Mouse ultra-high dose rate whole body irradiation fixing device

Abstract

The utility model discloses a mouse ultra-high dose rate whole body irradiation fixing device, which belongs to the field of medical instruments and comprises a placing cylinder, a fixing device and a fixing device, the light filter plate is detachably connected to the two ends, in the axial direction, of the containing cylinder, the light filter plate comprises an incident face and an emergent face, the contact area between radiation light and the incident face when the radiation light enters the light filter plate is smaller than the area of the incident face, and the contact area between the radiation light and the emergent face when the radiation light is emitted out of the emergent face is not smaller than the area of the emergent face; the placing frame comprises a supporting plate and a vertical plate, the supporting plate is perpendicular to the vertical plate, the placing barrel is connected with the vertical plate, and the central axis of the placing barrel is perpendicular to the outer wall of the vertical plate when the placing barrel is connected with the vertical plate. Through the arrangement, the whole body of the mouse can be uniformly irradiated, the radiation intensity at the contact part of the mouse and radiation light and the damage of the radiation light to the mouse can be reduced, and the experimental result is more accurate.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and in particular relates to a device for fixing ultra-high dose rate whole-body irradiation of mice. Background Art

[0002] Radiation exposure is a common experimental method widely used in medicine, biology, environmental science and other fields. The radiation exposure conditions are very important when irradiating mice, as they directly affect the reliability and accuracy of experimental results.

[0003] In the experiment, first of all, the radiation exposure time of the mice is very critical. Radiation exposure time that is too long or too short will affect the experimental results. Therefore, the appropriate exposure time needs to be determined according to the specific experimental purpose and exposure dose. Generally speaking, the exposure time should be stable to avoid sudden stops or extensions. Secondly, the radiation exposure dose of the mice is also crucial. The selection of the exposure dose must take into account the experimental purpose and the protection of the health of the mice. The exposure dose not only affects the experimental results, but also has a direct impact on the physiological health of the mice. Therefore, the appropriate exposure dose must be carefully selected. Currently, when conducting mouse irradiation experiments, the mice are usually attached to a board for irradiation. However, when a small irradiation source is used for irradiation, the light spot is too small to evenly irradiate the entire body of the mouse. In addition, direct irradiation of the mouse tends to cause the radiation dose to be concentrated at the location that first contacts the mouse's body surface, causing excessive radiation to cause harm to the mouse.

[0004] FLASH radiotherapy, a radiotherapy technique characterized by ultra-high dose rates, significantly reduces radiation damage to normal tissue while maintaining its tumor-killing potential. It has become a cutting-edge research topic in radiotherapy. Currently, the mainstream radiotherapy equipment in clinical use, the electron linear accelerator, struggles to simultaneously meet the dose rate and dose requirements of FLASH radiotherapy. Furthermore, its low efficiency in generating X-rays through bremsstrahlung radiation makes it unsuitable for FLASH radiotherapy. Pencil-beam scanning is considered the preferred beam delivery technology for proton FLASH radiotherapy. However, due to the time constraints of ultra-high dose rates, affected by the time required for scanning magnet deflection and energy switching, pencil-beam scanning can currently only produce a uniform dose distribution within a 4-cm diameter area, failing to meet the needs of FLASH radiotherapy over a wider area. my country's first superconducting accelerator-driven free electron laser (FELL)—a high-average-power terahertz FEL—can generate an ultra-high dose-rate gamma radiation field exceeding the FLASH effect threshold through bremsstrahlung radiation targeting. By achieving this at a closer distance, and at the expense of a smaller field size, pencil-beam scanning has achieved the world's first demonstration of the FLASH effect with high-energy X-rays / gamma radiation.

[0005] Most irradiation devices used for FLASH research, both domestically and internationally, achieve ultra-high dose rates at the expense of a narrow radiation field, and are therefore limited to studying local organ damage effects in mice, such as the lungs, brain, and gastrointestinal tract. The bone marrow, located throughout the mouse skeleton, is most sensitive to radiation damage. Mice are approximately 9 cm long, and existing devices struggle to achieve ultra-high dose rates within a 9 cm diameter radiation field. Consequently, there is limited literature, both domestically and internationally, examining ultra-high dose rate damage to the mouse bone marrow.

