Constant-temperature mixing equipment for synthesizing azacyclo-quinazoline compound

Abstract

The utility model relates to the technical field of experimental equipment, in particular to constant-temperature mixing equipment for synthesizing azacyclo-quinazoline compounds, which comprises a heating component, the heating component comprises a base, a heater is arranged on the top surface of the base, a supporting component is arranged on the rear side of the top surface of the base, and a clamping component is arranged on the front side of the supporting component. The supporting assembly and the clamping assembly are arranged on the top face of the base, an experiment clamping device does not need to be additionally used, the sliding block can slide along the guide rod, the height of the clamping assembly can be conveniently adjusted, and the device can adapt to experiment utensils of different sizes; self-locking is achieved through friction force, and the sliding block is prevented from sliding in the experiment process; the V-shaped plates are driven to be separated from each other through the elastic force of the elastic piece, so that the V-shaped frames approach each other, the experimental vessel is clamped through the cylindrical piece, clamping is convenient, and meanwhile the clamping stability can be improved through the cylindrical piece.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental equipment, in particular to a constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds. Background Art

[0002] Quinazoline compounds are nitrogen-containing heterocyclic compounds with numerous biological activities, including anticancer, anti-inflammatory, analgesic, anti-allergic, and antihypertensive properties. They are common fused heterocyclic skeletons and serve as important building blocks in many pharmaceutical and agricultural product molecules. Furthermore, many quinazoline derivatives possess excellent photophysical properties, making them useful as fluorescent probes, bioimaging reagents, and luminescent materials.

[0003] Quinazoline compounds require heating during synthesis, and the temperature must be kept constant to ensure the correct product. In the prior art, electric heating mantles are commonly used as heating devices, and the temperature is controlled by controlling the input voltage. The reaction typically uses a heated reflux reactor, utilizing a condenser tube to condense the vaporized solvent and reflux it back into the reaction flask, which can reduce the loss of reactants and improve yield.

[0004] In practical applications, reaction flasks and condensers require the use of additional experimental clamping devices to clamp and fix experimental containers such as flasks and condensers. The existing clamping device requires manually tightening screws to control the opening degree of the clamp, thereby controlling the clamping force. In addition, the height of the clamp is also fixed by screws, which is more troublesome to adjust. When clamping experimental equipment, it is easy to slip. Utility Model Content

[0005] In order to make up for the above deficiencies, the utility model provides a constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds.

[0006] The technical solution of the utility model is:

[0007] A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds, comprising:

[0008] A heating assembly, the heating assembly comprising a base, a heater being provided on the top surface of the base, and a control device being provided on the front side of the base, the control device being used to control the temperature of the heater;

[0009] A support assembly, the support assembly including a guide rod, the guide rod being fixedly mounted on the rear side of the top surface of the base, a slider being slidably mounted on the guide rod, the top and bottom surfaces of the slider being provided with self-locking devices, the self-locking devices being used to fix the slider and the guide rod;

[0010] The clamping assembly includes a support rod, which is fixedly installed on the front side of the slider. The front end of the support rod is provided with an experimental clamp. The experimental clamp head is rotatably installed with several cylindrical parts. The experimental clamp cooperates with the cylindrical parts to clamp the experimental vessel.

[0011] Preferably, the heater is hemispherical, and the outside of the heater is wrapped with a protective ring, and the protective ring is fixedly installed on the top surface of the base.

[0012] Preferably, through grooves are provided on the front and rear sides of the guide rod, and the inner shape of the slider is adapted to the guide rod.

[0013] Preferably, the self-locking device includes two eccentric wheels, which are rotatably mounted on the top surface of the slider via a rotating shaft and are symmetrical with respect to the guide rod. A pressing rod is provided above the eccentric wheels.

[0014] Preferably, torsion springs are sleeved on both sides of the eccentric wheel and on the rotating shaft, and the elastic force of the torsion springs can drive the eccentric wheel to rotate toward the guide rod.

[0015] Preferably, the experimental clamp includes two V-shaped plates, which are rotatably mounted on both sides of the head of the support rod through fixing plates, and an elastic member is fixedly mounted between the tail of the V-shaped plate and the support rod.

[0016] Preferably, a V-shaped frame is provided at the head of the V-shaped plate, the concave surfaces of the V-shaped frames are opposite to each other, the cylindrical member is rotatably connected to the V-shaped frame, and the radius of the cylindrical member is greater than the thickness of the V-shaped frame.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] The utility model provides a support assembly and a clamping assembly on the top surface of the base, and no additional experimental clamping device is needed. The slider can slide along the guide rod, which makes it convenient to adjust the height of the clamping assembly and adapt to experimental vessels of different sizes. By providing a self-locking device, the eccentric wheel is pressed against the guide rod by the elastic force of the torsion spring, and self-locking is achieved by friction to prevent the slider from sliding during the experiment; the elastic force of the elastic member is used to drive the V-shaped plates to separate from each other, so that the V-shaped frames are close to each other, and the cylindrical member is used to clamp the experimental vessel, which is convenient to clamp and can improve the clamping stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the heating component structure in the utility model;

[0021] Figure 3 for Figure 2 A schematic diagram of the structure at center A;

[0022] Figure 4 for Figure 2 A magnified schematic diagram of the structure at point B in the middle.

