Tranexamic acid liposome reaction tank with temperature control function

Abstract

The utility model relates to a tranexamic acid liposome reaction tank with a temperature control function, which belongs to the technical field of reaction tanks and comprises a reaction tank, and a heating cavity is arranged on the inner wall of the reaction tank. The reaction tank disclosed by the utility model has the beneficial effects that after the uniformly distributed heating pipes are electrified, the internal heating resistance wires are utilized to release heat outwards, and the heat is transferred through the inner wall to heat the inside, so that uniform temperature distribution of all parts in the reaction tank is ensured, and then the temperature sensor can detect the temperature in the reaction tank in real time; the heating pipes are connected in parallel, when the internal temperature is too high, part of the electric heating pipes can be closed through the control panel, and therefore the function of adjusting the internal temperature of the reaction tank is achieved. The preparation efficiency and precision of existing tranexamic acid are effectively improved, the preparation time is shortened, and the production efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of reaction tanks, in particular to a tranexamic acid liposome reaction tank with a temperature control function. Background Art

[0002] Tranexamic acid, also known as tranexamic acid, tranexamic acid, and hemostatic acid, is a white crystalline powder. The preparation process generally involves adding aminomethylbenzoic acid, water, concentrated sulfuric acid, and a catalyst to a reactor, stirring and heating, and introducing hydrogen gas for a hydrogenation reaction to obtain a reaction liquid. The reaction liquid and concentrated sulfuric acid are then added to another reactor, heated to 180°C to 200°C, and stirred to perform a conversion reaction to obtain tranexamic acid.

[0003] Traditional tranexamic acid preparation equipment, such as reaction tanks, often have problems such as difficult temperature control, uneven material mixing, and difficult to clean material residues. These problems not only affect preparation efficiency, but are also likely to lead to unstable product quality and uncontrollable phenomena during material addition. To address the above problems, we have launched a tranexamic acid liposome reaction tank with temperature control function. Utility Model Content

[0004] The purpose of the utility model is to provide a tranexamic acid liposome reaction tank with a temperature control function to solve the problems proposed in the above background technology that the temperature is often difficult to control, the materials are unevenly mixed and the material residues are difficult to clean.

[0005] The technical solution of the utility model is:

[0006] A reaction tank, wherein the inner wall of the reaction tank is provided with a heating cavity, the inner wall of the heating cavity is fixedly connected to a heating tube, and the upper end wall of the heating cavity is fixedly connected to a temperature sensor;

[0007] The upper end surface of the reaction tank is fittedly connected with a mounting cover, a motor is fixedly connected to the center of the upper end surface of the mounting cover, a feed pipe is fixedly connected to the edge of the upper end surface of the mounting cover, a scale groove is provided on the outer wall of the feed pipe, a valve is provided below the feed pipe, a drive rod is fixedly connected to the output end of the motor, and a stirring rod is fixedly connected to the outer wall of the drive rod.

[0008] Furthermore, the stirring rod is in a U-shaped structure, and the end of the stirring rod is fixedly connected to a scraper bracket, and the scraper bracket is fitted and connected to the inner wall of the reaction tank.

[0009] The stirring rod promotes the uniformity of the reaction and increases the contact area between the reactants, thereby accelerating the speed of the chemical reaction. The stirring rod is fixedly connected to the scraper bracket and rotates along the inner wall of the reaction tank to effectively scrape off the material adhering to the wall, preventing the accumulation of material on the wall and causing uneven reaction. It can break the thermal resistance layer on the surface of the material and distribute the heat more evenly to the material, thereby improving the reaction rate and efficiency.

[0010] Furthermore, a positioning rod is fixedly connected to the edge of the lower end surface of the mounting cover, a positioning block is fixedly connected to the upper end of the outer wall of the reaction tank, and the positioning rod and the positioning block are plug-in connected, a threaded rod is arranged between adjacent positioning rods, and a locking block is plug-in connected to the outer wall of the reaction tank and the threaded rod, a nut is connected to the outer surface of the threaded rod, and the nut is located below the locking block.

