Abiraterone intermediate AB production device

Abstract

The utility model relates to the technical field of intermediates, and discloses an abiraterone intermediate AB production device which comprises a reaction cylinder, a heating hollow ring is arranged on the outer side of the reaction cylinder, a plurality of heating rings are arranged in the heating hollow ring, a top cover cylinder is arranged at the top of the reaction cylinder, and a top cover is arranged at the bottom of the top cover cylinder. The bottom of the top cover cylinder is fixedly connected with a flange, the top cover cylinder is fixedly connected with the reaction cylinder through the flange, and the left side of the top of the top cover cylinder is communicated with a feeding pipe. The reaction cylinder is divided into four areas through the partition plate, the direct-current motor drives the partition plate and drives the T-shaped supporting plate to rotate, the stirring assembly enables the cylinder to have different rotating speeds in different areas, and after the cylinder rotates by one circle, the second electric valve is opened, and reaction mixed liquid is discharged. Therefore, the production of the abiraterone intermediate AB is automatically completed.

Description

Technical Field

[0001] The utility model relates to the technical field of intermediates, in particular to a production device for an abiraterone intermediate AB. Background Art

[0002] Abiraterone intermediate AB is a key intermediate in the synthesis of abiraterone. It is produced through specific reaction steps during the chemical synthesis process and is one of the core components of the final drug. The chemical structure of this intermediate contains multiple functional groups, which are further modified in subsequent synthesis steps to produce a final product with therapeutic effects. Due to its importance in drug synthesis, the purity and stability of abiraterone intermediate AB are crucial to the quality of the final drug. Therefore, the reaction conditions and purification steps need to be strictly controlled during the synthesis process.

[0003] After searching, the Chinese patent announcement number is: CN218166099U, which discloses a high-purity abiraterone intermediate AB production device, including a sealed chamber, the bottom of the inner wall of the sealed chamber is sealed and clamped with a separation seat, the upper inner wall of the separation seat is threadedly connected to a pressure seat, and the upper surface of the pressure seat is provided with a connecting disk. This high-purity abiraterone intermediate AB production device achieves extrusion dehydration to reduce the water content by providing a hydraulic rod, a connecting disk, a forming seat, a separation seat and a filter. However, in actual use, the device needs to achieve production through multiple reactors connected in series, which has the following defects: ① Multiple reactors occupy a large area, and automated control requires coordination of multiple equipment parameters, which is complicated to operate; ② Materials need to be transferred multiple times, which can easily cause cross-contamination and affect product quality.

[0004] Therefore, there is an urgent need for an integrated, automated and thoroughly clean production device. Utility Model Content

[0005] In order to make up for the above shortcomings, the utility model provides an abiraterone intermediate AB production device, which aims to improve the problems in the existing technology such as large footprint, difficulty in automated control, and easy cross contamination due to multiple material transfers involved in the process, thereby affecting product quality.

[0006] In order to achieve the above-mentioned object, the present invention adopts the following technical solution: A production device for an abiraterone intermediate AB includes a reaction cylinder, a heating hollow ring is provided on the outside of the reaction cylinder, a plurality of heating rings are provided inside the heating hollow ring, a top cover cylinder is provided on the top of the reaction cylinder, a flange is fixedly connected to the bottom of the top cover cylinder, the top cover cylinder is fixedly connected to the reaction cylinder through the flange, a feed pipe is connected to the left side of the top of the top cover cylinder, an electric valve 1 is provided on the outside of the feed pipe, a discharge pipe is connected to the left side of the bottom of the outer wall of the reaction cylinder, an electric valve 2 is provided on the outside of the discharge pipe, a DC motor is fixedly connected to the bottom of the outer wall of the reaction cylinder, an output end of the DC motor passes through the reaction cylinder and is fixedly connected to a partition, T-shaped support plates are fixedly connected to the outer wall of the partition, a stirring assembly is provided at the bottom of the T-shaped support plate, and a cleaning mechanism is provided on the top of the top cover cylinder, the cleaning mechanism is used to clean the inside of the device after production is completed.

