Magnetic bead separator

Abstract

The utility model relates to the technical field of immunological separation, and provides a magnetic bead separator which comprises a base, an electromagnetic component, a positioning component and a fixing piece, the base is provided with a placing area for placing an elisa plate; the electromagnetic assembly comprises a circuit board and a plurality of electromagnetic elements, the circuit board is arranged in the placement area, the plurality of electromagnetic elements are electrically connected with the circuit board and are arranged on the circuit board in an array arrangement mode, and the circuit board is configured to be electrically connected with an external power supply; the positioning assembly is arranged on the base and surrounds the placement area, and the positioning assembly is used for limiting the placement posture of the elisa plate in the placement area, so that the plurality of electromagnetic elements and the plurality of slots in the elisa plate are arranged in a one-to-one correspondence manner; the fixing piece is arranged on the base and is used for fixing the elisa plate; the magnetic bead separator disclosed by the utility model not only facilitates the installation and fixation of the elisa plate, but also can ensure the separation effect of target magnetic beads, and is beneficial to ensuring the accuracy and stability of detection results in subsequent immune multivariate detection.

Description

Technical Field

[0001] This invention relates to the field of immunological separation technology, and in particular to a magnetic bead separator for the detection of multiple immune cytokines. Background Technology

[0002] Magnetic polymer microspheres, or magnetic beads for short, are composite microspheres with specific magnetic properties and unique structures, formed by combining magnetic inorganic particles with organic polymers. Magnetic beads not only possess many of the characteristics of ordinary polymer microspheres but also exhibit magnetic responsiveness. Furthermore, they can be endowed with functional groups such as -OH, -COOH, -CHO, and -NH2 through copolymerization and surface modification, and can also exhibit guiding function under an applied magnetic field. Therefore, magnetic beads have wide applications and are extremely important tools and core raw materials for molecular cell biology research, molecular diagnostics, immunodiagnostics, and cell sorting. Their classic core-shell structure design and manufacturing, with a polymer microsphere core, a magnetic outer layer, and a special polymer modification on the outermost layer, results in uniform size distribution, high surface loading, extremely short magnetic response time, and high dispersion stability. This allows for rapid and efficient separation of analytes from samples, significantly improving detection efficiency.

[0003] Based on the functional characteristics of magnetic beads, existing magnetic bead separation technology involves combining nano- or micro-sized magnetic beads with target substances and then increasing an external magnetic field to promote the separation of the target substances from other substances, thereby achieving the purpose of separation, concentration, and purification. This magnetic bead separation technology is widely used in immunoassay, and can be combined with immunological methods and flow cytometry principles, using enzyme-linked immunosorbent assay (ELISA), chemiluminescence, and fluorescent coding labeling technologies to detect multiple indicators such as cytokines, antibodies, and antigens in rare or small samples.

[0004] In practical applications, it has been found that in order to achieve accurate separation of target magnetic beads, the current main method is to use a separation magnetic frame designed with permanent magnets. This separation magnetic frame is not only inconvenient for fixing ELISA plates, but also has the problem of magnetic instability. Over time, due to temperature changes, mechanical damage, corrosion and improper storage, the separation magnetic frame will experience magnetic loss, affecting the separation effect of target magnetic beads and making it difficult to ensure the accuracy and stability of immunoassay. Utility Model Content

[0005] This invention provides a magnetic bead separator to at least solve or improve the problems in the prior art where the magnetic separation frame is inconvenient for fixing ELISA plates and makes it difficult to ensure the separation effect of magnetic beads.

[0006] This utility model provides a magnetic bead separator, comprising:

[0007] The base has a placement area for placing the ELISA plate;

[0008] An electromagnetic component includes a circuit board and multiple electromagnetic elements. The circuit board is disposed in the placement area, and the multiple electromagnetic elements are electrically connected to the circuit board and arranged in an array on the circuit board. The circuit board is configured to be electrically connected to an external power source.

[0009] A positioning component is disposed on the base and arranged around the placement area. The positioning component is used to define the position of the ELISA plate in the placement area, so that the plurality of electromagnetic elements are arranged one-to-one with the plurality of slots on the ELISA plate.

[0010] A fixing element is provided on the base, and the fixing element is used to fix the enzyme labeling plate.

