Portable immunochromatography test strip field detection device based on smart phone

Abstract

The utility model provides a portable immunochromatography test strip field detection device based on a smart phone, and belongs to the technical field of detection devices. The on-site detection device comprises a detection box body, a mobile platform and a fixed base, and the front side surface of the detection box body is connected with the mobile platform and the fixed base from top to bottom; a transverse partition plate for dividing the detection box body into an upper cavity and a lower cavity is arranged in the detection box body, a light source is arranged at the top of the upper cavity, and the lower cavity of the detection box body is a power supply cavity; an insertion opening is formed in the right side surface of the detection box body; and a detection window corresponding to a test strip detection strip is formed in a top plate of the detection box body. The device can eliminate the interference of external factors such as light and temperature on the color change of the test strip, can be matched with various mobile phones to quickly position a detection window and photograph and analyze the test strip, and is good in repeatability and accuracy of a detection result, small in size and convenient to carry.

Description

Technical Field

[0001] The utility model belongs to the technical field of detection devices, and in particular relates to a portable immunochromatographic test strip on-site detection device based on a smart phone. Background Art

[0002] Lateral flow immunochromatography technology has become a major detection technology in the fields of food safety and medical treatment because of its fast detection, portability, and simple operation. It uses a combination of antigens and antibodies to qualitatively and quantitatively detect the concentration of the solution of the substance to be tested. However, the reading results of traditional immunochromatographic test strips such as colloidal gold and latex microspheres mainly rely on naked eye observation. Due to differences in personal vision and the influence of observation angle, different observers may have different judgments on the results of the same test strip, resulting in inaccurate results. In addition, at different times and under different environmental conditions, the color change of the test strip may be affected by external factors such as light and temperature, making the results less reproducible. After reading the test strip results with the traditional method, the data needs to be recorded manually, which is prone to errors. In addition, data storage, query and analysis are inconvenient, which is not conducive to the management and traceability of test results.

[0003] Existing colorimetric signal readers are often large and difficult to carry, limiting the flexibility of on-site testing. They are also usually complex and expensive, restricting their use in resource-constrained areas and homes, making them unsuitable for large-scale popularization. Summary of the Invention

[0004] The purpose of the present invention is to provide a portable immunochromatographic test strip on-site detection device based on a smart phone, which can eliminate the interference of external factors such as light and temperature on the color change of the test strip, can cooperate with various mobile phones to quickly locate the detection window, take pictures of the test strip and analyze it, and has good repeatability and accuracy of the test results. It is small in size and easy to carry.

[0005] The purpose of this utility model is achieved by the following technical solutions:

[0006] A portable immunochromatographic test strip on-site detection device based on a smartphone includes a detection box body, a mobile platform and a fixed base. The front side of the detection box body is connected to the mobile platform and the fixed base from top to bottom; a transverse partition is provided in the detection box body to separate the detection box body into upper and lower cavities, the top of the upper cavity is provided with a light source, and the lower cavity of the detection box body is a power supply cavity; a socket is provided on the right side of the detection box body, and a detection window corresponding to the test strip detection strip is provided on the top plate of the detection box body.

[0007] In a preferred technical solution, a longitudinal partition is further provided in the upper cavity of the detection box body to separate the upper cavity into an illumination cavity and a circuit cavity, and threading holes are provided on the transverse partition and the longitudinal partition.

[0008] Preferably, the light source is a light-emitting plate, the inner wall of the upper part of the light irradiation cavity of the detection box body is provided with a supporting plate for placing the light-emitting plate, the middle of the light-emitting plate is provided with a detection hole, the detection window on the top plate of the detection box body, the detection hole of the light-emitting plate and the strip of the test strip correspond to each other, and the supporting plate does not shield the light-emitting part of the light source.

[0009] Preferably, the supporting plate is provided with two supporting plates arranged on the inner walls of the front side and the rear side respectively, in the form of a strip extending from the light irradiation cavity to the circuit cavity, and parallel to the top plate.

[0010] Preferably, the fixed base and the moving platform are connected to the front side of the detection box body through a mortise and tenon structure.

[0011] Preferably, the detection device further comprises a test strip clamping groove for placing the test strip, the transverse partition plate in the light irradiation cavity of the detection box body is provided with two strip-shaped protrusions extending from the light irradiation cavity to the circuit cavity, a limiting groove of the test strip clamping groove is formed between the two strip-shaped protrusions, the socket of the detection box body corresponds to the limiting groove, and the test strip clamping groove is adapted to the socket and the limiting groove.