[0007] As a further description of the above technical solution:

[0008] The cleaning mechanism includes a hose, which is arranged on the rear side of the top end of the top cover cylinder. The bottom of the hose passes through the top cover cylinder and is connected to a spray head. A plurality of side wall scrapers are fixedly connected to the outside of the partition, and a plurality of bottom triangular scrapers are fixedly connected around the bottom of the partition. The right side of the top end of the top cover cylinder is connected to an automatic exhaust valve.

[0009] As a further description of the above technical solution:

[0010] The stirring assembly includes a cylinder, which is rotatably connected to the bottom of the T-shaped support plate, multiple sets of gears are fixedly connected to the top of the outer wall of the cylinder, a stirring blade is fixedly connected to the bottom of the cylinder, an arc-shaped gear ring 1 is fixedly connected to the front side of the inner wall of the top cover cylinder, an arc-shaped gear ring 2 is fixedly connected to the right side of the inner wall of the top cover cylinder, and an arc-shaped gear ring 3 is fixedly connected to the rear side of the inner wall of the top cover cylinder, and the multiple sets of gears are respectively meshed with arc-shaped gear ring 1, arc-shaped gear ring 2 and arc-shaped gear ring 3.

[0011] As a further description of the above technical solution:

[0012] A plurality of L-shaped fixing plates are fixedly connected to the outer side of the heating hollow ring, and a supporting leg is fixedly connected to the bottom of the L-shaped fixing plate.

[0013] As a further description of the above technical solution:

[0014] An observation window is provided on the front side of the outer wall of the heating hollow ring, and a sealing frame is fixedly connected to the outer side of the observation window.

[0015] As a further description of the above technical solution:

[0016] A semicircular ring is fixedly connected to the middle of the top end of the top cover cylinder, and an alarm is fixedly connected to the front side of the top end of the top cover cylinder.

[0017] As a further description of the above technical solution:

[0018] A pressure valve is fixedly connected to the left side of the outer wall of the top cover cylinder, and a valve handle is provided on the top of the pressure valve.

[0019] As a further description of the above technical solution:

[0020] A controller is fixedly connected to the right side of the outer wall of the heating hollow ring, and the controller is electrically connected to the electric valve 1, the electric valve 2, the DC motor, the heating ring and the automatic exhaust valve respectively.

[0021] The utility model has the following beneficial effects:

[0022] 1. In the present invention, material is added to the reaction cylinder through a feed pipe, the volume is controlled by electric valve 1, heating is performed by a heating ring, and a DC motor drives the partition to rotate. The partition divides the reaction cylinder into four zones, which drives the T-shaped support plate to rotate. The stirring assembly causes the cylinder to rotate at different speeds in different zones, achieving a change in stirring speed at different time periods. After one rotation, electric valve 2 opens to discharge the reaction mixture, thereby automatically completing the production of abiraterone intermediate AB.

[0023] 2. In the utility model, the cleaning liquid is sprayed to the bottom area of ​​the reaction cylinder through the hose and the spray head. When the partition rotates, the side wall scraper cleans the outer wall, and the bottom triangular scraper scrapes the bottom of the reaction cylinder. The cleaning liquid reacts with the residue on the inner wall to produce gas, and the automatic exhaust valve discharges the gas, which can complete the cleaning of the device and prevent contamination during next use. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a three-dimensional diagram of an abiraterone intermediate AB production device proposed in the present invention;

[0025] Figure 2 This is a front view of an abiraterone intermediate AB production device proposed in the present invention;

[0026] Figure 3 This is a side view of an abiraterone intermediate AB production device proposed in the present invention;

[0027] Figure 4 This is a top view of the reaction cylinder of an abiraterone intermediate AB production device proposed in the present invention;

[0028] Figure 5This is a cross-sectional view of a reaction cylinder of an abiraterone intermediate AB production device proposed in the present invention.

