Leukocyte filtering structure and leukocyte removing filter

Abstract

The utility model provides a leukocyte filtering structure and a leukocyte-depleted filter, which have the advantages of filtering many leukocytes and adsorbing little platelets and plasma. The leukocyte filtering structure comprises a plurality of filter membrane layers which are overlapped with one another, at least one filter membrane layer is provided with one or more through holes, and the through holes in the adjacent filter membrane layers are staggered with one another.

Description

Technical Field

[0001] This application relates to the technical fields of biomedicine and medical devices, and particularly to a leukocyte filtration structure and a leukocyte filter. Background Art

[0002] Platelet-rich plasma (PRP) is a product with a high concentration of platelet components obtained by centrifuging human whole blood, and has wide applications in multiple medical fields such as bone injury, sports injury, wound healing, and tissue regeneration. According to the different leukocyte concentrations contained in the prepared PRP, PRP can be divided into leukocyte-poor PRP (P-PRP) and leukocyte-rich PRP (L-PRP). Clinical practice has shown that excessive leukocyte transfusion may cause side reactions such as platelet transfusion ineffectiveness and non-hemolytic febrile transfusion reactions. Therefore, reducing the leukocyte concentration has become one of the key measures to ensure the efficacy of platelet-rich plasma. Using a leukocyte filter to filter leukocytes can directly reduce the leukocyte residue in platelet-rich plasma. However, the filtration structures of ordinary leukocyte filters often cannot have the advantages of filtering a large number of leukocytes, less platelet and plasma adsorption. Utility Model Content

[0003] One advantage of the present utility model is to provide a leukocyte filtration structure and a leukocyte filter, which can have the advantages of filtering a large number of leukocytes, less platelet and plasma adsorption.

[0004] Another advantage of the present utility model is to provide a leukocyte filtration structure and a leukocyte filter. In order to achieve the above advantages, expensive materials or complex structures are not required in the present utility model. Therefore, the present utility model successfully and effectively provides a solution, not only providing a simple leukocyte filtration structure and a leukocyte filter, but also increasing the practicability and reliability of the leukocyte filtration structure and the leukocyte filter.

[0005] Based on this, in order to achieve at least one of the above advantages or other advantages and purposes of the present utility model, the present utility model provides a leukocyte filtration structure, including:

[0006] A plurality of filter membrane layers stacked on top of each other, wherein at least one of the filter membrane layers has one or more through holes, and the through holes on adjacent filter membrane layers are offset from each other.

[0007] With such a setting, the white blood cell filtration structure can have the advantages of filtering a large number of white blood cells, less adsorption of platelets and plasma. By forming the through holes in the filter membrane layer, compared with the filter membrane layer without the through holes, the rate of filtering white blood cells using the filter membrane layer with the through holes is faster, thereby improving the permeability of the white blood cell filtration structure, and further reducing the amount of platelets and plasma retained in the filter membrane layer. The white blood cell filtration structure having multiple filter membrane layers can perform multiple filtrations, thereby increasing the amount of filtered white blood cells. Therefore, the white blood cell filtration structure can have the advantages of filtering a large number of white blood cells, less adsorption of platelets and plasma.

[0008] According to an embodiment of the present application, the multiple filter membrane layers include a first filter membrane layer without the through holes and one or more second filter membrane layers stacked on one side of the first filter membrane layer and having the through holes.

[0009] With such a setting, the first filter membrane layer without the through holes can perform a total filtration on the P-PRP (platelet-rich plasma with low white blood cells) obtained after filtration through the multiple second filter membrane layers, preventing a very small number of white blood cells from passing through the through holes of each second filter membrane layer by chance and remaining in the P-PRP (platelet-rich plasma with low white blood cells), thereby increasing the amount of filtered white blood cells.

[0010] According to an embodiment of the present application, the diameters of both the first filter membrane layer and the second filter membrane layer are less than 5 cm.

[0011] With such a setting, compared with a single-layer filter membrane of a larger size with the same filtration rate, the overall size of the white blood cell filtration structure is smaller, and compared with a multi-layer filter membrane with the same filtration efficiency, the filtration rate of the white blood cell filtration structure is faster. Therefore, the white blood cell filtration structure takes into account both a fast filtration rate and is suitable for situations with high size requirements.