[0011] According to the present invention, a magnetic bead separator is provided, wherein the electromagnetic element includes a ferromagnetic column, a coil, and a shielding cover;

[0012] The ferromagnetic column is disposed on the circuit board, and the coil is wound around the peripheral wall of the ferromagnetic column and electrically connected to the circuit board;

[0013] The shielding cover has its opening end located on the circuit board, and the shielding cover is electrically connected to the grounding terminal of the circuit board; the top end of the shielding cover has an opening, and a portion of the ferromagnetic column without the coil wound around it protrudes from the opening and extends into the slot.

[0014] According to the present invention, a magnetic bead separator is provided on the circuit board, and a power management module is provided on the base;

[0015] The power management module is configured to connect to an external power source via the power switch, and the power management module is electrically connected to each of the electromagnetic components.

[0016] The power management module is used to perform voltage conversion on the voltage signal input from the external power source.

[0017] According to the present invention, a magnetic bead separator is provided on the circuit board, and a magnetic induction element and a control module are provided on the base; the magnetic induction element and the control module are electrically connected, and the control module and the indicator light are electrically connected.

[0018] The magnetic sensing element is used to detect changes in the magnetic field of the electromagnetic element, and the control module is used to control the indicator light to illuminate when the magnetic sensing element detects changes in the magnetic field.

[0019] According to the present invention, a magnetic bead separator is provided on the base, and the charging interface is electrically connected to the power switch and the power management module. The charging interface is configured to be connected to an external power source through a power adapter cable.

[0020] According to the present invention, a magnetic bead separator is provided, wherein the positioning component includes a first positioning plate, a second positioning plate and a third positioning plate;

[0021] The first positioning plate is located on the first side of the placement area, the second positioning plate is located on the second side of the placement area, and the third positioning plate is located on the third side of the placement area.

[0022] According to the present invention, a magnetic bead separator is provided in which the first positioning plate, the second positioning plate and the third positioning plate are all elastic plates;

[0023] The elastic plate has a slot on one side facing the placement area, and the slot is used to lock onto the lower edge of the enzyme-labeled plate.

[0024] According to the present invention, a magnetic bead separator is provided, wherein the fixing component includes a hinge shaft, a fixing buckle, and an elastic component;

[0025] The hinge shaft is located outside the placement area and at a position close to the fourth side of the placement area; the first end of the fixing buckle is rotatably disposed on the hinge shaft; the elastic element is disposed between the base and the fixing buckle;

[0026] The elastic element is used to drive the fixing buckle to swing toward one side of the placement area. The second end of the fixing buckle is configured to abut against the side wall of the ELISA plate and press against the lower edge of the ELISA plate.

[0027] According to the present invention, a magnetic bead separator is provided, wherein the elastic element includes a torsion spring, the torsion spring is sleeved on the hinge shaft, one torsion arm of the torsion spring is connected to the base, and the other torsion arm of the torsion spring is connected to the fixing buckle.

[0028] According to the present invention, a magnetic bead separator is provided on the base, wherein a handheld part is provided.

[0029] The magnetic bead separator provided by this invention, by setting up an electromagnetic component, a positioning component, and a fixing component based on a base, allows the positioning component to correct the placement of the ELISA plate relative to the electromagnetic component. After the ELISA plate is fixed by the fixing component, simply connecting the circuit board to an external power source ensures that each electromagnetic component is powered on and operating. The magnetic force generated by each electromagnetic component facing its corresponding slot separates the test samples stored in each slot into magnetic beads. This design facilitates the installation and fixing of the ELISA plate, and eliminates concerns about magnetic instability caused by permanent magnets in the electromagnetic component during long-term use. This ensures effective separation of the target magnetic beads and helps guarantee the accuracy and stability of test results in subsequent multivariate immunoassays. Attached Figure Description

[0030] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0031] Figure 1 This is a top view of the magnetic bead separator provided by this utility model;

[0032] Figure 2 This is a schematic diagram of the main structure of the magnetic bead separator provided by this utility model;

[0033] Figure 3 This is a cross-sectional structural schematic diagram of the electromagnetic component provided by this utility model;

[0034] Figure 4 This utility model provides Figure 3 A magnified view of a portion of point K;

[0035] Figure 5 This is a schematic diagram of the structure of the enzyme-labeled plate provided by this utility model;

[0036] Figure label:

[0037] 10. Microplate; 1001. Groove; 1002. Bottom edge; 1011. Plate body; 1012. Support;

