Multi-mode imaging device
By designing a multi-mode imaging device and combining visible light and X-ray imaging modules, the problems of single mode and inaccurate positioning in small animal imaging devices have been solved, achieving higher precision experimental data acquisition and safer operation.
Patent Information
- Application Number
- CN202422673059.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-04
- Publication Date
- 2025-11-04
- Estimated Expiration
- 2034-11-04
AI Technical Summary
Existing small animal imaging devices have limited modes, inaccurate target signal localization, and low experimental data precision.
Design a multi-mode imaging device comprising a visible light imaging component, an X-ray imaging module, and an X-ray source device. Combined with a detachable X-ray imaging module, it realizes visible light and X-ray imaging and locates target signals by image superposition.
This improves the accuracy of experimental data, enabling clearer localization of target signals within specific organs of living samples, and enhancing the flexibility and safety of imaging.
Smart Images
Figure CN223504237U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of imaging device technology, and in particular to a multi-mode imaging device. Background Technology
[0002] Existing small animal in vivo imaging devices are mainly used for detecting bioluminescence and fluorescence signals in live animals, recording the spatiotemporal changes of target signals within the animal body, thereby obtaining relevant experimental data to aid in research on various diseases and drug development. However, existing small animal in vivo imaging devices have limited modes, typically only offering bioluminescence and fluorescence imaging, resulting in insufficient accuracy in locating target signals and a need to improve the precision of experimental data. Utility Model Content
[0003] The technical problem to be solved by this invention is to overcome the shortcomings of existing small animal imaging devices, such as single mode, inaccurate target signal positioning, and low experimental data accuracy, and to provide a multi-mode imaging device.
[0004] The present invention solves the above-mentioned technical problems through the following technical solution:
[0005] This utility model provides a multi-mode imaging device, which includes a housing, a sample stage assembly, a visible light imaging assembly, an X-ray imaging module, and an X-ray source device. The housing includes a dark box.
[0006] The sample stage assembly includes a placement surface for placing live samples. The placement surface, the visible light imaging component, and the X-ray imaging module are disposed within the dark chamber. The X-ray source device and the visible light imaging component are located on opposite sides of the placement surface. The X-ray source device is capable of emitting X-rays toward the placement surface. The imaging end of the visible light imaging component faces the placement surface and is used to image the live samples. The X-ray imaging module is disposed between the visible light imaging component and the placement surface and is detachably connected to the dark chamber. In the axial direction of the placement surface, the X-ray imaging module at least partially covers the placement surface.
[0007] In this design, the sample stage assembly includes a placement surface for holding live samples. The outer casing includes a dark chamber. The placement surface, visible light imaging component, and X-ray imaging module are housed within the dark chamber. The dark environment within the dark chamber facilitates imaging of the live samples. The X-ray source device and the visible light imaging component are positioned on opposite sides of the placement surface. The X-ray source device emits X-rays towards the placement surface, irradiating the live sample on the surface. The imaging end of the visible light imaging component faces the placement surface. The X-ray imaging module is positioned between the visible light imaging component and the placement surface, forming the X-ray image. Along the axial direction of the placement surface, the X-ray imaging module at least partially covers the surface, ensuring that the image of the live sample is fully projected onto the module. The X-ray imaging module is detachably connected to the dark chamber. When X-ray imaging is not required, the module can be removed, allowing users to select different modes according to their needs, thus enriching the application scenarios. By setting up visible light imaging components and X-ray imaging modules separately, both visible light target signal images and X-ray imaging images can be obtained. By superimposing the target signal obtained from visible light imaging and the structural image obtained from X-ray imaging, the specific organ location of the target signal in the living sample can be more clearly located, thus improving the accuracy of experimental data.
[0008] Preferably, the multi-mode imaging device has an internal slide rail, along which the visible light imaging component can slide.
[0009] In this design, the visible light imaging component can be moved along a sliding rail, allowing its position to be changed. This facilitates imaging of live samples from different locations, resulting in more flexible image capture. When a wider viewing angle is needed, the component can be slid to a position farther from the live sample for long-distance imaging, thus obtaining a larger shooting range. Conversely, when capturing detailed images, the component can be slid closer to the sample for close-up imaging, resulting in clearer details.
[0010] Preferably, the slide rail extends at an angle to the vertical direction.
