Reaction device for preparing desolsonide

Abstract

The utility model discloses a reaction device for preparing desolsonide, which comprises a kettle body, the top end of the kettle body is provided with a kettle cover, the kettle cover is provided with a mixing component for stirring and mixing desolsonide raw materials, the circumferential outer wall of the kettle body is provided with an outer shell, and the outer shell is provided with a reaction cavity. A cavity used for containing liquid is formed between the inner side wall of the outer shell and the circumferential outer wall of the kettle body, an electric heating plate used for heating the liquid in the cavity is arranged below the inner side wall of the outer shell, and a gas shunting assembly used for shunting gas is arranged below the interior of the kettle body; the upper part of one side of the circumferential outer wall of the kettle body is connected with a box body through a connecting rod, and an induced draft fan is arranged in the box body. According to the desolsonide raw material mixing device, the mixing effect of desolsonide raw materials in the reaction process is effectively improved, the desolsonide raw materials can be fully reacted, and the situation that the desolsonide raw materials in the discharging pipe cannot be fully reacted is avoided.

Description

Technical Field

[0001] This utility model relates to the field of dessonide preparation technology, specifically to a reaction apparatus for the preparation of dessonide. Background Technology

[0002] Desonide is a corticosteroid with strong anti-inflammatory effects. Due to its higher ratio of local to systemic effects compared to other drugs in its class, it is more suitable for local use. It is a first-line drug for treating asthma by inhalation and for treating allergic reactions by nasal spray. Desonide is prepared by adding 16α-hydroxyprednisolone, acetone, and methyl butyl sulfonate imidazole hydrogen sulfate acidic ionic liquid to a reaction vessel and reacting at a temperature between 10°C and 100°C.

[0003] A search revealed that patent publication number CN221413090U discloses a reaction vessel that can effectively increase the effective volume of the reaction vessel and ensure the stirring of raw materials inside the reaction vessel. It includes a reaction tank body, an inlet and an outlet on the reaction tank body, a stirring device on the reaction tank body, and a coil on the outside of the reaction tank body, the coil including a water inlet and a water outlet.

[0004] In practical use, existing dextromethorphan preparation reaction devices generally use a stirring rod to mix and stir the dextromethorphan raw materials to enable the dextromethorphan raw materials to react. However, the above method does not achieve the desired mixing and reaction effect of the dextromethorphan raw materials, and it is easy for the dextromethorphan raw materials in the discharge structure to not undergo effective reaction. Therefore, a new dextromethorphan preparation reaction device is designed. Utility Model Content

[0005] In view of the defects or deficiencies of the reaction device for the preparation of dextromethorphan, the purpose of this utility model is to provide a reaction device for the preparation of dextromethorphan, which not only effectively improves the mixing effect of dextromethorphan raw materials in the reaction process, allowing the dextromethorphan raw materials to react fully, but also avoids the situation where the dextromethorphan raw materials in the discharge pipe do not react fully.

[0006] To achieve the above-mentioned objectives, the present invention adopts the following technical solution:

[0007] This utility model provides a reaction apparatus for the preparation of dextromethorphan, comprising a vessel body, a vessel lid installed at the top of the vessel body, and a mixing component for stirring and mixing the dextromethorphan raw material on the vessel lid. An outer shell is provided on the circumferential outer wall of the vessel body, and a cavity for holding liquid is provided between the inner side wall of the outer shell and the circumferential outer wall of the vessel body. An electric heating plate for heating the liquid in the cavity is provided below the inner side wall of the outer shell. A gas diversion component for diverting gas is provided at the lower part of the interior of the vessel body. The upper part of one side of the circumferential outer wall of the vessel body is connected to a box body by a connecting rod, and an induced draft fan is provided inside the box body.

[0008] Preferably, the mixing assembly is composed of a geared motor, a rotating shaft, and a stirring paddle. The geared motor is installed at the top of the vessel lid. The output shaft of the geared motor extends through a sealed bearing at the center of the top of the vessel lid to the inside of the vessel lid and is connected to the rotating shaft via a coupling. A stirring paddle is installed below the outer wall of the rotating shaft and is located inside the vessel body.

[0009] Preferably, the gas diversion assembly is composed of a hollow diversion sphere, a third exhaust pipe, a first branch pipe, and a second branch pipe. The first branch pipe is provided on the circumferential outer wall of the hollow diversion sphere. The other end of the first branch pipe is installed on the inner wall of the vessel. The interior of the first branch pipe is connected to the interior of the hollow diversion sphere. There are six first branch pipes, and the six first branch pipes are arranged in a ring array.

[0010] Preferably, a second branch pipe is provided at the bottom center of the hollow flow-dividing sphere, the interior of the second branch pipe is connected to the interior of the hollow flow-dividing sphere, and the other end of the second branch pipe extends into the discharge pipe. The discharge pipe is located at the bottom center of the vessel body and is equipped with a solenoid valve. A third exhaust pipe is provided on the circumferential outer wall of both the first and second branch pipes, and a one-way valve is provided on the third exhaust pipe.

[0011] Preferably, a feeding pipe is provided on one side of the top of the vessel lid, and a first exhaust pipe and a first vent pipe are respectively provided on both sides of the outer circumferential wall of the vessel lid, and a solenoid valve is provided on the feeding pipe, the first exhaust pipe and the first vent pipe.

