Auxiliary sampling device of liquid chromatography-mass spectrometer

Abstract

The utility model relates to the technical field of sampling devices, in particular to a liquid chromatography-mass spectrometer auxiliary sampling device which comprises a bottom plate, a stirring outer bin is fixedly connected to the top of the bottom plate, a stirring barrel is detachably connected to the inner side wall of the stirring outer bin, a water pump is fixedly connected to the top of the bottom plate, and the water pump is communicated with the stirring outer bin. The output end of the water pump is fixedly connected with a liquid storage tank, the bottom of the liquid storage tank is fixedly connected with the top of the bottom plate, the top of the stirring outer bin is detachably connected with a sealing cover, the top of the sealing cover is fixedly connected with a motor, and the output end of the motor is fixedly connected with a rotating shaft. By arranging the sealing cover, the stirring barrel is automatically locked while the sealing cover is installed at the top of the stirring outer bin, the purpose of convenience is achieved, when the stirring barrel needs to be disassembled and cleaned through the arranged reset assembly, only the sealing plate needs to be disassembled, the limiting block is automatically separated from the limiting hole under the action of the reset assembly, and the stirring barrel is automatically locked. Therefore, the technical problem of convenience is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of sampling devices, in particular to a liquid chromatography-mass spectrometer auxiliary sampling device. Background Art

[0002] Liquid chromatography-mass spectrometry (HPLC-MS) is mainly used in drug metabolism and pharmacokinetic research, clinical pharmacology research, natural medicine (Chinese herbal medicine, etc.) development research, neonatal screening, protein and peptide identification, residue analysis, toxicology analysis, environmental analysis, environmental protection, food, tap water, health and epidemic prevention and other industries; Liquid chromatography-mass spectrometry (HPLC-MS), also known as liquid chromatography-mass spectrometry technology, uses liquid chromatography as the separation system and mass spectrometry as the detection system.

[0003] For example, the patent with announcement number CN217443267U discloses an automatic sampling device for liquid chromatography-mass spectrometry, including a base, a stirring outer chamber is fixed on the upper surface of the base, a pipe connector is installed below the stirring outer chamber, a delivery pipe is installed on the pipe connector, a water pump is installed on the delivery pipe, a liquid storage tank is fixedly installed on one side of the stirring outer chamber on the upper surface of the base, fixed legs are fixedly installed at the four corners of the lower surface of the mounting base, a sealing cover is fixedly installed on the stirring outer chamber, a motor is fixedly installed on the sealing cover, a stirring rod is fixedly installed on the output end of the motor, a mounting notch is provided in the stirring outer chamber, a stirring barrel is installed in the mounting notch, and a liquid outlet is fixedly installed at the bottom of the stirring barrel.

[0004] Through the above configuration, the automatic sample injection device for liquid chromatography-mass spectrometry described in the utility model of the prior art belongs to the field of sample injection devices and can conveniently and quickly remove the stirring barrel for cleaning. However, the automatic sample injection device of the prior art solution has the following defects during operation:

[0005] When in use, the above-mentioned device needs to use external tools to fix the mixing barrel to the inner wall of the mixing outer chamber with screws, and the mixing barrel needs to be cleaned after use, which requires the staff to disassemble the mixing barrel back and forth with the help of external tools. The operation is relatively cumbersome, further increasing the workload of the staff, and the sampling efficiency is low. Utility Model Content

[0006] The utility model aims to provide an auxiliary sample injection device for a liquid chromatography-mass spectrometer, which is mainly used to solve the technical problem in the prior art that the disassembly work of a stirring barrel is relatively slow.

[0007] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0008] The top of the stirring outer bin is fixedly connected to the stirring outer bin, the inner side wall of the stirring outer bin is detachably connected to the stirring barrel, the top of the bottom plate is fixedly connected to a water pump, and the water pump is communicated with the stirring outer bin, the output end of the water pump is fixedly connected to a liquid storage tank, the bottom of the liquid storage tank is fixedly connected to the top of the bottom plate, the top of the stirring outer bin is detachably connected to a sealing cover, the top of the sealing cover is fixedly connected to a motor, the output end of the motor is fixedly connected to a rotating shaft, the side wall of the rotating shaft is fixedly connected to a stirring rod, the bottom at the edge of the stirring barrel is fixedly connected to a connecting block, the side wall of the connecting block is provided with a limiting hole, the inner side wall of the stirring outer bin is provided with a connecting groove at the connecting block, the side wall of the connecting groove is provided with a rectangular through hole, the inner side wall of the rectangular through hole is slidably connected to the limiting block, the top of the stirring outer bin is provided with a rectangular groove, the lower side wall of the rectangular groove is provided with a sliding component, and the outer side wall of the limit block is fixedly connected with a reset component.

