HER2 gene mutation high-precision quantitative analysis device

Abstract

The utility model relates to the technical field of detection instruments, in particular to a high-precision quantitative analysis device for HER2 gene mutation, which comprises a machine body, a sampling mechanism capable of simultaneously sampling samples in a plurality of test tubes is mounted on the machine body, and a detection mechanism for detecting and analyzing the samples is arranged below the sampling mechanism; the sampling mechanism comprises two groups of moving assemblies mounted on the machine body, a mounting plate is fixedly arranged on the two groups of moving assemblies, and a variable pitch assembly and a sampling assembly are fixedly arranged on the side wall of the mounting plate; according to the HER2 gene mutation high-precision quantitative analysis device, under the action of the sampling assembly and the detection mechanism, due to the fact that multiple sampling barrels are arranged, multiple test tubes can be sampled and detected at the same time, the working efficiency is greatly improved, the purpose of quantitative sampling can be achieved by adopting an air pumping mode of an air pump for sampling, and the HER2 gene mutation high-precision quantitative analysis device has the advantages of being accurate and reliable in sampling; and the sample is not easy to pollute.

Description

Technical Field

[0001] This utility model relates to the field of detection instrument technology, specifically a high-precision quantitative analysis device for HER2 gene mutations. Background Technology

[0002] The HER2 gene mutation analysis device is used to detect mutations or amplifications in the HER2 gene (human epidermal growth factor receptor 2). The HER2 gene plays an important role in certain types of cancer, such as breast cancer and some gastric cancers. HER2 analysis is often used to determine whether a patient is suitable for specific targeted therapy. However, existing analysis devices work by taking a sample from a test tube, dropping it onto the detection area, and then sending the sample into the device for analysis. This method can only analyze a single sample from a single test tube at a time, resulting in low detection efficiency, difficulty in controlling the sample volume, and a high risk of sample contamination, which can affect the accuracy of the analytical results. Utility Model Content

[0003] To address the shortcomings of existing technologies, this invention provides a high-precision quantitative analysis device for HER2 gene mutations, solving the technical problem of low working efficiency in existing analysis devices.

[0004] To solve the above-mentioned technical problems, this utility model provides the following technical solution: a high-precision quantitative analysis device for HER2 gene mutations, comprising a body, wherein a sampling mechanism capable of simultaneously sampling samples from multiple test tubes is installed on the body, and a detection mechanism for detecting and analyzing the samples is provided below the sampling mechanism; the sampling mechanism includes two sets of moving components installed on the body, and a mounting plate is fixedly mounted on both sets of moving components, and a variable distance component and a sampling component are fixedly mounted on the side wall of the mounting plate;

[0005] The sampling assembly includes an air pump fixed on a mounting plate, an air tube connected to the air pump, one end of the air tube being connected to multiple sampling tubes through multiple connecting pipes, the sampling tubes being mounted on the pitch-changing assembly through a fixing sleeve, and a needle being connected to the bottom of the sampling tube.

[0006] Preferably, the moving component includes a cylinder one installed in the machine body, a connecting plate fixed on the telescopic shaft of the cylinder one, a cylinder two installed on the inner side of the connecting plate, and the telescopic shaft of the cylinder two fixed to the mounting plate by a fixing block.

[0007] Preferably, a stabilizing block is fixed on the side wall of the mounting plate, and the stabilizing block is slidably disposed in a stabilizing hole opened on the connecting plate.

[0008] Preferably, the pitch-changing assembly includes a motor fixed to a mounting plate, a drive wheel fixed to the output shaft of the motor, the drive wheel being connected to a driven wheel via a belt, the driven wheel being fixed to the top of a linear screw, both ends of the linear screw being rotatably connected to the mounting plate via bearing seats, a threaded block being helically connected to the linear screw, the threaded block being fixed to a pitch-changing plate, both ends of the pitch-changing plate being fixed with a slider one, and the two sliders one being slidably mounted on two slide rails one, both slide rails one being fixed to the mounting plate, the pitch-changing plate having multiple symmetrically distributed pitch-changing holes, guide blocks being slidably mounted in the pitch-changing holes, the guide blocks being fixed to a movable frame, a slider two being fixed to the top of the movable frame, the slider two being slidably mounted on a slide rail two, the slide rail two being fixed to the mounting plate, and the bottom of the movable frame being fixed to a fixed sleeve.

