Ultra-trace solution micron wire manufacturing system based on spiral structure guiding liquid

Abstract

The utility model belongs to the technical field of ultramicro solution distribution, and particularly relates to an ultramicro solution micron wire manufacturing system for guiding liquid based on a spiral structure. Requirements for ultramicro solution dispensing techniques with high precision, high stability and high efficiency appear increasingly in various fields. The utility model provides an ultramicro solution micron wire manufacturing system based on spiral structure guide liquid by combining a transfer printing type solution distribution mode and a piston type solution distribution mode. Accurate pressure supply of a solution is achieved through the micro-fluidic injection pump, the solution is conveyed into the solution non-mechanism liquid storage barrel, the needle head and the spiral pipetting needle are arranged at the bottom of the liquid storage barrel, spiral grooves are evenly formed in the spiral pipetting needle, and the solution flows out through a gap between the needle head and the spiral pipetting needle. And the solution is flatly laid in the spiral groove on the spiral pipetting needle and spirally slides down at a constant speed, so that liquid drops are not easy to form, continuous supply of the solution can be realized, and manufacturing of ultramicro micron wires is realized.

Description

Technical Field

[0001] The utility model belongs to the technical field of ultra-trace solution distribution, and in particular relates to an ultra-trace solution micrometer line manufacturing system based on a spiral structure guiding liquid. Background Art

[0002] With the advancement of microsystem integration and assembly technology, the packaging, connection, and sealing of ultra-precision components at the micro- and nano-scale have reached femtoliter to picoliter levels, placing even higher demands on packaging accuracy, dosage, and efficiency. With the development of bioanalysis and high-throughput screening technologies, the dosage of reagents in the biological sciences has reached nanoliter and even picoliter levels, placing even higher demands on the speed and accuracy of reagent dispensing. The demand for ultra-micro solution dispensing technologies with high precision, high stability, and high efficiency is growing in various fields. Existing technologies are no longer sufficient for practical applications, and research into different types of solution dispensing technologies and the proposal and development of new ones are essential.

[0003] Existing solution dispensing technologies are mainly divided into two categories: contact and non-contact. Among the contact dispensing methods, the time-pressure type is the most widely used. However, in order to achieve ultra-micro solution dispensing, the hollow needle must be processed to a few microns or smaller, which makes manufacturing difficult. In addition, the flow resistance of high-viscosity solutions can easily cause needle clogging, resulting in large economic losses. The piston type has the advantages of good stability and easy control, but its maintenance and adjustment are difficult and expensive. Subsequently, a transfer dispensing method was proposed. The pipette needle passes through the capillary filled with solution, moves vertically downward until it contacts and stops with the base surface, and then moves upward along the original route. During this process, the solution at the needle tip forms droplets on the base surface under the action of the solution's own viscosity, inertial force, and surface tension. This method is applicable to a wide range of solution viscosities and has good consistency in the transferred droplets. However, this method cannot achieve a continuous supply of solution, that is, it cannot perform continuous solution dispensing, cannot perform micron-level linear dispensing, and has low transfer and dispensing efficiency. The non-contact dispensing method uses external force to make the solution break through the surface tension and spray it onto the base surface at a certain speed to form droplets. This method only requires horizontal movement and the nozzle does not need to contact the substrate. Therefore, the efficiency of non-contact solution transfer is higher than that of contact solution transfer and it is not easy to be contaminated. However, the transfer amount and position accuracy of non-contact solution transfer are difficult to control.

[0004] Existing solution dispensing methods struggle to achieve continuous delivery of ultra-micro solutions across a wide viscosity range, making them incapable of fabricating micronized wires and failing to meet the ultra-micro application requirements in various fields. Therefore, a new technology for ultra-micro solution dispensing and ultra-micronized wire fabrication that ensures high precision, stability, and efficiency in transferring solutions while ensuring a controlled and continuous supply is needed. A new type of pipette tip is also needed that enables continuous and stable solution flow across its surface. Utility Model Content

[0005] The purpose of this utility model is to provide a micron-wire manufacturing system for ultra-trace solutions that can achieve continuous dispensing of ultra-trace solutions and stable formation of lines, using a spiral structure to guide liquid flow. This utility model combines transfer-type and piston-type solution dispensing methods to design a composite micron-wire manufacturing system for ultra-trace solutions. The system includes a pipette needle with a spiral structure, which uses the spiral structure to guide solution flow along the surface of the pipette needle, achieving the purpose of continuous solution supply, enabling the manufacture of ultra-trace solution micron-wires, and improving solution transfer efficiency.

