Test strip capable of being used for simultaneously detecting multiple indexes

Abstract

The utility model provides a test strip capable of being used for simultaneously detecting multiple indexes, a sample inlet is arranged on the test strip, a plurality of sample inlet channels and a plurality of electrode pairs used for detecting different indexes are arranged in the test strip, and the plurality of sample inlet channels respectively surround the periphery of the sample inlet and are respectively communicated with the sample inlet; and at least one part of each of the plurality of electrode pairs is positioned in the corresponding sample introduction channel. A blood sample flows to the plurality of sample introduction channels surrounding the periphery of the sample introduction port after being added from the sample introduction port, and the plurality of corresponding electrode pairs in the plurality of sample introduction channels are used for detecting different indexes at the same time, so that the detection efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of test strips, in particular to a test strip that can be used for simultaneous detection of multiple indicators. Background Art

[0002] In recent years, disposable electrochemical sensor test strips have been widely used in the field of point-of-care testing. However, traditional detection methods and supporting testing instruments generally have a single function, and a single test strip can only detect a single indicator.

[0003] In order to solve the above technical problems, the Chinese patent with announcement number CN209086198U discloses a dual-function electrochemical test strip for blood glucose and uric acid. The test strip is provided with a PET substrate, a gold electrode layer, a single-sided adhesive layer, a double-sided adhesive layer and a hydrophilic film layer from bottom to top; the gold electrode layer is formed by printing a gold electrode on the PET substrate, the single-sided adhesive layer is adhered to one side of the gold electrode layer, leaving part of the gold electrode exposed, the double-sided adhesive layer is adhered to and covered on the single-sided adhesive layer, and the double-sided adhesive layer is adhered and covered with a layer of hydrophilic film to form the hydrophilic film. The single-sided adhesive layer has a first and a second perforation on a side away from the exposed gold electrode, each of which exposes a pair of paths for the working and reference electrodes. The double-sided adhesive layer has a third perforation corresponding to the first and second perforations. The first and second perforations are respectively covered with a first enzyme layer capable of reacting with uric acid in the blood sample and a second enzyme layer capable of reacting with blood glucose in the blood sample. Thus, the first and second enzyme layers, the single-sided adhesive layer, the double-sided adhesive layer, and the hydrophilic film layer form a siphon pool capable of absorbing the blood sample. The blood sample is dripped into the third perforation and then flows sequentially into the first and second perforations, generating two sets of current signals, completing the detection of two indicators. However, the detection efficiency is limited.

[0004] Therefore, the existing technology still needs to be improved and developed. Utility Model Content

[0005] The purpose of the utility model is to provide a test strip that can be used for simultaneous detection of multiple indicators in response to the defects and shortcomings of the existing technology.

[0006] In order to achieve the above purpose, the technical solution adopted by the utility model is as follows:

[0007] The utility model provides a test strip that can be used for simultaneous detection of multiple indicators. The test strip is provided with an injection port, and the test strip is provided with multiple injection channels and multiple electrode pairs for detecting different indicators. The multiple injection channels respectively surround the outer circumference of the injection port and are respectively connected to the injection port; at least a part of each of the multiple electrode pairs is located in the corresponding injection channel.

[0008] Through the above-mentioned structural setting, after the blood sample is added from the injection port, it flows simultaneously to multiple injection channels surrounding the outer periphery of the injection port. The corresponding multiple electrode pairs in the multiple injection channels are used to simultaneously detect different indicators, which is conducive to improving detection efficiency.

[0009] It can be understood that the number of the injection channels and the number of electrode pairs are the same.

[0010] According to the above scheme, the test strip includes an insulating substrate, an electrode layer, an insulating intermediate layer, and a hydrophilic film layer connected in sequence from bottom to top; the electrode layer is provided with the multiple electrode pairs, and the injection port is opened on the hydrophilic film layer; the insulating intermediate layer is provided with a through hole and a plurality of slots, the through hole is correspondingly connected to the injection port, the plurality of slots are provided on the periphery of the through hole and are respectively connected to the through hole, and the plurality of injection channels are surrounded by the insulating substrate, the plurality of slots and the hydrophilic film layer.

[0011] According to the above solution, the insulating intermediate layer is an insulating film layer containing double-sided tape.

[0012] According to the above solution, the hydrophilic membrane layer is provided with a plurality of exhaust holes correspondingly connected to the plurality of injection channels. The exhaust holes are provided to discharge the air in the injection channels, which is beneficial to improving the accuracy of detection.

[0013] According to the above solution, the electrode pair includes a working electrode and a reference electrode. The working electrode and the reference electrode in the injection channel form a current loop, thereby detecting the index of the blood sample.

[0014] According to the above solution, the working electrode is electrically connected to a working electrode wire, and the reference electrode is electrically connected to a reference electrode wire.

[0015] Through the above-mentioned structural arrangement, the detection instrument is electrically connected to the working electrode and the reference electrode through the working electrode wire and the reference electrode wire respectively.

[0016] According to the above solution, the working electrode, the working electrode wire, the reference electrode and the reference electrode wire are all arranged on the insulating substrate by printing.

