Mobile phase suction filtration device for high performance liquid chromatograph

Abstract

The utility model discloses a mobile phase suction filtration device for a high performance liquid chromatograph, which comprises a main body unit comprising a suction filtration box, the upper end of the suction filtration box is provided with a liquid preparation box, the right end of the suction filtration box is provided with a high performance liquid chromatograph body, and the upper end of the liquid preparation box is provided with a connecting cover; and the operation unit comprises two suction filtration screen plates. The suction filtration screen plate can be used for filtering a prepared mobile phase, the interference of impurities and particulate matters in the mobile phase on the separation and analysis process of the high performance liquid chromatograph body is avoided, the filtered mobile phase penetrates through the round holes in the rectangular plate and falls into the lower end of the suction filtration box, the telescopic air cylinder is started, and the mobile phase can be separated and analyzed. The telescopic end of the telescopic air cylinder drives the rectangular plate and the conical rods to move downwards through the fixed block, the vertical rod and the movable rod, the conical rods can puncture bubbles in a mobile phase, and the situation that the bubbles in the mobile phase affect the signal stability and accuracy of a detector signal during analysis of a high performance liquid chromatograph body is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of high performance liquid chromatographs, in particular to a mobile phase filtration device for high performance liquid chromatographs. Background Art

[0002] The HPLC system consists of several parts, including a reservoir, pump, injector, chromatographic column, detector, and recorder. The mobile phase in the reservoir is pumped into the system by a high-pressure pump. The sample solution enters the mobile phase through the injector and is carried into the chromatographic column (stationary phase) by the mobile phase. Since the components in the sample solution have different distribution coefficients in the two phases, when they move relative to each other in the two phases, after repeated adsorption-desorption distribution processes, the components have large differences in movement speed and are separated into individual components, which flow out of the column in sequence. When passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the recorder, and the data is printed out in the form of a graph.

[0003] When using a high-performance liquid chromatograph to detect samples, the mobile phase usually needs to be prepared. Impurities and particulate matter that may exist in the mobile phase will interfere with the separation and analysis process, affecting the accuracy and reliability of the results. Impurities and particulate matter can easily adhere to the surface of the chromatographic column and corrode it, thereby reducing the service life of the column and the separation effect. In addition, the presence of bubbles in the mobile phase can seriously affect the signal stability and accuracy of the detector in liquid chromatography analysis. Utility Model Content

[0004] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and in the abstract and title of the utility model to avoid obscuring the purpose of this section, the abstract and the title of the utility model, and such simplifications or omissions shall not be used to limit the scope of the present invention.

[0005] Therefore, the purpose of the present utility model is to provide a mobile phase filtration device for a high performance liquid chromatograph, which is designed to solve the problem that "when using a high performance liquid chromatograph to detect samples, it is usually necessary to prepare the mobile phase. The impurities and particulate matter that may exist in the mobile phase will interfere with the separation and analysis process, affecting the accuracy and reliability of the results. The impurities and particulate matter are easy to adhere to the surface of the chromatographic column and corrode it, thereby reducing the service life and separation effect of the column. In addition, there are bubbles in the mobile phase. In liquid chromatography analysis, the presence of bubbles will seriously affect the signal stability and accuracy of the detector."

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0007] A mobile phase filtration device for high performance liquid chromatography, comprising:

[0008] The main unit includes a suction filter box, a liquid distribution box is provided at the upper end of the suction filter box, a high performance liquid chromatograph body is provided at the right end of the suction filter box, and a connection cover is provided at the upper end of the liquid distribution box;

[0009] The operating unit includes two suction filter plates, and the two suction filter plates are symmetrically arranged in the suction filter box. The side walls of the suction filter box are symmetrically fixedly connected with a first fixed plate and a second fixed plate. Each of the first fixed plate and the second fixed plate is commonly fixedly connected with a telescopic cylinder. The output end of each telescopic cylinder passes through the second fixed plate and is fixedly connected with a fixed block. The fixed block is fixedly connected with a vertical rod, and the vertical rod is fixedly connected with a moving rod. The opposite ends of the two moving rods are commonly fixedly connected with a rectangular plate, and the lower end surface of the rectangular plate is fixedly connected with a plurality of conical rods at equal intervals. A plurality of circular holes are opened at equal intervals, and a stirring assembly is provided in the liquid distribution box.

