Bacterial liquid filtering device

Abstract

The utility model relates to a bacterial liquid filtering device which comprises a mounting frame, a first fixing assembly is mounted at the position, close to the bottom end, of the mounting frame, a disposable filter is clamped and fixed to the inner side of the first fixing assembly, a second fixing assembly is mounted at the position, close to the middle, of the mounting frame, and a disposable syringe is clamped and fixed to the second fixing assembly. The second fixing assembly comprises a shell, the rear end of the shell is fixedly connected with the mounting frame, a lead screw is rotationally connected to the two sides of the shell in a penetrating mode, the outer side of the lead screw is in threaded connection with three moving blocks, and three sets of clamping blocks are arranged at the front end of the shell; according to the device, consumable disposable filters and disposable syringes can be conveniently and rapidly mounted and dismounted, the multiple disposable syringes are pressed down through the pressing-down assembly to filter bacterial liquid, after filtration is completed, consumable materials are easy to dismount and replace, and the operation efficiency is improved.

Description

Technical Field

[0001] This application relates to the technical field of bacterial liquid filtration devices, and in particular to a bacterial liquid filtration device. Background Technology

[0002] Bacterial outer membrane vesicles, as nanoscale particles, have the potential to be endocytosed by antigen-presenting cells (APCs) and efficiently present antigens. By injecting these vesicles, APCs can be stimulated, thereby activating specific T cells to recognize tumor antigens generated by mutations. This is particularly important in tumor immunotherapy. By pre-inoculating bacterial vesicles, the immunotherapeutic effect of tumor vaccines can be enhanced through immune training. To extract vesicles from the bacterial solution, gradient centrifugation of the bacteria is required. After centrifugation, the bacterial solution needs to be filtered to extract the vesicles.

[0003] Traditional bacterial filtration methods often rely on manual operation, such as using a syringe with a filter. This method is not only inefficient and cumbersome, but the filter may also detach during the filtration process due to excessive pressure from the syringe.

[0004] Therefore, those skilled in the art have provided a bacterial filtration device to solve the problems mentioned in the background art. Utility Model Content

[0005] To address the problems mentioned in the background art, this application provides a bacterial liquid filtration device.

[0006] The bacterial liquid filtration device provided in this application adopts the following technical solution:

[0007] A bacterial filtration device includes a mounting frame. A first fixing component is mounted on the mounting frame near its bottom, and a disposable filter is clamped and fixed inside the first fixing component. A second fixing component is mounted on the mounting frame near its middle, and a disposable syringe is clamped and fixed on the second fixing component. The disposable syringe is inserted into the second fixing component. A pressing component is mounted on the mounting frame near its top. The second fixing component includes a housing. The rear end of the housing is fixedly connected to the mounting frame. A lead screw is rotatably connected through both sides of the housing. Three moving blocks are threaded to the outer side of the lead screw. Three sets of clamping blocks are provided at the front end of the housing. The inner side of each clamping block is provided with an arc-shaped clamping opening. Each set of clamping blocks has two blocks, one of which is fixedly connected to a moving block, and the other of which is fixedly connected to the housing.

[0008] Preferably, the first fixing component includes two symmetrically arranged clamping bars, and three corresponding arc-shaped clamping grooves are respectively opened at the close ends of the two clamping bars. Two internally threaded tubes are fixedly connected to the front end of one of the internally threaded tubes, and two screws are movably connected to the front and rear ends of the other clamping bar, and the screws are threadedly connected to the internally threaded tubes.

[0009] Preferably, the pressing assembly includes a first connecting arm, a pull rod fixedly connected to the upper end of the first connecting arm, a second mounting component rotatably connected to the rear end of the inner side of the first connecting arm, the rear end of the second mounting component being fixedly connected to the mounting frame, the second connecting arm rotatably connected to the front end of the inner side of the first connecting arm, a first mounting component rotatably connected to the bottom end of the second connecting arm, a pressing plate fixedly connected to the bottom end of the first mounting component, and a U-shaped block fixedly connected to the rear end of the pressing plate, the U-shaped block being installed in a mounting groove opened on the mounting frame.

[0010] Preferably, a knob is installed at one end of the lead screw and at the front end of the screw rod.

[0011] Preferably, the clamping block is located directly above the arc-shaped clamping groove.

