Device capable of being used for assisting tail suspension experiment of rats / mice
By introducing a bracket ring and sliding ball structure into the tail suspension experimental apparatus, the range of activity of rats and mice was increased, the problem of rapid depression and death was solved, and the success rate and reliability of the experiment were improved.
Patent Information
- Application Number
- CN202422963235.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-29
- Publication Date
- 2025-10-03
- Estimated Expiration
- 2034-11-29
AI Technical Summary
In existing tail suspension experimental devices, rats and mice are prone to rapid death due to depression or other reasons due to their small range of activity, which affects the effectiveness of drug evaluation and increases the attrition rate.
A device including a cage, a bracket ring and a sliding ball was designed. A hollow track ring was provided inside the bracket ring, in which the sliding ball could slide. The connecting piece was used to hang the mouse's tail to increase the animal's range of activity.
By increasing the range of animal activities, the probability of death due to depression is reduced, the attrition rate is lowered, and the success rate and repeatability of the experiment are improved.
Smart Images
Figure CN223403030U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of auxiliary equipment for a rat / mice tail suspension experiment, in particular to a device that can be used to assist a rat / mice tail suspension experiment. Background Art
[0002] The tail suspension test apparatus can be used to establish models of stress-induced depression, hindlimb unloading, and bone loss. In depression research, the tail suspension test (TST) is a classic and rapid method for evaluating the efficacy of antidepressants, stimulants, and sedatives. In the hindlimb unloading model, the tails of mice and rats are suspended, preventing their hindlimbs from feeling the reaction force of the ground, thereby simulating bone loss caused by conditions such as weightlessness in space and long-term bed rest. This is often used in the development of anti-osteoporosis drugs and in bone biomechanics research.
[0003] The tail suspension test currently available on the market involves suspending mice or rats by their tails in a fixed position. During the experiment, these devices restrict the mice's range of movement because they are fixed in one spot. Suspended mice or rats can easily die from overeating, depression, and other causes, affecting drug evaluation. Furthermore, the rapid death of mice and rats increases their attrition rate and the cost of the tail suspension test.
[0004] Therefore, the present application designs a device that can increase the range of activity of mice / rat during tail suspension, so as to reduce the probability of animals dying due to the experiment itself and increase the success rate and repeatability of the tail suspension experiment. Utility Model Content
[0005] The main purpose of the utility model is to provide a device that can be used to assist rats / mice in tail suspension experiments, with the purpose of increasing the range of activities of the rats / mice with tail suspension, so as to reduce the probability of the rats / mice dying from rapid depression in the tail suspension experiment.
[0006] To achieve the above-mentioned purpose, the present invention proposes a device that can be used to assist in the tail suspension experiment of mice and rats, comprising:
[0007] Cage,
[0008] A bracket ring, wherein the bracket ring is disposed in the cage body, and the upper end of the bracket ring is connected to the upper wall of the cage body, the bracket ring is a hollow annular member, the bracket ring has a hollow track ring inside, the lower end of the bracket ring has a full circle of annular opening, the upper end of the bracket ring has an opening portion, the annular opening, the hollow track ring and the opening portion are connected;
[0009] a sliding ball, the sliding ball being movably disposed on the hollow track ring;
[0010] The diameter of the opening is larger than the diameter of the sliding ball, and the diameter of the sliding ball is larger than the width of the annular opening. A connecting piece is provided on the sliding ball, extending out of the annular opening, and used for hanging an external rope.
[0011] In one embodiment, the end of the connecting member away from the sliding ball has a fixing ring, and the fixing ring is used for hanging an external rope.
[0012] In one embodiment, the upper end of the bracket ring is further connected to a plurality of hooks, and the hooks are used to be hung on the upper wall of the cage.
[0013] In one embodiment, the connecting member is made of metal, the sliding ball is made of metal, and the connecting member is welded to the sliding ball.
[0014] In one embodiment, the surface of the sliding ball is coated with lubricating oil; and / or the inner wall of the bracket ring is coated with lubricating oil.
[0015] In one embodiment, the shape of the support ring is any one of a circular ring, an elliptical ring, a square ring, and a polygonal ring.
[0016] In one embodiment, the support ring is in the shape of a circular ring, and the plurality of hooks are evenly arranged around the axis of the support ring.
[0017] In one embodiment, the upper end of the bracket ring is welded to the upper wall of the cage body.
[0018] In one embodiment, the hook is a retractable structural member.
[0019] The technical solution of the utility model is a device for assisting the tail suspension experiment of mice. The rolling ring can be movably arranged in the bracket ring to increase the range of movement of the tail-suspended mice, so as to reduce the probability of rapid depression and death of mice in the tail suspension experiment. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.
