffin into the tissue groove 102. The working capsule 201 includes a fixed plate 203 and a movable plate 202 perpendicular to the groove bottom of the tissue groove 102, and an elastic capsule wall 204 arranged between the fixed plate 203 and the movable plate 202. The movable plate 202, the fixed plate 203, and the elastic capsule wall 204 enclose the working capsule 201, and the fixed plate 203 is fixedly connected to the groove wall of the tissue groove 102; the threaded rod 301 is threadedly connected to the adjustment hole 106 and passes through the adjustment hole 106, the fixed plate 203 and is rotatably connected to the movable plate 202. When the threaded rod 301 rotates, it drives the movable plate 202 to move in the tissue groove 102 to change the distance between the fixed plate 203 and the movable plate 202, thereby changing the size of the groove formed by the groove wall and the groove bottom of the tissue groove 102 and the movable plate 202. Refer to Figure 1 and Figure 4 , part of the space of the tissue groove 102 is occupied by the working capsule 201, and the remaining space can place multiple quality control cell line columns or other samples. To better describe this application, this space is named the wax injection space 103 here.

[0031] Refer to Figure 1 and Figure 2 , in an implementation manner of this application, the tissue groove 102 is a square groove, and its cross-section has a long side and a short side. The axial direction of the adjustment hole 106 is parallel to the long side direction of the tissue groove 102, and the movable plate 202 can move along the long side direction of the tissue groove 102 to Figure 2The direction is described as follows. Since the threaded rod 301 and the adjustment hole 106 are connected by threads, the threaded rod 301 plays a supporting role for the movable plate 202. When the threaded rod 301 rotates and moves leftward along its axial direction, the threaded rod 301 can push the movable plate 202 to move leftward against the elastic force of the elastic capsule wall 204, thereby reducing the size of the wax injection space 103 to reduce the area ratio of the paraffin in the section; when the threaded rod 301 rotates and moves rightward along its axial direction, under the elastic force of the elastic capsule wall 204, the movable plate 202 moves rightward along with the threaded rod 301, so that the size of the wax injection space 103 increases, and more samples can be placed. Moreover, the position of the movable plate 202 can be adjusted so that the area ratio of the paraffin in the section is within a suitable range.

[0032] Of course, according to needs, the installation position of the working capsule can also be adjusted so that the adjustment hole is parallel to the short side direction of the tissue groove 102, and the threaded rod 301 can drive the movable plate 202 to move along the short side direction of the tissue groove 102, which will not be elaborated here.

[0033] See Figure 3 , in an embodiment of the present application, along the long side direction of the tissue groove 102, a scale 104 is provided at the notch of the tissue groove 102. The experimenter can refer to the size of the glass slide and use the scale 104 to adjust the position of the movable plate 202 to obtain a suitable size of the wax injection space 103, which is convenient for subsequently selecting a suitable embedding bottom mold, or adjusting the position of the movable plate 202 in time according to the scale 104 to ensure that when embedding again, the area ratio of the paraffin in the section is within a suitable range.

[0034] See Figures 1 to 4, in an embodiment of the present application, the fixing plate 203 is detachably connected to the groove wall of the tissue groove 102. In an embodiment of the present application, the groove wall of the tissue groove 102 is provided with a first guide rail 105. The extending direction of the first guide rail 105 is the same as the depth direction of the tissue groove 102. The fixing plate 203 is provided with a sliding portion 205 that can slidably cooperate with the first guide rail 105. The sliding portion 205 is a protrusion provided on the fixing plate 203, and the first guide rail 105 is a groove opened on the groove wall of the tissue groove 102 that can slidably cooperate with the sliding portion 205; the working capsule 201 can move along the depth direction of the tissue groove 102 through the sliding portion 205 and the first guide rail 105 and fit with the bottom of the tissue groove 102, so that the working capsule 201 can be installed in the tissue groove 102. After the wax block is prepared, the working capsule 201 can be detached from the tissue groove 102 through the first guide rail 105 and the sliding portion 205 to clean the bottom die body 101 and the working capsule 201. Of course, the implementation manners of the first guide rail 105 and the sliding portion 205 can also be other ways, such as the first guide rail 105 is a protrusion and the sliding portion 205 is a groove, which will not be elaborated here.

[0035] Those skilled in the art to which the present application pertains can understand that other ways can also be used to realize the detachable connection between the fixing plate 203 and the groove wall of the tissue groove 102, such as the fixing plate 203 and the tissue groove 102 are connected by a snap connection method, which will not be elaborated here.

[0036] See Figure 2 , in an embodiment of the present application, the movable plate 202 is provided with a rotation fitting hole, which is arranged inside the working capsule 201. One end of the threaded rod 301 can be inserted into the rotation fitting hole to realize the rotational connection between the movable plate 202 and the threaded rod 301, so that the movable plate 202 does not restrict the rotation of the threaded rod 301, and the threaded rod 301 can drive the movable plate 202 to move.