[0011] The mounting cover is positioned with the reaction tank through the engagement of the positioning rod and the positioning block to prevent shaking. Then the threaded rod passes through the locking block and the nut is turned to lock it, thereby realizing the disassembly of the mounting cover shell, making it easier to clean the interior and better clean the mixing equipment.

[0012] The present invention provides a tranexamic acid liposome reaction tank with a temperature control function through improvement, which has the following improvements and advantages compared with the prior art:

[0013] First, the utility model uses internal heating resistance wires to release heat outward after the heating tubes are evenly distributed and energized, and heats the interior through the inner wall, thereby ensuring that the temperature distribution inside the reaction tank is uniform. Then, the temperature sensor can detect the internal temperature in real time and display the temperature on the control panel, so that the operator can appropriately regulate the internal temperature. The heating tubes are connected in parallel with each other. When the internal temperature is too high, the control panel can be used to turn off some of the electric heating tubes, thereby realizing the function of regulating the temperature inside the reaction tank, effectively improving the existing preparation efficiency and accuracy of tranexamic acid, shortening the preparation time, and improving production efficiency.

[0014] Secondly: The utility model ensures that the materials are fully mixed, promotes the uniform progress of the reaction, and increases the contact area between the reactants, thereby accelerating the speed of the chemical reaction. Then the scraper bracket rotates along the inner wall of the reaction tank to effectively scrape off the materials adhering to the wall, which can prevent the accumulation of materials on the wall and cause uneven reaction. It can also ensure the effective utilization of the materials in the reaction tank, improve production efficiency, and reduce the frequency and difficulty of cleaning the reaction tank, thereby reducing maintenance costs and time. Finally, it optimizes the heat transfer in the reaction tank, breaks the thermal resistance layer on the surface of the material, and makes the heat more evenly distributed in the material, thereby improving the reaction rate and efficiency.

[0015] Third: When feeding, first close the lower end of the feed pipe through the valve, and then add material to the inside of the feed pipe. The operator can clearly observe the amount of material in the feed pipe through the graduated groove, making the feeding process more precise and controllable, helping to ensure that the amount of material added each time meets the process requirements, thereby improving the quality and consistency of the product, and then open the valve to feed. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The present invention will be further explained below in conjunction with the accompanying drawings and Examples:

[0017] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0018] Figure 2 This is a schematic diagram of the internal connection structure of the reaction tank of the utility model;

[0019] Figure 3 It is a schematic diagram of the upper end surface connection structure of the mounting cover of the utility model.

[0020] Explanation of the accompanying drawings: 1. Reaction tank; 2. Heating cavity; 201. Heating tube; 202. Temperature sensor; 3. Mounting cover; 301. Motor; 302. Drive rod; 303. Stirring rod; 304. Scraper bracket; 4. Feed pipe; 401. Valve; 402. Scale groove; 5. Through pipe; 6. Positioning rod; 7. Positioning block; 8. Threaded rod; 9. Locking block; 10. Nut; 11. Control panel; 12. Power cord; 13. Discharge port. DETAILED DESCRIPTION

[0021] The following will be combined with the Figures 1 to 3 This utility model is described in detail, and the technical solutions in the embodiments of this utility model are clearly and completely described. Obviously, the embodiments described are only some of the embodiments of this utility model, not all of them. Based on the embodiments of this utility model, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this utility model.

[0022] The utility model provides a tranexamic acid liposome reaction tank with a temperature control function through improvement. Figure 1-Figure 3 As shown, it includes a reaction tank 1, the inner wall of the reaction tank 1 is provided with a heating cavity 2, the inner wall of the heating cavity 2 is fixedly connected to a heating tube 201, and the upper end wall of the heating cavity 2 is fixedly connected to a temperature sensor 202;

[0023] The upper end surface of the reaction tank 1 is fitted with a mounting cover 3, a motor 301 is fixedly connected to the center of the upper end surface of the mounting cover 3, a feed pipe 4 is fixedly connected to the edge of the upper end surface of the mounting cover 3, a scale groove 402 is provided on the outer wall of the feed pipe 4, a valve 401 is provided below the feed pipe 4, a drive rod 302 is fixedly connected to the output end of the motor 301, a stirring rod 303 is fixedly connected to the outer wall of the drive rod 302, and a control panel 11 is provided on the outer wall of the reaction tank 1.