[0029] Legend:

[0030] 1. Reaction cylinder; 2. Cleaning mechanism; 201. Hose; 202. Spray head; 203. Side scraper; 204. Bottom triangular scraper; 205. Automatic exhaust valve; 3. Heating hollow ring; 4. Flange; 5. Top cover cylinder; 6. Feed pipe; 7. Electric valve 1; 8. Discharge pipe; 9. Electric valve 2; 10. DC motor; 11. Partition; 12. T-shaped support plate; 13. Cylinder; 14. Multiple sets of gears; 15. Stirring blade; 16. Arc gear ring 1; 17. Arc gear ring 2; 18. Arc gear ring 3; 19. Heating ring; 20. L-shaped fixing plate; 21. Support foot; 22. Observation window; 23. Sealing frame; 24. Controller; 25. Semicircular ring; 26. Alarm; 27. Pressure valve; 28. Valve handle. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0032] Reference Figure 2 、 Figure 4 and Figure 5 The utility model provides an embodiment: a production device for an abiraterone intermediate AB, comprising a reaction cylinder 1, a heating hollow ring 3 is provided on the outside of the reaction cylinder 1, a plurality of heating rings 19 are provided inside the heating hollow ring 3, a top cover cylinder 5 is provided on the top of the reaction cylinder 1, a flange 4 is fixedly connected to the bottom of the top cover cylinder 5, the top cover cylinder 5 is fixedly connected to the reaction cylinder 1 through the flange 4, a feed pipe 6 is connected to the left side of the top of the top cover cylinder 5, an electric valve 1 7 is provided on the outside of the feed pipe 6, a discharge pipe 8 is connected to the left side of the bottom of the outer wall of the reaction cylinder 1, an electric valve 2 9 is provided on the outside of the discharge pipe 8, a DC motor 10 is fixedly connected to the bottom of the outer wall of the reaction cylinder 1, an output end of the DC motor 10 passes through the reaction cylinder 1 and is fixedly connected to a partition 11, a T-shaped support plate 12 is fixedly connected to the outer wall of the partition 11, a stirring assembly is provided at the bottom of the T-shaped support plate 12, and a cleaning mechanism 2 is provided on the top of the top cover cylinder 5, which is used to clean the inside of the device after production is completed;

[0033] Specifically, raw materials are added to the reaction cylinder 1 through the feed pipe 6, and the volume of the raw materials entering is controlled by starting the electric valve 1 7. Then, the reaction cylinder 1 is heated by starting the heating ring 19. Then, the DC motor 10 is started to drive the partition 11 to rotate, and the reaction cylinder 1 is divided into four areas by the partition 11. Under the drive of the DC motor 10, the partition 11 drives the T-shaped support plate 12 above it to rotate, and during the rotation process, the multiple sets of gears 14 in the stirring assembly will be meshed and connected with the arc-shaped gear ring 1 16, the arc-shaped gear ring 2 17 and the arc-shaped gear ring 3 18 in turn, so that the cylinder 13 rotates at different speeds in different areas, so that the reactants can be stirred at different speeds at different time periods. After completing one circle of rotation, the electric valve 9 is started to open to discharge the reaction mixed liquid.

[0034] Reference Figure 2 、 Figure 3 and Figure 5 The cleaning mechanism 2 includes a hose 201, which is arranged on the rear side of the top of the top cover cylinder 5. The bottom of the hose 201 passes through the top cover cylinder 5 and is connected to the spray head 202. A plurality of side wall scrapers 203 are fixedly connected to the outside of the partition 11. A plurality of bottom triangular scrapers 204 are fixedly connected around the bottom of the partition 11. The right side of the top of the top cover cylinder 5 is connected to an automatic exhaust valve 205.

[0035] Specifically, after the liquid is discharged, the external cleaning liquid is evenly sprayed in the bottom area through the hose 201 through the spray head 202, and in the process of its rotation with the partition 11, the outer wall is cleaned by the side wall scraper 203, and the bottom of the reaction cylinder 1 is scraped and cleaned by the bottom triangular scraper 204. Since the cleaning liquid reacts with the residue on the inner wall, a large amount of gas is generated. The generated gas can be discharged through the automatic exhaust valve 205, thereby completing the cleaning of the reaction cylinder 1.

