Biopharmaceutical rotating hub structure and tubular centrifuge

Abstract

The rotating hub structure comprises a rotating hub body and a cover body arranged on the rotating hub body, a three-edged plate is installed in the rotating hub body, the three-edged plate is provided with a plurality of sub-edged plates making contact with the inner wall of the rotating hub body, and the sub-edged plates are connected with the rotating hub body. A gasket is arranged between every two adjacent sub-edge plates, so that a solid-phase sample can be deposited on the gaskets. According to the rotating hub, a solid-phase sample in feed liquid can be precipitated on the liner in the centrifuging process, and after centrifuging is completed, the liner in the rotating hub body is taken out, so that the solid-phase sample can be quickly transferred, and the solid-phase sample can be conveniently collected or washed.

Description

Technical Field

[0001] This utility model belongs to the technical field of biological centrifuge equipment, and particularly relates to a rotating hub structure and tubular centrifuge for biopharmaceuticals. Background Technology

[0002] Vaccines are biological products used to provide active immunity to prevent specific diseases; centrifugation technology plays an important role in vaccine production, including bacterial isolation and collection, removal of suspended particles, sample concentration, quality control, and virus purification.

[0003] Currently, the liquid is usually injected into the rotating drum through the bottom inlet. Under the action of strong centrifugal force, the liquid is forced to flow upward along the inner wall of the rotating drum. Due to the density difference of different components in the liquid, they will be separated into layers according to the density difference in the centrifugal force field. The liquid phase with higher density forms the outer ring, the liquid phase with lower density forms the inner ring, and trace solids are deposited on the rotating drum wall. The clarified liquid phase flows to the liquid collection plate at the top of the rotating drum and is discharged from the drain port, while the solid sample is deposited on the rotating drum wall.

[0004] However, due to the small diameter and large depth of the rotating drum, it is difficult to scrape, collect or wash away the solid samples deposited on the drum wall, resulting in a decrease in yield and is time-consuming and labor-intensive, which is not conducive to the rapid transfer of time-sensitive samples. Utility Model Content

[0005] The purpose of this invention is to overcome the defects of the prior art and provide a rotating drum structure and tubular centrifuge for biopharmaceuticals, so that the solid sample in the feed liquid can be precipitated on the liner during the centrifugation process. After centrifugation, the liner in the rotating drum body can be removed to quickly transfer the solid sample, which is convenient for collection or rinsing.

[0006] The objective of this utility model is achieved through the following technical solution:

[0007] A rotating hub structure for biopharmaceuticals includes a hub body and a cover disposed on the hub body. A triangular prism is installed inside the hub body. The triangular prism has a plurality of sub-prisms that contact the inner wall of the hub body. A liner is disposed between each two adjacent sub-prisms to allow solid phase samples to precipitate on the liner.

[0008] In one embodiment, the gasket has an arcuate structure and fits against the inner wall of the hub body.

[0009] In one embodiment, each sub-prism of the triangular prism is equipped with multiple elastic strips on the side near the hub body. The two ends of the elastic strips are wound around the fixing posts of the sub-prisms. The portion of the elastic strip between the fixing posts is an arc-shaped segment protruding from the sub-prism. The arc-shaped segment abuts against the inner wall of the hub body. Through this embodiment, by utilizing the arc-shaped segment of the elastic strip protruding from the triangular prism and abutting against the hub body, the triangular prism can be easily fixed in the hub body and also easily removed with a simple structure.

[0010] In one embodiment, multiple elastic strips are evenly spaced along the same direction on the sub-prism plate. This embodiment allows multiple elastic strips on the same sub-prism plate to work together on the inner wall of the hub body, improving the stability of the triangular prism plate during centrifugation.

[0011] In one embodiment, the bottom of the rotating hub body is provided with a feed inlet, the top of the rotating hub body is connected with a liquid collection tray, and the liquid collection tray is provided with a drain outlet.

[0012] This invention also provides a tubular centrifuge for biopharmaceuticals, including the hub structure described above.

[0013] In one embodiment, the device further includes a drive motor and a head assembly connected to the drive motor, the head assembly being connected to the hub body to provide centrifugal force to the hub body.

[0014] In one embodiment, a housing is also included that covers the hub body.

[0015] The beneficial effects of this utility model are as follows:

[0016] (1) A liner is set inside the rotating hub structure so that the solid sample in the liquid can precipitate on the liner during centrifugation. After centrifugation, the liner inside the rotating hub body can be removed to quickly transfer the solid sample, which is convenient for collection or rinsing.

[0017] (2) The elastic strip on the sub-prism plate abuts against the inner wall of the hub body, which makes it easy to fix the triangular plate in the hub body and also makes it easy to remove it from the hub body. Attached Figure Description

[0018] The present invention will be described in more detail below based on embodiments and with reference to the accompanying drawings.

[0019] in:

[0020] Figure 1 A schematic diagram of the hub structure of this utility model is shown;

[0021] Figure 2A schematic diagram of the tubular centrifuge of this utility model is shown;

[0022] Figure 3 A schematic diagram of the elastic strip of this utility model is shown;

[0023] In the drawings, like reference numerals are used for like parts, but the drawings are not necessarily true to scale.

[0024] Figure label:

[0025] 1-Box body, 2-Drive motor, 3-Head assembly, 4-Collection tray, 5-Outlet, 6-Drum structure, 7-Inlet, 8-Pad, 9-Triangular plate, 901-Sub-triangular plate, 10-Elastic strip. Detailed Implementation

[0026] The present invention will be further described below with reference to the accompanying drawings.

