Norepinephrine bitartrate purification device

Abstract

The utility model belongs to the technical field of chemical production equipment, and discloses a norepinephrine bitartrate purifying device which comprises a dissolving tank, a microfiltration membrane filtering device, a crystallizing tank, a centrifugal machine, a washing tank and a drying machine which are sequentially communicated through pipelines and valves, a discharge port of the dissolving tank is communicated with a feed port of the microfiltration membrane filtering device, the microfiltration membrane filtering device is provided with a solid material outlet and a liquid material outlet, the liquid material outlet of the microfiltration membrane filtering device is communicated with a feed port of the crystallizing tank, a discharge port of the crystallizing tank is communicated with a feed port of the centrifugal machine, and the centrifugal machine is provided with a liquid material outlet and a solid material outlet. A solid material outlet of the centrifugal machine is communicated with a feeding hole of the washing tank, the washing tank is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the washing tank is respectively communicated with feeding holes of the drying machine, the dissolving tank and the crystallizing tank. The device is simple in structure and good in purification effect, and the obtained product is good in quality.

Description

Technical Field

[0001] The utility model belongs to the technical field of chemical production equipment, and particularly relates to a norepinephrine bitartrate purification device. Background Art

[0002] Norepinephrine bitartrate is often used to treat hypotension caused by acute myocardial infarction, extracorporeal circulation or pheochromocytoma resection; as an auxiliary treatment for replenishing blood volume during emergency treatment; it can also be used to maintain hypotension during intrathecal blockade and blood pressure after cardiac arrest resuscitation.

[0003] There are multiple existing synthetic routes for norepinephrine bitartrate, but most of the resulting products are of low purity (high isomer content), and the crude product needs to be further processed to obtain a product that meets quality standards. However, the existing purification process is cumbersome, requires a large amount of solvent, results in a large amount of waste, and makes subsequent processing difficult. Therefore, improvements to the purification process and equipment are needed. Summary of the Invention

[0004] The technical problem to be solved by the utility model is to provide a norepinephrine bitartrate purification device, which overcomes the defects of the prior art, has a simple structure, good purification effect and good product quality.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A noradrenaline bitartrate purification device comprises a dissolving tank, a microporous membrane filtration device, a crystallizing tank, a centrifuge, a washing tank, and a dryer, which are sequentially connected via pipelines and valves; the discharge port of the dissolving tank is connected to the feed port of the microporous membrane filtration device; the microporous membrane filtration device is provided with a solid material outlet and a liquid material outlet, the liquid material outlet of the microporous membrane filtration device is connected to the feed port of the crystallizing tank, and the discharge port of the crystallizing tank is connected to the feed port of the centrifuge; the centrifuge is provided with a liquid material outlet and a solid material outlet, the solid material outlet of the centrifuge is connected to the feed port of the washing tank; the washing tank is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the washing tank is respectively connected to the feed ports of the dryer, the dissolving tank, and the crystallizing tank.

[0007] Preferably, the dissolving tank is provided with a temperature-control jacket and a stirring device; the dissolving tank is also provided with a solid material (crude product and activated carbon) inlet, a liquid material (solvent water or methanol) inlet and a discharge port.

[0008] Preferably, the microporous membrane in the microporous membrane filtration device is a cellulose ester microporous membrane with a pore size range of 0.3 to 0.6 μm.

[0009] Preferably, the solid material outlet of the microporous membrane filtration device is connected to an activated carbon collection tank to collect and temporarily store the waste activated carbon.

[0010] Preferably, the crystallization tank is provided with a temperature control jacket and a stirring device.

[0011] Preferably, the liquid outlets of the centrifuge and the washing tank are both connected to a waste solvent collection tank.

[0012] Preferably, the centrifuge is a horizontal spiral filter centrifuge, model P-500, provided by Zhejiang Light Machinery Industry Co., Ltd.

[0013] Preferably, the dryer is a fluidized bed dryer; the model is ZLG7.5×0.60, and the manufacturer is Changzhou Changqun Drying Equipment Co., Ltd.

[0014] Preferably, the dryer is connected to a finished product storage tank to temporarily store the qualified products after drying.

[0015] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0016] The utility model first dissolves the material in a dissolving tank under the action of a solvent (water or lower alcohol), then adds activated carbon, heats up and stirs to decolorize, separates the decolorized material through a microporous membrane filtration device, and the obtained filtrate enters a crystallization tank for cooling and crystallization, then transports the material to a centrifuge for centrifugation, separates the uncrystallized isomers and the solvent in the material, washes the crystals with a solvent and then tests, if the chroma is unqualified, the crystals are returned to the dissolving tank for re-purification, if the chroma is qualified but the purity is unqualified, the crystals are returned to the crystallization tank for re-crystallization until a qualified product is obtained, and is dried and stored.