[0038] 1. Base; 101. Placement area; 102. Handheld part; 11. Power switch; 12. Indicator light; 13. Charging port;

[0039] 2. Electromagnetic components; 21. Circuit board; 22. Electromagnetic element; 221. Ferromagnetic column; 222. Coil; 223. Shielding cover;

[0040] 3. Positioning components; 31. First positioning plate; 32. Second positioning plate; 33. Third positioning plate;

[0041] 4. Fasteners; 41. Hinge shaft; 42. Fixing clips; 43. Elastic components;

[0042] 5. Power adapter cable. Detailed Implementation

[0043] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0044] The following is combined with Figures 1-5 The magnetic bead separator provided by the utility model embodiment will be described in detail through specific embodiments and application scenarios.

[0045] like Figure 1 and Figure 2 As shown, this utility model embodiment provides a magnetic bead separator, including: a base 1, an electromagnetic component 2, a positioning component 3, and a fixing component 4;

[0046] The base 1 has a placement area 101 for placing the microplate 10;

[0047] The electromagnetic component 2 includes a circuit board 21 and multiple electromagnetic elements 22. The circuit board 21 is located in the placement area 101. The multiple electromagnetic elements 22 are electrically connected to the circuit board 21 and are arranged in an array on the circuit board 21. The circuit board 21 is configured to be electrically connected to an external power source.

[0048] The positioning component 3 is located on the base 1 and is arranged around the placement area 101. The positioning component 3 is used to limit the position of the enzyme label plate 10 in the placement area 101 so that the multiple electromagnetic elements 22 are arranged one-to-one with the multiple slots 1001 on the enzyme label plate 10. The fixing component 4 is located on the base 1 and is used to fix the enzyme label plate 10.

[0049] Understandably, the base 1 can be a plastic base, and the upper surface of the base 1 is provided with a groove, the area where the groove is located forms a placement area 101, and the circuit board 21 is embedded in the groove.

[0050] The circuit board 21 is a printed circuit board (PCB) known in the art. The circuit board 21 is electrically connected to each electromagnetic component 22 based on the built-in circuit structure. The circuit board 21 is rectangular. The multiple electromagnetic components 22 can be configured to be arranged in an array along the length and width of the circuit board 21. Each electromagnetic component 22 can generate magnetic force through electromagnetic induction after being connected to a power source.

[0051] The positioning component 3 may employ multiple protrusions, clips, or other positioning structures arranged around the placement area 101. At least one positioning structure is provided with a foolproof structure that adapts to the periphery of the microplate 10. These positioning structures can cooperate with the periphery of the microplate 10, which not only limits the position of the microplate 10 in the placement area 101, but also limits the orientation of the microplate 10 relative to the placement area 101.

[0052] like Figure 5 As shown, the ELISA plate 10 includes a plate body 1011 and a support 1012. The support 1012 is dome-shaped, with a lower edge 1002 at its lower end and multiple arrayed mesh openings at its top, forming a mesh structure. The plate body 1011 is located at the top of the support 1012 and has multiple slots 1001. The slots 1001 and mesh openings are arranged opposite each other, and each slot 1001 is used to hold a certain volume of test sample, which includes, but is not limited to, serum or plasma. The dimensions of the ELISA plate 10 can be set as follows: length 12.5cm, width 9cm, and height 1.5cm. The spacing between different electromagnetic components 22 can be 1.0cm-1.5cm.

[0053] After assembling the ELISA plate 10, place the ELISA plate 10 in the placement area 101. Use the positioning component 3 to correct the placement posture of the ELISA plate 10 in the placement area 101, ensuring that the multiple electromagnetic elements 22 corresponding to the electromagnetic component 2 are positioned one-to-one with the multiple slots 1001 on the ELISA plate 10. After correcting the posture of the ELISA plate 10, use the fixing component 4 to fix the ELISA plate 10. Finally, connect the circuit board 21 to an external power source to ensure that each electromagnetic element 22 is energized, so that each electromagnetic element 22 can generate magnetic force toward its corresponding slot 1001 to separate the test samples stored in each slot 1001 using magnetic beads.