[0012] Preferably, the left and right sides of the detection box body are both provided with a movable plug-in plate structure and are matched with the plug-in slots at the corresponding positions of the detection box body; the bottom plate of the lower cavity of the detection box body is provided with a movable plug-in plate structure.

[0013] Preferably, the fixed base is an L-shaped plate formed by connecting two vertical plates, and the two vertical plates are connected through a connecting plate.

[0014] Preferably, the moving platform comprises a supporting plate, a sliding plate and a mobile phone seat arranged from bottom to top, the supporting plate is provided with a longitudinal sliding groove, and the bottom of the sliding plate is provided with a first sliding block matched with the longitudinal sliding groove; the sliding plate is provided with a transverse sliding groove, and the bottom of the mobile phone seat is provided with a second sliding block 2-7 matched with the transverse sliding groove; the end of the sliding plate away from the detection window of the detection box body is provided with an end cover connected through a clamping groove.

[0015] Preferably, the test strip clamping groove is in the form of a box and is clamped by a base and a cover plate, the base is provided with a plurality of strip-shaped protrusions along the length direction, forming a clamping groove for placing a plurality of test strips, and the base is provided with a plurality of protrusions along the width direction; the cover plate is provided with a display window corresponding to the detection strip on the test strip, and is provided with a sample adding hole corresponding to the sample adding part of the test strip.

[0016] Beneficial effects: the utility model cooperates with smart phone, carries out on -the -spot detection to color immunochromatography test strip (including colloidal gold test strip, latex microsphere etc.) including color. The photographing function of smart phone is adopted to the immunochromatography test strip, and the smart phone is equipped with conventional APP (prior art), and the APP has colorimetric signal reader function, can automatically position, recognize and obtain the colorimetric signal (the colored band on the photo) on the immunochromatography test strip photo (the photographing function obtains), the colorimetric signal in the image is converted into gray scale value, and accurate calculation is carried out, and finally the positive and negative determination and quantitative result of test strip are output, realize the rapid, convenient in vitro diagnostic analysis.The utility model can eliminate the interference of light, temperature and other external factors on the color change of test strip, improve the repeatability and accuracy of detection result.In addition, various models of mobile phones (such as Huawei P30 Pro, Vivo, Xiaomi, etc.) are placed on the mobile phone seat, and the position is adjusted by horizontal or vertical movement, can be quickly positioned to the detection window for imaging, and various detection data can be stored in the mobile phone, the data is not easy to lose, and it is beneficial to query and analysis.The utility model is convenient for the replacement of light-emitting plate, power supply and circuit, and the cost is low.The utility model is small in size, convenient to carry, and can be widely applied to on -the -spot rapid detection, such as field investigation, home self-test scene.The micro lens of smart phone is used to capture the chroma signal on the test strip, without additional lens.The detection window covers 25cm 2 The field of view, enough to capture C and T line of multiple test strips at the same time. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is the structure diagram of detection device.

[0018] Figure 2 It is the A-A section view of detection box body.

[0019] Figure 3 It is the top view of detection box body after removing top plate.

[0020] Figure 4 It is the structure diagram of support plate.

[0021] Figure 5 It is the B-B section view of 2-2 sliding plate.

[0022] Figure 6 It is the structure diagram of mobile phone seat.

[0023] Figure 7 It is the structure diagram of test strip card slot.

[0024] Figure 8 It is the structure diagram of base of test strip card slot.

[0025] Figure 9 It is the structure diagram of light-emitting plate.

[0026] Wherein, 1 detection box body, 2 mobile platform, 3 fixed base, 1-2 right plugboard, 1-3 socket, 1-4 handle, 1-5 detection window, 1-6 light chamber, 1-7 strip protrusion, 1-8 line cavity, 1-9 threading hole, 1-10 power cavity, 1-11 bottom plate, 1-12 transverse partition, 1-13 supporting plate, 1-14 longitudinal partition, 1-15 top plate, 1-17 protrusion, 1-18 front side, 1-19 right side, 1-20 left plugboard, 2-1 mobile phone holder, 2-2 sliding plate, 2-3 supporting plate, 2-4 longitudinal sliding groove, 2-5 bolt, 2-7 second sliding block (trapezoidal), 2-9 transverse sliding groove, 2-10 end cover, 4 test strip card slot, 4-1 display window, 4-2 sample hole, 4-3 is the first card slot, 4-4 third card slot, 4-5 protrusion, 5-1 patch type light emitting diode, 5-2 current limiting resistor, 5-3 PCB board, 5-4 detection hole. DETAILED DESCRIPTION