[0009] Preferably, the detection mechanism includes two electric push rods installed inside the machine body. A platform is fixed on the telescopic shaft of the two electric push rods. Multiple reagent plates are placed on the platform, and detection slots are provided on the reagent plates.

[0010] Preferably, the machine body is provided with a positioning groove.

[0011] By employing the above technical solution, this utility model provides a high-precision quantitative analysis device for HER2 gene mutations, which has at least the following beneficial effects:

[0012] 1. This high-precision quantitative analysis device for HER2 gene mutations, with its sampling component detection mechanism, can simultaneously sample and test multiple test tubes due to the presence of multiple sampling cylinders, greatly improving work efficiency. Furthermore, it uses an air pump for sampling, achieving quantitative sampling and possessing the advantages of accurate and reliable sampling, while minimizing the risk of sample contamination.

[0013] 2. This high-precision quantitative analysis device for HER2 gene mutations, by setting up a variable-distance component, can simultaneously sample test tubes of different sizes by changing the distance between multiple sampling tubes during sampling, and has the advantages of good sampling effect and strong adaptability. Attached Figure Description

[0014] The accompanying drawings, which are included to provide a further understanding of the present invention, form part of this application:

[0015] Figure 1 This is a three-dimensional structural diagram of the entire utility model;

[0016] Figure 2 This is a schematic diagram of the back structure of the sampling mechanism of this utility model;

[0017] Figure 3 This is a schematic diagram of the front of the sampling mechanism of this utility model;

[0018] Figure 4 This is a schematic diagram of the structure of the testing mechanism of this utility model;

[0019] Figure label:

[0020] 1. Machine body; 2. Sampling mechanism; 201. Moving component; 2011. Cylinder 1; 2012. Connecting plate; 2013. Stabilizing block; 2014. Cylinder 2; 2015. Fixing block; 202. Mounting plate; 203. Pitch-changing component; 2031. Motor; 2032. Driving wheel; 2033. Driven wheel; 2034. Linear screw; 2035. Threaded block; 2036. Pitch-changing plate; 2037. Slider 1; 203 8. Slide rail one; 2039. Guide block; 20310. Movable frame; 20311. Slider two; 20312. Slide rail two; 204. Sampling assembly; 2041. Air pump; 2042. Air pipe; 2043. Connecting pipe; 2044. Sampling cylinder; 2045. Fixing sleeve; 2046. Needle; 3. Detection mechanism; 301. Electric push rod; 302. Platform; 303. Reagent plate; 304. Detection groove; 4. Positioning groove. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] HER2 gene mutation refers to an alteration in the DNA sequence of the HER2 gene (human epidermal growth factor receptor 2). Mutations or overexpression of this gene are associated with certain types of cancer, particularly breast and stomach cancer.

[0023] Due to the inherent technical shortcomings of existing technologies, such as low work efficiency, please refer to... Figure 1-Figure 4The high-precision quantitative analysis device for HER2 gene mutations provided by this utility model can simultaneously sample and test multiple test tubes, greatly improving work efficiency. It uses an air pump 2041 for sampling, achieving quantitative sampling with advantages of accuracy and reliability, and is less prone to sample contamination. The device includes a body 1, on which a sampling mechanism 2 is installed for simultaneously sampling samples from multiple test tubes. Below the sampling mechanism 2 is a detection mechanism 3 for detecting and analyzing the samples. The sampling mechanism 2 includes two sets of moving components 201 mounted on the body 1, with a mounting plate 202 fixed to both sets of moving components 201. A variable distance component 203 and a sampling component 204 are fixed to the side wall of the mounting plate 202. A test tube rack containing test tubes is placed on the body 1, and then the sampling mechanism 2 simultaneously samples the test tubes in the same row. The sampled samples are dripped onto the detection mechanism 3, which is then returned to the body 1 for detection and analysis.

[0024] To achieve quantitative analysis and contamination-free sampling, please refer to... Figure 3 The sampling assembly 204 includes an air pump 2041 fixed on the mounting plate 202. An air tube 2042 is connected to the air pump 2041. One end of the air tube 2042 is connected to multiple sampling cylinders 2044 through multiple connecting tubes 2043. The sampling cylinders 2044 are mounted on the variable pitch assembly 203 through a fixing sleeve 2045. A needle 2046 is connected to the bottom of the sampling cylinder 2044. The air pump 2041 is used to draw air to draw the sample into the sampling cylinder 2044, which can achieve the purpose of quantitative sampling and avoid contact with the sample, thereby achieving the effect of pollution-free sampling.