[0006] Ionizing radiation dosimetry is the basis of research on radiation biological effects. Current experiments have shown that the average dose rate of the beam that triggers the FLASH effect is 40 Gy / s, and the instantaneous dose rate within the pulse is as high as 10 3 ~10 5 Gy / s, which is several orders of magnitude higher than conventional dose rate irradiation, which poses a huge challenge to dose measurement. Radiochromic film is currently the most commonly used FLASH dose measurement method. Its dose response is independent of the dose rate, but because the radiochromic reaction has a hysteresis and changes nonlinearly with time, it is difficult to achieve real-time dose measurement. After high-energy rays irradiate an object, the maximum energy or dose of the rays is not on the surface of the object, but at a certain depth inside the object. The area between the body surface and the highest dose point is called the dose build-up area. The dose build-up area is an important feature of the radiation beam energy deposition. The measurement of the body's irradiation dose must take into account the influence of the radiation dose build-up area.

[0007] In response to the problems of whole-body ultra-high dose rate irradiation of mice being restricted by small irradiation field and difficulty in real-time dose measurement, a mouse ultra-high dose rate whole-body irradiation fixation device was creatively designed. This device reduces the irradiation field required for whole-body irradiation of mice, avoids the influence of the dose build-up area on dose measurement, and can accurately measure the whole-body irradiation dose of each mouse at the same time without affecting the physiological activities of the mice.

[0008] Therefore, a fixing device for irradiation experiments is designed, which can ensure that the whole body of the mouse is uniformly irradiated. The fixing device is specifically a mouse irradiation fixing device. Utility Model Content

[0009] In order to overcome the problems raised in the background technology, the present invention adopts the following technical solutions:

[0010] A device for fixing ultra-high dose rate whole-body irradiation of mice comprises: a placement tube, which is provided with a placement channel along the axial direction; a filter plate, which is detachably connected to both ends of the placement tube in the axial direction, the filter plate comprising an incident surface and an exit surface, the contact area between the radiated light and the incident surface when entering the filter plate is smaller than the area of the incident surface, and the contact area between the radiated light and the exit surface when exiting from the exit surface is not smaller than the area of the exit surface; a placement frame, which comprises a support plate and a vertical plate, the support plate being perpendicular to the vertical plate, the placement tube being connected to the vertical plate and the central axis of the placement tube being perpendicular to the outer wall of the vertical plate when connected.

[0011] Furthermore, a placement groove is provided on the vertical plate, and the placement groove has an opening one, and the opening one faces away from the support plate. The placement tube can be clamped in the placement groove along a placement direction, and the placement direction is perpendicular to the support plate. The placement groove limits the axial movement of the placement tube, thereby preventing the placement tube from detaching from the placement groove.

[0012] Furthermore, the placement tube is provided with a plurality of tooth gaps along the radial direction, and the tooth gaps are distributed in a circular array on the outer wall of the placement tube around the central axis of the placement tube. When the placement tube rotates circumferentially in the placement groove, there is always at least one tooth gap exposed to the outside through the opening, thereby ensuring that the mice in the placement tube can always breathe through the tooth gaps.

[0013] Furthermore, a second opening is provided on a side of the placement groove facing away from the vertical plate, and the area of the second opening is smaller than the area of the filter plate.

[0014] Furthermore, the incident surface and the emitting surface of the filter plate are parallel.

[0015] Furthermore, when the filter plate is connected to the placement tube, both ends of the placement channel in the axial direction are blocked by the incident surface of one filter plate and the emitting surface of the other filter plate respectively.

[0016] Furthermore, the filter plate is made of a material selected from synthetic plastic polymers and plastic high polymer materials.

[0017] Alternatively, the filter plate is embodied as a radiation dose film.

[0018] Furthermore, the thickness of the placement tube is not less than 15 mm and not more than 30 mm.

[0019] Furthermore, the movement trajectory of the radiation light when it strikes the filter plate coincides with the central axis of the placement tube.

[0020] Furthermore, along the axial direction of the placement tube, the length of the support plate is greater than the length of the placement tube.