[0011] In this solution, by extending the slide rail at an angle to the vertical direction, the optical imaging axis of the visible light imaging component can be aligned with different points on the placement surface. Unlike traditional vertically extending slide rails, by tilting the slide rail at a certain angle, the axis of the visible light imaging component can be prevented from always being aligned with the same point on the placement surface, making it easier to capture images of special parts and details of live samples.
[0012] Preferably, the X-ray imaging module is an X-ray flat panel detector or an X-ray conversion screen assembly.
[0013] In this scheme, the X-ray imaging module can employ two imaging methods. One method uses an X-ray flat panel detector, which directly acquires the varying intensity of X-rays emitted from the X-ray source device irradiating a living sample, and then directly outputs an X-ray imaging image. The other method uses an X-ray conversion screen assembly, which converts the varying intensity of X-rays emitted from the X-ray source device irradiating a living sample into visible light, and then uses a visible light imaging component to acquire the converted visible light image.
[0014] Preferably, the darkroom includes an outer wall, a radiation shielding layer, and an inner wall, with the radiation shielding layer disposed between the inner wall and the outer wall.
[0015] In this solution, by setting a radiation shielding layer between the inner and outer walls, X-rays inside the darkroom can be isolated, thus preventing operators from being harmed by radiation.
[0016] Preferably, the sample stage assembly includes a moving track and an anesthesia mask, the anesthesia mask being able to slide along the moving track and being used to follow the movement of the live sample.
[0017] In this design, the anesthesia mask can slide along the moving track. When the live sample moves, the anesthesia mask can follow the live sample, so that no matter where the live sample is on the placement surface, the anesthesia mask can keep following, resulting in better anesthesia effect on the live sample and making it easier to take images.
[0018] Preferably, the X-ray source device is equipped with a key power switch, which is electrically connected to the switch of the X-ray source device;
[0019] And / or, the X-ray source device is also provided with an emergency stop switch, which is electrically connected to the switch of the X-ray source device;
[0020] And / or, the darkroom further includes a door, on which a switch control linkage device is provided, and the switch control linkage device is electrically connected to the switch of the X-ray source device.
[0021] In this design, the X-ray source device is equipped with a key power switch, which is electrically connected to the switch of the X-ray source device. The operator can only turn on the X-ray source device by turning on the key power switch with the key; otherwise, the X-ray source device cannot be powered on, thereby enhancing the safety of the X-ray source device.
[0022] The X-ray source device is also equipped with an emergency stop switch, which is electrically connected to the device's power switch. In an emergency requiring the X-rays to be stopped, the emergency stop switch can be used to shut down the X-ray source device, thus ensuring safety in such situations.
[0023] The darkroom also includes a door. When the door is open to place a live sample, the X-ray shielding is lost. Therefore, a switch control linkage device is installed on the door, which is electrically connected to the switch of the X-ray source device. When the door is opened, the switch control linkage device immediately shuts off the X-ray source device, preventing X-rays from escaping from the open position of the door, thereby further improving safety.
[0024] Preferably, the outer casing further includes a support frame, which is connected to the dark box, and the X-ray source device is disposed within the support frame.
[0025] In this design, the X-ray source device is housed within a support frame, which is connected to the dark box, making it easier to fix the X-ray source device and allow it to emit X-rays toward the dark box.
[0026] Preferably, the support frame has a first opening on the side near the dark box, and the dark box has a second opening on the side near the support frame. The X-ray source device is connected to the dark box through the first opening and the second opening.
[0027] In this scheme, the X-ray source device is connected to the dark chamber through the first opening and the second opening, so that the X-rays emitted by the X-ray source device located on the support frame can irradiate the living sample located in the dark chamber through the first opening and the second opening.
[0028] Preferably, the support frame is provided with a radiation shielding shell, which covers the emitting end of the X-ray source device.
[0029] In this design, a radiation shielding shell is installed inside the support frame and placed over the emitting end of the X-ray source device, thereby effectively shielding the X-rays emitted from the emitting end of the X-ray source device and preventing operators from being harmed by radiation.
