Nucleoside monomer synthesizing and dissolving equipment

Abstract

The utility model relates to nucleoside monomer synthesis dissolving equipment, which comprises dissolving equipment, and is characterized in that a movable screw rod, a screwing block, a fan and a water absorption filter screen are arranged, a packaging bottle is firstly inserted into the inner side of a drying box, a packaging bottle cap is inserted into the inner side of the screwing block to be clamped, and then a pressing plate and a sealing plate are pressed downwards, so that the sealing plate shields the packaging bottle; a pressing plate is matched with a drying box to fix a packaging bottle, then a draught fan is started, air inside the drying box is pumped out through the draught fan, air entering the drying box is dried through a water absorption filter screen, after water inside the drying box is pumped out, a square rod is rotated, and the square rod drives a movable screw rod and a screwing block to rotate and move; the packaging bottle cap is screwed off through the screwing block, the nucleoside monomers on the inner side of the packaging bottle can enter the inner side of the dissolving equipment through the input pipe, when the nucleoside monomers are injected into the packaging bottle, the packaging bottle can be away from the outside environment, outside water is further separated from the packaging bottle, and dissolving of the device is more stable.

Description

TECHNICAL FIELD

[0001] The utility model relates to nucleoside monomer synthesis dissolving equipment technical field especially is to point to a kind of nucleoside monomer synthesis dissolving equipment. BACKGROUND

[0002] Nucleoside monomer is important raw material for synthesizing genetic material (DNA and RNA) in organism, plays the cornerstone role in the synthesis of nucleic acid drug, primer / probe, plasmid etc., when nucleoside monomer carries out processing reaction, often need to use dissolving equipment to dissolve it, to facilitate subsequent processing.

[0003] But nucleoside monomer is dissolved nucleoside monomer or other modified monomer when carrying out nucleic acid synthesis, and direct dissolving method is used.Specific operation is: opening package bottle cap, then using syringe or measuring cylinder injection or pouring into a certain amount of volume of anhydrous acetonitrile, in this process, package bottle is exposed in outside environment, so that impurity or environmental moisture is easy to contact with nucleoside monomer, and then affect subsequent synthesis. UTILITY MODEL CONTENT

[0004] Therefore, the technical problem to be solved by the utility model lies in solving the problem that, in the prior art, when nucleoside monomer is dissolved or other modified monomer during nucleic acid synthesis, the package bottle is exposed in outside environment, so that impurity or environmental moisture is easy to contact with nucleoside monomer, and then affect subsequent synthesis.

[0005] To solve the above technical problems, the utility model provides a kind of nucleoside monomer synthesis dissolving equipment, including dissolving equipment, the input pipe is communicated on the dissolving equipment upper side, the square bar is rotatably connected in input pipe inner side, the moving screw rod is slidably connected on the square bar outer side, the moving screw rod and input pipe are threadedly connected, the twist block is fixedly connected on the moving screw rod outer side, the twist block and input pipe are used in cooperation, the drying box is communicated on the input pipe outer side, the fan is arranged in drying box inner side, the gas inlet pipe is communicated on the drying box outer side, the limit frame is fixedly connected on the input pipe outer side, the water absorption filter screen is slidably connected in limit frame inner side, the water absorption filter screen and gas inlet pipe are used in cooperation, the sealing plate is slidably connected on the drying box outer side, the pressing plate is slidably connected in drying box inner side, this step is by setting moving screw rod, twist block, fan and water absorption filter screen, first, package bottle is inserted into drying box inner side, package bottle cap is inserted into twist block inner side and is stuck, then, pressing plate and sealing plate are pressed down, so that sealing plate shields package bottle, package bottle is fixed by pressing plate cooperation drying box, then, fan is started, air in drying box inner side is extracted by fan, and air entering drying box inner side is dried by water absorption filter screen, when moisture in drying box inner side is extracted, square bar is rotated, moving screw rod and twist block are rotated and moved by square bar, so that twist block unscrews package bottle cap, so that nucleoside monomer in package bottle inner side can enter dissolving equipment inner side by input pipe, when nucleoside monomer is injected, package bottle can be away from outer side environment, further separate outer side moisture from it, so that the dissolution of device is more stable.