[0017] According to the above solution, the multiple reference electrodes are electrically connected in sequence to form a non-closed ring structure with an opening, and the multiple reference electrodes share a single reference electrode wire. This structure allows the detection instrument to be electrically connected to multiple reference electrodes via a single reference electrode wire, which helps to simplify the structure.

[0018] According to the above scheme, the number of the injection channels and electrode pairs is set to four, and the four electrode pairs are set to be the first electrode pair, the second electrode pair, the third electrode pair and the fourth electrode pair for detecting hematocrit, blood glucose, blood ketones and uric acid respectively.

[0019] According to the above solution, enzyme layers for detecting corresponding indicators are respectively provided on the working electrodes of the second electrode pair, the third electrode pair and the fourth electrode pair.

[0020] It can be understood that the working electrode of the second electrode pair is provided with an enzyme layer for detecting blood glucose, the working electrode of the third electrode pair is provided with an enzyme layer for detecting blood ketones, and the working electrode of the fourth electrode pair is provided with an enzyme layer for detecting uric acid.

[0021] The beneficial effects of the present invention are:

[0022] The utility model provides a sample injection port on a test strip, and the test strip is provided with a plurality of sample injection channels and a plurality of electrode pairs for detecting different indicators. The plurality of sample injection channels respectively surround the periphery of the sample injection port and are respectively connected to the sample injection port. At least a portion of the plurality of electrode pairs is located in the corresponding sample injection channels. After the blood sample is added from the sample injection port, it flows simultaneously into the plurality of sample injection channels surrounding the periphery of the sample injection port. The corresponding plurality of electrode pairs in the plurality of sample injection channels are used to simultaneously detect different indicators, which is conducive to improving the detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural diagram of the utility model;

[0024] Figure 2 It is an exploded schematic diagram of the present utility model.

[0025] In the figure: 1. Insulating substrate; 2. Electrode layer; 21. Electrode pair; 211. Working electrode; 212. Reference electrode; 22. Working electrode wire; 23. Reference electrode wire; 3. Insulating middle layer; 31. Through hole; 32. Slot; 4. Hydrophilic membrane layer; 41. Inlet; 42. Exhaust hole; 5. Injection channel. DETAILED DESCRIPTION

[0026] The technical solution of the present utility model is described below with reference to the accompanying drawings and embodiments.

[0027] like Figure 1-2 As shown, the utility model provides a test strip that can be used for simultaneous detection of multiple indicators, wherein the test strip is provided with a sampling port 41, and the test strip is provided with four sampling channels 5 and four electrode pairs 21 for detecting different indicators, wherein the four sampling channels 5 respectively surround the outer periphery of the sampling port 41 and are respectively connected to the sampling port 41; at least a portion of each of the four electrode pairs 21 is located in the corresponding sampling channel 5.

[0028] Through the above-mentioned structural setting, after the blood sample is added from the injection port 41, it flows simultaneously to the multiple injection channels 5 surrounding the outer periphery of the injection port 41. The corresponding multiple electrode pairs 21 in the multiple injection channels 5 are used to simultaneously detect different indicators, which is conducive to improving the detection efficiency.

[0029] The number of the injection channels 5 and the number of the electrode pairs 21 are the same. In some embodiments, the number of the injection channels 5 and the number of the electrode pairs 21 can be set according to actual needs.

[0030] Furthermore, the test strip includes an insulating substrate 1, an electrode layer 2, an insulating intermediate layer 3, and a hydrophilic film layer 4 connected in sequence from bottom to top; the electrode layer 2 is provided with the multiple electrode pairs 21, and the injection port 41 is opened on the hydrophilic film layer 4; the insulating intermediate layer 3 is provided with a through hole 31 and a plurality of slots 32, the through hole 31 is correspondingly connected to the injection port 41, the multiple slots 32 are provided on the outer periphery of the through hole 31 and are respectively connected to the through hole 31, and the multiple injection channels 5 are surrounded by the insulating substrate 1, the multiple slots 32 and the hydrophilic film layer 4.

[0031] Furthermore, the insulating intermediate layer 3 is an insulating film layer containing double-sided tape.

[0032] Furthermore, the hydrophilic membrane layer 4 is provided with a plurality of exhaust holes 42 correspondingly connected to the four injection channels 5. The exhaust holes 42 are provided to discharge the air in the injection channels 5, which is beneficial to improving the accuracy of the detection.

[0033] Specifically, the electrode pair 21 includes a working electrode 211 and a reference electrode 212. A current loop is formed by the working electrode 211 and the reference electrode 212 in the injection channel 5, thereby detecting the index of the blood sample.

[0034] Furthermore, the working electrode 211 is electrically connected to a working electrode wire 22 , and the reference electrode 212 is electrically connected to a reference electrode wire 23 .

[0035] Through the above-mentioned structural arrangement, the detection instrument is electrically connected to the working electrode 211 and the reference electrode 212 through the working electrode wire 22 and the reference electrode wire 23 respectively.

[0036] Furthermore, the working electrode 211 , the working electrode wire 22 , the reference electrode 212 and the reference electrode wire 23 are all disposed on the insulating substrate 1 by printing.