[0012] According to an embodiment of the present application, the number of the through holes in the second filter membrane layer ranges from 1 to 10.

[0013] With such a setting, by setting a reasonable number of the through holes, it is possible to prevent the occurrence of overlap between the through holes of two adjacent second filter membrane layers and at the same time reduce the occurrence of overlap between the two through holes of two second filter membrane layers separated by one second filter membrane layer, thereby ensuring the effect of filtering white blood cells by the white blood cell filtration structure.

[0014] According to an embodiment of the present application, the diameter of the through holes in the second filter membrane layer ranges from 0.5 to 10 mm.

[0015] With such a setting, by setting a reasonable number of the through holes, it is possible to prevent the overlap between the through holes of two adjacent second filter membrane layers and at the same time reduce the occurrence of the overlap between two through holes of two second filter membrane layers separated by one second filter membrane layer, thereby ensuring the effect of the white blood cell filtering structure in filtering white blood cells.

[0016] According to an embodiment of the present application, the number of the through holes in the second filter membrane layer is multiple and evenly distributed in the second filter membrane layer.

[0017] With such a setting, compared with the position on the second filter membrane layer where the through holes are not provided, the flow rate at the through hole is faster. By evenly arranging multiple through holes in the second filter membrane layer, the filtration rate of each position of the second filter membrane layer during the filtration of white blood cells by means of the second filter membrane layer can be controlled in a relatively average state, thereby improving the filtration effect of the white blood cell filtering structure.

[0018] According to an embodiment of the present application, the diameters of the through holes in the same second filter membrane layer are the same.

[0019] With such a setting, the flow rates at the through holes with different diameters are different, and the flow rate at the through hole with a larger diameter is greater. By setting the through holes with the same diameter in the same second filter membrane layer, the efficiency of the second filter membrane layer in filtering white blood cells can be ensured to be relatively average, thereby improving the filtration effect of the white blood cell filtering structure.

[0020] According to an embodiment of the present application, the diameters of the through holes in the second filter membrane layer closer to the first filter membrane layer change in a gradient manner.

[0021] With such a setting, the larger the diameter of the through hole in the second filter membrane layer, the faster the filtration rate of white blood cells, but the filtration effect is relatively reduced. The diameters of the through holes in the second filter membrane layer closer to the first filter membrane layer change in a trapezoidal manner, which can gradually and progressively filter PRP (platelet-rich plasma) during the process of filtering white blood cells by means of the white blood cell filtering structure, so that the white blood cell filtering structure has the advantages of fast rate and good filtration effect during the process of filtering white blood cells.

[0022] On the other hand, according to the present application, the present application further provides a leukocyte filter, which includes:

[0023] An outlet filter head with an outlet;

[0024] An inlet filter head with an inlet; and

[0025] Any of the above white blood cell filtration structures is disposed between the liquid outlet filter head and the liquid inlet filter head.

[0026] With such an arrangement, the white blood cell filter can achieve the function of filtering white blood cells by means of the white blood cell filtration structure, the liquid outlet filter head, and the liquid inlet filter head.

[0027] According to an embodiment of the present application, the liquid outlet filter head includes a liquid outlet clamping plate connected to the white blood cell filtration structure and a liquid outlet pipe protruding from the liquid outlet clamping plate. The white blood cell filter further includes a sealing ring that wraps the liquid outlet pipe.

[0028] With such an arrangement, the sealing ring can prevent the leakage of PRP (platelet-rich plasma) when filtering white blood cells by means of the white blood cell filter.

[0029] According to an embodiment of the present application, the liquid inlet filter head includes a liquid inlet clamping plate connected to the white blood cell filtration structure and a liquid inlet pipe protruding from the liquid inlet clamping plate. The white blood cell filter further includes an anti-fouling block that abuts against the liquid inlet pipe to block the orifice of the liquid inlet pipe.

[0030] With such an arrangement, the anti-fouling block can block the liquid inlet pipe, thereby isolating substances, and further preventing external substances from coming into contact with the PRP (platelet-rich plasma), and ultimately preventing the PRP (platelet-rich plasma) from being contaminated.