[0054] As can be seen from the above, the magnetic bead separator shown in this utility model, by setting an electromagnetic component 2, a positioning component 3, and a fixing component 4 based on a base 1, can correct the placement posture of the ELISA plate 10 relative to the electromagnetic component 2 through the positioning component 3. After fixing the ELISA plate 10 with the fixing component 4, it is only necessary to connect the circuit board 21 to an external power source to ensure that each electromagnetic component 22 is powered on and operates. The magnetic force generated by each electromagnetic component 22 towards its corresponding slot 1001 is used to separate the test samples inside each slot 1001. This design structure facilitates the installation and fixing of the ELISA plate 10. In long-term use, there is no need to consider the problem of magnetic instability caused by permanent magnets in the electromagnetic component 2, thereby ensuring the separation effect of the target magnetic beads and helping to ensure the accuracy and stability of the test results in subsequent immunoassay.

[0055] In some embodiments, such as Figure 3 and Figure 4 As shown, the electromagnetic element 22 includes a ferromagnetic column 221, a coil 222, and a shield 223;

[0056] A ferromagnetic column 221 is disposed on a circuit board 21, and a coil 222 is wound around the periphery of the ferromagnetic column 221 and electrically connected to the circuit board 21; the cover opening of the shield 223 is disposed on the circuit board 21, and the shield 223 is grounded through the circuit board 21; the top of the shield 223 is provided with an opening, and a part of the ferromagnetic column 221 without the coil 222 is exposed through the opening and extends into the slot 1001.

[0057] It is understood that the ferromagnetic column 221 can be made of iron or stainless steel, and the ferromagnetic column 221 and the coil 222 together constitute an electromagnet known in the art.

[0058] The shielding cover 223 can be an iron cover or a stainless steel mesh cover, and the shielding cover 223 is separately set from the ferromagnetic column 221 and the coil 222. Optionally, the shielding cover 223 can be built into an injection molded body, and the shielding cover 223 is constructed as an integral structure with the ferromagnetic column 221 through the injection molded body.

[0059] Since the circuit board 21 has a built-in circuit structure, it not only meets the design requirements of the energizing circuit of the coil 222 corresponding to each electromagnetic element 22, ensuring the simplicity of the wiring of each electromagnetic element 22, but also realizes the grounding design of the shield 223 corresponding to each electromagnetic element 22, ensuring that a shield cavity is formed between the shield 223 and the circuit board 21, so as to constrain the magnetic field lines generated by the coil 222 of each electromagnetic element 22 within the shield cavity. This design can ensure that when the coil 222 is energized, the part of the ferromagnetic column 221 exposed in the shield 223 can generate a strong magnetic force, which can prevent magnetic interference between different electromagnetic elements 22 to a certain extent, thereby ensuring the separation effect of the magnetic beads.

[0060] In some embodiments, such as Figure 1 and Figure 2 As shown, the circuit board 21 is equipped with a power management module and a control module, and the base 1 is equipped with a power switch 11.

[0061] The power management module is configured to connect to an external power source via power switch 11; the power management module is electrically connected to each electromagnetic component 22.

[0062] Understandably, the power management module is used to convert the voltage signal input from the external power source to provide the actual working voltage required for the coils 222 of each electromagnetic component 22, preventing damage to the coils 222 due to excessive voltage.

[0063] For example, the power management module may use a power management chip known in the art, such as a buck converter of model LM2596 or a buck-boost converter of model TPS63050.

[0064] Furthermore, the power switch 11 can be a rotary switch, and the operator can control the power management module to supply power to each electromagnetic component 22 by controlling the on / off state of the power switch 11.

[0065] In some embodiments, the circuit board 21 is further provided with a magnetic induction element and a control module, and the base 1 is further provided with an indicator light 12; the magnetic induction element and the control module are electrically connected, and the control module and the indicator light 12 are electrically connected; the magnetic induction element is used to detect the magnetic field change information of the electromagnetic element 22, and the control module is used to control the indicator light 12 to light up when the magnetic induction element detects the magnetic field change information, so that the staff can understand the working status of the magnetic bead separator in real time.

[0066] Understandably, the magnetic sensing element can be a Hall effect sensor or a magnetic induction sensor known in the art. The control module can be a central processing unit (CPU) known in the art, and the indicator light 12 can be an LED bead or an LED strip.

[0067] Multiple magnetic induction elements can be set, and multiple magnetic induction elements and multiple electromagnetic elements 22 are set one-to-one; the control module will control the indicator light 12 to light up only when each magnetic induction element can feed back magnetic field change information to the control module.