[0024] In the present embodiment: the heating cavity 2 offered in retort 1 inside is evenly distributed with the heating resistance wire of inside after the heating tube 201 energizes and utilizes heat to outwardly release heat, transmit heat by inwall and inside is carried out heat treatment, guarantee that the temperature distribution everywhere inside retort 1 is even, avoid the situation of local overheating or temperature deficiency, help to guarantee that tranexamic acid and lipid material evenly mix in preparation process, promote the uniform formation of liposome, then temperature sensor 202 can detect the temperature of its inside in real time, and temperature is displayed at control panel 11 places, so that the operator is carried out suitable regulation and control to the temperature of its inside, and be parallel connection mutually between the heating tube 201, when internal temperature is too high, can utilize control panel 11 to close the electric heating tube 201 of wherein a part, realize the function that the temperature of retort 1 inside is regulated with this, effectively improved preparation efficiency and the precision of existing tranexamic acid, shorten preparation time, improve production efficiency, then when reacting, driving rod 302 is rotated by motor 301, realize that driving rod 302 passes and installs lid 3 and rotates, thereby the stirring rod 303 that is U-shaped structure inside is rotated, guarantee that retort 1 The tranexamic acid, lipid material and other solvents or reagents in the reaction tank 1 are fully mixed to promote the uniform progress of the reaction and increase the contact area between the reactants, thereby accelerating the speed of the chemical reaction. The stirring rod 303 is fixedly connected to the scraper bracket 304 and rotates along the inner wall of the reaction tank 1 to effectively scrape off the materials adhering to the wall, thereby preventing the accumulation of materials on the wall and causing uneven reaction. It can also ensure the effective utilization of the materials in the reaction tank 1, improve production efficiency, and reduce the cleaning frequency and difficulty of the reaction tank 1, thereby reducing maintenance costs and time. Optimizing the heat transfer in the reaction tank 1 can break the thermal resistance layer on the surface of the material and distribute the heat more evenly to the material, thereby improving the reaction rate and efficiency. When feeding, first close the lower end of the feed pipe 4 through the valve 401, and then add material to the inside of the feed pipe 4. The operator can clearly observe the amount of material in the feed pipe 4 through the scale groove 402, making the feeding process more precise and controllable, helping to ensure that the amount of material added each time meets the process requirements, thereby improving the quality and consistency of the product, and then open the valve 401 to feed.

[0025] In addition, in actual application, the electric heating tube 201 can be selected as the Huihouying-finned electric heating tube 201, and the temperature sensor 202 can be selected as the Yueneng-PT131 high-temperature melt pressure sensor.

[0026] In a preferred embodiment, the stirring rod 303 has a U-shaped structure, and the end of the stirring rod 303 is fixedly connected to a scraper bracket 304. The scraper bracket 304 is fitted and connected to the inner wall of the reaction tank 1, which promotes the uniform progress of the reaction and increases the contact area between the reactants, thereby accelerating the speed of the chemical reaction. The stirring rod 303 is fixedly connected to the scraper bracket 304 and fits and rotates along the inner wall of the reaction tank 1, effectively scraping off the material adhering to the wall, preventing the accumulation of material on the wall and causing uneven reaction, breaking the thermal resistance layer on the surface of the material, and distributing heat more evenly to the material, thereby improving the reaction rate and efficiency.

[0027] In a preferred embodiment, the feeding pipes 4 are provided in two groups, and the two groups of feeding pipes 4 are symmetrically distributed about the motor 301 .