[0027] Structure and use method of the utility model in embodiment 1

[0028] Combining the drawings Figures 1-9 , a kind of portable immunochromatography test strip field detection device based on smart phone is described to the structure of the utility model: a detection box body 1, mobile platform 2 and fixed base 3, detection box body 1 front side 1-18 is connected with mobile platform 2 and fixed base 3 from top to bottom;Detection box body 1 is provided with the transverse partition 1-12 of the upper cavity and the lower cavity of detection box body, the top of upper cavity is equipped with light source, the lower cavity of detection box body is power cavity 1-10, for placing power supply.The right side 1-19 of detection box body is equipped with socket 1-3, for inserting test strip, the top plate 1-15 of detection box body is equipped with detection window 1-5 corresponding with test strip detection strip band.The test strip is inserted by socket, is placed on transverse partition, light source illuminates test strip, at this time just can place mobile phone on mobile platform, the camera of mobile phone carries out photographing to the detection strip band on test strip through detection window on the top plate of detection box, analyzes through APP, obtains detection result.Transverse partition is equipped with threading hole, it is convenient for line connection of light source and power supply.

[0029] The upper cavity of detection box body 1 is also equipped with the longitudinal partition 1-14 of the light chamber 1-6 and line cavity 1-8 of upper cavity, and the transverse partition and longitudinal partition are equipped with threading hole 1-9, for passing through line, so it is favorable for line inspection and installation.

[0030] The light source can select a light-emitting plate. The inner wall of the upper part of the light irradiation cavity is provided with a supporting plate 1-13 for placing the light-emitting plate, the middle of the light-emitting plate is provided with a detection hole 5-4, a detection window on the top plate of the detection box body corresponds to the detection hole of the light-emitting plate, and the detection window and the detection hole of the light-emitting plate both correspond to the detection strip of the test strip, and the supporting plate does not shield the light-emitting part of the light source. With such a structure, the test strip can receive stable light source, which is conducive to clear photography.

[0031] The supporting plate is provided with two, which are arranged on the inner walls of the front side and the rear side of the detection box body, in the form of a strip extending from the light irradiation cavity to the circuit cavity, and parallel to the top plate, so that the light-emitting plate can be parallel to the top plate, and the test strip can receive stable light source, which is conducive to clear photography.

[0032] The fixed base and the moving platform are both inserted on the front side of the detection box body through the mortise and tenon structure. The front side of the detection box body is provided with a protrusion 1-17, and the fixed base and the moving platform are provided with a groove matched with the protrusion 1-17, for connecting the moving platform, the fixed base and the detection box body. The size of the detection box body is 90*60*85mm (length* width*height). 3

[0033] The utility model discloses detection device still includes the test strip slot 4 of a plurality of test strips can be placed, the transverse baffle 1-12 in the light irradiation cavity 1-6 is provided with two strip-shaped protrusions 1-7 extending from the light irradiation cavity to the circuit cavity, and the limiting slot of the test strip slot is formed between the two strip-shaped protrusions, the socket 1-3 of the detection box body corresponds to the limiting slot, and the test strip slot is matched with the socket 1-3 and the limiting slot. The test strip slot is inserted from the socket 1-3 and is limited in the limiting slot between the two strip-shaped protrusions, so as to be positioned, which is conducive to clearly photographing the detection strip of the test strip.

[0034] The left and right sides of the detection box body are both adopted the movable plugboard structure, and are matched with the insertion slot of the corresponding position of the detection box body. The movable plugboard includes the left plugboard 1-20 and the right plugboard 1-2, the left plugboard corresponds to the circuit cavity of the left side of the detection box body, and the right plugboard corresponds to the light irradiation cavity of the right side of the detection box body, so that the light-emitting plate can be inserted above the supporting plate first, the circuit of the light-emitting plate is inserted into the circuit cavity, and then the left and right plugboards are inserted into the insertion slot, which is conducive to the installation and replacement of accessories. The socket 1-3 is arranged on the right plugboard.

[0035] The bottom plate 1-11 of the lower cavity of the detection box body is adopted the movable plugboard structure, which is convenient for installing the power supply.