[0010] As a preferred solution of the mobile phase filtration device for high performance liquid chromatography described in the utility model, wherein: the stirring assembly includes a servo motor, the servo motor is fixedly installed on the upper end surface of the connecting cover, the output end of the servo motor passes through the connecting cover and is fixedly connected to a rotating rod, the rotating rod is fixedly sleeved with multiple fixed sleeves, each of the fixed sleeves is symmetrically fixedly connected to multiple fixed rods, and each of the fixed rods is fixedly connected to a stirring plate at one end away from the fixed sleeve.

[0011] As a preferred solution of the mobile phase filtration device for a high performance liquid chromatograph described in the utility model, the liquid distribution box is fixedly sleeved with a circular ring plate, the circular ring plate is symmetrically fixedly connected to a plurality of support rods, the lower end of each of the support rods is fixedly connected to the upper end surface of the filtration box, a discharge pipe is fixedly inserted on the lower end surface of the liquid distribution box, the lower end of the discharge pipe is fixedly inserted on the upper end surface of the filtration box, and a first control valve is provided on the discharge pipe.

[0012] As a preferred embodiment of the mobile phase filtration device for a high performance liquid chromatograph described in the utility model, a liquid pump is arranged between the filtration box and the high performance liquid chromatograph body, the input end of the liquid pump is fixedly connected to a first connecting pipe, the left end of the first connecting pipe is fixedly inserted into the side wall of the filtration box, a second control valve is provided on the first connecting pipe, the output end of the liquid pump is fixedly connected to a second connecting pipe, and the end of the second connecting pipe facing away from the liquid pump is fixedly inserted into the high performance liquid chromatograph body.

[0013] As a preferred solution of the mobile phase filtration device for a high performance liquid chromatograph described in the utility model, wherein: the upper end surface of the connecting cover is symmetrically fixedly connected to a first handle, the side wall of the filtration box is symmetrically opened with connecting ports, each of the connecting ports is provided with a connecting plate, each of the filtration mesh plates is fixedly connected to the connecting plate, and each of the connecting plates is fixedly connected to a second handle.

[0014] As a preferred solution of the mobile phase filtration device for a high performance liquid chromatograph described in the utility model, wherein: sliding openings are symmetrically opened on the side walls of the filtration box, each of the movable rods passes through the sliding openings, each of the movable rods is fixedly connected to a connecting slide, and each of the connecting slides is slidably connected to the side walls of the filtration box.

[0015] Beneficial effects of the utility model:

[0016] The suction filter plate can filter the prepared mobile phase to prevent impurities and particulate matter in the mobile phase from interfering with the separation and analysis process of the high-performance liquid chromatography body. The filtered mobile phase passes through the circular hole on the rectangular plate and falls into the lower end of the suction filter box. The telescopic cylinder is started, and the telescopic end of the telescopic cylinder drives the rectangular plate and multiple conical rods to move downward through the fixed block, vertical rod and moving rod. The conical rods can puncture the bubbles in the mobile phase to prevent the bubbles in the mobile phase from affecting the signal stability and accuracy of the detector signal during the analysis of the high-performance liquid chromatography body. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without inventive work. Among them:

[0018] Figure 1 This is a schematic diagram of the overall structure of a mobile phase filtration device for high performance liquid chromatography proposed in the present invention;

[0019] Figure 2 This is a structural schematic diagram of a filtration box and a liquid distribution box in a mobile phase filtration device for a high performance liquid chromatograph proposed in the utility model;

[0020] Figure 3 This is a structural schematic diagram of a filtration mesh plate in a mobile phase filtration device for a high performance liquid chromatograph proposed in the present invention;

[0021] Figure 4 This is a schematic diagram of the structure of the rectangular plate and cone rod in a mobile phase filtration device for high performance liquid chromatography proposed in this utility model.

