Norepinephrine bitartrate mother liquor recycling device

Abstract

The utility model belongs to the technical field of chemical production equipment, and discloses a norepinephrine bitartrate mother liquor recycling device which comprises a mother liquor storage tank, a concentration device, a splitting kettle, a crystallization kettle, a centrifugal machine, a washing tank and a drying machine which are communicated in sequence, a discharge port of the mother liquor storage tank is communicated with a feed port of the concentration device; the concentration device is provided with a steam outlet and a concentrated material outlet, and the concentrated material outlet is communicated with the feeding hole of the splitting kettle; the splitting kettle is provided with a solid material outlet and a liquid material outlet, the liquid material outlet is communicated to a feed port of the crystallization kettle, and a discharge port of the crystallization kettle is connected to a feed port of the centrifugal machine; the centrifugal machine is provided with a residual liquid outlet and a solid material outlet, the residual liquid outlet is communicated to a feeding hole of the concentration device, and the solid material outlet is communicated to a feeding hole of the washing tank; the washing tank is provided with a liquid material outlet and a solid material outlet, and the solid material outlet is respectively communicated with the drying machine and the feeding hole of the crystallization kettle. According to the device, the mother liquor recycling effect is good, the yield of a product is increased, and the discharge of waste liquor is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of chemical production equipment, and particularly relates to a norepinephrine bitartrate mother liquor recovery and utilization device. Background Art

[0002] Norepinephrine bitartrate is often used to treat hypotension caused by acute myocardial infarction, extracorporeal circulation or pheochromocytoma resection; as an auxiliary treatment for replenishing blood volume during emergency treatment; it can also be used to maintain hypotension during intrathecal blockade and blood pressure after cardiac arrest resuscitation.

[0003] There are several existing synthetic routes for noradrenaline bitartrate. A common production method involves salting tartaric acid with racemic noradrenaline, then separating the R-type noradrenaline by controlling the crystallization temperature in the presence of a solvent. While this method is simple and efficient, it produces a crystallization mother liquor containing isomers and some uncrystallized noradrenaline bitartrate. Directly discharging this mother liquor without treating and utilizing it can firstly complicate wastewater treatment and impact the environment, and secondly, reduce product yield, leading to increased production costs. Therefore, recycling this mother liquor is particularly important. Summary of the Invention

[0004] The technical problem to be solved by the utility model is to provide a norepinephrine bitartrate mother liquor recycling device, which has good mother liquor recycling effect, increases product yield, reduces waste liquid discharge, and has good economic and social benefits.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A device for recycling and utilizing noradrenaline bitartrate mother liquor comprises a mother liquor storage tank, a concentrator, a split kettle, a crystallizer, a centrifuge, a washing tank, and a dryer, which are sequentially connected via pipelines and valves; the discharge port of the mother liquor storage tank is connected to the feed port of the concentrator; the concentrator is provided with a steam outlet and a concentrated material outlet, which are connected to the feed port of the split kettle; the split kettle is provided with a solid material outlet and a liquid material outlet, which are connected to the feed port of the crystallizer, and the discharge port of the crystallizer is connected to the feed port of the centrifuge; the centrifuge is provided with a residual liquid outlet and a solid material outlet, which are connected to the feed port of the concentrator, and the solid material outlet is connected to the feed port of the washing tank; the washing tank is provided with a liquid material outlet and a solid material outlet, which are respectively connected to the feed ports of the dryer and the crystallizer.

[0007] Preferably, the concentration device comprises a low-temperature vacuum distillation kettle and a vacuum unit; the steam outlet of the concentration device is connected to the exhaust gas treatment device through a pipeline and a vacuum pump.

[0008] The low-temperature, reduced-pressure distillation kettle comprises a distillation kettle provided with an interlayer, a cooling coil is provided in the interlayer of the distillation kettle, and the cooling coil is connected to an external cooling system; a motor is provided on the top of the distillation kettle, and a stirring rod is movably connected to the lower part of the motor, the stirring rod is built into the cavity of the distillation kettle, and its lower end extends to the bottom of the distillation kettle, and is provided with a stirring paddle, one end of the stirring paddle is fixedly connected to the stirring rod, and the other end is connected to a side wall scraper; a tank bottom scraper is provided at the bottom port of the stirring rod; a temperature probe and a pressure probe are also provided on the inner wall of the distillation kettle tank, a temperature display and a pressure display are provided on the top of the distillation kettle, and the top of the distillation kettle is also connected to a vacuum unit and an exhaust gas treatment device through a pipeline.

[0009] The vacuum unit system includes a vacuum buffer tank, a cold trap buffer tank, a water circulation vacuum pump, an oil circulation vacuum pump and a three-stage Roots vacuum pump.

[0010] Preferably, the split kettle is equipped with a temperature control jacket and a stirring device. The solid material outlet of the split kettle is connected to an isomer collection tank.

[0011] Preferably, the crystallization kettle is provided with a temperature control jacket and a stirring device.

[0012] Preferably, the liquid outlet of the washing tank is connected to a waste liquid collection tank.

[0013] Preferably, the centrifuge is a horizontal spiral filter centrifuge, model P-500, provided by Zhejiang Light Machinery Industry Co., Ltd.

[0014] Preferably, the dryer is a fluidized bed dryer; the model is ZLG7.5×0.60, and the manufacturer is Changzhou Changqun Drying Equipment Co., Ltd.

[0015] Preferably, the drying machine is connected to a finished product storage tank to temporarily store the qualified products after drying.