[0068] Of course, if the magnetic sensing element has high reliability, in order to reduce costs, the magnetic sensing element can be used to detect the magnetic field change information of one or part of the electromagnetic element 22. The control module then controls the indicator light 12 to light up based on the magnetic field change information detected by the magnetic sensing element.

[0069] In some embodiments, such as Figure 1 and Figure 2 As shown, the base 1 is also provided with a charging interface 13. The charging interface 13 is electrically connected to the power management module through the power switch 11. The charging interface 13 is configured to be connected to an external power source through the power adapter cable 5.

[0070] Specifically, the charging port 13 can be a USB port or a Type-C port. The first end of the power adapter cable 5 is plugged into the charging port 13, and the second end of the power adapter cable 5 can be connected to an external power source using a quick-connect connector or plug. The power adapter cable 5 can be configured with a retractable power supply box for storage.

[0071] In practical applications, a battery compartment can be installed on the back of the base 1, where a rechargeable battery, such as a lithium battery, is installed. The rechargeable battery and the power management module are electrically connected. In this way, the charging interface 13 only needs to be connected to an external power source via the power adapter cable 5 when the rechargeable battery is low on power. This design improves the ease of operation of the magnetic bead separator.

[0072] In some embodiments, such as Figure 1 and Figure 2 As shown, the positioning component 3 includes a first positioning plate 31, a second positioning plate 32, and a third positioning plate 33;

[0073] The first positioning plate 31 is located on the first side of the placement area 101, the second positioning plate 32 is located on the second side of the placement area 101, and the third positioning plate 33 is located on the third side of the placement area 101.

[0074] It is understood that the placement area 101 is a rectangular area, the first side and the third side of the placement area 101 are two sides of the placement area 101 along the width direction, and the second side of the placement area 101 is one side of the placement area 101 along the length direction.

[0075] Thus, the first positioning plate 31 and the third positioning plate 33 can be configured to extend along the width direction of the placement area 101, and the second positioning plate 32 can be configured to extend along the length direction of the placement area 101.

[0076] In some embodiments, such as Figure 2 As shown, in order to simultaneously position and fix the ELISA plate 10, the first positioning plate 31, the second positioning plate 32, and the third positioning plate 33 are all elastic plates. A slot is provided on the side of the elastic plate facing the placement area 101, which is used to engage with the lower edge 1002 of the ELISA plate 10. During installation of the ELISA plate 10, the operator needs to control the elastic plate to fold towards the side away from the placement area 101. Once the ELISA plate 10 is placed in the placement area 101, simply releasing the elastic plate will automatically correct its position using its elasticity, making the operation more convenient.

[0077] In some embodiments, such as Figure 1 and Figure 2 As shown, the fastener 4 includes a hinge shaft 41, a fixing buckle 42, and an elastic element 43;

[0078] The hinge shaft 41 is located outside the placement area 101 and is positioned near the fourth side of the placement area 101; the first end of the fixing buckle 42 is rotatably disposed on the hinge shaft 41; the elastic element 43 is disposed between the base 1 and the fixing buckle 42.

[0079] The elastic element 43 is used to drive the fixing buckle 42 to swing toward one side of the placement area 101. The second end of the fixing buckle 42 is configured to abut against the side wall of the enzyme labeling plate 10 and press against the lower edge 1002 of the enzyme labeling plate 10.

[0080] It is understood that the elastic element 43 can be a spring, a spring sheet, or a spring rod, and there is no specific limitation on this. During the installation of the ELISA plate 10, the fixing buckle 42 needs to be manually driven to swing towards the side away from the placement area 101 in order to place the ELISA plate 10 in the placement area 101; after the positioning component 3 completes the correction of the position of the ELISA plate 10, the operator can release the fixing buckle 42. The fixing buckle 42 can swing towards the side of the placement area 101 under the elastic force of the elastic element 43 until the second end of the fixing buckle 42 abuts against the side wall of the ELISA plate 10. At this time, the lower end of the fixing buckle 42 presses against the lower edge 1002 of the ELISA plate 10.

[0081] In some examples, the retaining clip 42 has a slot on one side facing the placement area 101, and the slot is configured to engage with a corner portion of the ELISA plate 10.

