Organ-like culture equipment and cleaning cover thereof

Abstract

The utility model discloses an organ-like culture clean cover which comprises a clean room and a clean assembly, an air inlet and an air outlet are arranged on the side wall of the clean room, a fan filter unit is arranged in the air inlet, and a first filter is arranged in the air outlet. The utility model further discloses organoid culture equipment which comprises the organoid culture clean cover. According to the organoid culture clean cover, the air inlet and the air outlet are formed in the side wall of the clean room, the fan filter unit is installed on the air inlet, and the first filter is installed on the air outlet; therefore, fresh air can be provided for the clean room by utilizing the fan filter unit, and air in the clean room is discharged through the air outlet and the first filter, so that the clean room is kept clean, a clean space can be provided for organoid culture and experiment, and the organoid culture and experiment process is not polluted.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the organoid culture technical field, and specifically is an organoid culture device and a clean cover thereof. BACKGROUND

[0002] Organoid culture refers to using a part of the patient's diseased body tissue to establish a model similar to the patient's diseased tissue through in vitro culture. This "organoid" can replace the patient to perform drug sensitivity experiments and the like. Organoid culture has great potential in the fields of disease model construction, clinical cancer research, and drug sensitivity testing.

[0003] In the prior art, organoid culture, whether artificial culture or culture through equipment, has a very high requirement for the cleanliness of the culture space. Traditional artificial culture needs to be performed in a P3 or P4 laboratory, which has a very high requirement for personnel quality and culture environment, resulting in waste of manpower and resources. SUMMARY

[0004] Therefore, the utility model aims to provide an organoid culture device and a clean cover thereof, which can provide a clean space for organoid culture and experiments and ensure that the organoid culture and experiments are not contaminated.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme.

[0006] The utility model discloses a kind of organoid culture clean covers, including clean room and clean component, air inlet and air outlet are equipped on the side wall of the clean room, fan filter unit is installed in the air inlet, first filter is installed in the air outlet.

[0007] Further, the air inlet and the air outlet are oppositely arranged at two ends of the clean room.

[0008] Further, the air inlet is arranged on the top surface of the clean room, and the air outlet is arranged at the bottom of the side wall on both sides of the clean room.

[0009] Further, the air inlets are uniformly arranged on the top surface of the clean room, and the fan filter units are one-to-one corresponding to the air inlets.

[0010] Further, the fan filter unit includes a fan and a second filter, and the second filter is arranged on the side of the fan facing the interior of the clean room.

[0011] Further, a protective cover is arranged outside the first filter, and the protective cover is arrayed with air holes.

[0012] Further, an ultraviolet disinfection device for ultraviolet sterilization and disinfection is arranged in the clean room.

[0013] Further, the clean room comprises a frame built by section bars, tempered glass is installed on the frame, and pressing blocks for pressing and fixing the tempered glass on the frame are arranged around the tempered glass.

[0014] Further, an inspection hole is arranged on the side wall of the clean room, and an inspection door is installed on the inspection hole.

[0015] Further, the online monitoring control system comprises a controller and a cleanliness sensor, the cleanliness sensor is electrically connected with the controller, the cleanliness sensor is arranged in the clean room and is used for collecting air cleanliness data in the clean room in real time, and the controller controls the fan filter unit to be opened or closed according to the cleanliness data collected by the cleanliness sensor.

[0016] Further, the online monitoring control system further comprises a pressure difference sensor for detecting the pressure difference between the inside and outside of the clean room, the pressure difference sensor is electrically connected with the controller, and the controller adjusts the power of the fan filter unit according to the pressure difference data between the inside and outside of the clean room collected by the pressure difference sensor.

[0017] Further, the alarm is electrically connected with the controller, and the alarm is used for issuing an alarm when the pressure difference data between the inside and outside of the clean room detected by the pressure difference sensor is abnormal.

[0018] Further, a control panel is installed on the outer wall of the clean room, a display screen is arranged on the control panel, the controller and the alarm are arranged in the control panel, and the display screen is electrically connected with the controller and is used for displaying the cleanliness data collected by the cleanliness sensor and the pressure difference data collected by the pressure difference sensor in real time.

[0019] The utility model also proposes a kind of organoid culture equipment, including the organoid culture clean cover as described above.