[0006] To achieve the above-mentioned objectives, the present invention adopts the following specific scheme: the ultra-trace solution micron line manufacturing system proposed in the present invention specifically includes a base and a microfluidic injection pump with a syringe, a vertical lifting mechanism is provided on the side of the base, the lifting component of the vertical lifting mechanism is connected to a clamping mechanism, and a solution dispensing mechanism is provided through the clamping mechanism;

[0007] The solution dispensing mechanism includes a liquid storage cylinder, a needle is provided at the bottom of the liquid storage cylinder, a spiral pipette needle is provided on the needle, spiral grooves are evenly provided on the spiral pipette needle, a fixing part is connected to the top of the liquid storage cylinder, a three-jaw chuck and a reducing tube are provided through the fixing part, the three-jaw chuck clamps the upper end of the spiral pipette needle, and the upper end opening of the reducing tube is connected to the liquid outlet of the syringe provided by the microfluidic injection pump through a pipeline.

[0008] As a preferred solution of the present invention, the vertical lifting mechanism includes two parallel slide rails arranged in the vertical direction on the side of the base, a vertical through groove is provided on the base between the two parallel slide rails, two sliders are provided through the two slide rails, the two sliders are fixedly connected to the clamping mechanism, a cylinder is provided on the base, and the telescopic rod of the cylinder is connected to the clamping mechanism through the through groove.

[0009] As another preferred embodiment of the present invention, the clamping mechanism includes a fixed plate, which is connected to the telescopic rod of the cylinder through the through slot by a nut, and the fixed plate 8 is fastened to the two sliders 6 by screws. A side plate is provided in parallel at each horizontal end of the fixed plate, and a parallel screw, a first guide shaft and a second guide shaft are provided between the two side plates. Two clamping blocks are symmetrically provided through the first guide shaft, the screw and the second guide shaft, and V-shaped clamping grooves are provided on opposite sides of the two clamping blocks.

[0010] The threads at both ends of the screw are set in opposite directions, a bearing and a retaining spring are set between the screw and the side plate, and a hexagonal groove is set on the side of one end of the screw to facilitate the insertion and rotation of a wrench.

[0011] As a third preferred solution of the present invention, a first sealing ring is provided between the fixing member and the reducing tube, and a second sealing ring is provided between the fixing member and the liquid storage cylinder.

[0012] Beneficial effects of the utility model:

[0013] (1) The utility model combines the advantages of the piston type in terms of stability, sealing and flow stability with the high precision of the transfer type, solving the problem of difficult control of liquid output and inability to achieve stable and accurate continuous flow supply, and realizing the manufacture of ultra-micro and ultra-fine solution micrometer lines that can accurately control liquid output and stabilize liquid supply;

[0014] (2) The utility model uses the spiral structure on the spiral pipette needle to play the role of fluid guidance, optimize the flow path of the fluid, and convert the linear falling motion of the solution along the pipette needle into a uniform spiral motion, thereby improving the efficiency of glue transfer; the design of the spiral structure can also effectively prevent the solution from gathering into droplets at the outlet of the needle tube, thereby improving the flow efficiency of the solution. The spiral structure increases the contact area between the solution and the pipette needle, and can more stably control the flow of the solution;

[0015] (3) The utility model can realize the manufacture of ultra-micro and ultra-fine solution micrometer lines, and is also suitable for solution distribution in various ways such as point, line and surface;

[0016] (4) The ultra-trace solution micrometer wire manufacturing system proposed in the present invention can adapt to different sizes of liquid storage cylinders by providing a clamping mechanism, and the pipette needle can be easily replaced by providing a three-jaw chuck;

[0017] (5) The present invention's method for manufacturing ultra-trace solution micrometer lines based on a spiral structure guiding liquid can ultimately stably manufacture solution lines with a width of about ten micrometers. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Schematic diagram of the overall structure of the ultra-trace solution micrometer wire manufacturing system.

[0019] Figure 2 Schematic diagram of the vertical lifting mechanism.

[0020] Figure 3 Schematic diagram of the clamping mechanism structure.

[0021] Figure 4 Schematic diagram of the screw structure.

[0022] Figure 5 Schematic diagram of the solution distribution mechanism.

[0023] Figure 6 This is the fixed part axis view.

[0024] Figure 7 A top view of the fixing parts.

[0025] Figure 8 Schematic diagram of the fixing assembly structure.

[0026] Figure 9 Diagram of the method for manufacturing ultra-trace solution micrometer wires.