[0036] Reference Figure 1 、 Figure 4 and Figure 5The stirring assembly includes a cylinder 13, which is rotatably connected to the bottom of the T-shaped support plate 12. Multiple sets of gears 14 are fixedly connected to the top of the outer wall of the cylinder 13. A stirring blade 15 is fixedly connected to the bottom of the cylinder 13. The front side of the inner wall of the top cover cylinder 5 is fixedly connected to an arc-shaped gear ring 16, the right side of the inner wall of the top cover cylinder 5 is fixedly connected to an arc-shaped gear ring 2 17, and the rear side of the inner wall of the top cover cylinder 5 is fixedly connected to an arc-shaped gear ring 3 18. Multiple sets of gears 14 are respectively meshed with the arc-shaped gear ring 16, the arc-shaped gear ring 2 17 and the arc-shaped gear ring 3 18. The outer side of the heating hollow ring 3 is fixedly connected to multiple L-shaped fixing plates 20, and the bottom of the L-shaped fixing plate 20 is fixedly connected to a support foot 21. An observation window 22 is provided on the front side of the outer wall of the heating hollow ring 3, and a sealing frame 23 is fixedly connected to the outer side of the observation window 22.

[0037] Specifically, when the partition 11 rotates, multiple sets of gears 14 are meshed and connected with the arc-shaped gear ring 16, the arc-shaped gear ring 2 17 and the arc-shaped gear ring 3 18 respectively, so that the cylinder 13 rotates at different speeds and drives the stirring blade 15 to stir the mixed liquid. The support legs 21 and the L-shaped fixing plate 20 can provide stable support for the device, and the internal reaction conditions can be easily observed through the observation window 22.

[0038] Reference Figure 1 、 Figure 2 and Figure 3 A semicircular ring 25 is fixedly connected to the middle of the top of the top cover cylinder 5, an alarm 26 is fixedly connected to the front side of the top of the top cover cylinder 5, a pressure valve 27 is fixedly connected to the left side of the outer wall of the top cover cylinder 5, a valve handle 28 is provided on the top of the pressure valve 27, and a controller 24 is fixedly connected to the right side of the outer wall of the heating hollow ring 3. The controller 24 is electrically connected to the electric valve 1 7, the electric valve 2 9, the DC motor 10, the heating ring 19 and the automatic exhaust valve 205 respectively;

[0039] Specifically, the semicircular ring 25 can be used to easily lift the top cover cylinder 5, the alarm 26 can be used to remind the staff when a fault occurs, the pressure valve 27 can be used to know the air pressure of the gas generated inside, and the valve handle 28 can be used to exhaust when the automatic exhaust valve 205 fails. The controller 24 can respectively control the starting and operating power between the electric valve 1 7, the electric valve 2 9, the DC motor 10, the heating ring 19 and the automatic exhaust valve 205.

[0040] Working principle: Before using the device, first, inject raw materials into the reaction cylinder 1 through the feed pipe 6, and control the injection amount of raw materials by starting the electric valve 1 7. Then, start the heating ring 19 to heat the reaction cylinder 1. Then, start the DC motor 10 to drive the partition 11 to rotate. The partition 11 divides the reaction cylinder 1 into four independent areas. Under the action of the DC motor 10, the partition 11 drives the T-shaped support plate 12 above it to rotate. During the rotation process, the multiple sets of gears 14 in the stirring assembly engage with the arc-shaped gear ring 1 16, the arc-shaped gear ring 2 17 and the arc-shaped gear ring 3 18 in turn, thereby realizing different speeds of the cylinder 13 in different areas. The reactants are subjected to different stirring speeds at different stages. When the cylinder 13 completes one rotation, the electric valve 2 9 is activated to discharge the liquid after the reaction mixture. After the liquid is discharged, the external cleaning liquid is introduced into the bottom area of ​​the reaction cylinder 1 through the hose 201 through the cleaning mechanism 2, and is evenly sprayed with the help of the spray head 202. Then, as the partition 11 rotates, the side wall scraper 203 cleans the outer wall of the reaction cylinder 1, and the bottom triangular scraper 204 scrapes and cleans the bottom. At the same time, the cleaning liquid reacts chemically with the residue on the inner wall to generate a large amount of gas, which is discharged through the automatic exhaust valve 205, thereby achieving thorough cleaning of the reaction cylinder 1.