[0020] The utility model has the advantages that:

[0021] The organoid culture clean cover of the utility model provides fresh air into clean room by fan filter unit, and gas in clean room is discharged through air outlet and first filter, so that clean room is kept clean, and clean space is provided for organoid culture and experiment, and organoid culture and experiment process are ensured not to be contaminated.

[0022] By setting the online monitoring control system, the cleanliness data in the clean room can be collected in real time by using the cleanliness sensor, and the controller can control the fan filter unit to open or close according to the cleanliness data, so that the technical purpose of saving energy and reducing consumption can be achieved, and the cleanliness in the clean room can meet the requirements of organoid cooperation and experiments.

[0023] By setting the pressure difference sensor, the pressure difference inside and outside the clean room can be collected in real time, and according to the collected pressure difference data, it can be known whether a fault occurs, such as that the fan filter unit or the first filter is blocked, and the clean room is leaked, and the controller sends a control instruction to the alarm according to the collected pressure difference data, so as to control the alarm to alarm. BRIEF DESCRIPTION OF DRAWINGS

[0024] In order to make the purpose, technical scheme and beneficial effects of the utility model clearer, the utility model provides the following drawings for description:

[0025] Figure 1 It is a structural schematic view of the organoid culture clean cover embodiment of the utility model;

[0026] Figure 2 It is a structural schematic view of the organoid culture clean cover in the embodiment after the access door is opened;

[0027] Figure 3 It is an exploded view of the organoid culture clean cover in the embodiment;

[0028] Figure 4 It is a principle block diagram of the online monitoring control system;

[0029] Figure 5 It is a structural schematic view of the control panel.

[0030] BRIEF DESCRIPTION OF DRAWINGS

[0031] 10-clean room; 101-frame; 102-tempered glass; 11-air inlet; 12-air outlet; 13-fan filter unit; 131-fan; 132-second filter; 14-first filter; 15-protective cover; 16-access opening; 17-access door;

[0032] 20-controller; 21-cleanliness sensor; 22-pressure difference sensor; 23-alarm; 24-control panel; 25-display screen; 26-switch button. DETAILED DESCRIPTION

[0033] The utility model will be further described below in combination with the drawings and specific embodiments, so that the person skilled in the art can better understand the utility model and can be implemented, but the embodiment is not as the limitation of the utility model.

[0034] AsFigures 1-5 As shown, the organoid culture clean cover of the embodiment comprises a clean chamber 10 and a clean assembly, the clean chamber 10 is provided with an air inlet 11 and an air outlet 12 on the side wall, the air inlet 11 is provided with a fan filter unit 13, and the air outlet 12 is provided with a first filter 14. Specifically, the air inlet 11 and the air outlet 12 are oppositely arranged at the two ends of the clean chamber 10, for example, the air inlet 11 and the air outlet 12 can be arranged at the upper and lower ends of the clean chamber 10, or can be arranged at the left and right ends of the clean chamber 10. In the embodiment, the air inlet 11 is arranged on the top surface of the clean chamber 10, and the air outlet 12 is arranged at the bottom of the side wall of the clean chamber 10, that is, the air inlet 11 and the air outlet 12 of the embodiment can be arranged at the upper and lower ends of the clean chamber 10. In order to realize more uniform distribution of the air flow, the air inlet 11 is uniformly arranged on the top surface of the clean chamber 10, at this time, the air inlet 11 can be provided as at least two, at this time, the fan filter unit 13 is correspondingly arranged with the air inlet 11. In the embodiment, three air inlets 11 are uniformly arranged on the top surface of the clean chamber 10, and three fan filter units 13 are respectively arranged in the three air inlets 11. Of course, in other embodiments, the number of air inlets 11 can also be four or more, that is, the number of air inlets 11 and fan filter units 13 can be set according to the actual application scene, which will not be described here.

[0035] Preferably, in the embodiment, the fan filter unit 13 comprises a fan 131 and a second filter 132, the second filter 132 is arranged on the side of the fan 131 facing the inside of the clean chamber 10, in this way, the air flow injected by the fan 131 is filtered by the second filter 132 before entering the clean chamber 10, so as to ensure the cleanliness of the gas entering the clean chamber 10.

[0036] Preferably, in the embodiment, the first filter 14 is provided with a protective cover 15, and the protective cover 15 is provided with air holes. The protective cover 15 is arranged to protect the first filter 14.