[0023] The meaning of each number in the figure is:

[0024] 1. Heating assembly; 11. Base; 12. Protective ring; 13. Heater; 14. Control knob; 15. Display assembly; 16. Switch;

[0025] 2. Support assembly; 21. Guide rod; 22. Slider; 23. Eccentric wheel; 24. Rotating shaft; 25. Torsion spring; 26. Pressing rod;

[0026] 3. Clamping assembly; 31. Support rod; 32. Fixing plate; 33. V-shaped plate; 34. V-shaped frame; 35. Elastic member; 36. Cylindrical member. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] Example 1:

[0029] See also Figure 1-4 The present invention describes the above technical solution in detail through the following embodiments:

[0030] A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds, comprising:

[0031] The heating assembly 1 includes a base 11 , a heater 13 is provided on the top surface of the base 11 , and a control device is provided on the front side of the base 11 , the control device is used to control the temperature of the heater 13 .

[0032] The control device includes a control knob 14, a display component 15 and a switch 16. The switch 16 is used to control the on and off of the circuit, the display component 15 is used to display information such as the set temperature and the current temperature of the heater 13, and the control knob 14 is used to control the input voltage of the heater 13.

[0033] The heater 13 is hemispherical in shape. The heater 13 is wrapped with a protective ring 12 . The protective ring 12 is fixedly mounted on the top surface of the base 11 .

[0034] The heater 13 is a resistance heating device, preferably a resistance wire, which is woven from the resistance wire and coated with a refractory material and an insulating material. The heater 13 generates heat when powered, and the amount of heat generated by the heater 13 and thus the temperature can be controlled by controlling the input voltage.

[0035] The protective ring 12 is made of high-temperature resistant plastic material to prevent the operator from touching the heater 13 and causing burns.

[0036] The support assembly 2 includes a guide rod 21, which is fixedly mounted on the rear side of the top surface of the base 11. A slider 22 is slidably mounted on the guide rod 21. The top and bottom surfaces of the slider 22 are provided with self-locking devices, which are used to fix the slider 22 and the guide rod 21.

[0037] The guide rod 21 is made of metal and is fixed to the rear side of the top surface of the base 11 by screws.

[0038] Through grooves are provided on the front and rear sides of the guide rod 21 , and the inner shape of the slider 22 is adapted to the guide rod 21 .

[0039] The through grooves on both sides of the guide rod 21 can prevent the slider 22 from rotating when moving, thereby limiting the moving direction of the slider 22 .

[0040] The self-locking device includes two eccentric wheels 23 , which are rotatably mounted on the top surface of the slider 22 via a rotating shaft 24 and are symmetrical with respect to the guide rod 21 . A pressing rod 26 is provided above the eccentric wheels 23 .

[0041] The eccentric wheel 23 and the pressing rod 26 are integrally formed, and the rotation of the eccentric wheel 23 can be controlled by the pressing rod 26. When the pressing rod 26 is away from the slider 22, the eccentric wheel 23 rotates toward the guide rod 21, squeezing the guide rod 21 to fix the slider 22.

[0042] Since eccentric wheels 23 are provided on both the upper and lower sides of the slider 22, when the slider 22 moves upward, the upper eccentric wheel 23 rotates toward the guide rod 21 under the action of friction, and the pressure between the eccentric wheel 23 and the guide rod 21 increases, thereby increasing the friction force, thereby preventing the slider 22 from moving.

[0043] When the slider 22 moves downward, the eccentric wheel 23 below rotates toward the guide rod 21 due to the friction force, and the pressure between the eccentric wheel 23 and the guide rod 21 increases, thereby increasing the friction force and preventing the slider 22 from moving.

[0044] Torsion springs 25 are sleeved on both sides of the eccentric wheel 23 and on the rotating shaft 24 . The elastic force of the torsion springs 25 can drive the eccentric wheel 23 to rotate toward the guide rod 21 .

[0045] Under the elastic force of the torsion spring 25 , the eccentric wheel 23 rotates toward the guide rod 21 to achieve self-locking. When unlocking is required, a force is applied to the pressing rod 26 toward the slider 22 to disengage the eccentric wheel 23 from the guide rod 21 .

[0046] The clamping assembly 3 includes a support rod 31, which is threadedly installed on the front side of the slider 22. A test clamp is provided at the front end of the support rod 31. Several cylindrical parts 36 are rotatably installed on the head of the test clamp. The test clamp cooperates with the cylindrical parts 36 to clamp the experimental vessel.

[0047] The support rod 31 is perpendicular to the guide rod 21 and is made of metal.