[0022] Figure 5 The utility model provides a schematic cross-sectional structural diagram of a filtration box in a mobile phase filtration device for a high performance liquid chromatograph.

[0023] In the figure: 100, main unit; 101, suction filter box; 102, liquid distribution box; 103, HPLC body; 104, annular plate; 105, support rod; 106, connecting cover; 107, feed pipe; 108, first control valve; 109, liquid pump; 110, first connecting pipe; 111, second connecting pipe; 112, second control valve; 113, first handle;

[0024] 200, working unit; 201, filter screen plate; 202, first fixed plate; 203, second fixed plate; 204, telescopic cylinder; 205, fixed block; 206, vertical rod; 207, moving rod; 208, rectangular plate; 209, tapered rod; 210, connecting slide; 211, connecting plate; 212, second handle; 213, stirring assembly; 213a, servo motor; 213b, rotating rod; 213c, fixed sleeve; 213d, fixed rod; 213e, stirring plate. DETAILED DESCRIPTION

[0025] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below with reference to the accompanying drawings.

[0026] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0027] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0028] Furthermore, the present invention is described in detail with reference to schematic diagrams. For ease of illustration, when describing embodiments of the present invention, cross-sectional views of device structures may be partially enlarged and not to scale. Furthermore, the schematic diagrams are merely illustrative and should not limit the scope of protection of the present invention. Furthermore, in actual production, three-dimensional dimensions, including length, width, and depth, should be included.

[0029] Reference Figure 1-5The utility model provides a mobile phase filtration device for high performance liquid chromatography, comprising:

[0030] The main unit 100 includes a filtration box 101, a liquid distribution box 102 is provided at the upper end of the filtration box 101, a high performance liquid chromatograph body 103 is provided at the right end of the filtration box 101, and a connection cover 106 is provided at the upper end of the liquid distribution box 102;

[0031] The operation unit 200 includes two suction filter plates 201, and the two suction filter plates 201 are symmetrically arranged in the suction filter box 101. The side walls of the suction filter box 101 are symmetrically fixedly connected with a first fixed plate 202 and a second fixed plate 203. Each of the first fixed plate 202 and the second fixed plate 203 is fixedly connected to a telescopic cylinder 204. The output end of each telescopic cylinder 204 passes through the second fixed plate 203 and is fixedly connected to a fixed block 205. The fixed block 205 is fixedly connected to a vertical rod 206, and the vertical rod 206 is fixedly connected to a moving rod 207. The opposite ends of the two moving rods 207 are fixedly connected to a rectangular plate 208. The lower end surface of the rectangular plate 208 is fixedly connected with a plurality of tapered rods 209 at equal intervals. The upper surface of the rectangular plate 208 is evenly spaced. There are multiple circular holes on the rectangular plate 208, and a stirring assembly 213 is provided in the liquid distribution box 102. The suction filter plate 201 can filter the prepared mobile phase to prevent impurities and particulate matter in the mobile phase from interfering with the separation and analysis process of the high-performance liquid chromatograph body 103. The filtered mobile phase passes through the circular holes on the rectangular plate 208 and falls into the lower end of the suction filter box 101. The telescopic cylinder 204 is started, and the telescopic end of the telescopic cylinder 204 drives the rectangular plate 208 and multiple tapered rods 209 to move downward through the fixed block 205, the vertical rod 206 and the moving rod 207. The tapered rods 209 can puncture bubbles in the mobile phase to prevent bubbles in the mobile phase from affecting the signal stability and accuracy of the detector signal during analysis by the high-performance liquid chromatograph body 103.

[0032] Among them, the stirring assembly 213 includes a servo motor 213a, which is fixedly installed on the upper end surface of the connecting cover 106. The output end of the servo motor 213a passes through the connecting cover 106 and is fixedly connected to a rotating rod 213b. The rotating rod 213b is fixedly sleeved with multiple fixed sleeves 213c. Each fixed sleeve 213c is symmetrically fixedly connected to multiple fixed rods 213d. Each fixed rod 213d is fixedly connected to a stirring plate 213e at one end away from the fixed sleeve 213c. The output end of the servo motor 213a is rotated by the rotating rod 213b, and the rotating rod 213b drives the stirring plate 213e to rotate through the fixed sleeve 213c and the fixed rod 213d. The fixed sleeve 213c and the stirring plate 213e can stir the added raw materials and accelerate the preparation of the mobile phase.

