Fine filtration device for preparing small molecule polypeptide medicine

Abstract

The utility model provides a fine filtration device for preparing small molecule polypeptide medicine, which belongs to the field of polypeptide medicine preparation and comprises a shell, a base, a feeding pipe and a discharging pipe, a plurality of gathering hoppers are fixedly connected to the inner wall of the shell, and scraping components are mounted on the gathering hoppers; a filter assembly; the filtering assembly comprises a plurality of fixing frames, the fixing frames penetrate through the shell in a sliding mode, filtering nets are fixedly installed on the inner walls of the fixing frames, a plurality of installing grooves are formed in the inner wall of the shell, the fixing frames are slidably arranged in the installing grooves respectively, a plurality of fixing assemblies are installed on the side wall of the shell, and the fixing assemblies are fixedly installed on the side wall of the shell. The multiple fixing assemblies correspond to the multiple fixing frames in a one-to-one mode. A user can conveniently mount and dismount the fixing frame, the practicability of the device is improved, impurities on the filter screen can be automatically scraped to the two sides of the fixing frame, the filter screen is prevented from being blocked by the impurities, and the filtering efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of polypeptide drug preparation technology, and in particular to a fine filtration device for preparing small molecule polypeptide drugs. Background Technology

[0002] When proteins or peptides are used as pharmaceutical raw materials, they usually need to be purified by column purification to remove unwanted impurities as much as possible. Before loading the column, insoluble substances in the solution need to be removed before subsequent operations can be carried out. Therefore, fine filtration is an essential step that is always present in the peptide purification process.

[0003] Application No. CN202221967269.3 discloses a fine filtration device for preparing small molecule polypeptide drugs, comprising a filter vessel, a piston tube installed through the upper end of the filter vessel, a piston installed inside the piston tube, an extension push rod installed on the lower surface of the piston, a filter mechanism installed at the lower end of the extension push rod on the inner side of the filter vessel, and an anti-detachment gasket installed above the filter mechanism on the inner wall of the filter vessel. Gas is filled into the piston tube via a gas pump through a connecting pipe. The piston tube, via the extension push rod at its lower end, pushes the filter mechanism to move. As the filter mechanism moves up and down, the first filter layer presses against the support plate, compressing and resetting it within the locking groove. This shaking accelerates the movement of the filtrate downwards towards the filter mechanism, thus separating the solid and liquid substances. However, since the filter mechanism is installed inside the filter vessel, it is inconvenient to disassemble and assemble. After prolonged use, the filter mechanism becomes clogged, affecting filtration efficiency, and the cleaning process is cumbersome. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a fine filtration device for the preparation of small molecule polypeptide drugs.

[0005] An embodiment of this utility model provides a fine filtration device for the preparation of small molecule polypeptide drugs, comprising:

[0006] The system comprises a housing, a base, a feed pipe, and a discharge pipe. Multiple collecting hoppers are fixedly connected to the inner wall of the housing, and each of the multiple collecting hoppers is equipped with a scraping assembly.

[0007] A filter assembly includes multiple fixed frames, each of which slides through a housing. A filter screen is fixedly installed on the inner wall of each fixed frame. Multiple mounting slots are formed on the inner wall of the housing, and the fixed frames slide within these slots. Multiple fixing components are installed on the side wall of the housing, each corresponding to one of the fixed frames. Each fixing component includes a fixing block fixedly connected to the side wall of the housing. Each fixing block has a fixing cavity, and a spring is fixedly connected to the inner wall of each cavity. A locking block is slidably connected within each cavity and fixedly connected to the spring. A locking groove is formed on the side wall of each fixed frame, and the locking block slides through the fixing block and the housing. The shapes of the locking block and the locking groove match. A pull rod slides through the fixing block and is fixedly connected to the locking block. The locking block is wedge-shaped.