[0021] Figure 1 This is a schematic structural diagram of an embodiment of a device for assisting in tail suspension experiments on mice and rats provided by the present invention;
[0022] Figure 2 A schematic structural diagram of a portion of the structure of an embodiment of a device for assisting in tail suspension experiments on mice and rats provided by the present invention from one perspective;
[0023] Figure 3 A schematic structural diagram of a portion of the structure of an embodiment of the device for assisting the tail suspension experiment on mice and rats provided by the present invention from another perspective;
[0024] Figure 4 This is a schematic cross-sectional view of an embodiment of a device for assisting in tail suspension experiments on mice and rats provided by the present invention.
[0025] Description of Figure Numbers:
[0026] 10. Bracket ring; 11. Annular opening; 12. Opening portion; 13. Hollow track ring; 20. Sliding ball; 21. Connector; 22. Fixing ring; 30. Hook; 40. Cage body. DETAILED DESCRIPTION
[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.
[0028] It should be noted that if directional indications are involved in the embodiments of the present invention, the directional indications are only used to explain the relative positional relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indications will also change accordingly.
[0029] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present invention, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited to "first" and "second" may explicitly or implicitly include at least one of such features. In addition, if "and / or" or "and / or" appears in the full text, its meaning includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or a scheme in which A and B are satisfied at the same time. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is mutually contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.
[0030] The tail suspension test currently available on the market involves suspending mice or rats by their tails in a fixed position. During the experiment, these devices restrict the mice's range of movement because they are fixed in place. This makes them susceptible to depression and death, impacting drug evaluation. Furthermore, these rapid deaths increase the mice's attrition rate and material costs. Therefore, the present invention designs a device that increases the range of movement of mice or rats during tail suspension, thereby reducing the probability of rapid depression and death in these experiments.
[0031] Please refer to Figures 1 to 4 As shown, an embodiment of the present application provides a device that can be used to assist in the tail suspension experiment of mice and rats, comprising a cage body 40, a support ring 10 and a sliding ball 20. The support ring 10 is arranged in the cage body 40, and the upper end of the support ring 10 is connected to the upper wall of the cage body 40. The support ring 10 is a hollow annular member, and a hollow track ring 13 is provided inside the support ring 10, and the sliding ball 20 is movably provided in the hollow track ring 13. The lower end of the support ring 10 has a full circle of annular opening 11, and the upper end of the support ring 10 has an opening portion 12, the diameter of the opening portion 12 is larger than the diameter of the annular opening 11, and the diameter of the sliding ball 20 is larger than the width of the annular opening 11. A connecting member 21 is provided on the sliding ball 20, and the connecting member 21 extends out of the annular opening 11, and the connecting member 21 is used for external rope suspension.
[0032] Specifically, a cage 40 is used to accommodate experimental rats and mice. A support ring 10 and a sliding ball 20 are both disposed within the cage 40, with the upper end of the support ring 10 connected to the upper wall of the cage 40. The support ring 10 is a ring-shaped closed member connected end to end. The support ring 10 has a hollow structure and contains a hollow track ring 13. The sliding ball 20 is disposed within the hollow track ring 13, allowing the sliding ball 20 to slide freely within the hollow track ring 13. In this embodiment, the lower end of the support ring 10 has a full-circle annular opening 11, and the upper end of the support ring 10 has an opening 12. The diameter of the opening 12 is larger than the diameter of the sliding ball 20, allowing the sliding ball 20 to pass through the opening 12, facilitating the insertion of the sliding ball 20 from the opening 12 into the hollow track ring 13. The diameter of the sliding ball 20 is larger than the width of the annular opening 11, preventing the sliding ball 20 from falling out of the annular opening 11. The sliding ball 20 is provided with a connecting piece 21 , which extends from the annular opening 11 . The connecting piece 21 is used for hanging an external rope to perform a rat / mouse hanging experiment.
[0033] When using the device of the present application, one end of a rope is suspended and connected to a connector 21 extending from an annular opening 11, while the other end of the rope is used to secure the tail of a rat or mouse. When the rat or mouse moves, it causes the connector 21 to slide within the annular opening 11, which in turn drives the sliding ball 20 to slide freely within the hollow track ring 13 of the support ring 10. This increases the rat or mouse's range of motion, reduces the probability of death from depression, and thus reduces the rat or mouse loss rate. This also facilitates the smooth conduct of rat or mouse suspension experiments.
