Multifunctional reaction kettle for ivabradine production

Abstract

The utility model discloses a multifunctional reaction kettle for ivabradine production, and relates to the technical field of pharmaceutical machinery, the multifunctional reaction kettle comprises a support frame, a reaction kettle body, a pressure control mechanism, a stirring mechanism and a temperature control mechanism, the temperature control mechanism comprises a temperature sensor, an electric heating coil, a cooling pipeline and refrigeration equipment, and the inner wall of the reaction kettle body is provided with a liquid storage cavity; the temperature sensor, the electric heating coil and the cooling pipeline are all fixedly arranged in the liquid storage cavity, heat conduction oil is arranged in the liquid storage cavity, the cooling pipeline penetrates through the reaction kettle body to be communicated with the refrigeration equipment, and through cooperation of the temperature sensor, the electric heating coil, the cooling pipeline and the refrigeration equipment, accurate control over the temperature in the reaction kettle can be achieved. No matter whether the temperature needs to be increased, decreased or maintained at a constant temperature, quick response can be achieved, the set requirements can be met, and the special requirements of different chemical reactions on the temperature in the ivabradine production process are met.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical machinery, in particular to a multifunctional reaction kettle for producing ivabradine. Background Art

[0002] Ivabradine is a drug used to treat patients with stable angina pectoris accompanied by sinus tachycardia. During the production process of ivabradine, a reactor is required to provide a stable reaction environment (such as controlling temperature, pressure and other conditions) and mixing of reactants to ensure product quality and output.

[0003] Among existing technical solutions, Chinese patent application number CN221674286U discloses a molecular reactor with adjustable internal temperature. The reactor comprises a reactor body, a top cover mounted on the outside of the upper end of the reactor body, and a discharge pipe located in the middle of the lower end of the reactor body. A heating water tank is located on the outside of the left end of the reactor body. Water in the heating water tank flows into a connecting pipe and then flows outside the reactor body, thereby achieving the purpose of regulating the temperature within the reactor body.

[0004] A drawback of the above-mentioned prior art solution is that temperature regulation is achieved by controlling the water temperature in the heating tank and flowing it outside the reactor. This limits the use of the reactor in reactions that require cooling or constant temperature. This is particularly true for certain chemical reactions in the ivabradine production process, particularly those that require low temperature or constant temperature conditions. Utility Model Content

[0005] The purpose of the utility model is to provide a multifunctional reactor for producing ivabradine, so as to solve the technical problem in the prior art that the reaction cannot be carried out under low temperature or constant temperature conditions.

[0006] The technical problem to be solved by the utility model can be achieved through the following technical solutions: a multifunctional reactor for ivabradine production, comprising a support frame, a reactor body, a temperature control mechanism, a pressure control mechanism and a stirring mechanism, wherein the reactor body is fixedly arranged on the top of the support frame, and the top and bottom of the reactor body are respectively provided with a feed port and a discharge port, the temperature control mechanism comprises a temperature sensor, an electric heating coil, a cooling pipe and a refrigeration device, a liquid storage cavity is provided on the inner wall of the reactor body, the temperature sensor, the electric heating coil and the cooling pipe are all fixedly arranged in the liquid storage cavity, the liquid storage cavity is provided with heat transfer oil, the cooling pipe The reactor body is connected to the refrigeration equipment, the pressure control mechanism includes a pressure sensor and a pressure relief valve, the top of the reactor body is provided with a pressure relief port and a detection port, the pressure sensor is fixedly connected to the reactor body, the detection end of the pressure sensor passes through the detection port and extends into the interior of the reactor body, the pressure relief valve is fixedly arranged at the port of the pressure relief port, the stirring mechanism includes a rotary motor, a rotating shaft and a stirring rod, the rotary motor is fixedly arranged on the top of the reactor body, the rotating shaft is rotatably arranged in the reactor body, and is coaxially fixedly connected to the output end of the rotary motor, and the stirring rod is fixedly arranged on the side of the rotating shaft.