[0041] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A device for producing an abiraterone intermediate AB, comprising a reaction cylinder (1), characterized in that: A heating hollow ring (3) is provided on the outside of the reaction cylinder (1), and a plurality of heating rings (19) are provided inside the heating hollow ring (3). A top cover cylinder (5) is provided on the top of the reaction cylinder (1), and a flange (4) is fixedly connected to the bottom of the top cover cylinder (5). The top cover cylinder (5) is fixedly connected to the reaction cylinder (1) through the flange (4). A feed pipe (6) is connected to the left side of the top of the top cover cylinder (5), and an electric valve (7) is provided on the outside of the feed pipe (6). The bottom left side of the outer wall of the reaction cylinder (1) is connected to the A discharge pipe (8) is provided on the outside of the discharge pipe (8) with an electric valve 2 (9); a DC motor (10) is fixedly connected to the bottom of the outer wall of the reaction cylinder (1); the output end of the DC motor (10) passes through the reaction cylinder (1) and is fixedly connected to a partition (11); a T-shaped support plate (12) is fixedly connected to the outer wall of the partition (11) on all sides; a stirring assembly is provided at the bottom of the T-shaped support plate (12); a cleaning mechanism (2) is provided on the top of the top cover cylinder (5); the cleaning mechanism (2) is used to clean the inside of the device after production is completed.

2. The abiraterone intermediate AB production device according to claim 1, characterized in that: The cleaning mechanism (2) includes a hose (201), which is arranged at the rear side of the top end of the top cover cylinder (5), and the bottom of the hose (201) passes through the top cover cylinder (5) and is connected to a spray head (202). The outer side of the partition (11) is fixedly connected to a plurality of side wall scrapers (203), and the bottom of the partition (11) is fixedly connected to a plurality of bottom triangular scrapers (204). The right side of the top end of the top cover cylinder (5) is connected to an automatic exhaust valve (205). The stirring assembly includes a cylinder (13), and the cylinder (13) is rotatably connected to the cylinder. The bottom of the T-shaped support plate (12) and the top of the outer wall of the cylinder (13) are fixedly connected with a plurality of gears (14); the bottom of the cylinder (13) is fixedly connected with a stirring blade (15); the front side of the inner wall of the top cover cylinder (5) is fixedly connected with an arc-shaped gear ring 1 (16); the right side of the inner wall of the top cover cylinder (5) is fixedly connected with an arc-shaped gear ring 2 (17); and the rear side of the inner wall of the top cover cylinder (5) is fixedly connected with an arc-shaped gear ring 3 (18); and the plurality of gears (14) are respectively meshed with the arc-shaped gear ring 1 (16), the arc-shaped gear ring 2 (17) and the arc-shaped gear ring 3 (18).

3. The abiraterone intermediate AB production device according to claim 1, characterized in that: A plurality of L-shaped fixing plates (20) are fixedly connected to the outer side of the heating hollow ring (3), and a supporting foot (21) is fixedly connected to the bottom of the L-shaped fixing plate (20).

4. The device for producing an abiraterone intermediate AB according to claim 1, wherein: An observation window (22) is provided on the front side of the outer wall of the heating hollow ring (3), and a sealing frame (23) is fixedly connected to the outer side of the observation window (22).

5. The device for producing an abiraterone intermediate AB according to claim 1, wherein: A semicircular ring (25) is fixedly connected to the middle of the top end of the top cover cylinder (5), and an alarm (26) is fixedly connected to the front side of the top end of the top cover cylinder (5).

6. The device for producing an abiraterone intermediate AB according to claim 1, wherein: A pressure valve (27) is fixedly connected to the left side of the outer wall of the top cover cylinder (5), and a valve handle (28) is provided on the top of the pressure valve (27).

7. The device for producing an abiraterone intermediate AB according to claim 1, characterized in that: A controller (24) is fixedly connected to the right side of the outer wall of the heating hollow ring (3), and the controller (24) is electrically connected to the electric valve 1 (7), the electric valve 2 (9), the DC motor (10), the heating ring (19) and the automatic exhaust valve (205).

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