[0006] In an embodiment of the utility model, the fan outer side rotatably connects with the cover plate, the pressing plate outer side slidably connects with the sealing ring, the sealing ring and drying box fixed connection, this step is by setting cover plate and sealing ring, when fan is not used, can rotate cover plate and shield its upper side, and sealing ring is sealed between pressing plate and drying box, so that impurity and moisture of outer side air are difficult to enter drying box inner side through fan or between pressing plate and drying box, improve the sealing property of device.

[0007] In an embodiment of the utility model, the sealing plate inner side slidably connects with the moving rod, the moving rod outer side fixedly connects with the push plate, the sealing plate outer side fixedly connects with the tension spring, the tension spring and moving rod one end fixed connection, this step is by setting moving rod, push plate and tension spring, after package bottle is inserted into drying box inner side, can be pushed moving rod and push plate close to package bottle by tension spring, so that push plate cooperation input pipe further fixes and clamps package bottle, so that package bottle and package bottle cap are more stable in separation and connection, improve the stability of device use.

[0008] In an embodiment of the utility model, the limiting frame inner side is slidably connected with an insertion rod, the insertion rod is slidably connected with the water absorption filter screen, the insertion rod is provided, and the water absorption filter screen is conveniently installed and disassembled through the connection or separation of the insertion rod and the water absorption filter screen, thereby being conveniently disassembled and replaced after long-term use, and the convenience of device use is improved.

[0009] In an embodiment of the utility model, the limiting frame inner side is fixedly connected with a limiting plate, and the limiting plate is used in cooperation with the water absorption filter screen, the limiting plate is provided, the movable position of the water absorption filter screen is limited through the limiting plate when the water absorption filter screen is replaced, the insertion rod is aligned with the water absorption filter screen, thereby the insertion rod is conveniently inserted into the inner side of the water absorption filter screen, and the convenience of device use is improved.

[0010] In an embodiment of the utility model, a fixing groove is formed in the surface of the input pipe, and an ultraviolet lamp is arranged in the inner side of the fixing groove, the fixing groove and the ultraviolet lamp are provided, the inner side of the input pipe is irradiated through the ultraviolet lamp at regular intervals when the input pipe is not used, thereby the input pipe is disinfected, the inner side of the input pipe is kept clean, and the stability of device use is improved.

[0011] In an embodiment of the utility model, the inner side of the input pipe is fixedly connected with an inclined plate, and a guide groove is formed in the surface of the inclined plate, the inclined plate and the guide groove are provided, the nucleoside monomer is guided, the nucleoside monomer can be more quickly and conveniently introduced into the inner side of the dissolving equipment, and the convenience of device use is improved.

[0012] In an embodiment of the utility model, the inner side of the screw block is uniformly convex, and the screw block is used in cooperation with the moving screw, the screw block is provided, the cap of the packaging bottle is in the shape of the inner side of the screw block, the inner side of the screw block can be clamped on the cap of the packaging bottle, the friction coefficient between the screw block and the cap of the packaging bottle is increased, the rotation of the screw block on the cap of the packaging bottle driven by the moving screw is more stable, and the stability of device use is improved.

[0013] Compared with the prior art, the above technical scheme of the utility model has the following advantages:

[0014] The utility model relates to a nucleoside monomer synthesis dissolving equipment, through setting up mobile screw rod, twist block, fan and water suction filter screen, first insert the packing bottle into the inboard of drying box, insert the packing bottle cap into the inboard of twist block and hold, then press down the pressing plate and sealing plate, make the sealing plate shelter the packing bottle, then start the fan, the air inboard of drying box is extracted through the fan, and the air into the inboard of drying box is dried through the water suction filter screen, when the moisture inboard of drying box is extracted, rotate square bar, make twist block unscrew the packing bottle cap through square bar drive mobile screw rod and twist block rotation and remove, make the nucleoside monomer in the inboard of packing bottle can enter the inboard of dissolving equipment through input pipe, when injecting nucleoside monomer, the packing bottle can be far from the outside environment, further separate the outside moisture from it, make the dissolution of device more stable.