[0027] Figure 10 Schematic diagram of the structure of the spiral pipette needle.

[0028] Figure 11 This is a force analysis diagram of the glue flow in the spiral structure of the spiral pipette needle.

[0029] In the accompanying drawings, 1 is a microfluidic injection pump, 2 is a clamping mechanism, 3 is a vertical lifting mechanism, 4 is a solution dispensing mechanism, 5 is a slide rail, 6 is a slider, 7 is a nut, 8 is a fixed plate, 9 is a cylinder, 10 is a base, 11 is a side plate, 12 is a bearing, 13 is a retaining spring, 14 is a first guide shaft, 15 is a lead screw, 16 is a second guide shaft, 17 is a clamping block, 18 is a reducer, 19 is a first sealing ring, 20 is a three-jaw chuck, 21 is a fixing part, 22 is a second sealing ring, 23 is a liquid storage cylinder, 24 is a needle, and 25 is a spiral pipette needle. DETAILED DESCRIPTION

[0030] The ultra-trace solution micron wire manufacturing system proposed in the present invention is described in detail below with reference to the accompanying drawings.

[0031] like Figure 1 As shown, the present invention specifically includes a base 10 and a microfluidic syringe pump 1 with a built-in syringe. The microfluidic syringe pump 1 is a precise, low-flow syringe pump. The microfluidic syringe pump 1 includes a syringe base, an operating screen, a syringe clamp with a tight grip and a safer grip, and a syringe. The flow value is entered in the operating screen and the syringe pump is started, which can generate precise pressure to push the syringe. The top of the syringe is connected to a pump tube to supply pressure to the solution.

[0032] A vertical lifting mechanism 3 is provided on the side of the base 10, and the lifting component of the vertical lifting mechanism 3 is connected to the clamping mechanism 2, and a solution dispensing mechanism 4 is provided through the clamping mechanism 2;

[0033] like Figure 5 As shown, the solution dispensing mechanism 4 includes a liquid storage cylinder 23, a needle 24 is provided at the bottom of the liquid storage cylinder 23, a spiral pipette needle 25 is provided on the needle 24, and spiral grooves are evenly provided on the spiral pipette needle 25. A fixing part 21 with a through hole is connected to the top of the liquid storage cylinder 23, and a three-jaw chuck 20 and a reducing tube 18 are provided through the fixing part 21. The three-jaw chuck 20 clamps the upper end of the spiral pipette needle 25, and connects the upper end opening of the reducing tube 18 and the liquid outlet of the built-in syringe of the microfluidic injection pump 1 through a pipeline; needles 24 of different specifications can be replaced according to the viscosity of the solution, and the gap between the needle 24 and the spiral pipette needle 25 is changed to prevent the solution from being blocked or flowing independently.

[0034] The structure of the fixing member 21 is as follows: Figure 6 and Figure 7 As shown, the fixing part 21 with a through hole can simultaneously fix the three-jaw chuck 20, connect the reducer 18, connect the liquid storage cylinder 23, and seal the solution; a runway-shaped through hole is provided inside the fixing part 21, which can increase the flow area of ​​the solution, and the regular shape is not easy to be blocked, and is a key part.

[0035] Figure 8 The installation and tolerance requirements of the fixing part 21 with a through hole are met. As a key component, the fixing part 21 with a through hole simultaneously realizes multiple functions such as fixing, connection and sealing, so the production and manufacturing of this part are required to have certain precision requirements; the precision of the fixing part 21 also directly affects the concentricity of the spiral pipette needle 25 and the needle head 24 after installation and reasonably controls the gap to avoid the occurrence of solution leakage.

[0036] The spiral pipette needle 25 has a structure as follows: Figure 3 As shown, the spiral pipette needle 25 is one of the core components of the ultra-trace solution micrometer line manufacturing system; the manufacturing process of the spiral pipette needle 25 is as follows: a cylindrical substrate of suitable material and size is selected, and the surface is polished to be smooth and flat; on this substrate, a groove with a certain depth and width is cut along a spiral path, and finally a fine grinding process is used to process the end of the substrate into a conical tip with a diameter of micrometer level.

[0037] like Figure 9 As shown, the utility model is a liquid dispensing method that combines the transfer type and piston type dispensing methods.

[0038] like Figure 10 As shown, the installation of the spiral pipette needle 25 must ensure parallelism with the base surface, concentricity with the needle head 24, and reasonable control of the gap to avoid leakage of the glue.