[0031] According to an embodiment of the present application, the diameter of the through holes on the filter membrane layer closer to the liquid inlet clamping plate in the white blood cell filtration structure is larger.

[0032] With such an arrangement, the larger the diameter of the through hole, the faster the rate of filtering white blood cells, but the filtering effect is relatively reduced. The larger the diameter of the through hole on the filter membrane layer closer to the liquid inlet clamping plate, the PRP (platelet-rich plasma) can first perform a relatively fast rough filtration during the process of filtering white blood cells by means of the white blood cell filter, and then gradually improve the filtering effect of white blood cells, so that the white blood cell filter has the advantages of fast rate and good filtering effect during the process of filtering white blood cells. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0034] Figure 1Schematic diagram of the white blood cell filtration structure provided by an embodiment of the present application;

[0035] Figure 2 Explosion diagram showing the white blood cell filtration structure provided by the above embodiment of the present application;

[0036] Figure 3 Cross-sectional view of the leukocyte filter according to another embodiment of the present application;

[0037] Figure 4 Explosion diagram showing the leukocyte filter (excluding the sealing ring and anti-fouling block) of the above embodiment of the present application.

[0038] Reference numerals: 1, leukocyte filter; 10, white blood cell filtration structure; 11, filter membrane layer; 110, through hole; 111, first filter membrane layer; 112, second filter membrane layer; 20, sealing ring; 30, liquid outlet filter head; 301, liquid outlet; 31, liquid outlet clamping plate; 32, liquid outlet pipe; 40, liquid inlet filter head; 401, liquid inlet; 41, liquid inlet clamping plate; 42, liquid inlet pipe; 50, anti-fouling block. Detailed implementation manners

[0039] To make the above objects, features, and advantages of the present application more obvious and understandable, the following will describe the detailed implementation manners of the present application in conjunction with the accompanying drawings. Many specific details are set forth in the following description to fully understand the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present application. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0040] It should be noted that when a component is referred to as "fixed to" or "disposed on" another component, it can be directly on the other component or there may also be an intermediate component. When a component is considered to be "connected" to another component, it can be directly connected to the other component or there may be an intermediate component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of the present application are only for the purpose of illustration and do not represent the only implementation manner.

[0041] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present application, the meaning of "a plurality" is at least two, such as two, three, etc., unless otherwise specifically defined.

[0042] In this application, unless otherwise clearly specified or limited, the first feature being "on" or "under" the second feature may mean that the first feature is in direct contact with the second feature, or the first feature is in indirect contact with the second feature through an intermediate medium. Moreover, the first feature being "above", "over" or "on top of" the second feature may mean that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" or "underneath" the second feature may mean that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0043] Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as commonly understood by those skilled in the technical field to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used in the specification of this application includes any and all combinations of one or more of the related listed items.

[0044] Considering that the filtration structure of a common leukocyte filter often cannot have the advantages of filtering a large number of leukocytes while adsorbing few platelets and plasma. To solve this problem, this application provides a leukocyte filtration structure and a leukocyte filter, which can adsorb few platelets and plasma while filtering a large number of leukocytes.

[0045] Specifically, please refer to the attached Figures 1 to 2 In one embodiment of this application, a leukocyte filtration structure 10 can not only filter a large number of leukocytes when filtering leukocytes, but also ensure the effect of adsorbing few platelets and plasma.

[0046] More specifically, as Figures 1 to 2 shown, the leukocyte filtration structure 10 includes a plurality of filter membrane layers 11 stacked on top of each other, wherein at least one of the filter membrane layers 11 has one or more through holes 110, and the through holes 110 on the adjacent filter membrane layers 11 are offset from each other.

[0047] It is worth noting that the staggered arrangement of the through-holes 110 on adjacent filter membrane layers 11 can be understood as meaning that the through-holes 110 on two adjacent filter membrane layers 11 do not intersect and are staggered. This can reduce the possibility of some white blood cells passing directly through the through-holes 110 and not being filtered out during leukocyte filtration using the leukocyte filtration structure 10. The provision of the through-holes 110 on the filter membrane layer 11 results in a faster leukocyte filtration rate compared to a filter membrane layer 11 without the through-holes 110, thereby improving the permeability of the leukocyte filtration structure 10 and reducing the amount of platelets and plasma retained in the filter membrane layer 11. The leukocyte filtration structure 10 with multiple filter membrane layers 11 can perform multiple filtrations, thereby increasing the amount of leukocytes filtered. Therefore, the leukocyte filtration structure 10 can achieve the advantages of filtering more white blood cells while minimizing platelet and plasma adsorption.