[0034] In an optional embodiment, the end of the connecting member 21 away from the sliding ball 20 has a fixing ring 22, and the fixing ring 22 is used for hanging an external rope. A fixing ring 22 is set at the end of the connecting member 21 extending out of the hollow track ring 13 to facilitate fixing the external rope.
[0035] In an optional embodiment, the connecting member 21 is made of metal, the sliding ball 20 is made of metal, and the connecting member 21 is integrally fixed to the sliding ball 20 by welding.
[0036] In some optional embodiments, the shape of the support ring 10 can be any of a circular ring, an elliptical ring, a square ring, and a polygonal ring. As long as the support ring 10 is a closed ring connected end to end and the sliding ball 20 can slide within the hollow track ring 13 within the support ring 10, it is sufficient. Of course, it is understood that the shape of the support ring 10 can also be an irregular ring structure.
[0037] In an optional embodiment, the upper end of the support ring 10 is further connected to a plurality of hooks 30, which are used to be hung on the upper wall of the cage 20. The hooks 30 can be fixed to the support ring 10 by welding. The number of hooks 30 can be two, three, or more, as long as the support ring 10 can be hung stably. The position of the hooks 30 can be set according to the actual situation. Figure 2 In the embodiment, the support ring 10 is in the shape of a circular ring, and the number of the hooks 30 is three, and the three hooks 30 are evenly arranged around the axis of the support ring 10 .
[0038] In an optional embodiment, the hook 30 is a retractable structural member, and the length of the hook 30 can be adjusted to adapt to rats and mice of different sizes. The present application sets the hook to be retractable to increase the application scenarios of the device.
[0039] In some embodiments, the upper end of the bracket ring 10 can also be fixed to the upper wall of the cage body 40 by welding, so that the bracket ring 10 is hung on the upper wall of the cage body 40.
[0040] In an optional embodiment, the surface of the sliding ball 20 is coated with lubricating oil; and / or the inner wall of the bracket ring 10 is coated with lubricating oil. To increase the smoothness of the sliding ball 20 sliding within the hollow track, the surface of the sliding ball 20 is coated with lubricating oil, or the inner wall of the bracket ring 10 is coated with lubricating oil, thereby facilitating the movement of the suspended rat / mouse.
[0041] The above description is merely an exemplary embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made using the contents of the present invention specification and drawings under the technical concept of the present invention, or direct / indirect application in other related technical fields are included in the patent protection scope of the present invention.
Claims
1. A device that can be used to assist in tail suspension experiments on mice and rats, characterized in that: include: Cage, A bracket ring, wherein the bracket ring is disposed in the cage body, and the upper end of the bracket ring is connected to the upper wall of the cage body, the bracket ring is a hollow annular member, the bracket ring has a hollow track ring inside, the lower end of the bracket ring has a full circle of annular opening, the upper end of the bracket ring has an opening portion, the annular opening, the hollow track ring and the opening portion are connected; a sliding ball, the sliding ball being movably disposed on the hollow track ring; The diameter of the opening is larger than the diameter of the sliding ball, and the diameter of the sliding ball is larger than the width of the annular opening. A connecting piece is provided on the sliding ball, and the connecting piece passes through the annular opening. The connecting piece is used for hanging an external rope.
2. The device for assisting the tail suspension test in rats and mice according to claim 1, wherein: One end of the connecting piece away from the sliding ball is provided with a fixing ring, and the fixing ring is used for hanging an external rope.
3. The device for assisting the tail suspension test in rats and mice according to claim 1, wherein: The upper end of the bracket ring is also connected to a plurality of hooks, and the hooks are used to be hung on the upper wall of the cage body.
4. The device for assisting the tail suspension test in rats and mice according to claim 1, wherein: The connecting piece is made of metal, the sliding ball is made of metal, and the connecting piece is welded to the sliding ball.
5. The device for assisting the tail suspension test in rats and mice according to claim 1, wherein: The surface of the sliding ball is coated with lubricating oil; and / or the inner wall of the bracket ring is coated with lubricating oil.
6. The device for assisting the tail suspension test in rats and mice according to claim 3, wherein: The shape of the bracket ring is any one of a circular ring, an elliptical ring, a square ring, and a polygonal ring.
7. The device for assisting the tail suspension test in rats and mice according to claim 3, wherein: The support ring is in the shape of a circular ring, and a plurality of hooks are evenly arranged around the axis of the support ring.
8. The device for assisting the tail suspension test in rats and mice according to claim 1, wherein: The upper end of the bracket ring is welded to the upper wall of the cage body.
9. The device for assisting the tail suspension test in rats and mice according to claim 3, wherein: The hook is a retractable structural member.