[0082] In some embodiments, such as Figure 2 As shown, in order to reduce the layout space occupied by the elastic element 43 and ensure the force application effect of the elastic element 43 on the fixed buckle 42, the elastic element 43 is a torsion spring. The torsion spring is sleeved on the hinge shaft 41. One torsion arm of the torsion spring is connected to the base 1, and the other torsion arm of the torsion spring is connected to the fixed buckle 42.

[0083] In some embodiments, such as Figure 1 As shown, a handheld part 102 is provided on the base 1. The handheld part 102 is located on the side of the base 1. The handheld part 102 has a wave-shaped palm curve grip point that conforms to human mechanics, making it convenient for the operator to hold the handheld part 102 and perform transfer operations on the magnetic bead separator.

[0084] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A magnetic bead separator, characterized in that, include: The base has a placement area for placing the ELISA plate; An electromagnetic component includes a circuit board and multiple electromagnetic elements. The circuit board is disposed in the placement area, and the multiple electromagnetic elements are electrically connected to the circuit board and arranged in an array on the circuit board. The circuit board is configured to be electrically connected to an external power source. A positioning component is disposed on the base and arranged around the placement area. The positioning component is used to define the position of the ELISA plate in the placement area, so that the plurality of electromagnetic elements are arranged one-to-one with the plurality of slots on the ELISA plate. A fixing element is provided on the base, and the fixing element is used to fix the enzyme labeling plate.

2. The magnetic bead separator according to claim 1, characterized in that, The electromagnetic component includes a ferromagnetic column, a coil, and a shielding cover; The ferromagnetic column is disposed on the circuit board, and the coil is wound around the peripheral wall of the ferromagnetic column and electrically connected to the circuit board; The shielding cover has its opening end located on the circuit board, and the shielding cover is grounded through the circuit board; the top end of the shielding cover has an opening, and a portion of the ferromagnetic column without the coil wound around it protrudes from the opening and extends into the slot.

3. The magnetic bead separator according to claim 1, characterized in that, The circuit board is equipped with a power management module, and the base is equipped with a power switch. The power management module is configured to connect to an external power source via the power switch, and the power management module is electrically connected to each of the electromagnetic components. The power management module is used to perform voltage conversion on the voltage signal input from the external power source.

4. The magnetic bead separator according to claim 3, characterized in that, The circuit board is also equipped with a magnetic induction element and a control module, and the base is also equipped with an indicator light; the magnetic induction element and the control module are electrically connected, and the control module and the indicator light are electrically connected. The magnetic sensing element is used to detect changes in the magnetic field of the electromagnetic element, and the control module is used to control the indicator light to illuminate when the magnetic sensing element detects changes in the magnetic field.

5. The magnetic bead separator according to claim 3, characterized in that, The base is also provided with a charging interface, which is electrically connected to the power switch and the power management module. The charging interface is configured to connect to an external power source via a power adapter cable.

6. The magnetic bead separator according to any one of claims 1 to 5, characterized in that, The positioning component includes a first positioning plate, a second positioning plate, and a third positioning plate; The first positioning plate is located on the first side of the placement area, the second positioning plate is located on the second side of the placement area, and the third positioning plate is located on the third side of the placement area.

7. The magnetic bead separator according to claim 6, characterized in that, The first positioning plate, the second positioning plate, and the third positioning plate are all elastic plates; The elastic plate has a slot on one side facing the placement area, and the slot is used to lock onto the lower edge of the enzyme-labeled plate.

8. The magnetic bead separator according to claim 6, characterized in that, The fastener includes a hinge shaft, a fixing buckle, and an elastic element; The hinge shaft is located outside the placement area and at a position close to the fourth side of the placement area; the first end of the fixing buckle is rotatably disposed on the hinge shaft; the elastic element is disposed between the base and the fixing buckle; The elastic element is used to drive the fixing buckle to swing toward one side of the placement area. The second end of the fixing buckle is configured to abut against the side wall of the ELISA plate and press against the lower edge of the ELISA plate.

9. The magnetic bead separator according to claim 8, characterized in that, The elastic element includes a torsion spring, which is sleeved on the hinge shaft. One torsion arm of the torsion spring is connected to the base, and the other torsion arm of the torsion spring is connected to the fixing buckle.

10. The magnetic bead separator according to any one of claims 1 to 5, characterized in that, The base is equipped with a hand-held part.

Images