[0007] As a further solution of the present invention: the reactor body includes a thermal insulation layer and a heat-conducting layer, the thermal insulation layer is fixedly connected to the top of the support frame, an annular groove is opened on the inner side of the thermal insulation layer, the heat-conducting layer is fixedly arranged at the notch of the annular groove, and the heat-conducting layer and the annular groove constitute the liquid storage chamber.

[0008] As a further solution of the present invention: the thermal insulation layer is provided with a first through hole and a second through hole, and both ends of the cooling pipe are respectively connected to the refrigeration equipment through the first through hole and the second through hole.

[0009] As a further solution of the present invention: a liquid injection port and a liquid discharge port connected to the liquid storage cavity are provided on the outside of the reactor body, and end covers are provided at the ports of the liquid injection port and the liquid discharge port.

[0010] As a further solution of the present invention: a hopper and a material guide pipe are fixedly provided on the top and bottom of the reactor body respectively, the hopper is connected to the feed port, and the material guide pipe is connected to the discharge port.

[0011] As a further solution of the present invention: the bottom of the reactor body is a funnel-shaped structure.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] 1. The temperature control mechanism utilizes a combination of temperature sensors, electric heating coils, cooling pipes, and refrigeration equipment to precisely control the temperature within the reactor. Whether the temperature needs to be raised, lowered, or maintained constant, it can quickly respond and meet the set requirements, meeting the specific temperature requirements of different chemical reactions during the ivabradine production process.

[0014] 2. Thermal oil is used as the heat transfer medium because of its high heat capacity, good thermal stability, and fluidity in a wide temperature range. This makes the reactor suitable for chemical reactions under various temperature conditions, improving the flexibility and applicability of the reactor.

[0015] 3. The pressure control mechanism uses a pressure sensor and a pressure relief valve to monitor and control the pressure inside the reactor in real time, ensuring that it operates within a safe range. If the pressure rises abnormally, the pressure relief valve will automatically open to release excess pressure, effectively preventing safety accidents caused by excessive pressure and ensuring production safety and stability.

[0016] Additional aspects and advantages of the present invention will be given in part in the following description and will become apparent from the following description or learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0018] Figure 1 The present invention is a schematic diagram of the three-dimensional structure of a multifunctional reactor for producing ivabradine.

[0019] Figure 2 It is a structural diagram of the pressure control mechanism in the utility model.

[0020] Figure 3 It is a structural sectional view of the temperature control mechanism in the utility model.

[0021] Figure 4 It is a structural sectional view of the stirring mechanism in the utility model.

[0022] Reference numerals include:

[0023] 1. Support frame; 2. Reactor body; 201. Feed port; 202. Discharge port; 203. Liquid storage chamber; 204. Pressure relief port; 205. Detection port; 206. Insulation layer; 207. Heat conductive layer; 208. Annular groove; 209. First through hole; 210. Second through hole; 211. Liquid injection port; 212. Discharge port; 213. End cover; 3. Temperature control mechanism; 31. Temperature sensor; 32. Electric heating coil; 33. Cooling pipe; 34. Refrigeration equipment; 4. Pressure control mechanism; 41. Pressure sensor; 42. Pressure relief valve; 5. Stirring mechanism; 51. Rotating motor; 52. Rotating shaft; 53. Stirring rod; 6. Hopper; 7. Material guide pipe. DETAILED DESCRIPTION

[0024] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0025] like Figures 1 to 4 As shown, a multifunctional reactor for ivabradine production includes a support frame 1, a reactor body 2, a temperature control mechanism 3, a pressure control mechanism 4, a stirring mechanism 5 and a control terminal. The reactor body 2 is fixedly arranged on the top of the support frame 1. The top and bottom of the reactor body 2 are respectively provided with a feed port 201 and a discharge port 202. The temperature control mechanism 3, the pressure control mechanism 4, and the stirring mechanism 5 are all electrically connected to the control terminal.