[0016] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0017] The utility model first concentrates the mother liquor obtained in the previous process through a concentration device, and then decomposes the concentrated mother liquor with 75% ethanol, and the isomers therein are precipitated because they are insoluble, and the solution is transported to a crystallization kettle for cooling and crystallization, and then the material is transported to a centrifuge for centrifugation to obtain mother liquor and crystals, and the mother liquor is returned to the concentration device for further processing, and the crystals are washed with a solvent and then tested. If the purity is still unqualified (high isomer content), the crystals are returned to the crystallization kettle for recrystallization until a qualified product is obtained, and then dried and stored.

[0018] In short, the utility model has good mother liquor recycling effect, increases product yield, reduces waste liquid discharge, and has good economic and social benefits. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a structural diagram of the first embodiment of the present utility model;

[0020] In the figure, 1. mother liquor storage tank; 2. concentration device; 3. splitting kettle; 4. crystallization kettle; 5. centrifuge; 6. washing tank; 7. dryer; 8. isomer collection tank; 9. waste liquid collection tank. DETAILED DESCRIPTION

[0021] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0022] Example 1:

[0023] like Figure 1 As shown, a noradrenaline bitartrate mother liquor recovery and utilization device comprises a mother liquor storage tank 1, a concentrator 2, a split kettle 3, a crystallization kettle 4, a centrifuge 5, a washing tank 6 and a dryer 7 which are sequentially connected through a pipeline (not shown) and a valve (not shown); the discharge port of the mother liquor storage tank 1 is connected to the feed port of the concentrator 2; the concentrator 2 is provided with a steam outlet (not shown) and a concentrated material outlet (not shown), and the concentrated material outlet is connected to the feed port of the split kettle 3; the split kettle 3 is provided with a steam outlet (not shown) and a concentrated material outlet (not shown), and the concentrated material outlet is connected to the feed port of the split kettle 3; There is a solid material outlet (not marked) and a liquid material outlet (not marked). The liquid material outlet of the splitting kettle 3 is connected to the feed port of the crystallization kettle 4, and the discharge port of the crystallization kettle 4 is connected to the feed port of the centrifuge 5; the centrifuge 5 is provided with a residual liquid outlet (not marked) and a solid material outlet. The residual liquid outlet is connected to the feed port of the concentrator 2, and the solid material outlet is connected to the feed port of the washing tank 6; the washing tank 6 is provided with a liquid material outlet and a solid material outlet. The solid material outlet of the washing tank 6 is respectively connected to the feed port of the dryer 7 and the crystallization kettle 4.

[0024] The solid material outlet of the splitting kettle 3 is connected to the isomer collecting tank 8, and the liquid material outlet of the washing tank 6 is connected to the waste liquid collecting tank 9.

[0025] In actual production, the mother liquor obtained in the previous process is first transported from the mother liquor storage tank 1 to the concentrating device 2 for low-temperature vacuum concentration. When the mother liquor is concentrated to solid precipitation, the concentration is stopped and the concentrated mother liquor is transferred to the splitting kettle 3, and 75% of the weight of the mother liquor after four times of concentration is added to stir and mix. The isomers are split at 30°C, and the isomers are precipitated as solids. After splitting for one hour, the split reaction solution is transported to the crystallization kettle 4, stirred and cooled. When the temperature drops to 0-5°C, stirring is stopped and crystallization is started. The crystallization time is 1-3 hours. After crystallization is completed, the material is transported to the centrifuge 5 for separation, and the residual liquid is separated and transported to the concentrating device 2 for further processing. The crystals are then transported to the washing tank 6, and water of one times the weight of the crystals is added for washing. After washing twice, the crystals are tested. If the purity is unqualified, the crystals are returned to the crystallization kettle 4, water of one times the weight of the crystals is added for dissolution and recrystallization is performed until a qualified product is obtained. The qualified product is dried in a drying machine 7 and stored.

[0026] It should be understood that these embodiments are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the contents of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of this application.

Claims

1. A norepinephrine bitartrate mother liquor recycling device, characterized in that: The invention comprises a mother liquor storage tank, a concentrating device, a split kettle, a crystallizing kettle, a centrifuge, a washing tank and a dryer which are sequentially connected through pipelines and valves; the discharge port of the mother liquor storage tank is connected to the feed port of the concentrating device; the concentrating device is provided with a steam outlet and a concentrated material outlet, and the concentrated material outlet is connected to the feed port of the split kettle; the split kettle is provided with a solid material outlet and a liquid material outlet, the liquid material outlet of the split kettle is connected to the feed port of the crystallizing kettle, and the discharge port of the crystallizing kettle is connected to the feed port of the centrifuge; the centrifuge is provided with a residual liquid outlet and a solid material outlet, the residual liquid outlet is connected to the feed port of the concentrating device, and the solid material outlet is connected to the feed port of the washing tank; the washing tank is provided with a liquid material outlet and a solid material outlet, and the solid material outlet of the washing tank is respectively connected to the feed ports of the dryer and the crystallizing kettle.

2. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The concentration device comprises a low-temperature reduced-pressure distillation kettle and a vacuum unit.

3. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The split kettle has a temperature control jacket and a stirring device.

4. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The crystallization kettle is provided with a temperature control jacket and a stirring device.

5. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The liquid outlet of the washing tank is connected to a waste liquid collection tank.

6. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The centrifuge is a horizontal spiral filtering centrifuge.

7. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The drying machine is a fluidized bed drying machine.

8. The noradrenaline bitartrate mother liquor recycling device according to claim 1, wherein: The dryer is connected to a finished product storage tank.

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