[0048] For example, Figure 2 As shown, the multiple filter membrane layers 11 include a first filter membrane layer 111 and one or more second filter membrane layers 112 . The first filter membrane layer 111 does not have the through hole 110 , and the second filter membrane layer 112 is stacked on one side of the first filter membrane layer 111 and has the through hole 110 .

[0049] It is worth noting that, in this way, the first filter membrane layer 111 without the through hole 110 can perform a total filtration on the P-PRP (leukocyte-poor platelet-rich plasma) obtained by filtering through multiple second filter membrane layers 112, preventing a very small number of white blood cells from accidentally passing through the gap between the first filter membrane layer 111 and the second filter membrane layer 112 in the filter membrane layer 11 and the gap between each second filter membrane layer 112, continuously passing through the through holes 110 of each second filter membrane layer 112, and remaining in the P-PRP (leukocyte-poor platelet-rich plasma), thereby increasing the amount of filtered white blood cells.

[0050] It is worth noting that the first filter membrane layer 111 can be arranged between multiple second filter membrane layers 112, that is, the filtration of PRP (platelet-rich plasma) by means of the first filter membrane layer 111 is advanced from the end to the middle in the filtration order.

[0051] Alternatively, as Figure 2 As shown, the diameters of the first filter membrane layer 111 and the second filter membrane layer 112 are both less than 5 cm.

[0052] More preferably, the diameters of both the first filter membrane layer 111 and the second filter membrane layer 112 are less than 3 cm. Compared with a single-layer filter membrane of a larger size with the same filtration rate, the overall size of the white blood cell filtration structure 10 is smaller, and compared with a multi-layer filter membrane with the same filtration efficiency, the filtration rate of the white blood cell filtration structure 10 is faster. The white blood cell filtration structure 10 takes into account both a fast filtration rate and is suitable for situations with high requirements for size.

[0053] Optionally, as Figure 2 shown, the number of the through holes 110 in the second filter membrane layer 112 ranges from 1 to 10.

[0054] More preferably, the number of the through holes 110 in the second filter membrane layer 112 ranges from 1 to 4. In this way, by setting a reasonable number of the through holes 110, the occurrence of overlap between the through holes 110 of two adjacent second filter membrane layers 112 can be prevented, and at the same time, the occurrence of overlap between two through holes 110 of two second filter membrane layers 112 with one second filter membrane layer 112 in between can be reduced, thereby ensuring the effect of the white blood cell filtration structure 10 in filtering white blood cells.

[0055] Optionally, as Figure 2 shown, the diameter of the through holes 110 in the second filter membrane layer 112 ranges from 0.5 to 10 mm.

[0056] More preferably, the diameter of the through holes 110 in the second filter membrane layer 112 ranges from 0.5 to 5 mm. In this way, by setting a reasonable number of the through holes 110, the occurrence of overlap between the through holes 110 of two adjacent second filter membrane layers 112 can be prevented, and at the same time, the occurrence of overlap between two through holes 110 of two second filter membrane layers 112 with one second filter membrane layer 112 in between can be reduced, thereby ensuring the effect of the white blood cell filtration structure 10 in filtering white blood cells.

[0057] Optionally, as Figure 2 shown, the number of the through holes 110 in the second filter membrane layer 112 is multiple and evenly distributed on the second filter membrane layer 112. Compared with the positions on the second filter membrane layer 112 where no through holes 110 are opened, the flow rate at the through holes 110 is faster. By evenly arranging multiple through holes 110 in the second filter membrane layer 112, the filtration rate at each position of the second filter membrane layer 112 during the filtration of white blood cells by means of the second filter membrane layer 112 can be controlled in a relatively average state, thereby improving the filtration effect of the white blood cell filtration structure 10.