[0039] The traditional cylindrical pipette needle cannot achieve continuous supply of solution, resulting in a "candied haws phenomenon" in which the solution gathers into droplets and drips down under the action of gravity, making it impossible to achieve continuous flow of the solution; a spiral pipette needle 25 is used to supply the solution. The spiral structure increases the contact area between the solution and the pipette needle, allowing the solution to flow along the spiral structure, effectively preventing the solution from gathering into droplets at the needle tube outlet, achieving continuous supply of solution, and improving the flow efficiency of the glue solution.

[0040] Figure 11The flow state of the glue solution in the spiral structure is demonstrated. The existence of the spiral groove affects the flow of the glue, making it more resistant in the direction perpendicular to the spiral groove, and the droplets are not easy to spread; there is adhesion and shearing between the wall of the spiral groove and the glue. The introduction of the spiral groove increases the actual contact area between the solid and the liquid, increases the interaction force between the solid and the liquid, and increases the adhesion force, thereby reducing the contact angle and weakening the rolling property of the droplets; the spiral groove guides the glue, and the resistance to the movement of droplets parallel to the spiral groove is small, and the droplets are easy to spread. At this time, gravity G is the main driving force for the glue to flow in the spiral groove, acting on each unit volume of the liquid to generate downward pressure, and the inclination angle of the spiral groove directly affects the component of gravity; the wall and inclination angle of the spiral groove will cause the glue to generate an inertial force FA along the direction of the spiral groove; the roughness of the wall of the spiral groove of the glue will generate a friction force FL that affects the flow of the liquid, thereby affecting the flow direction and speed of the liquid.

[0041] like Figure 2 As shown, the vertical lifting mechanism 3 includes two parallel slide rails 5 arranged in the vertical direction on the side of the base 10, and a vertical through groove is provided on the base 10 between the two parallel slide rails 5. Two sliders 6 are provided through the two slide rails 5. The two sliders 6 are fixedly connected to the clamping mechanism 2. A cylinder 9 is provided on the base 10, and the telescopic rod of the cylinder 9 is connected to the clamping mechanism 2 through the through groove.

[0042] like Figure 3 As shown, the clamping mechanism 2 includes a fixed plate 8, which is connected to the telescopic rod of the cylinder 9 through the through slot by a nut 7, and is fastened to the two sliders 6 by screws. A side plate 11 is provided in parallel at each horizontal end of the fixed plate 8, and a parallel screw 15, a first guide shaft 14 and a second guide shaft 16 are provided between the two side plates 11. Two clamping blocks 17 are symmetrically provided through the first guide shaft 14, the screw 15 and the second guide shaft 16, and V-shaped clamping grooves are provided on opposite sides of the two clamping blocks 17;

[0043] like Figure 4 As shown, the threads at both ends of the screw 15 are set in opposite directions, a bearing 12 and a retaining spring 13 are set between the screw 15 and the side plate 11, and a hexagonal groove is set on the side of one end of the screw 15 to facilitate the insertion and rotation of a wrench; the screw 15 can be rotated by inserting a wrench to adjust the distance between the two clamping blocks 17 for clamping liquid storage cylinders 23 of different sizes.

[0044] As a third preferred solution of the present invention, a first sealing ring 19 is provided between the fixing member 21 and the reducing tube 18 , and a second sealing ring 22 is provided between the fixing member 21 and the liquid storage cylinder 23 .

[0045] The method for manufacturing ultra-trace solution micrometer wires based on the above system includes four stages: solution extrusion, liquid bridge connection, translation into wires, and solution back suction;

[0046] The specific steps include:

[0047] Step 1: Select a needle 24 and a spiral pipette needle 25 of corresponding specifications according to the required solution line size and solution viscosity, and install the spiral pipette needle 25 in the three-jaw chuck 20 to ensure its precise positioning in subsequent operations;

[0048] Step 2: Control the telescopic rod of the air cylinder 9 to work, driving the clamping mechanism 2 and the solution dispensing mechanism 4 to move in the vertical direction, so that the spiral pipette needle 25 reaches the predetermined solution line manufacturing position, so as to facilitate the formation and deposition of droplets at an appropriate height;

[0049] Step 3: Set the relevant parameters of the microfluidic syringe pump 1 and start the microfluidic syringe pump 1. The solution enters the liquid reservoir 23 through the pipeline, and the solution flows out of the liquid reservoir 23 from the gap between the needle 24 and the spiral pipette needle 25. The spiral groove on the spiral pipette needle 25 guides the solution to move in a uniform spiral motion in the groove, and finally forms an initial droplet at the tip of the spiral pipette needle 25;

[0050] Step 4: Control the substrate to move horizontally along a predetermined trajectory. A liquid bridge is formed between the tip of the spiral pipette needle 25 and the substrate due to the surface tension and adhesion of the droplet. The continuous movement of the substrate stretches the liquid bridge, producing ultra-micro and ultra-fine solution micrometer lines to meet specific application requirements.