[0037] See Figure 2 , in an embodiment of the present application, the fixing plate 203 is provided with a guide cylinder 206. The rotation fitting hole and the guide cylinder 206 are coaxially arranged. The threaded rod 301 can pass through the adjustment hole 106 and the guide cylinder 206 and be inserted into the rotation fitting hole. The fixing plate 203 is fixedly connected to the groove wall of the tissue groove 102, and the guide cylinder 206 can limit the radial movement of the threaded rod 301 and play a guiding role for the threaded rod 301, so that the threaded rod 301 can stably drive the movable plate 202 to move along the axial direction of the threaded rod 301.

[0038] In an embodiment of the present application, the working bladder 201 can be detachably connected to the tissue groove 102 in the above-described manner; one end of the threaded rod 301 can be inserted or clamped into the rotation fitting hole, and the threaded rod 301 is connected to the adjustment hole 106 by a thread, so that the threaded rod 301 is detachably connected to the bottom mold main body 101. The threaded rod 301 can be withdrawn from the working bladder 201 and the bottom mold main body 101, so that the threaded rod 301 is detachably connected to the working bladder 201 and the bottom mold main body 101, facilitating the cleaning of the threaded rod 301, the working bladder 201, and the bottom mold main body 101 after they are disassembled.

[0039] In an embodiment of the present application, the tissue groove 102 and the movable plate 202 have thermal conductivity. The movable plate 202 abuts against the groove wall and the groove bottom of the tissue groove 102, and there is heat conduction between the movable plate 202 and the tissue groove 102. When paraffin is injected into the wax injection space, the paraffin can dissipate heat evenly in all directions through the movable plate 202 and the tissue groove 102, accelerating the cooling of the paraffin.

[0040] In an embodiment of the present application, the elastic bladder wall 204 has high temperature resistance and can be made of heat-resistant rubber to ensure that the elastic bladder wall 204 can still work properly when it comes into contact with paraffin at a relatively high temperature.

[0041] It should be understood that although this specification is described according to various embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

[0042] The series of detailed descriptions listed above are only specific descriptions of the feasible embodiments of the present application, and they are not intended to limit the protection scope of the present application. Any equivalent implementation or change made without departing from the technical spirit of the present application, such as the combination, division, or repetition of features, should be included in the protection scope of the present application.

Claims

1. An embedding bottom mold for preparing pathological quality control products, characterized in that, It includes a threaded rod, a bottom mold body provided with tissue grooves, and a working bladder arranged in the tissue grooves. The groove wall of the tissue grooves is provided with adjustment holes parallel to the groove bottom; The outer wall of the working bladder fits against the groove bottom and the groove wall of the tissue grooves. The working bladder includes a fixed plate and a movable plate perpendicular to the groove bottom of the tissue grooves, and an elastic bladder wall arranged between the fixed plate and the movable plate. The fixed plate is fixedly connected to the groove wall of the tissue grooves; The threaded rod is threadedly connected to the adjustment holes, passes through the adjustment holes, the fixed plate and is rotationally connected to the movable plate. When the threaded rod rotates, it drives the movable plate to move in the tissue grooves so as to change the size of the grooves formed by the groove wall and the groove bottom of the tissue grooves and the movable plate.

2. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The tissue grooves are square grooves, and its cross-section has a long side and a short side. The axial direction of the adjustment holes is parallel to the long side direction of the tissue grooves, and the movable plate can move along the long side direction of the tissue grooves.

3. The embedding bottom mold for preparing pathological quality control products according to claim 2, characterized in that, Along the long side direction of the tissue grooves, scales are provided at the notch of the tissue grooves.

4. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The fixed plate is detachably connected to the groove wall of the tissue grooves.

5. The embedding bottom mold for preparing pathological quality control products according to claim 4, characterized in that, The groove wall of the tissue grooves is provided with a first guide rail, and the extending direction of the first guide rail is the same as the depth direction of the tissue grooves. The fixed plate is provided with a sliding part that can be slidably matched with the first guide rail. The working bladder can move along the depth direction of the tissue grooves through the sliding part and the first guide rail and fit against the groove bottom of the tissue grooves.

6. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The movable plate is provided with a rotation fitting hole, and the rotation fitting hole is arranged inside the working bladder. One end of the threaded rod can be inserted into the rotation fitting hole.

7. The embedding bottom mold for preparing pathological quality control products according to claim 6, characterized in that, The fixed plate is provided with a guiding cylinder, the rotation fitting hole and the guiding cylinder are coaxially arranged, and the threaded rod can pass through the adjustment holes, the guiding cylinder and be inserted into the rotation fitting hole.

8. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The working bladder is detachably connected to the tissue grooves, and the threaded rod is detachably connected to the working bladder and the bottom mold body.

9. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The tissue grooves and the movable plate have heat conductivity, and the movable plate abuts against the groove wall and the groove bottom of the tissue grooves.

10. The embedding bottom mold for preparing pathological quality control products according to claim 1, characterized in that, The elastic bladder wall has high temperature resistance.

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