Waste liquid emptying device for radiopharmaceuticals
By designing an automated waste liquid drainage device, the problems of poor sealing and radiation damage in the waste liquid bottle in the radiopharmaceutical synthesizer are solved, and automatic liquid discharge and safe operation are achieved.
Patent Information
- Application Number
- CN202422182552.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-06
- Publication Date
- 2025-08-26
- Estimated Expiration
- 2034-09-06
AI Technical Summary
During the discharge process, existing radiopharmaceutical synthesizers have problems such as poor sealing of waste liquid bottles and frequent unboxing operations, resulting in radiation damage.
Design a waste liquid drainage device for radioactive drugs, including a collection unit and a liquid discharge unit, automatically discharge waste liquid through sealing connection, use a liquid level meter to monitor the liquid level and control the peristaltic pump and valve to achieve automatic discharge, ensuring sealing and safety.
It realizes that there is no need to disassemble the waste liquid bottle during the automatic discharge process, avoiding poor sealing and ray damage, and ensuring the smooth progress and safe operation of the synthesis process.
Smart Images

Figure CN223273034U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of radioactive drug synthesis, in particular to a waste liquid emptying device for radioactive drugs. Background Art
[0002] Radiopharmaceutical synthesizers are equipment used to synthesize radiopharmaceuticals. Using specific techniques and methods, radionuclides are combined with appropriate ligands to produce radiopharmaceuticals for medical diagnosis and treatment. These drugs possess specific radioactive properties and can be used to detect and diagnose diseases.
[0003] During the radiopharmaceutical synthesis process, a certain amount of waste liquid is typically generated. The existing technology collects this waste liquid in a waste liquid bottle. When excessive waste liquid is generated, it needs to be promptly discharged from the synthesizer. Specifically, this is done by opening the synthesizer, removing the waste liquid bottle, and pouring out the waste liquid. However, this method of draining the waste liquid has the following problems: 1. Each time the waste liquid is emptied out, the bottle cap often leaks when the waste liquid bottle is reinstalled, resulting in poor airtightness of the waste liquid bottle and affecting the subsequent collection of waste liquid; 2. Due to the radiation inside the hot chamber of the synthesizer, which can cause harm to the operator, frequent opening of the box to pour out the waste liquid is not possible.
[0004] Therefore, the existing drainage technology has the problems of poor air tightness in collecting the waste liquid again and difficulty in emptying the waste liquid in time. Utility Model Content
[0005] In order to solve the above technical problems, the utility model provides a waste liquid emptying device for radioactive drugs, which automatically discharges waste liquid after a liquid discharge unit is sealed and connected to a collection unit.
[0006] In order to achieve the above object, the present invention is implemented through the following technical solutions:
[0007] A radiopharmaceutical waste liquid emptying device, comprising:
[0008] The collecting unit is arranged in the synthesizer and is sealedly connected to the synthesizer to collect waste liquid generated by the synthesizer.
[0009] The liquid discharge unit is located at one side of the collecting unit and is sealed with the collecting unit for discharging the waste liquid of the collecting unit to the outside of the synthesizer.
[0010] Compared with the prior art, the utility model has the following advantages:
[0011] Waste liquid generated within the synthesizer is automatically discharged into the collection unit. The drain unit automatically drains the liquid through the automatic opening and closing of the valve. During the entire process, there's no need to open the synthesizer to remove the waste liquid bottle, thus avoiding issues like poor sealing when reinstalling the waste liquid bottle and potential harm from radiation inside the box. Furthermore, during the entire drainage process, the collection and drain units maintain a sealed, slightly negative pressure, ensuring a smooth synthesis process.
[0012] More preferably, the collecting unit includes:
[0013] The waste liquid pipe is arranged on the synthesizer, and its inlet is sealedly connected to the synthesis module of the synthesizer.
[0014] The waste liquid bottle is located on one side of the synthesis module, and its bottle mouth is plugged into the outlet of the waste liquid tube, and the waste liquid tube extends into the waste liquid bottle.
[0015] The first liquid level gauge is arranged on the upper part of the waste liquid bottle, located at the upper limit of the liquid level of the waste liquid bottle, and is electrically connected to the synthesis module for transmitting a high liquid level alarm signal to the synthesis module.