[0008] Furthermore, the scraping assembly includes two sliding grooves, both of which are located on the lower end face of the collecting hopper. Sliding blocks are slidably connected within each sliding groove. A threaded rod is rotatably connected to the inner wall of one sliding groove, and a guide rod is fixedly connected to the inner wall of the other sliding groove. The threaded rod passes through one of the sliding blocks, and the guide rod slides through the other sliding block. Cylinders are fixedly installed on the lower end faces of both sliding blocks. Scrapers are fixedly connected to the output ends of both cylinders. A servo motor is fixedly installed on the side wall of the housing, and the rotating end of the servo motor is fixedly connected to the threaded rod. A differential pressure transmitter is fixedly installed on the side wall of the housing.

[0009] Furthermore, two pads are fixedly connected to the lower end face of the base, and the end face of the two pads away from the shell is provided with anti-slip texture.

[0010] Furthermore, each of the multiple pull rods is fixedly connected with a pull ring, and the side wall of the fixing frame is provided with a sealing gasket layer, the sealing gasket layer being made of rubber.

[0011] Furthermore, a solenoid valve is fixedly installed on the discharge pipe, a fixed flange is fixedly connected to the end of the feed pipe away from the housing, and a pressure sensor is installed on the lower end face of the scraper.

[0012] Furthermore, the lower inner wall of the housing is funnel-shaped.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. By pulling the pull ring, the locking block can be moved out of the slot on the fixed frame, making it easy for users to clean the filter and for the device to be used again. When installing the fixed frame, the user inserts the fixed frame into the housing, and the locking block will automatically fix the fixed frame. The installation and disassembly process is more convenient and improves the practicality of the device.

[0015] 2. When the device is filtering, the differential pressure transmitter detects the pressure difference on both sides of the matched filter screen to determine whether the filter screen is clogged. When the set upper limit of the differential pressure is reached, the cylinder drives the scraper to descend, and then the servo motor starts to work, driving the scraper to move. The scraper scrapes the impurities on the filter screen to both sides of the fixed frame to prevent impurities from clogging the filter screen and improve the filtration efficiency. Attached Figure Description

[0016] Figure 1 This is a three-dimensional structural schematic diagram of a fine filtration device for preparing small molecule polypeptide drugs as described in an embodiment of this utility model.

[0017] Figure 2 This is a three-dimensional side view of the structure of a fine filtration device for preparing small molecule polypeptide drugs as described in an embodiment of this utility model.

[0018] Figure 3 This is a three-dimensional sectional view of the fixed block structure of a fine filtration device for preparing small molecule polypeptide drugs as described in an embodiment of this utility model.

[0019] Figure 4 This is a three-dimensional sectional view of the sliding groove structure of a fine filtration device for preparing small molecule polypeptide drugs as described in an embodiment of this utility model.

[0020] In the above figures: 1 housing, 2 base, 3 discharge pipe, 4 collecting hopper, 5 fixed frame, 6 fixed block, 7 spring, 8 locking block, 9 sliding block, 10 threaded rod, 11 guide rod, 12 cylinder, 13 scraper, 14 servo motor, 15 differential pressure transmitter, 16 pull ring. Detailed Implementation

[0021] The technical solution of this utility model will be further described below with reference to the accompanying drawings and embodiments.

[0022] like Figures 1-4 As shown in the figure, this utility model embodiment proposes a fine filtration device for the preparation of small molecule polypeptide drugs, comprising:

[0023] The device comprises a shell 1, a base 2, an inlet pipe, and an outlet pipe 3. The lower inner wall of the shell 1 is funnel-shaped to facilitate solution collection and discharge through the outlet pipe. The base 2 is fixedly connected to the lower end face of the shell 1. Two pads are fixedly connected to the lower end face of the base 2. The end face of the two pads away from the shell 1 is provided with anti-slip texture to improve the stability of the device. The inlet pipe and the outlet pipe 3 are connected to the shell 1. Multiple collecting hoppers 4 are fixedly connected to the inner wall of the shell 1. Each of the multiple collecting hoppers 4 is equipped with a scraping component. The filter assembly includes multiple fixed frames 5, which slide through the shell 1. Filter screens are fixedly installed on the inner walls of the multiple fixed frames 5. The filter screens are located at the center of the fixed frames 5. The filter screens have gradually smaller pore sizes from top to bottom. Multiple mounting grooves are opened on the inner wall of the shell 1.