[0025] To facilitate control of the forward, backward, and up-down movement of sampling mechanism 2, please refer to... Figure 2 The moving component 201 includes a cylinder 2011 installed inside the body 1. A connecting plate 2012 is fixed on the telescopic shaft of the cylinder 2011. A cylinder 2014 is installed on the inner side of the connecting plate 2012. The telescopic shaft of the cylinder 2014 is fixed to the mounting plate 202 through a fixing block 2015. The operation of the cylinder 2011 can control the forward and backward movement of the overall sampling mechanism 2, and the operation of the cylinder 2014 can control the up and down movement of the sampling mechanism 2, thereby facilitating the sampling work.

[0026] To ensure the stability of the mounting plate 202 during its up-and-down movement, a stabilizing block 2013 is fixedly provided on the side wall of the mounting plate 202. The stabilizing block 2013 is slidably disposed in the stabilizing hole opened on the connecting plate 2012. Under the action of the stabilizing block 2013, the mounting plate 202 is less likely to shake during movement, thus making the sampling more stable.

[0027] Because the spacing between test tubes of different sizes varies, the spacing between multiple sampling cylinders 2044 needs to be adjusted when performing simultaneous sampling. To solve this problem, please refer to... Figure 3 The pitch control assembly 203 includes a motor 2031 fixed on a mounting plate 202. A drive wheel 2032 is fixed on the output shaft of the motor 2031. The drive wheel 2032 is connected to a driven wheel 2033 via a belt. The driven wheel 2033 is fixed to the top of a linear screw 2034. Both ends of the linear screw 2034 are rotatably connected to the mounting plate 202 via bearing seats. A threaded block 2035 is helically connected to the linear screw 2034. The threaded block 2035 is fixed to a pitch control plate 2036. Both ends of the pitch control plate 2036 are fixed with sliders 2037, and the two sliders 2037 are slidably mounted on two slide rails 2038. Both slide rails 2038 are fixed to the mounting plate 202. The pitch control plate 2036 has multiple symmetrically distributed pitch control holes, and guide blocks 20 are slidably mounted in the pitch control holes. 39. Guide block 2039 is fixedly connected to movable frame 20310. Slider 20311 is fixedly installed on top of movable frame 20310. Slider 20311 is slidably mounted on slide rail 20312. Slide rail 20312 is fixedly connected to mounting plate 202. Bottom of movable frame 20310 is fixedly connected to fixed sleeve 2045. Driven by motor 2031 and driven by drive wheel 2032 and driven wheel 2033, linear screw 2034 is rotated. The rotation of linear screw 2034 drives variable pitch plate 2036 to move up and down through helical transmission with threaded block 2035. Under the action of variable pitch hole on variable pitch plate 2036, multiple movable frames 20310 can be moved horizontally through guide block 2039. The spacing between adjacent sampling tubes 2044 can be adjusted evenly to adapt to the sampling work of test tubes of different sizes.

[0028] To perform sample detection and analysis, please refer to... Figure 4 The detection mechanism 3 includes two electric push rods 301 installed inside the body 1. A stage 302 is fixedly mounted on the telescopic shaft of the two electric push rods 301. Multiple reagent plates 303 are placed on the stage 302, and detection grooves 304 are provided on the reagent plates 303. After the sample drips into the detection grooves 304 on the reagent plates 303, the stage 302 is retracted into the body 1 under the action of the electric push rods 301. Then, the sample in the detection grooves 304 can be analyzed inside the body 1.

[0029] To ensure the accuracy of the test tube rack placement, a positioning groove 4 is provided on the machine body 1; the positioning groove 4 is used to prevent the test tube rack from being tilted or other problems when placed.