[0012] In summary, this application includes the following beneficial technical effects:

[0013] 1. A forward-rotating screw, in conjunction with a moving block and a clamping block, clamps the disposable syringe. The disposable syringe is inserted into a disposable filter. The forward-rotating screw, in conjunction with an internally threaded tube, drives a clamping strip to hold and fix the disposable filter installed in an arc-shaped clamping groove. Pulling the pull rod, in conjunction with the first connecting arm, pull rod, second connecting arm, first mounting component, and second mounting component, moves the lower pressure plate downward, squeezing the piston of the disposable syringe and causing the liquid inside to flow to the disposable filter for filtration. Reverse rotation of the screw and lead screw allows for easy release of the disposable syringe and disposable filter. This allows for convenient installation and removal of the disposable filter and disposable syringe. Multiple disposable syringes are pressed down by the lowering assembly to filter the bacterial solution. After filtration, the consumables are easy to remove and replace, improving operational efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this application;

[0015] Figure 2 yes Figure 1 Enlarged view of point A in the middle;

[0016] Figure 3 This is a rear view of the entire application;

[0017] Figure 4 This is a schematic diagram of the structure of the first fixing component of this application;

[0018] Figure 5 This is a schematic diagram of the structure of the second fixing component of this application;

[0019] Figure 6 This is a schematic diagram of the internal structure of the second fixing component of this application.

[0020] Explanation of reference numerals in the attached drawings: 1. Mounting bracket; 2. First fixing component; 201. Clamping bar; 202. Arc-shaped clamping groove; 203. Internally threaded tube; 204. Screw; 3. Disposable filter; 4. Second fixing component; 401. Housing; 402. Lead screw; 403. Moving block; 404. Clamping block; 5. Disposable syringe; 6. Pressing component; 601. First connecting arm; 602. Pull rod; 603. Second connecting arm; 604. First mounting piece; 605. Pressing plate; 606. U-shaped block; 607. Second mounting piece. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Example 1

[0023] like Figure 1 , 3 As shown in Figures 5 and 6, this application discloses a bacterial liquid filtration device, including a mounting frame 1. A first fixing component 2 is installed on the mounting frame 1 near its bottom end. A disposable filter 3 is installed on the inner side of the first fixing component 2. A second fixing component 4 is installed on the mounting frame 1 near its middle end. A disposable syringe 5 is installed on the second fixing component 4 and is inserted into the second fixing component 4. A pressing component 6 is installed on the mounting frame 1 near its top end. The second fixing component 4 includes a housing 401. The rear end of the housing 401 is fixedly connected to the mounting frame 1. A lead screw 402 is installed through both sides of the housing 401. Three moving blocks 403 are installed on the outer side of the lead screw 402. Three sets of clamping blocks 404 are provided at the front end of the housing 401. An arc-shaped clamping opening is provided on the inner side of each clamping block 404. There are two clamping blocks 404 in each set. One clamping block 404 is fixedly connected to the moving block 403, and the other clamping block 404 is fixedly connected to the housing 401.

[0024] When the lead screw 402 rotates in the reverse direction, the moving block 403 drives one of the clamping blocks 404 away from the other clamping block 404. At this time, the disposable syringe 5 can be installed, and the outlet of the disposable syringe 5 is connected to the disposable filter 3. When the lead screw 402 rotates in the forward direction, the two clamping blocks 404 clamp and fix the disposable syringe 5. The piston of the disposable syringe 5 is driven to move downward by the pressing component 6. The bacterial liquid squeezed out of the disposable syringe 5 is filtered through the disposable filter 3, and the filtered bacterial liquid is collected by the container.

[0025] like Figure 1 , 3 As shown in Figure 4, the first fixing component 2 includes two symmetrically arranged clamping bars 201. Three corresponding arc-shaped clamping grooves 202 are respectively opened at the close ends of the two clamping bars 201. Two internally threaded tubes 203 are installed at the front end of one of the internally threaded tubes 203. Two screws 204 are installed through the front and rear ends of the other clamping bar 201. The screws 204 are threadedly connected to the internally threaded tubes 203. Rotating the screws 204 moves them backward in the internally threaded tubes 203, placing the disposable filter 3 in the arc-shaped clamping groove 202. The screws 204 drive the other clamping bar 201 to move backward, clamping and fixing the disposable filter 3.

[0026] like Figure 1 As shown, a knob is installed at one end of the lead screw 402 and the front end of the screw 204. By installing the knob on the lead screw 402 and the screw 204, it is easy to rotate the lead screw 402 and the screw 204.

[0027] like Figure 1 As shown, the clamping block 404 is located directly above the arc-shaped clamping groove 202.

[0028] like Figure 1-3 As shown, the pressing assembly 6 includes a first connecting arm 601, a pull rod 602 mounted on the upper end of the first connecting arm 601, a second mounting member 607 mounted on the rear end of the inner side of the first connecting arm 601, the rear end of the second mounting member 607 being fixedly connected to the mounting bracket 1, a second connecting arm 603 mounted on the front end of the inner side of the first connecting arm 601, a first mounting member 604 mounted on the bottom end of the second connecting arm 603, a pressing plate 605 mounted on the bottom end of the first mounting member 604, and a U-shaped block 606 mounted on the rear end of the pressing plate 605. The U-shaped block 606 is installed in the mounting groove on the mounting frame 1. Pulling the pull rod 602 forward causes the front end of the first connecting arm 601 to rotate downward through the second mounting part 607. The front end of the first connecting arm 601 drives the lower pressure plate 605 to move downward through the second connecting arms 603 and 304. The U-shaped block 606, in conjunction with the mounting groove on the mounting frame 1, limits the lower pressure plate 605, causing the lower pressure plate 605 to move vertically. The lower pressure plate 605 squeezes the piston of the disposable syringe 5, squeezing out the bacterial liquid inside the disposable syringe 5.