[0037] Preferably, in the embodiment, the clean chamber 10 is provided with an ultraviolet disinfection device (not shown in the figure) for ultraviolet sterilization and disinfection.

[0038] Specifically, in the embodiment, the first filter 14 adopts a H14 high efficiency filter, and the second filter 132 adopts a HEPA high efficiency filter. The fan filter unit 13 is used to draw external air into the clean chamber 10 through the fan, the clean air obtained by filtering the passing air by the second filter 132 arranged at the rear end of the fan 131 is input into the clean chamber 10, and the internal contaminated air is filtered by the first filter 14 to become clean air and is discharged to the outside, so that an internal hundred-level clean environment can be created and the internal contaminated substances can be prevented from being discharged to the outside.

[0039] In the embodiment, the clean room 10 comprises a frame 101 built by section bars, and tempered glass 102 is installed on the frame 101. The tempered glass 102 is provided with pressing blocks around the four sides for pressing and fixing the tempered glass 102 on the frame 101, so as to ensure the overall rigidity and sealing performance of the clean room 10, and the inside of the clean room 10 can be observed through the tempered glass to observe the organoid culture and experimental process in real time. In the preferred embodiment of the present embodiment, the side wall of the clean room 10 is provided with an access opening 16, and an access door 17 is installed on the access opening 16 to facilitate the maintenance and repair of the equipment in the clean room 10. Specifically, the access opening 16 and the access door 17 can be provided with multiple access openings and access doors according to the need to facilitate the maintenance and repair of the equipment in different areas of the clean room 10.

[0040] The organoid culture clean cover of the present embodiment further comprises an online monitoring control system. Specifically, as shown in Figure 4 the online monitoring control system comprises a controller 20 and a cleanliness sensor 21, and the cleanliness sensor 21 is electrically connected with the controller 20. The cleanliness sensor 21 is arranged in the clean room 10 and is used to collect the air cleanliness data in the clean room in real time, and the controller 20 controls the fan filter unit 13 to be opened or closed according to the cleanliness data collected by the cleanliness sensor 21. For example, when the cleanliness data collected by the cleanliness sensor 21 is lower than a set first threshold value, the controller 20 controls the fan filter unit 13 to be opened; when the cleanliness data collected by the cleanliness sensor 21 is higher than a set second threshold value, the controller 20 controls the fan filter unit 13 to be closed; in this way, the cleanliness in the clean room 10 can be maintained between the set first threshold value and the second threshold value. Specifically, the first threshold value is lower than the second threshold value.

[0041] In a preferred embodiment of this example, the online monitoring and control system further includes a differential pressure sensor 22 for detecting the pressure difference between the inside and outside of the cleanroom 10. The differential pressure sensor 22 is electrically connected to the controller 20, and the controller 20 adjusts the power of the fan filter unit 13 based on the pressure difference data between the inside and outside of the cleanroom 10 collected by the differential pressure sensor 22. Specifically, under normal operating conditions of the fan-filter unit 13, if the differential pressure difference data collected by the differential pressure sensor 22 is lower than the set first differential pressure threshold, it indicates that there may be a leak in the cleanroom 10. In this case, the controller 20 should issue a control command to increase the power of the fan-filter unit 13 and increase the air intake to maintain the differential pressure difference between the inside and outside of the cleanroom 10 within the set range. If the differential pressure difference data collected by the differential pressure sensor 22 is greater than the set second differential pressure threshold, it indicates that the first filter 14 is clogged. In this case, the controller 20 should issue a control command to decrease the power of the fan-filter unit 13 and decrease the air intake to maintain the differential pressure difference between the inside and outside of the cleanroom 10 within the set range. In this way, the differential pressure difference between the inside and outside of the cleanroom 10 can always be maintained between the first and second differential pressure thresholds. Specifically, the first differential pressure threshold is less than the second differential pressure threshold.

[0042] In a preferred embodiment of this example, the online monitoring and control system further includes an alarm 23 for fault alarm. The alarm 23 is electrically connected to the controller 20. When the differential pressure data collected by the differential pressure sensor 22 is abnormal, such as when the differential pressure data is lower than a first differential pressure threshold or higher than a second differential pressure threshold, the controller 20 sends a control command to the alarm 23, and the alarm 23 issues a fault alarm. In particular, under normal operating conditions of the fan filter unit 13, when the differential pressure data is greater than the set second differential pressure threshold, relevant information reminding the user to update the filter cotton can also be displayed on the display screen 25.