[0030] As can be seen from the above embodiments: A test tube rack containing test tubes is placed on the machine body 1. Then, under the action of the sampling mechanism 2, the movement of the entire sampling mechanism 2 is controlled by the operation of cylinders 2011 and 2014. After the sampling cylinder 2044 moves above the test tubes, the linear screw 2034 is rotated by the motor 2031 and the transmission action of the drive wheel 2032 and the driven wheel 2033. The rotation of the linear screw 2034, through the helical transmission action with the threaded block 2035, drives the variable pitch plate 2036 to move up and down. Under the action of the variable pitch hole on the variable pitch plate 2036, multiple movable frames 20310 can be driven horizontally by the guide block 2039. The sampling mechanism 2 can be moved to evenly adjust the spacing between adjacent sampling cylinders 2044 to accommodate sampling of test tubes of different sizes. Then, the needle 2046 at the bottom of the sampling cylinder 2044 is inserted into the test tube. At this time, the air pump 2041 works to draw the sample into the sampling cylinder 2044, and the sampling is completed. Then, the sampling mechanism 2 is reset, and the sampling cylinder 2044 can be positioned above the detection mechanism 3. The air pump 2041 is controlled again to drop the sample into the detection groove 304 on the reagent plate 303. Then, under the action of the electric push rod 301, the stage 302 is retracted into the machine body 1. Then, the sample in the detection groove 304 is analyzed in the machine body 1.

[0031] It should be noted that the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0032] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A high-precision quantitative analysis device for HER2 gene mutations, comprising an organism (1), characterized in that: The body (1) is equipped with a sampling mechanism (2) that can simultaneously sample samples from multiple test tubes. Below the sampling mechanism (2) is a detection mechanism (3) for detecting and analyzing the samples. The sampling mechanism (2) includes two sets of moving components (201) installed on the body (1). The two sets of moving components (201) are fixedly mounted on a mounting plate (202). A pitch-changing component (203) and a sampling component (204) are fixedly mounted on the side wall of the mounting plate (202). The sampling assembly (204) includes an air pump (2041) fixed on the mounting plate (202), an air tube (2042) connected to the air pump (2041), one end of the air tube (2042) being connected to a plurality of sampling cylinders (2044) through a plurality of connecting tubes (2043), the sampling cylinders (2044) being mounted on the pitch-changing assembly (203) through a fixing sleeve (2045), and a needle (2046) being connected to the bottom of the sampling cylinders (2044).

2. The high-precision quantitative analysis device for HER2 gene mutations according to claim 1, characterized in that: The moving component (201) includes a cylinder (2011) installed in the body (1). A connecting plate (2012) is fixed on the telescopic shaft of the cylinder (2011). A cylinder (2014) is installed on the inner side of the connecting plate (2012). The telescopic shaft of the cylinder (2014) is fixed to the mounting plate (202) through a fixing block (2015).

3. The high-precision quantitative analysis device for HER2 gene mutations according to claim 2, characterized in that: A stabilizing block (2013) is fixed on the side wall of the mounting plate (202), and the stabilizing block (2013) is slidably disposed in a stabilizing hole opened on the connecting plate (2012).

4. The high-precision quantitative analysis device for HER2 gene mutations according to claim 1, characterized in that: The pitch-changing assembly (203) includes a motor (2031) fixed on a mounting plate (202). A drive wheel (2032) is fixed on the output shaft of the motor (2031). The drive wheel (2032) is connected to a driven wheel (2033) via a belt. The driven wheel (2033) is fixed to the top of a linear screw (2034). Both ends of the linear screw (2034) are rotatably connected to the mounting plate (202) via bearing seats. A threaded block (2035) is helically connected to the linear screw (2034). The threaded block (2035) is fixed to a pitch-changing plate (2036). Both ends of the pitch-changing plate (2036) are fixed with sliders (2037). Two sliders (2037) are slidably mounted on two slide rails (2038), and both slide rails (2038) are fixedly mounted on the mounting plate (202). The pitch plate (2036) has multiple pitch holes that are symmetrically distributed. A guide block (2039) is slidably mounted in the pitch hole. The guide block (2039) is fixedly mounted on the movable frame (20310). A slider (20311) is fixedly mounted on the top of the movable frame (20310). The slider (20311) is slidably mounted on slide rail (20312), and slide rail (20312) is fixedly mounted on the mounting plate (202). The bottom of the movable frame (20310) is fixedly mounted on the fixed sleeve (2045).

5. The high-precision quantitative analysis device for HER2 gene mutations according to claim 1, characterized in that: The detection mechanism (3) includes two electric push rods (301) installed inside the body (1). A platform (302) is fixed on the telescopic shaft of the two electric push rods (301). Multiple reagent plates (303) are placed on the platform (302). Detection slots (304) are provided on the reagent plates (303).

6. The high-precision quantitative analysis device for HER2 gene mutations according to claim 1, characterized in that: The body (1) is provided with a positioning groove (4).

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