[0027] This utility model provides a hub structure 6 for biopharmaceutical manufacturing, such as... Figure 1 As shown, it includes a rotating hub body and a cover body disposed on the rotating hub body. A triangular plate 9 is installed inside the rotating hub body. The triangular plate 9 has multiple sub-ribs 901 that contact the inner wall of the rotating hub body. A liner 8 is disposed between two adjacent sub-ribs 901 so that solid phase samples can precipitate on the liner 8.

[0028] It should be noted that the pad 8 set between two adjacent sub-prism plates 901 adheres to the inner wall of the rotating drum body under the action of centrifugal force. The liquid entering the rotating drum body rises along the pad 8 under the action of centrifugal force. The liquid phase flows to the liquid collection plate 4 at the top of the rotating drum for collection, while the solid phase sample precipitates on the pad 8. After centrifugation, the pad 8 inside the rotating drum body can be removed.

[0029] In one embodiment, Figure 1 As shown, the liner 8 has an arc-shaped structure and fits against the inner wall of the rotating drum body, so that it can fit better against the inner wall of the rotating drum body under centrifugal force, and allow the liquid to move along the liner 8 to the maximum extent.

[0030] In one embodiment, Figure 3 As shown, each sub-prism 901 of the triangular plate 9 is equipped with multiple elastic strips 10 on the side near the hub body. The two ends of the elastic strips 10 are wrapped around the fixing posts of the sub-prism 901. The part of the elastic strips 10 located between the fixing posts is an arc-shaped segment protruding from the sub-prism 901. The arc-shaped segment abuts against the inner wall of the hub body. That is, by using the elastic strips 10 provided on the sub-prism 901 to abut against the inner wall of the hub body, it is convenient to directly fix the triangular plate 9 in the hub body, and it is also convenient to remove it from the hub body.

[0031] Furthermore, multiple elastic strips 10 are evenly spaced along the same direction on the sub-prism plate 901, so that multiple elastic strips 10 on the same sub-prism plate 901 can work together on the inner wall of the rotating hub body, thereby improving the stability of the triangular plate 9 during the centrifugal process.

[0032] Specifically, a liquid collection plate 4 is connected to the top of the rotating hub body, and the liquid collection plate 4 has a drain port, such as... Figure 2 As shown, the liquid is fed into the bottom of the rotating hub body, and the liquid sample rises along the liner 8 to the collection plate 4 under the action of centrifugal force, while the solid sample settles on the liner 8 to complete the solid-liquid separation.

[0033] In one embodiment, the present invention also provides a tubular centrifuge, such as Figure 2 As shown, it includes the hub structure 6 mentioned above, as well as the drive motor 2 and the head assembly 3 connected to the drive motor 2. The head assembly 3 is connected to the hub body to provide centrifugal force to the hub body.

[0034] Specifically, it also includes a housing 1 that covers the rotating hub body to improve safety during centrifugation operations;

[0035] In one embodiment, during centrifugation, the liquid is injected into the rotating drum body through the inlet 7 at the bottom. Under the action of centrifugal force, the liquid flows upward along the liner 8. The liquid phase flows to the collection plate 4 and is discharged from the drain port, while the solid sample settles on the liner 8. After centrifugation, the rear cover at the bottom of the rotating drum body is opened to remove the liner 8. The sample on the liner 8 can be scraped to achieve the purpose of collecting the sample or cleaning the rotating drum. By using the liner 8, the harvesting efficiency of solid samples can be improved, the yield of solid samples can be increased, and the working time of cleaning the rotating drum can be reduced.

[0036] In the description of this utility model, it should be understood that the terms "upper", "lower", "bottom", "top", "front", "rear", "inner", "outer", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0037] While specific embodiments of the present invention have been described herein with reference to them, it should be understood that these embodiments are merely examples of the principles and applications of the present invention. Therefore, it should be understood that many modifications can be made to the exemplary embodiments, and other arrangements can be designed without departing from the spirit and scope of the present invention as defined by the appended claims. It should be understood that different dependent claims and features described herein can be combined in ways different from those described in the original claims. It is also understood that features described in conjunction with individual embodiments can be used in other described embodiments.

Claims

1. A hub structure for biopharmaceutical manufacturing, characterized in that, The device includes a rotating hub body and a cover body disposed on the rotating hub body. A triangular plate is installed inside the rotating hub body. The triangular plate has multiple sub-ribs that contact the inner wall of the rotating hub body. A liner is disposed between each two adjacent sub-ribs to allow solid phase samples to precipitate on the liner.

2. The hub structure for biopharmaceutical manufacturing according to claim 1, characterized in that, The gasket has an arc-shaped structure and fits against the inner wall of the hub body.

3. The rotating hub structure for biopharmaceutical manufacturing according to claim 1, characterized in that, Each sub-prism of the triangular plate has multiple elastic strips installed on the side near the hub body. The two ends of the elastic strips are wrapped around the fixing posts of the sub-prisms. The part of the elastic strip between the fixing posts is an arc-shaped segment protruding from the sub-prism, and the arc-shaped segment abuts against the inner wall of the hub body.

4. The rotating hub structure for biopharmaceutical manufacturing according to claim 3, characterized in that, Multiple elastic strips are evenly spaced along the same direction on the sub-prism plate.

5. The rotating hub structure for biopharmaceutical manufacturing according to claim 1, characterized in that, The bottom of the rotating hub body is provided with a feed inlet, and the top of the rotating hub body is connected with a liquid collection plate, which is provided with a drain outlet.

6. A tubular centrifuge for biopharmaceutical applications, characterized in that, Includes the hub structure as described in any one of claims 1 to 5.

7. A tubular centrifuge for biopharmaceutical production according to claim 6, characterized in that, It also includes a drive motor and a head assembly connected to the drive motor, the head assembly being connected to the hub body to provide centrifugal force to the hub body.

8. A tubular centrifuge for biopharmaceutical production according to claim 7, characterized in that, It also includes a housing that covers the hub body.

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