[0043] In this embodiment, a control panel 24 is installed on the outer side wall of the cleanroom 10. For example... Figure 5 As shown, the control panel 24 in this embodiment is equipped with a display screen 25, and the controller 20 and alarm 23 are located within the control panel 24. The display screen 25 is electrically connected to the controller 20 and is used to display in real time the cleanliness data collected by the cleanliness sensor 21 and the differential pressure data collected by the differential pressure sensor 22. Of course, a switch button 26 can also be provided on the control panel 24 to manually control the opening and closing of the ultraviolet disinfection device and the fan filter unit 13.

[0044] This embodiment also proposes an organoid culture device including the organoid culture clean hood described above.

[0045] The above-described embodiments are only preferred embodiments for fully illustrating the present application, and the protection scope of the present application is not limited thereto. Any equivalent substitutions or transformations made by the skilled in the art based on the present application are within the protection scope of the present application. The protection scope of the present application is subject to the claims.

Claims

1. An organoid culture clean enclosure, characterized by: The clean room and clean assembly, the side wall of the clean room is provided with an air inlet and an air outlet, a fan filter unit is installed in the air inlet, and a first filter is installed in the air outlet.

2. The organoid culture clean bench according to claim 1, wherein: The air inlet and the air outlet are oppositely arranged at two ends of the clean room.

3. The organoid culture clean bench of claim 1, wherein: The air inlet is arranged on the top surface of the clean room, and the air outlet is arranged at the bottom of the side wall of the clean room.

4. The organoid culture clean bench according to claim 3, wherein: The air inlets are uniformly arranged on the top surface of the clean room, and the fan filter units are arranged one-to-one corresponding to the air inlets.

5. The organoid culture clean bench of claim 1, wherein: The fan filter unit comprises a fan and a second filter, and the second filter is arranged on the side of the fan facing the interior of the clean room.

6. The organoid culture clean bench of claim 1, wherein: The first filter is provided with a protective cover, and the protective cover is provided with a plurality of air permeable holes.

7. The organoid culture clean bench of claim 1, wherein: An ultraviolet disinfection device for ultraviolet sterilization and disinfection is arranged in the clean room.

8. The organoid culture clean bench of claim 1, wherein: The clean room comprises a frame built by profiles, a tempered glass is installed on the frame, and a pressing block is arranged around the tempered glass for pressing and fixing the tempered glass on the frame.

9. The organoid culture clean bench of claim 1, wherein: An access hole is arranged on the side wall of the clean room, and an access door is installed on the access hole.

10. The organoid culture clean bench according to any one of claims 1-9, wherein: An online monitoring and control system is further included, the online monitoring and control system comprises a controller and a cleanliness sensor, the cleanliness sensor is electrically connected with the controller, the cleanliness sensor is arranged in the clean room and is used for collecting air cleanliness data in the clean room in real time, and the controller controls the fan filter unit to be opened or closed according to the cleanliness data collected by the cleanliness sensor.

11. The organoid culture clean bench of claim 10, wherein: The online monitoring and control system further comprises a pressure difference sensor for detecting the pressure difference between the inside and outside of the clean room, the pressure difference sensor is electrically connected with the controller, and the controller adjusts the power of the fan filter unit according to the pressure difference data between the inside and outside of the clean room collected by the pressure difference sensor.

12. The organoid culture clean bench of claim 11, wherein: An alarm for fault alarm is further included, the alarm is electrically connected with the controller, and the alarm is used for issuing an alarm when the pressure difference data between the inside and outside of the clean room detected by the pressure difference sensor is abnormal.

13. The organoid culture clean bench of claim 12, wherein: A control panel is installed on the outer wall of the clean room, a display screen is arranged on the control panel, the controller and the alarm are arranged in the control panel, and the display screen is electrically connected with the controller and is used for displaying the cleanliness data collected by the cleanliness sensor and the pressure difference data collected by the pressure difference sensor in real time.

14. An organoid culture device, characterized by: The clean room comprises an organoid culture clean cover.

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