[0030] The positive and progressive effects of this utility model are as follows:
[0031] This invention provides a multi-mode imaging device, comprising a housing, a sample stage assembly, a visible light imaging component, an X-ray imaging module, and an X-ray source device. The housing includes a dark box. The sample stage assembly includes a placement surface for placing a live sample. The housing includes a dark box, within which the placement surface, visible light imaging component, and X-ray imaging module are housed. The dark environment within the dark box facilitates imaging of the live sample. The X-ray source device and the visible light imaging component are positioned on opposite sides of the placement surface. The X-ray source device emits X-rays towards the placement surface, irradiating the live sample on the placement surface. The imaging end of the visible light imaging component faces the placement surface. The X-ray imaging module is positioned between the visible light imaging component and the placement surface, forming an X-ray image. Along the axial direction of the placement surface, the X-ray imaging module at least partially covers the placement surface, ensuring that the image of the live sample is fully imaged onto the X-ray imaging module. The X-ray imaging module is detachably connected to the darkroom. When X-ray imaging is not needed, the module can be removed, allowing users to select different modes according to their needs, thus enriching the application scenarios. By separately setting up the visible light imaging component and the X-ray imaging module, both visible light target signal images and X-ray imaging images can be obtained. By superimposing the target signal obtained from visible light imaging and the structural image from X-ray imaging, the specific organ location of the target signal in a living sample can be more clearly located, improving the accuracy of experimental data. Attached Figure Description
[0032] Figure 1 This is a three-dimensional structural diagram of a multi-mode imaging device according to an embodiment of the present invention.
[0033] Figure 2 This is a cross-sectional view of a multi-mode imaging device according to an embodiment of the present invention.
[0034] Figure 3 This is a partial cross-sectional three-dimensional structural schematic diagram of a multi-mode imaging device according to an embodiment of the present invention.
[0035] Explanation of reference numerals in the attached figures:
[0036] Casing 100
[0037] Black Box 110
[0038] outer wall 111
[0039] X-ray shielding layer 112
[0040] Inner wall 113
[0041] Second opening 114
[0042] Door body 115
[0043] Support frame 120
[0044] First opening 121
[0045] X-ray shielding shell 122
[0046] Operation panel 130
[0047] Sample stage assembly 200
[0048] Placement surface 210
[0049] Moving track 220
[0050] 230 anesthesia masks
[0051] Visible light imaging capture unit 300
[0052] X-ray imaging module 400
[0053] X-ray source device 500
[0054] Slide rail 600
[0055] X-ray range 700 Detailed Implementation
[0056] The present invention will be further described below by way of embodiments, but the present invention is not limited to the scope of the following embodiments.
[0057] like Figures 1-3 As shown, this embodiment provides a multi-mode imaging device, which includes a housing 100, a sample stage assembly 200, a visible light imaging assembly 300, an X-ray imaging module 400, and an X-ray source device 500. The housing 100 includes a dark box 110.
[0058] The sample stage assembly 200 includes a placement surface 210 for placing live samples. The placement surface 210, visible light imaging assembly 300, and X-ray imaging module 400 are housed within a dark box 110. The dark environment within the dark box 110 facilitates imaging of live samples. An X-ray source device 500 and the visible light imaging assembly 300 are located on opposite sides of the placement surface 210. The X-ray source device 500 emits X-rays towards the placement surface 210. Figure 1 The X-ray range 700 is shown. The imaging end of the visible light imaging assembly 300 faces the placement surface 210. The visible light imaging assembly 300 is used to image live samples. The X-ray imaging module 400 is located between the visible light imaging assembly 300 and the placement surface 210.
[0059] Along the axial direction of the placement surface 210, the X-ray imaging module 400 at least partially covers the placement surface 210, thereby enabling the image of the live sample to be fully imaged onto the X-ray imaging module 400. In this embodiment, the X-ray imaging module 400 completely covers the placement surface 210. In other embodiments, the X-ray imaging module 400 may only cover the main part of the placement surface 210; those skilled in the art can select an appropriate coverage range according to actual needs.
[0060] The X-ray imaging module 400 is detachably connected to the darkroom 110. When X-ray imaging is not required, the X-ray imaging module 400 can be removed. Users can select different modes according to actual needs, making the modes more diverse and the application scenarios wider. The X-ray imaging module 400 can be removed by a pull-out method for easy disassembly by operators, or other methods deemed suitable by those skilled in the art can be selected.