[0015] The utility model relates to a nucleoside monomer synthesis dissolving equipment through setting up cover plate and sealing ring, when not using the fan, can rotate cover plate and shelter its upper side, and through sealing ring between the pressing plate and drying box seal, make the moisture of impurity and outside air difficult to enter the inboard of drying box through the fan or between the pressing plate and drying box, improved the sealing property of device. ACCURACY OF DRAWINGS

[0016] In order to make the content of the utility model more easily be clearly understood, below according to the specific embodiment of the utility model and combining with attached drawing, the utility model is further detailed.

[0017] Figure 1 It is the front view of the utility model;

[0018] Figure 2 It is the input pipe structure schematic view of the utility model;

[0019] Figure 3 It is the twist block structure schematic view of the utility model;

[0020] Figure 4 It is the limiting frame structure schematic view of the utility model;

[0021] Figure 5 It is the sealing plate structure schematic view of the utility model;

[0022] The attached drawing of specification sign explanation: 1, dissolving equipment;2, input pipe;3, square bar;4, mobile screw rod;5, twist block;6, drying box;7, fan;8, inlet pipe;9, limiting frame;10, water suction filter screen;11, sealing plate;12, pressing plate;13, cover plate;14, sealing ring;15, moving rod;16, push plate;17, tension spring;18, plug rod;19, limiting plate;20, fixed groove;21, ultraviolet lamp;22, inclined plate;23, guide groove. DETAILED DESCRIPTION

[0023] The present invention will be further described below with reference to the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it. However, the embodiments are not intended to limit the present invention.

[0024] Reference Figures 1 to 5 As shown, a nucleoside monomer synthesis and dissolution equipment of the present invention comprises a dissolution equipment 1, the upper side of the dissolution equipment 1 is connected with an input pipe 2, the inner side of the input pipe 2 is rotatably connected with a square rod 3, the outer side of the square rod 3 is slidably connected with a movable screw 4, the movable screw 4 is threadedly connected to the input pipe 2, the outer side of the movable screw 4 is fixedly connected with a twisting block 5, the twisting block 5 and the input pipe 2 are used in conjunction with the input pipe 2. The outer side of the input pipe 2 is connected with a drying box 6, the inner side of the drying box 6 is provided with a fan 7, the outer side of the drying box 6 is connected with an air inlet pipe 8, the outer side of the input pipe 2 is fixedly connected with a limiting frame 9, the inner side of the limiting frame 9 is slidably connected with a water absorption filter 10, the water absorption filter 10 is used in conjunction with the air inlet pipe 8, the outer side of the drying box 6 is slidably connected with a sealing plate 11, and the inner side of the drying box 6 is slidably connected with a pressing plate 12. This step is achieved by setting a movable screw. The rod 4, the screw block 5, the fan 7 and the water absorption filter 10 are used to first insert the packaging bottle into the inner side of the drying box 6, insert the packaging bottle cap into the inner side of the screw block 5 and clamp it, and then press the pressing plate 12 and the sealing plate 11 downward so that the sealing plate 11 blocks the packaging bottle, and fixes the packaging bottle through the pressing plate 12 in cooperation with the drying box 6, and then start the fan 7, and the air inside the drying box 6 is extracted by the fan 7, and the air entering the drying box 6 is dried through the water absorption filter 10. When the moisture inside the drying box 6 is drained, the square rod 3 is rotated, and the moving screw 4 and the screw block 5 are driven to rotate and move by the square rod 3, so that the screw block 5 unscrews the packaging bottle cap, so that the nucleoside monomer inside the packaging bottle can enter the inside of the dissolution device 1 through the input pipe 2. When the nucleoside monomer is injected, the packaging bottle can be away from the external environment, further isolating the external moisture from it, making the dissolution of the device more stable.