[0051] Step 5: After the substrate completes the horizontal lateral movement according to the predetermined trajectory, the vertical lifting mechanism 3 is controlled to drive the solution dispensing mechanism 4 to rise, and the microfluidic injection pump 1 is controlled to perform a back suction operation to effectively suck back the residual solution at the needle tip, thereby avoiding liquid solidification blockage and ensuring the accuracy of subsequent operations.

[0052] The continuous supply of solution cooperates with the movement of the spiral pipette needle 25. Part of the solution spreads and adheres to the base surface by relying on adhesion and surface tension. Combined with the transfer principle, the distribution of ultra-trace solution is completed. At the same time, by controlling the movement of the solution distribution mechanism 4, the manufacture of ultra-fine, continuous micron wires is achieved.

[0053] It can be understood that the above specific description of the present invention is only used to illustrate the present invention and is not limited to the technical solutions described in the embodiments of the present invention. Ordinary technicians in this field should understand that the present invention can still be modified or replaced by equivalents to achieve the same technical effects; as long as the use requirements are met, they are within the scope of protection of the present invention.

Claims

1. A system for manufacturing ultra-trace solution micrometer wires based on a spiral structure guiding liquid, characterized in that: The invention comprises a base (10) and a microfluidic injection pump (1) with a syringe, wherein a vertical lifting mechanism (3) is provided on the side of the base (10), a lifting component of the vertical lifting mechanism (3) is connected to a clamping mechanism (2), and a solution dispensing mechanism (4) is provided through the clamping mechanism (2); The solution dispensing mechanism (4) includes a liquid storage cylinder (23), a needle (24) is provided at the bottom of the liquid storage cylinder (23), a spiral pipette needle (25) is provided on the needle (24), and spiral grooves are uniformly provided on the spiral pipette needle (25). A fixing member (21) is connected to the top of the liquid storage cylinder (23), and a three-jaw chuck (20) and a reducing tube (18) are provided through the fixing member (21). The three-jaw chuck (20) clamps the upper end of the spiral pipette needle (25), and connects the upper end opening of the reducing tube (18) and the liquid outlet of the syringe provided by the microfluidic injection pump (1) through a pipeline.

2. The ultra-trace solution micrometer wire manufacturing system based on spiral structure guiding liquid as claimed in claim 1, characterized in that: The vertical lifting mechanism (3) includes two parallel slide rails (5) arranged along the vertical direction on the side of the base (10), a vertical through slot is provided on the base (10) between the two parallel slide rails (5), two sliders (6) are provided through the two slide rails (5), the two sliders (6) are fixedly connected to the clamping mechanism (2), a cylinder (9) is provided on the base (10), and a telescopic rod of the cylinder (9) is connected to the clamping mechanism (2) through the through slot.

3. The ultra-trace solution micrometer wire manufacturing system based on spiral structure guiding liquid as claimed in claim 2, characterized in that: The clamping mechanism (2) includes a fixed plate (8), the fixed plate (8) is connected to the telescopic rod of the cylinder (9) through the through slot by a nut (7), the fixed plate 8 is fastened to the two sliders 6 by screws, a side plate (11) is provided in parallel at each horizontal end of the fixed plate (8), a parallel lead screw (15), a first guide shaft (14) and a second guide shaft (16) are provided between the two side plates (11), two clamping blocks (17) are symmetrically provided through the first guide shaft (14), the lead screw (15) and the second guide shaft (16), and V-shaped clamping grooves are provided on opposite sides of the two clamping blocks (17); The threads at both ends of the lead screw (15) are arranged in opposite directions, a bearing (12) and a retaining spring (13) are arranged between the lead screw (15) and the side plate (11), and a hexagonal groove for facilitating the insertion and rotation of a wrench is arranged on the side surface of one end of the lead screw (15).

4. The ultra-trace solution micrometer wire manufacturing system based on spiral structure guiding liquid as claimed in claim 1, characterized in that: A first sealing ring (19) is provided between the fixing member (21) and the reducing tube (18), and a second sealing ring (22) is provided between the fixing member (21) and the liquid storage cylinder (23).

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