[0024] Multiple fixed frames 5 slide in multiple mounting slots respectively. Multiple fixing components are installed on the side wall of the housing 1. Each fixing component corresponds to one of the multiple fixed frames 5. The fixing components include fixing blocks 6 fixedly connected to the side wall of the housing 1. Each fixing block 6 has a fixing cavity. A spring 7 is fixedly connected to the inner wall of each fixing cavity. A locking block 8 is slidably connected in the fixing cavity. The locking block 8 is fixedly connected to the spring 7. The side wall of the fixed frame 5 has a locking groove. The locking block 8 slides through the fixing block 6 and the housing 1. The shape of the locking block 8 matches the locking groove. A pull rod slides through the fixing block 6. The pull rod is fixedly connected to the locking block 8. The locking block 8 is wedge-shaped. Pull rings 16 are fixedly connected to each pull rod. The side wall of the fixed frame 5 is provided with a sealing gasket. The sealing gasket is made of rubber. The pull rings 16 make it easy for the user to pull the pull rod, improving the portability of the device. The sealing gasket improves the sealing performance at the connection between the fixed frame 5 and the housing 1.

[0025] The scraping assembly includes two sliding grooves, both located on the lower end face of the collecting hopper 4. Sliding blocks 9 are slidably connected within each groove. A threaded rod 10 is rotatably connected to the inner wall of one sliding groove, while a guide rod 11 is fixedly connected to the inner wall of the other sliding groove. The threaded rod 10 threadedly passes through one sliding block 9, and the guide rod 11 slidably passes through the other sliding block 9. Cylinders 12 are fixedly mounted on the lower end faces of both sliding blocks 9. Scrapers 13 are fixedly connected to the output ends of both cylinders 12. A servo motor 14 is fixedly mounted on the side wall of the housing 1, with its rotating end fixedly connected to the threaded rod 10. Equipped with a differential pressure transmitter 15, which is existing technology, the working principle is to measure the pressure difference between two pressure ports and convert this differential pressure signal into an electrical signal output. It can detect the pressure difference on both sides of the filter screen, thereby controlling the rotation of the corresponding servo motor 14. It will not be described in detail here. A solenoid valve is fixedly installed on the discharge pipe 3. A fixed flange is fixedly connected to the end of the feed pipe away from the housing 1. A pressure sensor is installed on the lower end face of the scraper 13. The solenoid valve can automatically control the opening and closing state of the discharge pipe 3. The pressure sensor can detect whether the scraper 13 contacts the fixed frame 5, so as to prevent the cylinder 12 from falling and damaging the fixed frame 5.

[0026] It is worth noting that the entire device controls the servo motor 14, cylinder 12, differential pressure transmitter 15, solenoid valve and pressure sensor through the main control system. Since the servo motor 14, cylinder 12, differential pressure transmitter 15, solenoid valve and pressure sensor matched with the main control system are common equipment and belong to existing mature technology, their electrical connection relationship and specific circuit structure will not be described in detail here.

[0027] The detailed working process of this utility model is as follows:

[0028] First, the user places the device in the designated location. Then, the peptide solution is injected into the housing 1 through the feed pipe. The peptide solution first falls onto the collecting hopper 4, and then drips onto the filter screen on the fixed frame 5. It then passes through the filter screen sequentially, achieving multi-layer filtration of the peptide solution and improving its quality. During the filtration process, the differential pressure transmitter 15 detects the pressure difference across the matched filter screen to determine if the filter screen is clogged. When the differential pressure transmitter 15 reaches the set upper limit of the differential pressure, the cylinder 12 starts working, driving the scraper 13 to descend, causing the scraper 13 to contact the inner wall of the fixed frame 5. The pressure sensor on the scraper 13 determines whether the scraper 13 is in contact with the inner wall of the fixed frame 5. Then, the servo motor 14 starts working, driving the threaded rod 10 to rotate, thus causing the sliding block 9 to move in the sliding groove. The internal sliding mechanism drives the scraper 13 to move, scraping impurities on the filter screen to both sides of the fixed frame 5, preventing impurities from clogging the filter screen and improving filtration efficiency. After the device has filtered a batch of peptide solution, the user pulls the pull ring 16, causing the spring 7 in the fixed cavity to contract, which moves the locking block 8 out of the slot on the fixed frame 5. The user can then pull the fixed frame 5 to remove it from the housing 1, allowing the user to clean the fixed frame 5 and the filter screen. After cleaning, the user simply inserts the fixed frame 5 back into the housing 1. The side wall of the fixed frame 5 pushes the locking block 8, causing the spring 7 to contract and the locking block 8 to temporarily retract into the fixed cavity. When the slot on the fixed frame 5 is aligned with the locking block 8, the spring 7 returns to its original position, and the locking block 8 automatically moves into the slot, achieving automatic fixation of the fixed frame 5. This makes the installation and disassembly process more convenient and improves the practicality of the device.