[0058] Optionally, as Figure 2As shown, the through holes 110 in the same second filter membrane layer 112 have the same diameter. The flow rates at the through holes 110 with different diameters are different, and the flow rate is greater at the through holes 110 with a larger diameter. By providing the through holes 110 with the same diameter in the same second filter membrane layer 112, the efficiency of filtering white blood cells by the second filter membrane layer 112 can be ensured to be relatively average, thereby improving the filtering effect of the white blood cell filtering structure 10.

[0059] Optionally, as Figure 2 shown, the diameters of the through holes 110 in the second filter membrane layer 112 that are closer to the first filter membrane layer 111 change in a gradient manner.

[0060] Preferably, as Figure 2 shown, the diameters of the through holes 110 in the second filter membrane layer 112 that are closer to the first filter membrane layer 111 are smaller. The larger the diameter of the through holes 110 in the second filter membrane layer 112, the faster the rate of filtering white blood cells, but the filtering effect is relatively reduced. During the process of filtering white blood cells by the PRP (platelet-rich plasma) with the aid of the white blood cell filtering structure 10, coarse filtering with a faster rate can be carried out first, and then the filtering effect of white blood cells can be gradually improved, so that the white blood cell filtering structure 10 has the advantages of both fast rate and good filtering effect during the process of filtering white blood cells.

[0061] Exemplarily, as Figure 2 shown, in an embodiment of the present application, the number of layers of the filter membrane layer 11 is 4 layers, including 1 layer of the first filter membrane layer 111 and 3 layers of the second filter membrane layer 112. The diameter of each filter membrane layer 11 is 15 mm. The number of through holes 110 in each second filter membrane layer 112 is 3. The diameters of the through holes 110 in the second filter membrane layer 112 that first filter the PRP are all 5 mm, the diameters of the through holes 110 in the second filter membrane layer 112 that filter the PRP next are all 3 mm, and the diameters of the through holes 110 in the second filter membrane layer 112 that finally filter the PRP are all 1 mm. Moreover, the through holes 110 in the second filter membrane layer 112 are evenly distributed in each second filter membrane layer 112.

[0062] It should be noted that the diameters of the through holes 110 in two adjacent second filter membrane layers 112 can be the same.

[0063] It should be noted that, as Figures 3 to 4As shown in the figure, another embodiment of the present application provides a leukocyte filter 1, and the leukocyte filter 1 includes: a liquid outlet filter head 30 having a liquid outlet 301; a liquid inlet filter head 40 having a liquid inlet 401; and the leukocyte filtration structure 10, and the leukocyte filtration structure 10 is disposed between the liquid outlet filter head 30 and the liquid inlet filter head 40. In this way, the leukocyte filter 1 can achieve the function of filtering leukocytes by means of the leukocyte filtration structure 10, the liquid outlet filter head 30, and the liquid inlet filter head 40.

[0064] It should be noted that the diameters of the first filter membrane layer 111 and the second filter membrane layer 112 being less than 5 cm can make the size of the leukocyte filtration structure 10 smaller, and further make the volume of the leukocyte filter 1 smaller, thereby reducing the amount of the platelets and the plasma remaining in the leukocyte filter 1.

[0065] Optionally, as Figure 4 shown, the liquid outlet filter head 30 includes a liquid outlet clamping plate 31 connected to the leukocyte filtration structure 10 and a liquid outlet pipe 32 protruding from the liquid outlet clamping plate, and the leukocyte filter 1 further includes a sealing ring 20 wrapping the liquid outlet pipe 32. In this way, the sealing ring 20 can prevent the leakage of the PRP (platelet-rich plasma) when filtering leukocytes by means of the leukocyte filter 1.

[0066] Optionally, as Figure 4 shown, the liquid inlet filter head 40 includes a liquid inlet clamping plate 41 and a liquid inlet pipe 42, the liquid inlet clamping plate 41 is connected to the leukocyte filtration structure 10, the liquid inlet pipe 42 protrudes from the liquid inlet clamping plate 41, and the leukocyte filter 1 further includes an anti-fouling block 50, and the anti-fouling block 50 abuts against the liquid inlet pipe 42 to block the pipe orifice of the liquid inlet pipe 42. In this way, the anti-fouling block 50 can block the liquid inlet pipe 42, thereby used for isolating substances, and further preventing external substances from contacting the PRP (platelet-rich plasma), and finally preventing the contamination of the PRP (platelet-rich plasma).