[0026] The temperature control mechanism 3 includes a temperature sensor 31, an electric heating coil 32, a cooling pipe 33 and a refrigeration device 34. A liquid storage cavity 203 is opened on the inner wall of the reactor body 2. The temperature sensor 31, the electric heating coil 32 and the cooling pipe 33 are all fixedly arranged in the liquid storage cavity 203. Heat transfer oil is provided in the liquid storage cavity 203. The cooling pipe 33 runs through the reactor body 2 and is connected to the refrigeration device 34.

[0027] When the reaction temperature needs to be raised, temperature sensor 31 monitors the temperature of the thermal oil in liquid reservoir 203, i.e., the temperature inside reactor body 2, in real time, and feeds the signal back to the control terminal. If the temperature falls below a set value, the control terminal activates heating coil 32, which heats the reactor with the thermal oil in liquid reservoir 203, rapidly raising the temperature and maintaining it within the set range.

[0028] When the reaction needs to be cooled or maintained at a low temperature, temperature sensor 31 also detects the current temperature and activates refrigeration unit 34. Refrigeration unit 34 lowers the temperature of cooling pipe 33 by injecting a refrigerant (such as Freon) into cooling pipe 33, thereby reducing the temperature of the heat transfer oil in liquid storage chamber 203. Utilizing the excellent thermal conductivity of the heat transfer oil, the heat in the reactor is removed, achieving effective cooling.

[0029] Thermal oil is used as the heat transfer medium because of its high heat capacity and good thermal stability, as well as fluidity in a wide temperature range (-10°C to 100°C). This makes the reactor suitable for chemical reactions under various temperature conditions, improving the flexibility and applicability of the reactor.

[0030] The pressure control mechanism 4 includes a pressure sensor 41 and a pressure relief valve 42. A pressure relief port 204 and a detection port 205 are provided on the top of the reactor body 2. The pressure sensor 41 is fixedly connected to the reactor body 2. The detection end of the pressure sensor 41 passes through the detection port 205 and extends into the interior of the reactor body 2. The pressure relief valve 42 is fixedly arranged at the port of the pressure relief port 204, and the pressure relief valve 42 is an electrically controlled valve.

[0031] The pressure sensor 41 continuously monitors the pressure in the reactor to ensure that it is within a safe range. Once the pressure exceeds a preset upper limit, the control terminal will automatically open the pressure relief valve 42 to release excess pressure to prevent the pressure in the reactor body 2 from being too high and causing a safety accident.

[0032] The stirring mechanism 5 includes a rotating motor 51, a rotating shaft 52 and a stirring rod 53. The rotating motor 51 is fixedly arranged on the top of the reactor body 2. The rotating shaft 52 is rotatably arranged in the reactor body 2 and is coaxially fixedly connected to the output end of the rotating motor 51. The stirring rod 53 is fixedly arranged on the side of the rotating shaft 52.

[0033] A rotary motor 51 drives a rotating shaft 52 and a stirring rod 53 fixed to the rotating shaft 52 to rotate within the reactor, uniformly mixing and stirring the reactants, promoting sufficient contact between the reactants and increasing the reaction rate. The operation of the stirring mechanism 5 can be adjusted according to the reaction requirements to ensure reaction efficiency and product quality.

[0034] Temperature control mechanism 3, which utilizes a combination of temperature sensor 31, electric heating coil 32, cooling pipe 33, and refrigeration equipment 34, enables precise control of the temperature within the reactor. Whether the temperature needs to be raised, lowered, or maintained constant, it responds quickly and meets the set requirements, meeting the specific temperature requirements of the different chemical reactions during the ivabradine production process.

[0035] The pressure control mechanism 4, through the coordinated use of a pressure sensor 41 and a pressure relief valve 42, monitors and controls the pressure within the reactor in real time, ensuring that it operates within a safe range. If the pressure rises abnormally, the pressure relief valve 42 automatically opens to release excess pressure, effectively preventing accidents caused by excessive pressure and ensuring safe and stable production.