[0016] The second liquid level gauge is arranged at the lower part of the waste liquid bottle, located at the lower limit of the liquid level of the waste liquid bottle, and is electrically connected to the synthesis module to transmit a low liquid level alarm signal to the synthesis module.
[0017] Using this technical solution, the waste liquid pipe transports waste liquid generated during the synthesis process to the waste liquid bottle. When the liquid level in the waste liquid bottle reaches the upper limit, the first liquid level gauge sends an electrical signal representing a high liquid level alarm to the synthesis module, allowing the drainage unit to drain the waste liquid in the waste liquid bottle. When the liquid level in the waste liquid bottle reaches the lower limit, the second liquid level gauge sends an electrical signal representing a low liquid level alarm to the synthesis module, allowing the waste liquid bottle to continue collecting waste liquid.
[0018] More preferably, the liquid discharge unit comprises:
[0019] The liquid discharge pipe is located at one side of the waste liquid bottle, and its inlet extends into the inner bottom wall of the waste liquid bottle.
[0020] The waste liquid barrel is arranged outside the synthesizer, and the drain pipe is inserted into the waste liquid barrel to collect waste liquid from the waste liquid bottle.
[0021] The peristaltic pump is arranged on the discharge pipe, located between the waste liquid barrel and the waste liquid bottle, and is connected to the synthesis module through electrical signal control. It is used to discharge the waste liquid in the waste liquid bottle into the waste liquid barrel through the discharge pipe.
[0022] The two-way liquid valve is arranged on the discharge pipe, located between the peristaltic pump and the waste liquid bottle, and is electrically connected to the synthesis module to assist the peristaltic pump in extracting the waste liquid.
[0023] Using this technical solution, the synthesis module sends a start control electrical signal to the peristaltic pump, causing it to pump waste liquid from the waste bottle through the drainage tube and transfer it to the waste liquid bucket. Alternatively, the synthesis module sends a stop control signal to the peristaltic pump, causing it to stop pumping waste liquid. The two-way liquid valve opens or closes synchronously with the peristaltic pump, preventing air leakage from the waste bottle after the drainage process is completed.
[0024] More preferably, the drainage unit further comprises:
[0025] The vacuum tube is arranged on the waste liquid bottle, and its inlet extends into the waste liquid bottle.
[0026] The negative pressure pump is located on one side of the waste liquid bottle and is connected to the outlet of the vacuum tube.
[0027] With the above technical solution, since the vacuum tube, waste liquid bottle, waste liquid tube and synthesizer are connected, when the negative pressure pump is started, the area from the vacuum tube to the synthesizer is in a negative pressure state, ensuring that the drug is successfully synthesized under the negative pressure state.
[0028] Further optimization is that the waste liquid pipe, drain pipe and vacuum pipe are made of polytetrafluoroethylene, and the diameter is 4mm.
[0029] By adopting the above technical solution, waste liquid pipes, drain pipes and vacuum tubes made of polytetrafluoroethylene are selected, which have strong corrosion resistance and can form a sealed connection with the waste liquid bottle to ensure a negative pressure state during the drug synthesis process.
[0030] Further optimization is that both the first liquid level gauge and the second liquid level gauge use non-contact liquid level sensors.
[0031] By adopting the above technical solution, the liquid level in the waste liquid bottle can be accurately measured and an accurate electrical signal can be sent to the synthesis module.
[0032] Further optimization is that the two-way liquid valve uses a two-way solenoid valve.
[0033] By adopting the above technical solution, during the process of discharging the waste liquid, the on-off of the waste liquid can be automatically controlled by the two-way solenoid valve.
[0034] Further optimization is to use high borosilicate glass bottles for waste liquid bottles.
[0035] The above technical solution has excellent sealing performance and strong corrosion resistance.
[0036] Further optimization is that the waste liquid pipe, the drain pipe and the vacuum tube are integrally connected to the bottle mouth of the waste liquid bottle.
[0037] By adopting the above technical solution, the sealing performance between the waste liquid bottle and the waste liquid pipe, the discharge pipe and the vacuum pipe is improved. BRIEF DESCRIPTION OF THE DRAWINGS
[0038] Figure 1 2 is a diagram of the liquid discharge process of this embodiment.