[0025] Reference Figure 2 As shown, the outer side of the fan 7 is rotatably connected to a cover plate 13, and the outer side of the pressure plate 12 is slidably connected to a sealing ring 14, and the sealing ring 14 is fixedly connected to the drying box 6. In this step, by setting the cover plate 13 and the sealing ring 14, when the fan 7 is not in use, the cover plate 13 can be rotated to cover its upper side, and the sealing ring 14 is used to seal the pressure plate 12 and the drying box 6, so that impurities and moisture in the outside air are difficult to enter the inside of the drying box 6 through the fan 7 or the pressure plate 12 and the drying box 6, thereby improving the sealing performance of the device.

[0026] Reference Figure 2 and Figure 5As shown, the sealing plate 11 inside the sliding connection has a moving rod 15, the moving rod 15 outside is fixedly connected with a push plate 16, the sealing plate 11 outside is fixedly connected with a tension spring 17, and the tension spring 17 and the moving rod 15 are fixedly connected. This step is provided by setting the moving rod 15, the push plate 16 and the tension spring 17. After the packaging bottle is inserted into the drying box 6, the tension spring 17 can push the moving rod 15 and the push plate 16 to approach the packaging bottle, so that the push plate 16 cooperates with the input pipe 2 to further fix and clamp the packaging bottle, so that the separation and connection of the packaging bottle and the packaging bottle cap are more stable, and the stability of the device is improved.

[0027] Referring to Figure 3 As shown, the limiting frame 9 inside is slidingly connected with an insertion rod 18, and the insertion rod 18 is slidingly connected with the water absorption filter screen 10. This step is provided by setting the insertion rod 18. By connecting or separating the insertion rod 18 and the water absorption filter screen 10, the water absorption filter screen 10 is convenient to install and disassemble, and then it is convenient to disassemble and replace after long-term use, and the convenience of the device is improved.

[0028] Referring to Figure 3 As shown, the limiting frame 9 inside is fixedly connected with a limiting plate 19, and the limiting plate 19 is used in cooperation with the water absorption filter screen 10. This step is provided by setting the limiting plate 19. When the water absorption filter screen 10 is replaced, the limiting plate 19 can limit the movable position thereof, so as to align with the insertion rod 18, so as to facilitate the insertion of the insertion rod 18 into the inside of the water absorption filter screen 10, and the convenience of the device is improved.

[0029] Referring to Figure 2 As shown, the input pipe 2 is provided with a fixed groove 20 on the surface, and the fixed groove 20 is provided with a ultraviolet lamp 21 inside. This step is provided by setting the fixed groove 20 and the ultraviolet lamp 21. When the input pipe 2 is not used, the ultraviolet lamp 21 can be started regularly to irradiate the inside of the input pipe 2, so as to disinfect it, and then the inside of the input pipe 2 is kept clean, and the stability of the device is improved.

[0030] Referring to Figure 2 As shown, the input pipe 2 is fixedly connected with an inclined plate 22 inside, and the inclined plate 22 is provided with a guide groove 23 on the surface. This step is provided by setting the inclined plate 22 and the guide groove 23. The nucleoside monomer is guided so that it can enter the inside of the dissolving equipment 1 more quickly and conveniently, and the convenience of the device is improved.

[0031] Referring to Figure 4As shown, the inside of the twisting block 5 is uniformly convex, the twisting block 5 and the moving screw rod 4 are used in cooperation, this step is through setting the twisting block 5, the bottle cap of the packaging bottle is the shape of the inside of the twisting block 5, so that the inside of the twisting block 5 can be clamped on the packaging bottle cap, and the friction coefficient between the twisting block 5 and the packaging bottle cap is increased, so that the rotation of the moving screw rod 4 to the packaging bottle cap driven by the twisting block 5 is more stable, and the stability of the device is improved.