[0036] The fixed base 3 is an L-shaped plate formed by connecting two vertical plates, and the two vertical plates are connected by a connecting plate, so that the structure is more firm. The fixed base is conducive to keeping the balance of the whole detection device and facilitating the operation of the detection device.

[0037] ​The mobile platform 2 comprises, from bottom to top, a support plate 2-3, a slide plate 2-2, and a mobile phone holder 2-1. The support plate 2-3 is an L-shaped plate formed by two rectangular plates connected vertically together. One plate is provided with a longitudinal groove 2-4, and the other plate is provided with a groove for connection to the detection box. The slide plate 2-2 comprises a rectangular plate with a transverse groove 2-9 and a first slider at its bottom that mates with the longitudinal groove 2-4 of the support plate. The mobile phone holder 2-1 comprises a rectangular plate with vertical plates perpendicularly connected at both ends. The mobile phone is placed on the rectangular plate. A second slider 2-7 is located below the rectangular plate of the mobile phone holder, which mates with the transverse groove 2-9 of the slide plate. Specifically, the rectangular plate of the mobile phone holder has a threaded hole, into which a bolt 2-5 is screwed and then connected to the second slider via threads. The end of the slide plate 2-2, facing away from the detection window of the detection box, is equipped with an end cap 2-10 connected via a slot to facilitate the installation and positioning of the second slider. Various smartphones (such as Huawei P30 Pro, Vivo, Xiaomi, etc.) are placed on the mobile phone holder. By adjusting the position on the longitudinal and transverse slides, the cameras of various mobile phones can be placed above the detection window to take pictures of the test strip.

[0038] The test strip holder 4 is box-shaped, formed by a base and a cover plate. The base is provided with several rows of protruding strips along its length, with each row forming a slot for a test strip. The base is equipped with slots for three test strips, including a first slot 4-3, a second slot, and a third slot 4-4. Several protrusions 4-5 are provided along the base's width to compress the test strips and prevent them from shifting. The cover plate has a display window 4-1 corresponding to the detection strip on the test strip, and a sample loading hole 4-2 corresponding to the sample loading area on the test strip.

[0039] A hole for installing a power switch is provided on the rear side of the detection box body.

[0040] Handles 1-4 are provided on the left and right plugboards to facilitate the installation of the plugboards.

[0041] The light-emitting board is a light-emitting diode array light source, consisting of a square PCB board 5-3 with a detection hole 5-4 in the center and several surface-mount LEDs 5-1 evenly distributed on the PCB. The surface-mount LEDs are model 5730, with a wavelength range of 630-635nm. To reduce costs, a current-limiting resistor 5-2 is used to control excessive current. The detection hole 5-4 corresponds to the detection window and has a diameter of 24mm.

[0042] The light emitting board, the switch and the power supply arranged in the power supply cavity are connected in series through a circuit (arranged in the circuit cavity). The switch is inserted through a hole for installing the power switch on the rear side of the detection box body.

[0043] Installation method of portable immunochromatography test strip on-site detection device based on smart phone

[0044] 1. Open the bottom plate of the detection box, place the battery (a rechargeable lithium battery) in the power cavity, and place the line connected with the power supply in the line cavity through the threading hole of the transverse partition plate, and install the bottom plate.

[0045] 2. Remove the left and right plug plates of the detection box, place the light-emitting plate on the supporting plate of the light cavity, place the line connected with the light-emitting plate in the line cavity through the threading hole on the longitudinal partition plate, connect the light-emitting plate, switch and power supply in series through the line, place the line in the line cavity, pass the switch out of the hole for installing the power switch on the rear side of the detection box, and then insert the left and right plug plates into the plug slots of the detection box.

[0046] 3. Insert the protrusions 1-17 of the detection box into the grooves of the fixed base and support plate, install the fixed base and support plate, open the end cover of the sliding plate, place the second sliding block of the mobile phone seat in the transverse sliding groove of the sliding plate, and fix the upper end cover. Then, place the first sliding block of the sliding plate in the longitudinal sliding groove of the support plate.

[0047] The smart phone used in cooperation with the utility model has a photographing function and is provided with a conventional APP (prior art), the APP has a colorimetric signal reader function, can automatically locate, identify and acquire a colorimetric signal (a colored strip on a photo) on a photo (obtained by the photographing function) of an immunochromatography test strip, convert the colorimetric signal in the image into a gray value, and perform accurate calculation, finally output a positive / negative judgment and quantitative result of the test strip, and realize rapid and convenient in-vitro diagnosis analysis.