[0039] Figure numerals: 1-synthesis module; 2-peristaltic pump; 3-two-way liquid valve; 4-waste liquid barrel; 5-waste liquid bottle; 6-first liquid level gauge; 7-second liquid level gauge; 8-negative pressure pump; 9-waste liquid pipe; 10-drain pipe; 11-vacuum tube. DETAILED DESCRIPTION
[0040] The following is combined with Figure 1 The utility model is further introduced in detail.
[0041] A radiopharmaceutical waste liquid emptying device, such as Figure 1 Shown, including:
[0042] The collecting unit is arranged in the synthesizer and is sealedly connected to the synthesizer to collect waste liquid generated by the synthesizer.
[0043] The liquid discharge unit is located at one side of the collecting unit and is sealed with the collecting unit for discharging the waste liquid of the collecting unit to the outside of the synthesizer.
[0044] Waste liquid generated within the synthesizer is automatically discharged into the collection unit. The drainage unit automatically drains the liquid by automatically opening and closing the valve. During the entire process, there's no need to open the synthesizer to remove the waste liquid bottle 5, thus avoiding issues like poor sealing and harmful radiation exposure from the box when reinstalling the waste liquid bottle 5. Furthermore, during the entire drainage process, the collection and drainage units maintain a sealed, slightly negative pressure. After the waste liquid is drained, the peristaltic pump is promptly stopped and the two-way valve is closed, ensuring smooth operation of the subsequent synthesis process.
[0045] Specifically, the collection unit in this embodiment includes:
[0046] The waste liquid pipe 9 is provided on the synthesizer, and its inlet is sealedly connected to the synthesis module 1 of the synthesizer.
[0047] The waste liquid bottle 5 is located at one side of the synthesis module 1 , and its bottle mouth is plugged into the outlet of the waste liquid pipe 9 , and the waste liquid pipe 9 extends into the waste liquid bottle 5 .
[0048] The first liquid level gauge 6 is provided on the upper portion of the waste liquid bottle 5 , at the upper limit of the liquid level of the waste liquid bottle 5 , and is electrically connected to the synthesis module 1 , for transmitting a high liquid level alarm signal to the synthesis module 1 .
[0049] The second liquid level gauge 7 is provided at the lower part of the waste liquid bottle 5 , at the lower limit of the liquid level of the waste liquid bottle 5 , and is electrically connected to the synthesis module 1 for transmitting a low liquid level alarm signal to the synthesis module 1 .
[0050] The waste liquid pipe 9 transports the waste liquid generated during the synthesis process to the waste liquid bottle 5. When the liquid level in the waste liquid bottle 5 reaches the upper limit, the first liquid level gauge 6 sends an electrical signal representing a high liquid level alarm to the synthesis module 1, so that the drainage unit can drain the waste liquid in the waste liquid bottle 5. When the liquid level in the waste liquid bottle 5 reaches the lower limit, the second liquid level gauge 7 sends an electrical signal representing a low liquid level alarm to the synthesis module 1, so that the waste liquid bottle 5 can continue to collect waste liquid.
[0051] Specifically, the liquid discharge unit in this embodiment includes:
[0052] The liquid discharge pipe 10 is located at one side of the waste liquid bottle 5 , and its inlet extends into the inner bottom wall of the waste liquid bottle 5 .
[0053] The waste liquid barrel 4 is arranged outside the synthesizer, and the drain pipe 10 is inserted into the waste liquid barrel 4 to collect waste liquid from the waste liquid bottle 5.
[0054] The peristaltic pump 2 is disposed on the drainage tube 10, located between the waste liquid barrel 4 and the waste liquid bottle 5, and is connected to the synthesis module 1 via electrical signal control. It is used to discharge the waste liquid in the waste liquid bottle 5 into the waste liquid barrel 4 via the drainage tube 10. In this embodiment, the peristaltic pump 2 has a flow rate range of 0.008-825.0 mL / min. The peristaltic pump 2 can control the flow rate within this range and can evacuate the waste liquid in the waste liquid bottle 5 in a short period of time.
[0055] The two-way liquid valve 3 is provided on the discharge pipe 10 , located between the peristaltic pump 2 and the waste liquid bottle 5 , and is electrically connected to the synthesis module 1 , for assisting the peristaltic pump 2 in pumping out the waste liquid.