[0048] The experimental clamp includes two V-shaped plates 33 , which are rotatably mounted on both sides of the head of the support rod 31 through fixing plates 32 . An elastic member 35 is fixedly mounted between the tail of the V-shaped plate 33 and the support rod 31 .

[0049] Two fixing plates 32 are welded to the upper and lower sides of the support rod 31, parallel to the ground. The concave surfaces of the V-shaped plates 33 face outward, and the corners of the V-shaped plates 33 are pivotally connected to the fixing plates 32 via pins. The elastic member 35 can be a coil spring. The elastic force of the elastic member 35 forces the tail ends of the V-shaped plates 33 away from the support rod 31, thereby bringing the heads of the two V-shaped plates 33 closer together.

[0050] A V-shaped frame 34 is welded to the head of the V-shaped plate 33 , and the concave surfaces of the V-shaped frame 34 are opposite. A cylindrical member 36 is rotatably connected to the V-shaped frame 34 , and the radius of the cylindrical member 36 is greater than the thickness of the V-shaped frame 34 .

[0051] The cylindrical member 36 has a rubber member on the outside and a metal shaft on the inside. The cylindrical member 36 is installed vertically.

[0052] Driven by the elastic force of the elastic member 35 , the heads of the V-shaped plates 33 approach each other, so that the V-shaped frame 34 and the cylindrical member 36 approach each other, thereby clamping the experimental vessel.

[0053] The cylindrical member 36 can increase the stability of the clamping of the vessel and prevent the vessel from sliding by utilizing friction.

[0054] In this embodiment, when using the device, the operator places the heating component 1 on a horizontal and stable laboratory table.

[0055] Adjust the height of the slider 22 according to the size of the experimental vessel.

[0056] During adjustment, pinch the upper and lower pressing rods 26 from both sides with both hands to separate the eccentric wheel 23 from the guide rod 21, then control the slider 22 to slide to a suitable height, release the pressing rod 26, and under the elastic force of the torsion spring 25, the eccentric wheel 23 rotates toward the guide rod 21 to achieve self-locking.

[0057] Then proceed to the installation of the experimental vessel.

[0058] The two V-shaped plates 33 are pinched to move the V-shaped frame 34 and the cylindrical member 36 away from each other, thereby clamping the experimental vessel.

[0059] Finally, turn on the switch 16 and rotate the control knob 14 to adjust the input voltage of the heater 13.

[0060] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely preferred examples of the present invention and are not intended to limit the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention, and such changes and improvements fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds, characterized in that, include: A heating assembly (1), the heating assembly (1) comprising a base (11), a heater (13) being provided on the top surface of the base (11), and a control device being provided on the front side of the base (11), the control device being used to control the temperature of the heater (13); A support assembly (2), the support assembly (2) comprising a guide rod (21), the guide rod (21) being fixedly mounted on the rear side of the top surface of the base (11), a slider (22) being slidably mounted on the guide rod (21), the top and bottom surfaces of the slider (22) being provided with self-locking devices, the self-locking devices being used to fix the slider (22) and the guide rod (21); The clamping assembly (3) comprises a support rod (31), the support rod (31) is fixedly mounted on the front side of the slider (22), a front end of the support rod (31) is provided with an experimental clamp, a head of the experimental clamp is rotatably mounted with a plurality of cylindrical members (36), and the experimental clamp cooperates with the cylindrical members (36) to clamp the experimental vessel.

2. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds as claimed in claim 1, characterized in that: The heater (13) is hemispherical, and the outside of the heater (13) is wrapped with a protective ring (12), and the protective ring (12) is fixedly mounted on the top surface of the base (11).

3. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds as claimed in claim 1, characterized in that: Through grooves are provided on the front and rear sides of the guide rod (21), and the inner shape of the slider (22) is adapted to the guide rod (21).

4. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds as claimed in claim 1, characterized in that: The self-locking device comprises two eccentric wheels (23), which are rotatably mounted on the top surface of the slider (22) via a rotating shaft (24) and are symmetrical with respect to the guide rod (21). A pressing rod (26) is provided above the eccentric wheels (23).

5. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds as claimed in claim 4, characterized in that: Torsion springs (25) are sleeved on both sides of the eccentric wheel (23) and on the rotating shaft (24). The elastic force of the torsion springs (25) can drive the eccentric wheel (23) to rotate in the direction of the guide rod (21).

6. The constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds according to claim 1, characterized in that: The experimental clamp comprises two V-shaped plates (33), which are rotatably mounted on both sides of the head of the support rod (31) via a fixing plate (32), and an elastic member (35) is fixedly mounted between the tail of the V-shaped plate (33) and the support rod (31).

7. A constant temperature mixing device for synthesizing nitrogen heterocyclic quinazoline compounds as claimed in claim 6, characterized in that: The head of the V-shaped plate (33) is provided with a V-shaped frame (34), the concave surfaces of the V-shaped frame (34) are opposite, the cylindrical member (36) is rotatably connected to the V-shaped frame (34), and the radius of the cylindrical member (36) is greater than the thickness of the V-shaped frame (34).

Images