[0017] In short, the utility model has a simple structure, good purification effect, and the obtained product is of good quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a structural diagram of the first embodiment of the present utility model;

[0019] In the figure, 1. dissolution tank; 2. microporous membrane filtration device; 3. crystallization tank; 4. centrifuge; 5. washing tank; 6. dryer; 7. activated carbon collection tank; 8. waste solvent collection tank. DETAILED DESCRIPTION

[0020] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0021] Example 1:

[0022] like Figure 1As shown, a noradrenaline bitartrate purification device comprises a dissolving tank 1, a microporous membrane filter 2, a crystallizer 3, a centrifuge 4, a washing tank 5 and a dryer 6 which are sequentially connected through a pipeline (not shown) and a valve (not shown); the discharge port of the dissolving tank 1 is connected to the feed port of the microporous membrane filter 2; the microporous membrane filter 2 is provided with a solid material outlet (not shown) and a liquid material outlet (not shown), the liquid material outlet of the microporous membrane filter 2 is connected to the feed port of the crystallizer 3, and the discharge port of the crystallizer 3 is connected to the feed port of the centrifuge 4; the centrifuge 4 is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the centrifuge 4 is connected to the feed port of the washing tank 5; the washing tank 5 is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the washing tank 5 is respectively connected to the feed ports of the dryer 6, the dissolving tank 1 and the crystallizer 3.

[0023] The solid material outlet of the microporous membrane filtration device 2 is connected to the activated carbon collection tank 7; the liquid material outlets of the centrifuge 4 and the washing tank 5 are both connected to the waste solvent collection tank 8.

[0024] In actual production, the crude product (100 kg) prepared in the previous process is first transported to the dissolution tank 1, and the solvent (taking water as an example, 80 kg is added), heated to 60 ° C and stirred until the crude product is dissolved, and then 2.5 kg of activated carbon is added to keep warm and stir for decolorization for half an hour. The material is transported to the microporous membrane filtration device 2 for filtration while hot, and the obtained filter residue is transported to the activated carbon collection tank 7 for temporary storage and centralized processing; the obtained filtrate is transported to the crystallization tank 3, stirred and cooled first, and when the temperature drops to 0-5 ° C, the stirring is stopped and the crystallization is started. Crystallization, the crystallization time is 1 to 3 hours. After the crystallization is completed, the material is transported to the centrifuge 4 for separation, the solvent and isomers are separated and transported to the waste solvent collection tank 8, and then the crystals are transported to the washing tank 5, 50 kg of solvent is added for washing, and the crystals are tested after washing twice. If the color is unqualified, the crystals are returned to the dissolution tank 1 for re-purification. If the color is qualified but the purity is unqualified, the crystals are returned to the crystallization tank 3 for re-crystallization until a qualified product is obtained. The qualified product is dried by the dryer 6 and stored.

[0025] It should be understood that these embodiments are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the contents of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of this application.

Claims

1. A norepinephrine bitartrate purification device, characterized in that: The invention comprises a dissolving tank, a microporous membrane filtration device, a crystallization tank, a centrifuge, a washing tank and a dryer which are sequentially connected through pipelines and valves; the discharge port of the dissolving tank is connected to the feed port of the microporous membrane filtration device; the microporous membrane filtration device is provided with a solid material outlet and a liquid material outlet, the liquid material outlet of the microporous membrane filtration device is connected to the feed port of the crystallization tank, and the discharge port of the crystallization tank is connected to the feed port of the centrifuge; the centrifuge is provided with a liquid material outlet and a solid material outlet, the solid material outlet of the centrifuge is connected to the feed port of the washing tank; the washing tank is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the washing tank is respectively connected to the feed ports of the dryer, the dissolving tank and the crystallization tank.

2. The norepinephrine bitartrate purification device according to claim 1, wherein: The dissolving tank is provided with a temperature control jacket and a stirring device.

3. The norepinephrine bitartrate purification device according to claim 1, wherein: The microporous membrane in the microporous membrane filtration device is a cellulose ester microporous membrane with a pore size range of 0.3 to 0.6 μm.

4. The norepinephrine bitartrate purification device according to claim 1, wherein: The solid material outlet of the microporous membrane filtration device is connected to the activated carbon collection tank.

5. The norepinephrine bitartrate purification device according to claim 1, wherein: The crystallization tank is provided with a temperature control jacket and a stirring device.

6. The norepinephrine bitartrate purification device according to claim 1, wherein: The liquid material outlets of the centrifuge and the washing tank are both connected to the waste solvent collection tank.

7. The norepinephrine bitartrate purification device according to claim 1, wherein: The centrifuge is a horizontal spiral filtering centrifuge.

8. The norepinephrine bitartrate purification device according to claim 1, wherein: The dryer is a fluidized bed dryer, and the dryer is connected to a finished product storage tank.

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