[0056] The synthesis module 1 sends a start control electrical signal to the peristaltic pump 2 to control the peristaltic pump 2 to pump the waste liquid in the waste liquid bottle 5 through the drainage tube 10 and transfer it to the waste liquid barrel 4. Alternatively, the synthesis module 1 sends a stop control signal to the peristaltic pump 2, causing the peristaltic pump 2 to stop pumping the waste liquid. The two-way liquid valve 3 opens or closes synchronously with the peristaltic pump 2 to prevent leakage from the waste liquid bottle 5 after the drainage process is completed, which would cause the synthesizer to fail to achieve the required negative pressure state when synthesizing drugs.
[0057] Specifically, the liquid discharge unit in this embodiment further includes:
[0058] A vacuum tube 11 is mounted on the waste liquid bottle 5, with its inlet extending into the waste liquid bottle 5. A negative pressure pump 8 is located on one side of the waste liquid bottle 5 and connected to the outlet of the vacuum tube 11. Since the vacuum tube 11, waste liquid bottle 5, and waste liquid tube 9 are all connected to the synthesizer, when the negative pressure pump 8 is activated, a negative pressure condition exists between the vacuum tube 11 and the synthesizer, ensuring smooth drug synthesis under negative pressure.
[0059] Specifically, the waste liquid pipe 9, drain pipe 10, and vacuum tube 11 in this embodiment are made of polytetrafluoroethylene and have a diameter of 4 mm. The waste liquid pipe 9, drain pipe 10, and vacuum tube 11 made of polytetrafluoroethylene have strong corrosion resistance and can form a sealed connection with the waste liquid bottle 5, ensuring a negative pressure state during the drug synthesis process.
[0060] Specifically, the first liquid level gauge 6 and the second liquid level gauge 7 in this embodiment are both non-contact liquid level sensors, which can accurately measure the liquid level in the waste liquid bottle 5 and send accurate electrical signals to the synthesis module 1 .
[0061] Specifically, the two-way liquid valve 3 in this embodiment is a two-way solenoid valve. During the process of discharging the waste liquid, the two-way solenoid valve can automatically control the on-off of the waste liquid.
[0062] Specifically, the waste liquid bottle 5 in this embodiment is made of a high borosilicate glass bottle, which has excellent sealing performance and strong corrosion resistance.
[0063] Specifically, the waste liquid pipe 9 , the drain pipe 10 and the vacuum tube 11 in this embodiment are integrally connected to the bottle mouth of the waste liquid bottle 5 , thereby improving the sealing performance between the waste liquid bottle 5 and the waste liquid pipe 9 , the drain pipe 10 and the vacuum tube 11 .
[0064] Please combine Figure 1 The automatic liquid discharge process of this embodiment is described in detail as follows:
[0065] During the synthesis process, the negative pressure pump 8 is activated to provide a slightly negative pressure working environment for the synthesis process, ensuring smooth progress. Waste liquid generated during the synthesis process is collected in the waste liquid bottle 5 via the waste liquid pipe 9. When the liquid level in the waste liquid bottle 5 reaches the upper limit, the first liquid level gauge 6 sends a high liquid level alarm signal to the synthesis module 1. Upon receiving the alarm signal, the synthesis module 1 displays an alarm on the synthesizer. The operator clicks the waste liquid drain button on the synthesizer, which sends an electrical signal indicating activation to the peristaltic pump 2 and the two-way liquid valve 3. The peristaltic pump 2 and the two-way liquid valve 3 open simultaneously, and the waste liquid is discharged into the waste liquid tank 4 through the drain pipe 10.
[0066] When the liquid level in the waste liquid barrel 4 drops to the lower limit, it indicates that the waste liquid bottle 5 has been emptied. The second liquid level meter 7 sends a low liquid level alarm signal to the synthesis module 1 and displays it on the synthesizer. The operator clicks the stop button on the synthesizer, and the synthesis module 1 sends an electrical signal representing stop to the peristaltic pump 2 and the two-way liquid valve 3. The peristaltic pump 2 stops working and the two-way liquid valve 3 is closed to empty the waste liquid in the waste liquid bottle 5.