[0033] Furthermore, the liquid distribution box 102 is fixedly sleeved with a circular ring plate 104, and the circular ring plate 104 is symmetrically fixedly connected with multiple support rods 105. The lower end of each support rod 105 is fixedly connected to the upper end surface of the filtration box 101. A discharge pipe 107 is fixedly inserted into the lower end surface of the liquid distribution box 102, and the lower end of the discharge pipe 107 is fixedly inserted into the upper end surface of the filtration box 101. A first control valve 108 is provided on the discharge pipe 107. When the first control valve 108 is started, the prepared mobile phase is added to the filtration box 101 through the discharge pipe 107.

[0034] Furthermore, a liquid pump 109 is arranged between the filtration box 101 and the high-performance liquid chromatograph body 103, and the input end of the liquid pump 109 is fixedly connected to the first connecting pipe 110, the left end of the first connecting pipe 110 is fixedly inserted into the side wall of the filtration box 101, and the first connecting pipe 110 is provided with a second control valve 112. The output end of the liquid pump 109 is fixedly connected to the second connecting pipe 111, and the end of the second connecting pipe 111 facing away from the liquid pump 109 is fixedly inserted into the high-performance liquid chromatograph body 103. Opening the second control valve 112 and the liquid pump 109 can transport the filtered mobile phase to the high-performance liquid chromatograph body 103.

[0035] Furthermore, the upper end surface of the connecting cover 106 is symmetrically fixedly connected with a first handle 113, and the side wall of the filtration box 101 is symmetrically provided with connecting ports, each connecting port is provided with a connecting plate 211, each filtration mesh plate 201 is fixedly connected to the connecting plate 211, and each connecting plate 211 is fixedly connected with a second handle 212. The connecting cover 106 can be removed from the liquid distribution box 102 through the first handle 113, and the raw materials for preparing the mobile phase can be added to the liquid distribution box 102.

[0036] Furthermore, sliding openings are symmetrically opened on the side walls of the filtration box 101, and each movable rod 207 passes through the sliding opening. Each movable rod 207 is fixedly connected to a connecting slide 210, and each connecting slide 210 is slidably connected to the side wall of the filtration box 101. The movable rod 207 moves in the sliding opening, and the connecting slide 210 can seal the sliding opening.

[0037] During use, the connecting cover 106 can be removed from the liquid distribution box 102 through the first handle 113, the raw materials for preparing the mobile phase are added to the liquid distribution box 102, and the connecting cover 106 is then installed on the liquid distribution box 102 through the first handle 113, and the servo motor 213a is started. The output end of the servo motor 213a rotates through the rotating rod 213b, and the rotating rod 213b drives the stirring plate 213e to rotate through the fixed sleeve 213c and the fixed rod 213d. The fixed sleeve 213c and the stirring plate 213e can stir the added raw materials to accelerate the preparation of the mobile phase. The first control valve 108 is started, and the prepared mobile phase is added to the suction box 10 through the discharge pipe 107. 1, the suction filter plate 201 can filter the prepared mobile phase to prevent impurities and particulate matter in the mobile phase from interfering with the separation and analysis process of the high-performance liquid chromatograph body 103. The filtered mobile phase passes through the circular hole on the rectangular plate 208 and falls into the lower end of the suction filter box 101. The telescopic cylinder 204 is started, and the telescopic end of the telescopic cylinder 204 drives the rectangular plate 208 and multiple tapered rods 209 to move downward through the fixed block 205, the vertical rod 206 and the moving rod 207. The tapered rods 209 can puncture bubbles in the mobile phase to prevent bubbles in the mobile phase from affecting the signal stability and accuracy of the detector signal during analysis by the high-performance liquid chromatograph body 103.

[0038] It is worth noting that the entire device is controlled by a controller. Since the controller is a commonly used device and belongs to existing mature technology, its electrical connection relationship and specific circuit structure will not be described in detail here.