[0048] The use method of the portable immunochromatography test strip on-site detection device based on the smart phone is as follows: three test strips are respectively loaded into the first card slot, the second card slot and the third card slot of the test strip card slot, and a sample to be detected is added dropwise in the sample adding hole. The portable immunochromatography test strip on-site detection device based on the smart phone is placed horizontally, the test strip card slot is inserted into the limiting groove of the light cavity through the insertion opening, after sufficient reaction, the switch is opened, at this time the light-emitting plate emits light and illuminates the display window area in the test strip card slot. The smart phone is placed in the mobile phone seat, the mobile phone is moved left and right and back and forth through the transverse sliding groove and the longitudinal sliding groove, so that the camera of the mobile phone is quickly aligned with the detection window of the detection box, the strip at the display window of the test strip card slot is photographed and imaged, uploaded to the App, automatically identified and analyzed, and finally the detection result: positive / negative result or quantitative result is automatically output.

Claims

1. A portable immunochromatographic test strip on-site detection device based on a smartphone, characterized in that The invention comprises a detection box body, a mobile platform and a fixed base, wherein the front side of the detection box body is connected to the mobile platform and the fixed base from top to bottom; a transverse partition is provided in the detection box body to separate the detection box body into an upper cavity and a lower cavity; a light source is provided on the top of the upper cavity, and the lower cavity of the detection box body is a power cavity; a socket is provided on the right side of the detection box body, and a detection window corresponding to the test strip is provided on the top plate of the detection box body.

2. The detection device according to claim 1, characterized in that A longitudinal partition is further provided in the upper cavity of the detection box body for dividing the upper cavity into an illumination cavity and a circuit cavity, and threading holes are provided on the transverse partition and the longitudinal partition.

3. The detection device according to claim 1 or 2, characterized in that The light source is a light-emitting board, and the inner wall of the upper part of the illumination cavity of the detection box body is provided with a support plate for placing the light-emitting board. A detection hole is provided in the middle of the light-emitting board. The detection window on the top plate of the detection box body, the detection hole of the light-emitting board and the strip of the test strip correspond to each other, and the support plate does not block the light-emitting part of the light source.

4. The detection device according to claim 3, characterized in that There are two supporting plates, which are respectively arranged on the inner walls of the front side and the rear side, and are in the shape of strips extending from the illumination cavity to the circuit cavity and are parallel to the top plate.

5. The detection device according to claim 4, characterized in that The fixed base and the movable platform are both plugged into the front side surface of the detection box body through a mortise and tenon structure.

6. The detection device according to claim 5, characterized in that The detection device also includes a test strip slot for placing a test strip. Two strip-shaped protrusions extending from the illumination chamber to the circuit chamber are provided on the transverse partition within the illumination chamber of the detection box body. A limiting groove of the test strip slot is formed between the two strip-shaped protrusions. The socket of the detection box body corresponds to the limiting groove, and the test strip slot is adapted to the socket and the limiting groove.

7. The detection device according to claim 6, characterized in that The left and right sides of the detection box body both adopt a movable plug-in structure and cooperate with the slots at corresponding positions on the detection box body; the bottom plate of the lower cavity of the detection box body adopts a movable plug-in structure.

8. The detection device according to claim 7, characterized in that The fixed base is an L-shaped plate formed by connecting two vertical plates, and the two vertical plates are connected by a connecting plate.

9. The detection device according to claim 8, characterized in that The mobile platform includes a support plate, a skateboard and a mobile phone holder arranged from bottom to top, the support plate is provided with a longitudinal slide groove, the bottom of the skateboard is provided with a first slider that cooperates with the longitudinal slide groove; the skateboard is provided with a transverse slide groove, and the bottom of the mobile phone holder is provided with a second slider 2-7 that cooperates with the transverse slide groove; the end of the skateboard away from the detection window of the detection box body is provided with an end cover connected by a card slot.

10. The detection device according to claim 9, characterized in that The test strip slot is box-shaped and is formed by a base and a cover plate being clamped together. The base is provided with a plurality of strip-shaped protrusions along the length direction to form a slot for placing a plurality of test strips, and the base is provided with a plurality of protrusions along the width direction; the cover plate is provided with a display window corresponding to the detection strip on the test strip, and a sample addition hole is provided corresponding to the sample addition position of the test strip.

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