[0037] Furthermore, the multiple reference electrodes 212 are electrically connected in sequence to form a non-closed ring structure with an opening, and the multiple reference electrodes 212 share a single reference electrode wire 23. With this structure, the detection instrument can be electrically connected to the multiple reference electrodes 212 via a single reference electrode wire 23, which helps to simplify the structure.

[0038] Furthermore, the four electrode pairs 21 are configured as a first electrode pair, a second electrode pair, a third electrode pair and a fourth electrode pair for detecting hematocrit, blood glucose, blood ketones and uric acid, respectively.

[0039] In some embodiments, the type of the electrode pair 21 can be set according to actual needs.

[0040] Furthermore, the working electrodes 211 of the second electrode pair, the third electrode pair, and the fourth electrode pair are respectively provided with enzyme layers for detecting corresponding indicators.

[0041] It can be understood that the working electrode 211 of the second electrode pair is provided with an enzyme layer for detecting blood glucose, the working electrode 211 of the third electrode pair is provided with an enzyme layer for detecting blood ketones, and the working electrode 211 of the fourth electrode pair is provided with an enzyme layer for detecting uric acid.

[0042] When the test strip of the present invention is in use, a blood sample is added from the sampling port 41. After the blood sample is added from the sampling port 41, it flows simultaneously into the four sampling channels 5 surrounding the outer periphery of the sampling port 41. The blood sample entering the sampling channel 5 contacts the working electrode 211 and the reference electrode 212 located in the sampling channel 5. The detection instrument is electrically connected to the four working electrodes 211 and the four reference electrodes 212 through four working electrode wires 22 and one reference electrode wire 23 respectively. The corresponding working electrodes 211 and the reference electrodes 212 in the four sampling channels 5 respectively form current loops, thereby detecting the hematocrit, blood sugar, blood ketones and uric acid in the blood sample.

[0043] The above description is only a preferred embodiment of the present invention. Therefore, any equivalent changes or modifications made according to the structure, features and principles described in the scope of the present invention patent application are included in the scope of the present invention patent application.

Claims

1. A test strip that can be used for simultaneous detection of multiple indicators, wherein the test strip is provided with a sampling port (41), the test strip is provided with multiple sampling channels (5) and multiple electrode pairs (21) for detecting different indicators, and is characterized in that: The plurality of injection channels (5) respectively surround the outer periphery of the injection port (41) and are respectively connected to the injection port (41); at least a portion of the plurality of electrode pairs (21) is located in the corresponding injection channel (5).

2. The test strip for simultaneous detection of multiple indicators according to claim 1, characterized in that: The test strip comprises an insulating substrate (1), an electrode layer (2), an insulating intermediate layer (3), and a hydrophilic film layer (4) which are sequentially connected from bottom to top; The electrode layer (2) is provided with the plurality of electrode pairs (21), and the injection port (41) is opened on the hydrophilic membrane layer (4); The insulating intermediate layer (3) is provided with a through hole (31) and a plurality of slots (32); the through hole (31) is correspondingly connected to the injection port (41); the plurality of slots (32) are arranged on the periphery of the through hole (31) and are respectively connected to the through hole (31); the plurality of injection channels (5) are surrounded by the insulating substrate (1), the plurality of slots (32) and the hydrophilic film layer (4).

3. The test strip for simultaneous detection of multiple indicators according to claim 2, characterized in that: The insulating intermediate layer (3) is an insulating film layer containing double-sided adhesive tape.

4. The test strip for simultaneous detection of multiple indicators according to claim 2, characterized in that: The hydrophilic membrane layer (4) is provided with a plurality of exhaust holes (42) correspondingly connected to the plurality of injection channels (5).

5. The test strip for simultaneous detection of multiple indicators according to claim 2, characterized in that: The electrode pair (21) includes a working electrode (211) and a reference electrode (212).

6. The test strip for simultaneous detection of multiple indicators according to claim 5, characterized in that: The working electrode (211) is electrically connected to a working electrode wire (22), and the reference electrode (212) is electrically connected to a reference electrode wire (23).

7. The test strip for simultaneous detection of multiple indicators according to claim 6, characterized in that: The working electrode (211), the working electrode wire (22), the reference electrode (212), and the reference electrode wire (23) are all arranged on the insulating substrate (1) by printing.

8. The test strip for simultaneous detection of multiple indicators according to claim 6, characterized in that: The plurality of reference electrodes (212) are electrically connected in sequence to form a non-closed ring structure with an opening, and the plurality of reference electrodes (212) share a reference electrode wire (23).

9. The test strip for simultaneous detection of multiple indicators according to claim 1, characterized in that: The number of the injection channels (5) and the number of the electrode pairs (21) are both set to four, and the four electrode pairs (21) are set to be a first electrode pair, a second electrode pair, a third electrode pair and a fourth electrode pair for detecting hematocrit, blood glucose, blood ketones and uric acid, respectively.

10. The test strip for simultaneous detection of multiple indicators according to claim 9, characterized in that: The working electrodes (211) of the second electrode pair, the third electrode pair and the fourth electrode pair are respectively provided with enzyme layers for detecting corresponding indicators.

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