[0061] By setting up a visible light imaging component 300 and an X-ray imaging module 400 respectively, both visible light target signal images and X-ray imaging images can be obtained. After superimposing the target signal obtained from visible light imaging and the structural image obtained from X-ray imaging, the specific organ location of the target signal in the living sample can be more clearly located, thus improving the accuracy of experimental data.
[0062] When the multi-mode imaging device is working, the placement surface 210 remains stationary, ensuring that the anesthetized live samples are not disturbed and moved during the experiment, thus avoiding abnormal experimental data or failure.
[0063] The multi-mode imaging device features an internal slide rail 600, along which the visible light imaging component 300 can slide. This allows the visible light imaging component 300 to change its position, facilitating imaging of live samples from different locations and obtaining images from various angles, thus offering greater flexibility. When a wider viewing angle is needed, the visible light imaging component 300 can be slid along the slide rail 600 to a position farther from the live sample for long-distance imaging, thereby obtaining a larger imaging range. Conversely, when capturing detailed images, the visible light imaging component 300 can be slid along the slide rail 600 to a position closer to the live sample for close-up imaging, resulting in clearer images of the details.
[0064] The slide rail 600 extends at an angle to the vertical direction, so that the optical imaging axis of the visible light imaging component 300 can be aligned with different points on the placement surface 210. Unlike the traditional vertically extending slide rail 600, by tilting the slide rail 600 at a certain angle, its imaging center can move according to the different angles of the slide rail 600 relative to the rear wall of the dark box 110. This avoids the visible light imaging component 300's axis always being aligned with the same point on the placement surface 210, making it easier to photograph special parts and details of live samples. Those skilled in the art can select the specific tilt angle of the slide rail 600 according to actual needs.
[0065] The X-ray imaging module 400 can be either an X-ray flat panel detector or an X-ray conversion screen assembly. The X-ray imaging module 400 can employ two imaging methods. One method involves the X-ray imaging module 400 acting as an X-ray flat panel detector. This detector directly acquires the varying intensity of X-rays emitted by the X-ray source device 500 as they irradiate a living sample, and then directly outputs an X-ray imaging image. The X-ray flat panel detector communicates wirelessly with a router outside the dark box 110. The router has two or more antennas distributed inside and outside the dark box 110 to ensure strong wireless communication signals. The other method involves the X-ray imaging module 400 acting as an X-ray conversion screen assembly. This method converts the varying intensity of X-rays emitted by the X-ray source device 500 as they irradiate a living sample into visible light, and then the visible light imaging unit 300 acquires the converted visible light image.
[0066] The sample stage assembly 200 includes a moving track 220 and an anesthesia mask 230. The anesthesia mask 230 can slide along the moving track 220 and is used to follow the movement of the live sample. When the live sample moves, the anesthesia mask 230 can follow the live sample, so that no matter where the live sample is on the placement surface 210, the anesthesia mask 230 can stay in the same position, resulting in better anesthesia effect on the live sample and facilitating imaging.
[0067] Because X-rays are involved, to ensure operator safety and prevent exposure to X-ray radiation, the multi-mode imaging device employs multiple protective measures, including: a key power switch, an emergency stop switch, a switch control linkage device, and a multi-layered housing.
[0068] The X-ray source device 500 is equipped with a key power switch, which is electrically connected to the switch of the X-ray source device 500. The operator can only turn on the X-ray source device 500 by turning on the key power switch with the key; otherwise, the X-ray source device 500 cannot be powered on, thereby enhancing the safety of the X-ray source device 500.
[0069] The X-ray source device 500 is also equipped with an emergency stop switch, which is electrically connected to the switch of the X-ray source device 500. In an emergency requiring the X-rays to be stopped, the X-ray source device 500 can be shut down via the emergency stop switch, thus ensuring safety in emergency situations.
[0070] The darkroom 110 includes an outer wall 111, a radiation shielding layer 112, and an inner wall 113. The radiation shielding layer 112 is located between the inner wall 113 and the outer wall 111, thereby isolating X-rays inside the darkroom 110 and preventing radiation damage to operators. The inner wall 113 is made of steel plate, which is easy to process and shape, and also provides a certain degree of radiation protection. The radiation shielding layer 112 is made of lead plate with lead equivalent or lead-containing material compatible with the voltage of the X-ray source device 500. The outer wall 111 is composed of steel plate, lead, or other materials depending on the location, which is easy to process and shape, and also provides a certain degree of radiation protection.