[0067] In summary, the above process realizes the automatic drainage process inside the synthesizer, avoiding opening the synthesizer to disassemble the waste liquid bottle 5 and manually pouring out the waste liquid. Moreover, the entire drainage process is in a sealed state, which improves the airtightness and avoids the harm of radiation in the box to the human body, thereby achieving the purpose of automatically discharging the waste liquid with the help of the synthesizer.
[0068] This specific embodiment is merely an explanation of the utility model and is not a limitation of the utility model. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed, but as long as they are within the scope of protection of the utility model, they are protected by patent law.
Claims
1. A radiopharmaceutical waste liquid emptying device, characterized in that: include: a collecting unit, disposed in the synthesizer and sealedly connected to the synthesizer, for collecting waste liquid generated by the synthesizer; The liquid discharge unit is located at one side of the collecting unit and is sealed with the collecting unit, and is used for discharging the waste liquid to the outside of the synthesizer through self-opening and closing.
2. The radiopharmaceutical waste liquid emptying device according to claim 1, characterized in that: The collecting unit comprises: A waste liquid pipe (9) is provided on the synthesizer, and its inlet is sealedly connected to the synthesis module (1) of the synthesizer; A waste liquid bottle (5) is located on one side of the synthesis module (1), the bottle mouth of which is plugged into the outlet of the waste liquid pipe (9), and the waste liquid pipe (9) extends into the waste liquid bottle (5); a first liquid level gauge (6), arranged on the upper portion of the waste liquid bottle (5), located at the upper limit of the liquid level of the waste liquid bottle (5), and electrically connected to the synthesis module (1), for transmitting a high liquid level alarm signal to the synthesis module (1); The second liquid level meter (7) is arranged at the lower part of the waste liquid bottle (5), located at the lower limit of the liquid level of the waste liquid bottle (5), and is electrically connected to the synthesis module (1) for transmitting a low liquid level alarm signal to the synthesis module (1).
3. The radiopharmaceutical waste liquid emptying device according to claim 2, characterized in that: The drainage unit comprises: a liquid discharge pipe (10), located on one side of the waste liquid bottle (5), with its inlet extending into the inner bottom wall of the waste liquid bottle (5); A waste liquid barrel (4) is arranged outside the synthesizer, and the drain pipe (10) is inserted into the waste liquid barrel (4) to collect waste liquid from the waste liquid bottle (5); a peristaltic pump (2), arranged on the liquid discharge pipe (10), located between the waste liquid barrel (4) and the waste liquid bottle (5), and connected to the synthesis module (1) via electrical signal control, for discharging the waste liquid in the waste liquid bottle (5) into the waste liquid barrel (4) via the liquid discharge pipe (10); A two-way liquid valve (3) is provided on the liquid discharge pipe (10), located between the peristaltic pump (2) and the waste liquid bottle (5), and is electrically connected to the synthesis module (1) for assisting the peristaltic pump (2) in extracting waste liquid.
4. The radiopharmaceutical waste liquid emptying device according to claim 3, characterized in that: The drainage unit further comprises: a vacuum tube (11), arranged on the waste liquid bottle (5), with its inlet extending into the waste liquid bottle (5); The negative pressure pump (8) is located on one side of the waste liquid bottle (5) and is connected to the outlet of the vacuum tube (11).
5. The radiopharmaceutical waste liquid emptying device according to claim 4, characterized in that: The waste liquid pipe (9), the drain pipe (10) and the vacuum tube (11) are made of polytetrafluoroethylene and have a diameter of 4 mm.
6. The radiopharmaceutical waste liquid emptying device according to claim 2, characterized in that: The first liquid level gauge (6) and the second liquid level gauge (7) both adopt non-contact liquid level sensors.
7. The radiopharmaceutical waste liquid emptying device according to claim 4, characterized in that: The two-way liquid valve (3) is a two-way electromagnetic valve.
8. The radiopharmaceutical waste liquid emptying device according to claim 2, characterized in that: The waste liquid bottle (5) is a borosilicate glass bottle.
9. The radiopharmaceutical waste liquid emptying device according to claim 5, characterized in that: The waste liquid pipe (9), the drain pipe (10), and the vacuum tube (11) are connected to the bottle mouth of the waste liquid bottle (5) in one-piece molding.