[0067] Optionally, as Figure 4 shown, the diameter of the through hole 11 at the filter membrane layer 11 closer to the liquid inlet clamping plate 41 in the leukocyte filtration structure 10 is larger. In this way, the larger the diameter of the through hole 110, the faster the rate of filtering leukocytes, but the filtering effect is relatively reduced. The larger the diameter of the through hole 110 on the filter membrane layer 11 closer to the liquid inlet clamping plate 41 can enable the PRP (platelet-rich plasma) to first perform a relatively fast rough filtration during the process of filtering leukocytes by means of the leukocyte filter 1, and then gradually improve the filtering effect of filtering leukocytes, so that the leukocyte filter 1 has the advantages of fast rate and good filtering effect during the process of filtering leukocytes.

[0068] Exemplarily, as Figure 4 shown, in another embodiment of the present application, the number of layers of the filter membrane layer 11 is 2 layers, including 1 layer of the first filter membrane layer 111 and 1 layer of the second filter membrane layer 112. The diameter of each filter membrane layer 11 is 25 mm. The number of through holes 110 in the second filter membrane layer 112 is 2. The diameters of the through holes 110 in the second filter membrane layer 112 are all 2 mm, and the through holes 110 in the second filter membrane layer 112 are evenly distributed in the second filter membrane layer 112.

[0069] Particularly, the first one to contact the blood can be the first filter membrane layer 111, that is, the white blood cell filtering structure 10 is placed upside down on the white blood cell filter 1.

[0070] The technical features of the above embodiments can be combined without changing the basic principle of the present invention. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0071] The above embodiments only represent several implementation manners of the present application. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several deformations and improvements can be made, and these all belong to the protection scope of the present application. Therefore, the patent protection scope of the present application should be subject to the appended claims.

Claims

1. A leukocyte filtration structure, characterized in that, Comprising: A plurality of filter membrane layers stacked on top of each other, wherein at least one of the filter membrane layers has one or more through holes, and the through holes on adjacent filter membrane layers are offset from each other.

2. The leukocyte filtration structure according to claim 1, wherein The plurality of filter membrane layers include a first filter membrane layer without the through holes and one or more second filter membrane layers stacked on one side of the first filter membrane layer and having the through holes.

3. The leukocyte filtration structure according to claim 2, characterized in that, The diameters of both the first filter membrane layer and the second filter membrane layer are less than 5 cm.

4. The leukocyte filtration structure according to claim 3, characterized in that The number of the through holes in the second filter membrane layer ranges from 1 to 10.

5. The leukocyte filtration structure according to claim 4, wherein The diameter of the through holes in the second filter membrane layer ranges from 0.5 to 10 mm.

6. The leukocyte filtration structure according to claim 5, wherein The diameters of the through holes in the second filter membrane layer closer to the first filter membrane layer change in a gradient manner.

7. The leukocyte filtration structure according to claim 6, characterized in that, The number of the through holes in the second filter membrane layer is multiple and evenly distributed on the second filter membrane layer.

8. The leukocyte filtration structure according to claim 7, characterized in that, The diameters of the through holes in the same second filter membrane layer are the same.

9. A leukocyte filter, characterized in that, The leukocyte filter comprises: An outlet filter head having an outlet; An inlet filter head having an inlet; and The leukocyte filtration structure according to any one of claims 1 to 8, the leukocyte filtration structure being disposed between the outlet filter head and the inlet filter head.

10. The leukocyte filter according to claim 9, characterized in that, The outlet filter head includes an outlet clamping plate connected to the leukocyte filtration structure and an outlet pipe protruding from the outlet clamping plate, and the leukocyte filter further includes a sealing ring wrapping the outlet pipe.

11. The leukocyte filter according to claim 10, wherein, The inlet filter head includes an inlet clamping plate connected to the leukocyte filtration structure and an inlet pipe protruding from the inlet clamping plate, and the leukocyte filter further includes an anti-fouling block, the anti-fouling block abutting against the inlet pipe to block the pipe orifice of the inlet pipe.

12. The leukocyte filter according to claim 11, wherein The diameters of the through holes in the filter membrane layer closer to the inlet clamping plate in the leukocyte filtration structure are larger.

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