[0071] The darkroom 110 also includes a door 115. When the door 115 is open to place a live sample, the X-ray shielding is lost. The door 115 is equipped with a switch control linkage device, which is electrically connected to the switch of the X-ray source device 500. When the door 115 is opened, the switch control linkage device immediately shuts off the X-ray source device 500, preventing X-rays from escaping from the open position of the door 115, thereby further improving safety.
[0072] The outer casing 100 is also equipped with an operation panel 130, which has various operation switches, making it easier for operators to operate.
[0073] The housing 100 also includes a support frame 120, which is connected to the dark box 110. The X-ray source device 500 is located inside the support frame 120, which makes it easier to fix the X-ray source device 500 and make the X-ray source device 500 emit X-rays toward the dark box 110.
[0074] The support frame 120 has a first opening 121 on the side near the dark box 110, and the dark box 110 has a second opening 114 on the side near the support frame 120. The X-ray source device 500 is connected to the dark box 110 through the first opening 121 and the second opening 114, so that the X-rays emitted by the X-ray source device 500 located on the support frame 120 can irradiate the living sample located in the dark box 110 through the first opening 121 and the second opening 114.
[0075] The support frame 120 is equipped with a radiation shielding shell 122, which covers the emitting end of the X-ray source device 500, thereby effectively shielding the X-rays from the emitting end of the X-ray source device 500 and preventing operators from being harmed by radiation.
[0076] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship of the device or component during normal use. They are used only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or component referred to must have a specific orientation at any time, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model in this respect.
[0077] While specific embodiments of this utility model have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of this utility model is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of this utility model, but all such changes and modifications shall fall within the scope of this utility model.
Claims
1. A multi-mode imaging device, characterized in that, The multi-mode imaging device includes a housing, a sample stage assembly, a visible light imaging assembly, an X-ray imaging module, and an X-ray source device, wherein the housing includes a dark box; The sample stage assembly includes a placement surface for placing live samples. The placement surface, the visible light imaging component, and the X-ray imaging module are disposed within the dark chamber. The X-ray source device and the visible light imaging component are located on opposite sides of the placement surface. The X-ray source device is capable of emitting X-rays toward the placement surface. The imaging end of the visible light imaging component faces the placement surface and is used to image the live samples. The X-ray imaging module is disposed between the visible light imaging component and the placement surface and is detachably connected to the dark chamber. In the axial direction of the placement surface, the X-ray imaging module at least partially covers the placement surface.
2. The multi-mode imaging device as described in claim 1, characterized in that, The multi-mode imaging device has an internal slide rail, along which the visible light imaging component can slide.
3. The multi-mode imaging device as described in claim 2, characterized in that, The slide rail extends at an angle to the vertical direction.
4. The multi-mode imaging device as described in claim 1, characterized in that, The X-ray imaging module is an X-ray flat panel detector or an X-ray conversion screen assembly.
5. The multi-mode imaging device as described in claim 1, characterized in that, The darkroom includes an outer wall, a radiation shielding layer, and an inner wall, with the radiation shielding layer disposed between the inner wall and the outer wall.
6. The multi-mode imaging device as described in claim 1, characterized in that, The sample stage assembly includes a moving track and an anesthesia mask, which is slidable along the moving track and is used to follow the movement of the live sample.
7. The multi-mode imaging device as described in claim 1, characterized in that, The X-ray source device is equipped with a key power switch, which is electrically connected to the switch of the X-ray source device. And / or, the X-ray source device is also provided with an emergency stop switch, which is electrically connected to the switch of the X-ray source device; And / or, the darkroom further includes a door, on which a switch control linkage device is provided, and the switch control linkage device is electrically connected to the switch of the X-ray source device.
8. The multi-mode imaging device as described in claim 1, characterized in that, The outer casing also includes a support frame, which is connected to the dark box, and the X-ray source device is disposed within the support frame.
9. The multi-mode imaging device as described in claim 8, characterized in that, The support frame has a first opening on the side near the dark box, and the dark box has a second opening on the side near the support frame. The X-ray source device is connected to the dark box through the first opening and the second opening.
10. The multi-mode imaging device as described in claim 8, characterized in that, The support frame is equipped with a radiation shielding shell, which covers the emitting end of the X-ray source device.