[0032] Working principle: first, insert the packaging bottle into the inside of the drying box 6, clamp the packaging bottle cap into the inside of the twisting block 5, then press down the pressing plate 12 and the sealing plate 11, so that the sealing plate 11 shields the packaging bottle, then start the fan 7, the air inside the drying box 6 is sucked out, and the air entering the inside of the drying box 6 is dried through the water absorption filter screen 10, when the moisture inside the drying box 6 is sucked dry, rotate the square rod 3, drive the moving screw rod 4 and the twisting block 5 to rotate and move through the square rod 3, so that the twisting block 5 unscrews the packaging bottle cap, so that the nucleoside monomer inside the packaging bottle can enter the inside of the dissolving equipment 1 through the input pipe 2, after pouring out, reverse the moving screw rod 4, drive the twisting block 5 and the packaging bottle cap to rotate in reverse through the moving screw rod 4, so that the packaging bottle cap is screwed on the outside of the packaging bottle again, and the opening of the input pipe 2 is sealed again through the twisting block 5, then lift the sealing plate 11, then take out the packaging bottle inside the drying box 6.

[0033] Obviously, the above embodiments are only examples for clearly illustrating, not limiting the embodiments. For those skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, all the embodiments need not and cannot be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A nucleoside monomer synthesis and dissolution device, comprising a dissolution device (1), characterized in that: The dissolving device (1) is connected to an input pipe (2) on the upper side, and a square rod (3) is rotatably connected to the inner side of the input pipe (2), and a movable screw (4) is slidably connected to the outer side of the square rod (3), and the movable screw (4) and the input pipe (2) are threadedly connected, and a screw block (5) is fixedly connected to the outer side of the movable screw (4), and the screw block (5) and the input pipe (2) are used in conjunction with each other, and the outer side of the input pipe (2) is connected to a drying box (6), and a fan (7) is provided on the inner side of the drying box (6), and the outer side of the drying box (6) is connected to an air inlet pipe (8), and the outer side of the input pipe (2) is fixedly connected to a limiting frame (9), and the inner side of the limiting frame (9) is slidably connected to a water absorption filter (10), and the water absorption filter (10) and the air inlet pipe (8) are used in conjunction with each other, and the outer side of the drying box (6) is slidably connected to a sealing plate (11), and the inner side of the drying box (6) is slidably connected to a pressure plate (12).

2. A nucleoside monomer synthesis and dissolution equipment according to claim 1, characterized in that: The outer side of the fan (7) is rotatably connected to a cover plate (13), the outer side of the pressure plate (12) is slidably connected to a sealing ring (14), and the sealing ring (14) is fixedly connected to the drying box (6).

3. A nucleoside monomer synthesis and dissolution equipment according to claim 2, characterized in that: The inner side of the sealing plate (11) is slidably connected to a moving rod (15), the outer side of the moving rod (15) is fixedly connected to a push plate (16), the outer side of the sealing plate (11) is fixedly connected to a tension spring (17), and the tension spring (17) is fixedly connected to one end of the moving rod (15).

4. A nucleoside monomer synthesis and dissolution device according to claim 3, characterized in that: The inner side of the limiting frame (9) is slidably connected to an inserting rod (18), and the inserting rod (18) is slidably connected to the water absorption filter (10).

5. A nucleoside monomer synthesis and dissolution device according to claim 4, characterized in that: The inner side of the limiting frame (9) is fixedly connected to a limiting plate (19), and the limiting plate (19) is used in conjunction with the water absorption filter (10).

6. A nucleoside monomer synthesis and dissolution device according to claim 5, characterized in that: A fixing groove (20) is provided on the surface of the input pipe (2), and an ultraviolet lamp (21) is provided inside the fixing groove (20).

7. The nucleoside monomer synthesis and dissolution equipment according to claim 6, characterized in that: An inclined plate (22) is fixedly connected to the inner side of the input pipe (2), and a guide groove (23) is provided on the surface of the inclined plate (22).

8. The nucleoside monomer synthesis and dissolution equipment according to claim 7, characterized in that: The inner side of the screw block (5) is in a uniform convex shape, and the screw block (5) and the moving screw rod (4) are used in conjunction with each other.

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