[0039] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, and all of these should be included in the scope of the claims of the present invention.

Claims

1. A mobile phase filtration device for high performance liquid chromatography, characterized in that: include: The main unit (100) comprises a suction filter box (101), a liquid distribution box (102) is provided at the upper end of the suction filter box (101), a high performance liquid chromatograph body (103) is provided at the right end of the suction filter box (101), and a connection cover (106) is provided at the upper end of the liquid distribution box (102); The operation unit (200) comprises two suction filter plates (201), the two suction filter plates (201) are symmetrically arranged in the suction filter box (101), the side walls of the suction filter box (101) are symmetrically fixedly connected with a first fixed plate (202) and a second fixed plate (203), each of the first fixed plate (202) and the second fixed plate (203) is fixedly connected to a telescopic cylinder (204), and the output end of each telescopic cylinder (204) passes through the second fixed plate (203) and is fixed. A fixed block (205) is connected, the fixed block (205) is fixedly connected to a vertical rod (206), the vertical rod (206) is fixedly connected to a moving rod (207), the opposite ends of the two moving rods (207) are fixedly connected to a rectangular plate (208), the lower end surface of the rectangular plate (208) is fixedly connected to a plurality of cone rods (209) at equal intervals, a plurality of circular holes are opened on the rectangular plate (208) at equal intervals, and a stirring assembly (213) is provided in the liquid distribution box (102).

2. The mobile phase filtration device for high performance liquid chromatography according to claim 1, wherein: The stirring assembly (213) comprises a servo motor (213a), the servo motor (213a) being fixedly mounted on the upper end surface of the connection cover (106), the output end of the servo motor (213a) passing through the connection cover (106) and being fixedly connected to a rotating rod (213b), the rotating rod (213b) being fixedly sleeved with a plurality of fixed sleeves (213c), each of the fixed sleeves (213c) being symmetrically fixedly connected to a plurality of fixed rods (213d), and each of the fixed rods (213d) having an end facing away from the fixed sleeve (213c) being fixedly connected to a stirring plate (213e).

3. The mobile phase filtration device for high performance liquid chromatography according to claim 1, wherein: The liquid distribution box (102) is fixedly sleeved with a circular plate (104), and the circular plate (104) is symmetrically fixedly connected to a plurality of support rods (105), and the lower end of each support rod (105) is fixedly connected to the upper end surface of the suction filter box (101). A discharge pipe (107) is fixedly inserted on the lower end surface of the liquid distribution box (102), and the lower end of the discharge pipe (107) is fixedly inserted on the upper end surface of the suction filter box (101). A first control valve (108) is provided on the discharge pipe (107).

4. The mobile phase filtration device for high performance liquid chromatography according to claim 1, wherein: A liquid pump (109) is provided between the suction box (101) and the high performance liquid chromatograph body (103); the input end of the liquid pump (109) is fixedly connected to a first connecting pipe (110); the left end of the first connecting pipe (110) is fixedly inserted into the side wall of the suction box (101); a second control valve (112) is provided on the first connecting pipe (110); the output end of the liquid pump (109) is fixedly connected to a second connecting pipe (111); the end of the second connecting pipe (111) facing away from the liquid pump (109) is fixedly inserted into the high performance liquid chromatograph body (103).

5. The mobile phase filtration device for high performance liquid chromatography according to claim 1, wherein: A first handle (113) is symmetrically fixedly connected to the upper end surface of the connection cover (106); a connection port is symmetrically opened on the side wall of the suction filter box (101); a connection plate (211) is provided in each connection port; each suction filter screen plate (201) is fixedly connected to the connection plate (211); and a second handle (212) is fixedly connected to each connection plate (211).

6. The mobile phase filtration device for high performance liquid chromatography according to claim 1, wherein: The side wall of the filtration box (101) is symmetrically provided with sliding openings, each of the movable rods (207) passes through the sliding openings, each of the movable rods (207) is fixedly connected to a connecting slide (210), and each of the connecting slides (210) is slidably connected to the side wall of the filtration box (101).

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