[0009] The working principle and beneficial effects of this utility model:

[0010] 1. Working principle: When using this device, first align the connecting block at the edge of the mixing barrel with the connecting groove, then install the mixing barrel on the inner wall of the mixing outer bin, pour the required solution into the interior of the mixing barrel, and then connect the sealing cover to the top of the mixing outer bin. In this process, the sealing cover hits the sliding component, and the sliding component hits the limit block, so that the limit block moves along the inner wall of the rectangular through hole toward the limit hole. In this process, the reset component is squeezed until the limit block is inserted into the inside of the limit hole, thereby fixing the mixing barrel. Then start the motor and use the rotating shaft to drive the stirring rod to rotate, thereby stirring the solution inside the mixing barrel. Finally, the mixed solution can be pumped into the liquid storage tank by the water pump to complete the sampling work.

[0011] 2.Beneficial effects:

[0012] The prior art solves the technical problem that the mixing barrel can be taken out and cleaned conveniently and quickly by setting fixing screws. However, the prior art has the technical problem that the disassembly of the mixing barrel is relatively slow. The present solution uses a sliding assembly to automatically lock the mixing barrel when the sealing cover is installed on the top of the mixing outer bin, thereby achieving the purpose of convenience. The reset assembly is set so that when the mixing barrel needs to be disassembled for cleaning, only the sealing plate needs to be removed. Under the action of the reset assembly, the limit block automatically disengages from the limit hole, thereby achieving the technical problem of convenience.

[0013] Preferably: the sliding assembly includes a rectangular slide groove provided on the lower side wall of the rectangular groove, an installation groove is provided inside the mixing outer bin, and the rectangular slide groove is connected to the installation groove, the inner side wall of the rectangular slide groove is slidably connected to a connecting rod, the top of the connecting rod is fixedly connected to a resistance plate, and the lower end of the connecting rod is in resistance with the end of the limit block. When the mixing barrel needs to be fixed, it is only necessary to install the sealing cover to the top of the mixing outer bin. In this process, the resistance plate is pushed by the bottom of the sealing cover to make the connecting rod move downward along the inner side wall of the rectangular slide groove, and then the lower end of the connecting rod is in resistance with the limit block, so that the limit block moves along the inner side wall of the rectangular through hole toward the direction of the limit hole until the limit block is inserted into the inside of the limit hole, thereby quickly achieving the fixing of the mixing barrel.

[0014] Preferably: a second spring is sleeved on the outer wall of the connecting rod, the upper end of the second spring is fixedly connected to the top of the resistance plate, and the lower end of the second spring is fixedly connected to the lower side wall of the rectangular groove. The second spring is compressed during the process of the resistance plate sliding downward along the inner side wall of the rectangular groove. When the mixing barrel needs to be disassembled, the sealing cover is opened, and the resistance plate automatically resets under the action of the compressed second spring, thereby releasing the resistance of the connecting rod to the limit block.

[0015] Preferably, one end of the limiting block close to the connecting rod is provided with a mask structure, so that when the connecting rod contacts the limiting block, the inclined surface structure at the end of the limiting block can slide along the inner wall of the rectangular through hole.

[0016] Preferably: the reset assembly includes a connecting ring fixedly connected to the outer wall of the limit block, the outer wall of the limit block is sleeved with a first spring, one end of the first spring is fixedly connected to the connecting ring, and the other end of the first spring is fixedly connected to the inner wall of the mounting groove. When the connecting rod contacts the limit block, the limit block slides along the inner wall of the rectangular through hole toward the limit hole, and the connecting ring slides along the inner wall of the mounting groove. At this time, the first spring is compressed. When the connecting rod does not contact the limit block, the limit block automatically detaches from the inside of the limit hole under the action of the compressed first spring, so that the mixing barrel can be quickly removed for cleaning.

[0017] Preferably, the number of the connecting rods, the limiting blocks and the connecting blocks are four and they are equidistantly distributed around the mixing barrel, thereby increasing the stability of fixing the mixing barrel.

[0018] Preferably: the contact plate is adapted to the rectangular groove, and the contact plate can be flush with the top of the stirring outer bin. When the sealing cover is installed on the top of the stirring outer bin, the contact block is located inside the rectangular groove to prevent the contact block from causing a gap between the sealing plate and the stirring outer bin. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the three-dimensional structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the internal structure of the mixing outer bin of the utility model;

[0021] Figure 3 This is a schematic structural diagram of the rectangular groove, rectangular slide groove and installation groove of the utility model;

[0022] Figure 4 This is a structural diagram of the limit block, connecting block and limit hole of the utility model.