Claims

1. A fine filtration device for preparing small molecule polypeptide drugs, characterized in that, include: The shell (1), base (2), feed pipe and discharge pipe (3) are provided. Multiple collecting hoppers (4) are fixedly connected to the inner wall of the shell (1). Each of the multiple collecting hoppers (4) is equipped with a scraping component. A filter assembly; the filter assembly includes multiple fixed frames (5), each of which slides through the housing (1). A filter screen is fixedly installed on the inner wall of each of the multiple fixed frames (5). Multiple mounting slots are opened on the inner wall of the housing (1), and the multiple fixed frames (5) slide within these slots respectively. Multiple fixing components are installed on the side wall of the housing (1), each of which corresponds one-to-one with a fixed frame (5). Each fixing component includes a fixing block (…) fixedly connected to the side wall of the housing (1). 6) Each of the multiple fixing blocks (6) has a fixing cavity, and a spring (7) is fixedly connected to the inner wall of each fixing cavity. A locking block (8) is slidably connected inside the fixing cavity. The locking block (8) is fixedly connected to the spring (7). A slot is opened on the side wall of the fixing frame (5). The locking block (8) slides through the fixing block (6) and the shell (1). The shape of the locking block (8) matches the shape of the slot. A pull rod slides through the fixing block (6). The pull rod is fixedly connected to the locking block (8). The locking block (8) is wedge-shaped.

2. The fine filtration device for preparing small molecule polypeptide drugs according to claim 1, characterized in that: The scraping assembly includes two sliding grooves, both of which are located on the lower end face of the collecting hopper (4). Sliding blocks (9) are slidably connected in both sliding grooves. A threaded rod (10) is rotatably connected to the inner wall of one sliding groove, and a guide rod (11) is fixedly connected to the inner wall of the other sliding groove. The threaded rod (10) is threaded through one of the sliding blocks (9), and the guide rod (11) is slidably connected through the other sliding block (9). Cylinders (12) are fixedly installed on the lower end faces of both sliding blocks (9). Scrapers (13) are fixedly connected to the output ends of both cylinders (12). A servo motor (14) is fixedly installed on the side wall of the housing (1). The rotating end of the servo motor (14) is fixedly connected to the threaded rod (10). A differential pressure transmitter (15) is fixedly installed on the side wall of the housing (1).

3. The fine filtration device for preparing small molecule polypeptide drugs according to claim 1, characterized in that: Two pads are fixedly connected to the lower end face of the base (2), and the end face of the two pads away from the shell (1) is provided with anti-slip texture.

4. The fine filtration device for preparing small molecule polypeptide drugs according to claim 1, characterized in that: Each of the pull rods is fixedly connected with a pull ring (16), and the side wall of the fixing frame (5) is provided with a sealing gasket layer, which is made of rubber.

5. The fine filtration device for preparing small molecule polypeptide drugs according to claim 2, characterized in that: A solenoid valve is fixedly installed on the discharge pipe (3), a fixed flange is fixedly connected to the end of the feed pipe away from the housing (1), and a pressure sensor is installed on the lower end face of the scraper (13).

6. The fine filtration device for preparing small molecule polypeptide drugs according to claim 2, characterized in that: The lower inner wall of the shell (1) is funnel-shaped.

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