[0036] refer to Figure 3 and Figure 4 As shown, in some specific embodiments, the reactor body 2 includes a thermal insulation layer 206 and a heat-conducting layer 207. The thermal insulation layer 206 is fixedly connected to the top of the support frame 1. An annular groove 208 is defined on the inner side of the thermal insulation layer 206. The heat-conducting layer 207 is fixedly disposed at the notch of the annular groove 208. The heat-conducting layer 207 and the annular groove 208 form a liquid storage chamber 203. The thermal insulation layer 206 is defined by a first through hole 209 and a second through hole 210. The two ends of the cooling pipe 33 pass through the first through hole 209 and the second through hole 210, respectively, to communicate with the refrigeration equipment 34.

[0037] The insulation layer 206 is used to reduce heat exchange between the interior of the reactor and the external environment. This means that during the heating or cooling process, the insulation layer 206 can effectively prevent heat loss or external cold from entering, thereby improving energy efficiency and helping to maintain the stability of the temperature inside the reactor.

[0038] Thermally conductive layer 207 is used to evenly transfer the heat generated by electric heating coil 32 or the cooling energy transferred by refrigeration device 34 to the materials within the reactor. Because thermally conductive layer 207 cooperates with annular groove 208 and thermal oil is filled in liquid reservoir 203, it ensures rapid transfer and even distribution of heat or cooling energy within thermally conductive layer 207, thereby achieving precise control of the internal temperature of the reactor.

[0039] refer to Figure 3 As shown, in some specific embodiments, a liquid injection port 211 and a liquid discharge port 212 communicating with the liquid storage chamber 203 are provided on the outside of the reactor body 2 , and end caps 213 are provided at the ports of the liquid injection port 211 and the liquid discharge port 212 .

[0040] The inlet 211 is used to inject thermal oil into the liquid storage chamber 203, and the drain port 212 is used to drain the medium in the liquid storage chamber 203 when it is necessary to replace the thermal oil, clean the liquid storage chamber 203, or perform other maintenance work. The end cover 213 is used to seal the inlet 211 and drain port 212 to prevent leakage of thermal oil during operation, while also facilitating opening the end cover 213 for liquid injection when necessary.

[0041] refer to Figure 1 and Figure 3As shown, in some specific embodiments, a hopper 6 and a guide pipe 7 are fixedly installed at the top and bottom of the reactor body 2, respectively. The hopper 6 is connected to the feed port 201, and the raw materials required for the reaction are conveniently added into the reactor through the hopper 6. The guide pipe 7 is connected to the discharge port 202, and the materials after the reaction are conveniently discharged from the reactor through the guide pipe 7 for subsequent processing or collection.

[0042] refer to Figure 3 As shown, in some specific embodiments, the bottom of the reactor body 2 is funnel-shaped, that is, the bottom gradually contracts inward, ultimately forming a smaller discharge opening 202. This allows the material to automatically converge toward the outlet after the reaction is completed, reducing material residue at the bottom of the reactor. This not only improves discharge efficiency but also reduces the difficulty and cost of cleaning.

[0043] To facilitate understanding of the embodiments of this solution by those skilled in the art, the working principle of the embodiments of this solution will now be described in conjunction with specific application scenarios:

[0044] Inject an appropriate amount of thermal oil into the liquid storage chamber 203 through the liquid inlet 211. Seal the end caps 213 of the liquid inlet 211 and the liquid outlet 212 to prevent leakage of the thermal oil. Feed the raw materials into the reactor through the hopper 6 at the top of the reactor body 2. Close the feed port 201 and the discharge port 202 to ensure that the interior of the reactor is sealed.

[0045] When the reaction temperature needs to be raised, temperature sensor 31 monitors the temperature of the thermal oil in reservoir 203 in real time and feeds the signal back to the control terminal. If the temperature falls below the set value, the control terminal activates heating coil 32, heating the reactor with the thermal oil until the set temperature is reached and maintained.

[0046] When the reaction needs to be cooled, the temperature sensor 31 also detects the current temperature and starts the refrigeration device 34. The refrigeration device 34 sends refrigerant into the cooling pipe 33 to reduce the temperature of the heat transfer oil in the cooling pipe 33 and the liquid storage chamber 203, thereby cooling the reactor.