[0029] All standard parts used in this utility model can be purchased from the market, and irregular parts can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art, and the circuit connection adopts conventional connection methods in the prior art, which will not be described in detail here.

[0030] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0031] The implementation principle of the bacterial liquid filtration device in this application embodiment is as follows:

[0032] First, place the disposable filter 3 in the arc-shaped clamping groove 202 of the first fixing component 2. Then, rotate the screw 204 clockwise by turning the knob, causing it to move backward through the internal thread tube 203, thereby driving the clamping bar 201 to clamp and fix the disposable filter 3. Connect the outlet of the disposable syringe 5 to the inlet of the disposable filter 3. Then, place the disposable syringe 5, which has been used to draw bacterial solution, between the two clamping blocks 404. Rotate the screw 402 clockwise by turning the knob, causing it to move the moving block 403 and the clamping block 404 fixedly connected to the moving block 403, so that the two clamping blocks 404 clamp and fix the disposable syringe 5. By pulling the pull rod 602 on the first connecting arm 601 of the pressing component 6 forward, the first connecting arm 601 is moved through... Rotate the second mounting component 607 downwards. Simultaneously, the front end of the first connecting arm 601 drives the lower pressure plate 605 downwards through the second connecting arm 603 and the first mounting component 604. The U-shaped block 606, in conjunction with the mounting groove on the mounting bracket 1, limits the lower pressure plate 605. The lower pressure plate 605 squeezes the piston part of the disposable syringe 5, squeezing out the bacterial solution inside the disposable syringe 5 and filtering it through the disposable filter 3. The filtered bacterial solution flows into the container below through the outlet of the disposable filter 3 for collection. After filtration is completed, by rotating the knobs on the first fixing component 2 and the second fixing component 4 in the opposite direction, the clamps on the disposable filter 3 and the disposable syringe 5 are released, allowing for easy disassembly of the disposable filter 3 and the disposable syringe 5 for future use.

[0033] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A bacterial filtrate filtration device, comprising a mounting frame (1), wherein a first fixing component (2) is mounted on the mounting frame (1) near its bottom end, a disposable filter (3) is clamped and fixed inside the first fixing component (2), a second fixing component (4) is mounted on the mounting frame (1) near its middle end, a disposable syringe (5) is clamped and fixed on the second fixing component (4), the disposable syringe (5) is inserted into the second fixing component (4), and a pressing component (6) is mounted on the mounting frame (1) near its top end, characterized in that, The second fixing component (4) includes a housing (401), the rear end of the housing (401) is fixedly connected to the mounting bracket (1), and a lead screw (402) is rotatably connected through both sides of the housing (401). Three moving blocks (403) are threadedly connected to the outer side of the lead screw (402). Three sets of clamping blocks (404) are provided at the front end of the housing (401). An arc-shaped clamping opening is provided on the inner side of the clamping block (404). There are two clamping blocks (404) in each set. One clamping block (404) is fixedly connected to the moving block (403), and the other clamping block (404) is fixedly connected to the housing (401).

2. The bacterial filtration device according to claim 1, characterized in that: The first fixing component (2) includes two symmetrically arranged clamping bars (201). The two clamping bars (201) have three corresponding arc-shaped clamping grooves (202) at their close ends. Two internally threaded tubes (203) are fixedly connected to the front end of one of the internally threaded tubes (203). Two screws (204) are movably connected to the front and rear ends of the other clamping bar (201). The screws (204) are threadedly connected to the internally threaded tubes (203).

3. The bacterial filtration device according to claim 1, characterized in that: The pressing assembly (6) includes a first connecting arm (601), a pull rod (602) is fixedly connected to the upper end of the first connecting arm (601), a second mounting piece (607) is rotatably connected to the rear end of the inner side of the first connecting arm (601), the rear end of the second mounting piece (607) is fixedly connected to the mounting frame (1), a second connecting arm (603) is rotatably connected to the front end of the inner side of the first connecting arm (601), a first mounting piece (604) is rotatably connected to the bottom end of the second connecting arm (603), a pressing plate (605) is fixedly connected to the bottom end of the first mounting piece (604), a U-shaped block (606) is fixedly connected to the rear end of the pressing plate (605), and the U-shaped block (606) is installed in the mounting groove opened on the mounting frame (1).

4. A bacterial filtration device according to claim 1 or 2, characterized in that: A knob is installed at one end of the lead screw (402) and at the front end of the screw (204).

5. A bacterial filtration device according to claim 1 or 2, characterized in that: The clamping block (404) is located directly above the arc-shaped clamping groove (202).

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