[0023] The figure marks in the drawings of the specification include: 1. motor; 2. sealing cover; 3. outer mixing chamber; 4. bottom plate; 5. water pump; 6. liquid storage tank; 7. resistance plate; 8. connecting rod; 9. mixing barrel; 10. rotating shaft; 11. stirring rod; 12. connecting block; 13. limiting block; 14. rectangular groove; 15. rectangular slide; 16. mounting groove; 17. rectangular through hole; 18. first spring; 19. connecting groove; 20. limiting hole; 21. second spring; 22. connecting ring. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0025] like Figure 1-4As shown, an auxiliary sampling device for liquid chromatography-mass spectrometry spectrometer includes a bottom plate 4, the top of the bottom plate 4 is fixedly connected to a stirring outer chamber 3, the inner side wall of the stirring outer chamber 3 is detachably connected to a stirring barrel 9, the top of the bottom plate 4 is fixedly connected to a water pump 5, and the water pump 5 is communicated with the stirring outer chamber 3, the output end of the water pump 5 is fixedly connected to a liquid storage tank 6, the bottom of the liquid storage tank 6 is fixedly connected to the top of the bottom plate 4, the top of the stirring outer chamber 3 is detachably connected to a sealing cover 2, the top of the sealing cover 2 is fixedly connected to a motor 1, the output end of the motor 1 is fixedly connected to a rotating shaft 10, the side wall of the rotating shaft 10 is fixedly connected to a stirring rod 11, the bottom of the edge of the stirring barrel 9 is fixedly connected to a connecting block 12, the connecting block 12 A limiting hole 20 is provided on the side wall of the mixing outer bin 3, a connecting groove 19 is provided on the inner wall of the mixing outer bin 3 and located at the connecting block 12, a rectangular through hole 17 is provided on the side wall of the connecting groove 19, and the inner wall of the rectangular through hole 17 is slidably connected to the limiting block 13, a rectangular groove 14 is provided on the top of the mixing outer bin 3, and a sliding component is provided on the lower side wall of the rectangular groove 14, and the sliding component includes a rectangular chute 15 provided on the lower side wall of the rectangular groove 14, a mounting groove 16 is provided inside the mixing outer bin 3, and the rectangular chute 15 is connected to the mounting groove 16, and the inner side wall of the rectangular chute 15 is slidably connected to a connecting rod 8, and the top of the connecting rod 8 is fixedly connected to the contact plate 7, and the lower end of the connecting rod 8 is fixed to the limiting block 1 3, the end of the sealing cover 2 is in contact with the top of the mixing outer chamber 3. In this process, the contact plate 7 is pushed by the bottom of the sealing cover 2. When the contact plate 7 slides downward along the inner wall of the rectangular groove 14, the second spring 21 is compressed, causing the connecting rod 8 to move downward along the inner wall of the rectangular slide 15, and then the lower end of the connecting rod 8 is in contact with the limit block 13, so that the limit block 13 moves along the inner wall of the rectangular through hole 17 toward the limit hole 20 until the limit block 13 is inserted into the inside of the limit hole 20, thereby quickly achieving the fixing of the mixing barrel 9. The outer wall of the limit block 13 is fixedly connected to the reset component, which includes a reset component fixedly connected to the outer wall of the limit block 13 The connecting ring 22 of the side wall and the outer wall of the limit block 13 are sleeved with a first spring 18, one end of the first spring 18 is fixedly connected to the connecting ring 22, and the other end of the first spring 18 is fixedly connected to the inner wall of the mounting groove 16. When the limit block 13 moves along the inner wall of the rectangular through hole 17 toward the limit hole 20, the connecting ring 22 slides along the inner wall of the mounting groove 16 during this process. At this time, the first spring 18 is compressed until the limit block 13 is inserted into the inside of the limit hole 20. When the connecting rod 8 does not resist the limit block 13, the limit block 13 automatically disengages from the inside of the limit hole 20 under the action of the compressed first spring 18, and the mixing barrel 9 can be quickly removed for cleaning.

[0026] From the above, it can be seen that the specific implementation of the present utility model is as follows:

[0027] When the device is in use, first align the connecting block 12 at the edge of the stirring barrel 9 with the connecting groove 19, then install the stirring barrel 9 on the inner wall of the stirring outer chamber 3, pour the solution into the interior of the stirring barrel 9, and then connect the sealing cover 2 with the top of the stirring outer chamber 3. In this process, the bottom of the sealing cover 2 pushes the contact plate 7. When the contact plate 7 slides downward along the inner wall of the rectangular groove 14, the second spring 21 is compressed, causing the connecting rod 8 to move downward along the inner wall of the rectangular slide 15, and then the lower end of the connecting rod 8 contacts the limit block 13, causing the limit block 13 to move along the inner wall of the rectangular through hole 17 toward the limit hole 20. In this process, the connecting ring 22 slides along the inner wall of the installation groove 16, and the first spring 18 is compressed. Compress until the limit block 13 is inserted into the inside of the limit hole 20, thereby quickly fixing the mixing barrel 9, and then start the motor 1, use the rotating shaft 10 to drive the stirring rod 11 to rotate, so as to stir the solution inside the mixing barrel 9. Finally, the mixed solution can be pumped into the liquid storage tank 6 by the water pump 5 to complete the sampling work. When the mixing barrel 9 needs to be cleaned, it is only necessary to open the sealing cover 2. Under the action of the compressed second spring 21, the resistance plate 7 automatically resets, thereby releasing the resistance of the connecting rod 8 to the limit block 13. When the connecting rod 8 does not resist the limit block 13, the limit block 13 automatically disengages from the inside of the limit hole 20 under the action of the compressed first spring 18, and the mixing barrel 9 can be quickly removed for cleaning.

[0028] The above is only an embodiment of the present invention, and the commonly known specific structures and characteristics of the scheme are not described in detail here. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the structure of the present invention, and these should also be regarded as the scope of protection of the present invention. These will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection claimed by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A liquid chromatography-mass spectrometer auxiliary sampling device, comprising a bottom plate (4), the top of the bottom plate (4) is fixedly connected to a stirring outer chamber (3), the inner side wall of the stirring outer chamber (3) is detachably connected to a stirring barrel (9), the top of the bottom plate (4) is fixedly connected to a water pump (5), and the water pump (5) is communicated with the stirring outer chamber (3), the output end of the water pump (5) is fixedly connected to a liquid storage tank (6), the bottom of the liquid storage tank (6) is fixedly connected to the top of the bottom plate (4), the top of the stirring outer chamber (3) is detachably connected to a sealing cover (2), the top of the sealing cover (2) is fixedly connected to a motor (1), the output end of the motor (1) is fixedly connected to a rotating shaft (10), and the side wall of the rotating shaft (10) is fixedly connected to a stirring rod (11), characterized in that The bottom of the edge of the mixing barrel (9) is fixedly connected with a connecting block (12), the side wall of the connecting block (12) is provided with a limiting hole (20), the inner side wall of the mixing outer chamber (3) is provided with a connecting groove (19) at the connecting block (12), the side wall of the connecting groove (19) is provided with a rectangular through hole (17), the inner side wall of the rectangular through hole (17) is slidably connected to the limiting block (13), the top of the mixing outer chamber (3) is provided with a rectangular groove (14), the lower side wall of the rectangular groove (14) is provided with a sliding component, and the outer side wall of the limiting block (13) is fixedly connected with a reset component.

2. The liquid chromatography-mass spectrometer auxiliary injection device according to claim 1, characterized in that: The sliding assembly includes a rectangular chute (15) provided on the lower side wall of the rectangular groove (14); a mounting groove (16) is provided inside the mixing outer bin (3); the rectangular chute (15) is connected to the mounting groove (16); a connecting rod (8) is slidably connected to the inner side wall of the rectangular chute (15); a contact plate (7) is fixedly connected to the top of the connecting rod (8); and the lower end of the connecting rod (8) contacts the end of the limit block (13).

3. The liquid chromatography-mass spectrometer auxiliary injection device according to claim 2, characterized in that: The outer side wall of the connecting rod (8) is sleeved with a second spring (21), the upper end of the second spring (21) is fixedly connected to the top of the contact plate (7), and the lower end of the second spring (21) is fixedly connected to the lower side wall of the rectangular groove (14).

4. The liquid chromatography-mass spectrometer auxiliary injection device according to claim 2, characterized in that: The end of the limiting block (13) close to the connecting rod (8) is provided with a mask structure.

5. The liquid chromatography-mass spectrometer auxiliary sample injection device according to claim 4, characterized in that: The reset assembly includes a connecting ring (22) fixedly connected to the outer wall of the limit block (13); the outer wall of the limit block (13) is sleeved with a first spring (18); one end of the first spring (18) is fixedly connected to the connecting ring (22); and the other end of the first spring (18) is fixedly connected to the inner wall of the mounting groove (16).

6. The liquid chromatography-mass spectrometer auxiliary sample injection device according to claim 1, characterized in that: The number of the connecting rods (8), the limiting blocks (13) and the connecting blocks (12) is four and they are distributed equidistantly around the mixing barrel (9).

7. The liquid chromatography-mass spectrometer auxiliary injection device according to claim 2, characterized in that: The abutment plate (7) is adapted to the rectangular groove (14), and the abutment plate (7) can be flush with the top of the stirring outer bin (3).

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