[0047] The pressure sensor 41 continuously monitors the pressure in the reactor to ensure that it is within a safe range. Once the pressure exceeds the preset upper limit, the control terminal will automatically open the pressure relief valve 42 to release the excess pressure and prevent the occurrence of safety accidents.

[0048] The rotary motor 51 drives the rotating shaft 52 and the stirring rod 53 fixed to the rotating shaft 52 to rotate in the reactor to uniformly mix and stir the reaction materials. The operation of the stirring mechanism 5 can be adjusted according to the reaction requirements to promote sufficient contact between the reactants and increase the reaction rate.

[0049] After the reaction is completed, the reaction product is discharged through the material guide pipe 7 at the bottom of the reactor body 2. Due to the funnel-shaped structure of the bottom, the material can automatically be concentrated to the outlet, thereby improving the discharge efficiency.

[0050] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

Claims

1. A multifunctional reactor for producing ivabradine, comprising a support frame (1) and a reactor body (2), wherein the reactor body (2) is fixedly arranged on the top of the support frame (1), and a feed port (201) and a discharge port (202) are respectively provided on the top and bottom of the reactor body (2), characterized in that: Also includes: A temperature control mechanism (3), the temperature control mechanism (3) comprising a temperature sensor (31), an electric heating coil (32), a cooling pipe (33) and a refrigeration device (34); a liquid storage cavity (203) is provided on the inner wall of the reactor body (2); the temperature sensor (31), the electric heating coil (32) and the cooling pipe (33) are all fixedly arranged in the liquid storage cavity (203); heat transfer oil is arranged in the liquid storage cavity (203); the cooling pipe (33) passes through the reactor body (2) and is connected to the refrigeration device (34); A pressure control mechanism (4), the pressure control mechanism (4) comprising a pressure sensor (41) and a pressure relief valve (42); a pressure relief port (204) and a detection port (205) are provided on the top of the reactor body (2); the pressure sensor (41) is fixedly connected to the reactor body (2); a detection end of the pressure sensor (41) passes through the detection port (205) and extends into the interior of the reactor body (2); and the pressure relief valve (42) is fixedly arranged at the end of the pressure relief port (204); A stirring mechanism (5) includes a rotating motor (51), a rotating shaft (52) and a stirring rod (53). The rotating motor (51) is fixedly arranged on the top of the reactor body (2). The rotating shaft (52) is rotatably arranged in the reactor body (2) and is coaxially fixedly connected to the output end of the rotating motor (51). The stirring rod (53) is fixedly arranged on the side of the rotating shaft (52).

2. The multifunctional reactor for producing ivabradine according to claim 1, characterized in that: The reactor body (2) comprises a thermal insulation layer (206) and a heat-conducting layer (207); the thermal insulation layer (206) is fixedly connected to the top of the support frame (1); an annular groove (208) is provided on the inner side of the thermal insulation layer (206); the heat-conducting layer (207) is fixedly arranged at the notch of the annular groove (208); and the heat-conducting layer (207) and the annular groove (208) constitute the liquid storage chamber (203).

3. The multifunctional reactor for producing ivabradine according to claim 2, characterized in that: The thermal insulation layer (206) is provided with a first through hole (209) and a second through hole (210), and both ends of the cooling pipe (33) pass through the first through hole (209) and the second through hole (210) respectively to communicate with the refrigeration equipment (34).

4. The multifunctional reactor for producing ivabradine according to claim 1, characterized in that: A liquid injection port (211) and a liquid discharge port (212) communicating with the liquid storage chamber (203) are provided on the outside of the reactor body (2), and end caps (213) are provided at the ends of the liquid injection port (211) and the liquid discharge port (212).

5. The multifunctional reactor for producing ivabradine according to claim 1, characterized in that: A hopper (6) and a material guide pipe (7) are fixedly provided on the top and bottom of the reactor body (2), respectively. The hopper (6) is connected to the feed port (201), and the material guide pipe (7) is connected to the discharge port (202).

6. The multifunctional reactor for producing ivabradine according to claim 1, characterized in that: The bottom of the reactor body (2) is a funnel-shaped structure.

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