[0021] Beneficial effects of the utility model:

[0022] By setting up a placement tube with slits, anesthetized mice can be placed in a curled-up posture and maintain normal breathing of the mice; by setting up a filter plate, the radiation light can be diffused before entering the mouse's body surface, thereby reducing the radiation light density while increasing the contact area with the mouse, and then the whole body of the mouse can be evenly irradiated, reducing the radiation intensity at the contact point between the mouse and the radiation light and its damage to the mouse, and making the experimental results more accurate, with excellent technical effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without inventive work. Among them:

[0024] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0025] Figure 2 This is a schematic diagram of the overall structure when the tube and filter plate are assembled;

[0026] Figure 3 for Figure 2 Schematic diagram of the cross-section structure;

[0027] Figure 4 It is a schematic diagram of the overall structure of the placement tube;

[0028] Figure 5 Schematic diagram of the overall structure of the placement rack;

[0029] In the figure, 1, placement tube; 11, placement channel; 12, tooth gap; 2, filter plate; 21, incident surface; 22, emission surface; 3, placement rack; 31, support plate; 32, vertical plate; 321, placement slot; 3211, opening one; 3212, opening two. DETAILED DESCRIPTION

[0030] The following is a clear and complete description of the technical solutions in the embodiments of the present invention through specific embodiments. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Those skilled in the art can easily understand other advantages and functions of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0031] A device for fixing mice for ultra-high dose rate whole body irradiation, such as Figure 1-5 As shown, it includes: a placement tube 1, which is provided with a placement channel 11 along the axial direction; a filter plate 2, which is detachably connected to both ends of the placement tube 1 in the axial direction. The filter plate 2 includes an incident surface 21 and an exit surface 22. When the radiated light enters the filter plate 2, the contact area with the incident surface 21 is smaller than the area of the incident surface 21. When the radiated light exits the exit surface 22, the contact area with the exit surface 22 is not less than the area of the exit surface 22. A placement frame 3, which includes a support plate 31 and a vertical plate 32, is perpendicular to the vertical plate 32. The placement tube 1 is connected to the vertical plate 32, and when connected, the central axis of the placement tube 1 is perpendicular to the outer wall of the vertical plate 32. Along the axial direction of the placement tube 1, the length of the support plate 31 is greater than the length of the placement tube 1. The axial thickness of the placement tube 1 is not less than 15 mm and not more than 30 mm, and the inner diameter of the placement tube 1 is 40 mm-50 mm, so that mice aged 5-8 weeks and weighing 22-25 grams can be placed in the placement tube 1 in a curled-up posture.

[0032] In some embodiments of the present application, Figure 1-5 As shown, a placement slot 321 is provided on the vertical plate 32. The placement slot 321 has an opening 1 3211. The opening 1 3211 faces away from the support plate 31. The placement tube 1 can be snapped into the placement slot 321 along a placement direction perpendicular to the support plate 31. The placement slot 321 restricts the axial movement of the placement tube 1, thereby preventing the placement tube 1 from escaping from the placement slot 321. A second opening 3212 is provided on the side of the placement slot 321 facing away from the vertical plate 32. The area of the second opening 3212 is smaller than that of the filter plate 2.

[0033] In some embodiments of the present application, Figure 1-5 As shown, the placement tube 1 is provided with a plurality of tooth gaps 12 radially extending therethrough, and the tooth gaps 12 are distributed in a circular array on the outer wall of the placement tube 1 around the central axis of the placement tube 1. When the placement tube 1 rotates circumferentially in the placement groove 321, there is always at least one tooth gap 12 exposed to the outside through the opening 3211, thereby ensuring that the mice in the placement tube 1 can always breathe through the tooth gaps 12.