[0028] In a preferred embodiment, two groups of through pipes 5 are provided on the upper end surface of the mounting cover 3, and the through pipes 5 and the feed pipes 4 are distributed in a cross shape, and the through pipes 5 are provided in two groups, one group of through pipes 5 is used for connecting to an external gas pipe to introduce hydrogen for hydrogenation reaction to obtain reaction liquid, and the other group is used for adding water.

[0029] In a preferred embodiment, a positioning rod 6 is fixedly connected to the edge of the lower end face of the mounting cover 3, a positioning block 7 is fixedly connected to the upper end of the outer wall of the reaction tank 1, and the positioning rod 6 is plugged into the positioning block 7, and a threaded rod 8 is arranged between adjacent positioning rods 6, and a locking block 9 is plugged into the outer wall of the reaction tank 1 and the threaded rod 8. A nut 10 is connected to the outer surface of the threaded rod 8, and the nut 10 is located below the locking block 9. The mounted mounting cover 3 is positioned with the reaction tank 1 by the engagement of the positioning rod 6 and the positioning block 7 to prevent shaking, and then the threaded rod 8 passes through the locking block 9, and the nut 10 is rotated to lock it, thereby realizing the disassembly of the mounting cover 3 shell, thereby facilitating cleaning of the interior and better cleaning of the stirring equipment.

[0030] In a preferred embodiment, a discharge port 13 is provided at the lower end of the reaction tank 1, and a power line 12 is connected to the outer wall of the lower end of the reaction tank 1 for powering on the equipment, and then the discharge port 13 is used for discharging materials from the reaction tank.

[0031] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. a tranexamic acid liposome reaction tank with temperature control function, characterized in that: The invention comprises a reaction tank (1), wherein the inner wall of the reaction tank (1) is provided with a heating cavity (2), the inner wall of the heating cavity (2) is fixedly connected to a heating tube (201), and the upper end wall of the heating cavity (2) is fixedly connected to a temperature sensor (202); The upper end surface of the reaction tank (1) is fitted with a mounting cover (3), the center of the upper end surface of the mounting cover (3) is fixedly connected to a motor (301), the edge of the upper end surface of the mounting cover (3) is fixedly connected to a feed pipe (4), the outer wall of the feed pipe (4) is provided with a scale groove (402), a valve (401) is provided below the feed pipe (4), the output end of the motor (301) is fixedly connected to a drive rod (302), and the outer wall of the drive rod (302) is fixedly connected to a stirring rod (303).

2. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: The outer wall of the reaction tank (1) is provided with a control panel (11).

3. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: The stirring rod (303) has a U-shaped structure, and the end of the stirring rod (303) is fixedly connected to a scraper bracket (304), and the scraper bracket (304) is closely connected to the inner wall of the reaction tank (1).

4. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: The feeding pipes (4) are arranged in two groups, and the two groups of feeding pipes (4) are symmetrically distributed with respect to the motor (301).

5. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: Two groups of through pipes (5) are provided on the upper end surface of the mounting cover (3), and the through pipes (5) and the feed pipes (4) are distributed in a cross shape, and the through pipes (5) are provided in two groups.

6. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: A positioning rod (6) is fixedly connected to the edge of the lower end surface of the mounting cover (3), a positioning block (7) is fixedly connected to the upper end of the outer wall of the reaction tank (1), and the positioning rod (6) and the positioning block (7) are plug-connected, a threaded rod (8) is provided between adjacent positioning rods (6), a locking block (9) is plug-connected to the outer wall of the reaction tank (1) and the threaded rod (8), a nut (10) is connected to the outer surface of the threaded rod (8), and the nut (10) is located below the locking block (9).

7. a kind of tranexamic acid liposome reaction tank with temperature control function according to claim 1, is characterized in that: The lower end of the reaction tank (1) is provided with a discharge port (13), and the outer wall of the lower end of the reaction tank (1) is connected to a power line (12).

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