[0034] In some embodiments of the present application, Figure 1-5 As shown, the incident surface 21 and the exit surface 22 of the filter plate 2 are parallel. When the filter plate 2 is connected to the placement tube 1, the axial ends of the placement channel 11 are blocked by the incident surface 21 of one filter plate 2 and the exit surface 22 of the other filter plate 2, respectively. The filter plate 2 is made of a synthetic plastic polymer or a plastic polymer material. The trajectory of the radiation light when it strikes the filter plate 2 coincides with the central axis of the placement tube 1. The placement tube 1 is made of a plastic or resin that can be used as a molten material for 3D printing. Alternatively, the filter plate 2 is specifically a radiation dose film, which is placed at both ends of the placement tube 1. During use, the front and rear film doses are calculated based on a calibrated film dose curve. The average of the film doses on both sides is the radiation dose at the center of the irradiation when the mouse is irradiated. The radiation dose film is specifically selected from EBT3, EBT4, or EBT-XD. The material of the placement frame 3 is transparent polymethyl methacrylate, which is hydrophilic but insoluble in water and is a homogeneous water phantom. The thickness of the vertical plate 32 is not more than 30 mm, and the thickness is not less than the built-up area of the radiation dose, so that the film dose at both ends of the placement tube 1 in the axial direction can accurately measure the central dose of the irradiated mouse.

[0035] When using this device, mice are first anesthetized one by one, rolled into a ball, and placed in a curled-up position in a placement tube 1 to secure their position. Radiation dose films are inserted in front and behind the placement tube 1, and a baffle of a certain thickness is inserted behind the rear film to ensure that there is no gap between the mouse placement tube 1 and the placement slot 321. Once the mice are secured, their position and posture are maintained. The experimental mice are 5-8 weeks old and weigh 22-25 grams. The placement rack 3 containing the mice is placed in the irradiation field, and then the light source is turned on. Using vertical and horizontal laser positioning systems, the center of the mouse placement tube 1 is aligned with the center of the irradiation field. The radiation beam then enters the filter plate 2 and moves uniformly within the filter plate 2. The radiation then passes through the filter plate 2 and evenly contacts half of the mouse's body, resulting in the entire mouse being uniformly irradiated. The irradiation device can be an ultra-high dose rate X-ray irradiation device, an ultra-high dose rate electron irradiation device, an ultra-high dose rate proton irradiation device, or an ultra-high dose rate heavy ion irradiation device.

Claims

1. A mouse ultra-high dose rate whole body irradiation fixation device, characterized in that: include: A placement tube is provided with a placement channel running through it in the axial direction; a filter plate detachably connected to both ends of the placement cylinder in the axial direction, the filter plate comprising an incident surface and an exit surface, wherein the contact area of the radiation light with the incident surface when entering the filter plate is smaller than the area of the incident surface, and the contact area of the radiation light with the exit surface when exiting the filter plate is not smaller than the area of the exit surface; The placement rack includes a support plate and a vertical plate, wherein the support plate is perpendicular to the vertical plate, and the placement tube is connected to the vertical plate and when connected, the center axis of the placement tube is perpendicular to the outer wall of the vertical plate.

2. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: The vertical plate is provided with a placement groove having an opening 1, the opening 1 facing away from the support plate, the placement tube can be clamped in the placement groove along a placement direction, and the placement groove limits the axial movement of the placement tube.

3. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 2, characterized in that: The placement tube is provided with a plurality of tooth gaps along the radial direction, and the tooth gaps are distributed in a ring array on the outer wall of the placement tube around the central axis of the placement tube. When the placement tube rotates circumferentially in the placement groove, at least one tooth gap is always exposed to the outside through opening 1.

4. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 2, characterized in that: A second opening is provided on a side of the placement groove facing away from the vertical plate, and the area of the second opening is smaller than the area of the filter plate.

5. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: The incident surface and the emitting surface of the filter plate are parallel.

6. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: When the filter plate is connected to the placement tube, both ends of the placement channel in the axial direction are blocked by the incident surface of one filter plate and the emitting surface of the other filter plate respectively.

7. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: The filter plate is made of a material selected from synthetic plastic polymers and plastic high polymer materials.

8. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: The thickness of the placement tube is not less than 15 mm and not more than 30 mm.

9. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 1, characterized in that: The movement trajectory of the radiation light when it strikes the filter plate coincides with the central axis of the placement tube.

10. The ultra-high dose rate whole body irradiation fixation device for mice according to claim 4, characterized in that: Along the axial direction of the placement tube, the length of the support plate is greater than the length of the placement tube.

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