[0012] Preferably, a liquid filling pipe and a second exhaust pipe are respectively provided on the upper sides of the outer circumferential outer wall of the outer shell, and a liquid drain pipe is provided on both sides of the bottom of the outer shell. The interiors of the liquid drain pipe, the liquid filling pipe and the second exhaust pipe are all connected to the cavity, and a solenoid valve is provided on the liquid drain pipe, the liquid filling pipe and the second exhaust pipe. Four support columns are provided on the outer circumferential outer wall of the outer shell, and the four support columns are distributed in a ring array.

[0013] Preferably, an air inlet pipe and a second air outlet pipe are respectively provided at the center of the top and bottom of the box body. The other end of the air inlet pipe is connected to the first connecting pipe through a pipe joint, and the other end of the first connecting pipe is connected to the first air outlet pipe through a pipe joint. The other end of the second air outlet pipe is connected to the second connecting pipe through a pipe joint, and the other end of the second connecting pipe extends through the outer wall of the outer shell and the outer wall of the vessel body to the interior of the vessel body and is connected to the hollow flow divider sphere.

[0014] Compared with existing technologies, one or more of the above technical solutions have the following beneficial effects:

[0015] In this invention, through the coordinated arrangement of a series of structures such as an induced draft fan and a gas diversion component, when the desonide manufacturing raw materials are mixed and reacted inside the reactor, the starting of the geared motor drives the stirring paddle on the outer wall of the rotating shaft to rotate. When the stirring paddle rotates, it stirs and mixes the desonide manufacturing raw materials inside the reactor. During the mixing and reaction of the desonide manufacturing raw materials, a certain amount of gas is generated. The starting of the induced draft fan draws in the gas inside the reactor and transports the gas to the gas diversion component. The gas in the gas diversion component is discharged from the third exhaust pipe on the first branch pipe and the second branch pipe. When the gas is discharged from the third exhaust pipe, it forms bubbles and flows upward in the solution inside the reactor, increasing the fluidity of the solution. This effectively improves the mixing effect of the desonide raw materials during the reaction process, allowing the desonide raw materials to react fully.

[0016] In this invention, through the coordinated arrangement of a series of structures such as the second branch pipe, when the gas is discharged from the third exhaust pipe on the second branch pipe, the gas will flow upward in the discharge pipe, increasing the fluidity of the solution in the discharge pipe, thereby avoiding the situation where the dextromethorphan raw material in the discharge pipe does not react sufficiently. Attached Figure Description

[0017] The accompanying drawings, which form part of this specification, are used to provide a further understanding of this utility model. The illustrative embodiments of this utility model and their descriptions are used to explain this utility model and do not constitute an improper limitation of this utility model.

[0018] Figure 1 This is a schematic diagram of the overall three-dimensional structure of this utility model.

[0019] Figure 2 This is a cross-sectional view of the present invention.

[0020] Figure 3 This is a schematic diagram of the structure of the hybrid component of this utility model.

[0021] Figure 4 This is a schematic diagram of the gas diversion component of this utility model.

[0022] Figure 5 This is a cross-sectional view of the housing of this utility model.

[0023] In the picture:

[0024] Mixing components; 110, geared motor; 120, rotating shaft; 130, stirring paddle;

[0025] 210. Cauldron lid; 220. Feeding pipe; 230. First exhaust pipe;

[0026] 310. Discharge pipe;

[0027] 410. Outer shell; 420. Support column; 430. Drain pipe; 440. Filling pipe; 450. Second exhaust pipe; 460. Cavity; 470. Electric heating plate;

[0028] First connecting pipe;

[0029] 610. Air intake pipe; 620. Exhaust fan; 630. Second exhaust pipe;

[0030] Second connecting pipe;

[0031] 800. Gas splitting assembly; 810. Hollow splitting sphere; 820. Third exhaust pipe; 830. First branch pipe; 840. Second branch pipe. Detailed Implementation

[0032] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0033] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0034] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of exemplary embodiments according to the invention. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0035] like Figure 1-5As shown, a reaction apparatus for preparing dextromethorphan includes a vessel body 300, a vessel lid 200 mounted on the top of the vessel body 300, and a mixing component 100 for stirring and mixing the dextromethorphan raw material on the vessel lid 200. An outer shell 400 is disposed on the circumferential outer wall of the vessel body 300. A cavity 450 for holding liquid is disposed between the inner side wall of the outer shell 400 and the circumferential outer wall of the vessel body 300. A heating element for heating the liquid within the cavity 450 is disposed below the inner side wall of the outer shell 400. The electric heating plate 460 can heat the liquid in the cavity 450. The heated liquid will heat the reaction solution in the vessel body 300 in a water bath, so that the reaction solution in the vessel body 300 can react at a temperature of 10°C to 100°C. A gas diversion component 800 for diverting gas is provided at the lower part of the interior of the vessel body 300. The upper part of one side of the outer circumferential wall of the vessel body 300 is connected to the box body 600 through a connecting rod, and an induced draft fan 620 is provided inside the box body 600.

[0036] The mixing assembly 100 is composed of a geared motor 110, a rotating shaft 120 and a stirring paddle 130. The geared motor 110 is installed at the top of the vessel cover 200. The output shaft of the geared motor 110 extends through a sealed bearing at the center of the top of the vessel cover 200 to the inside of the vessel cover 200 and is connected to the rotating shaft 120 via a coupling. The stirring paddle 130 is installed below the outer wall of the rotating shaft 120 and is located inside the vessel body 300.

[0037] The gas diversion assembly 800 is composed of a hollow diversion sphere 810, a third exhaust pipe 820, a first branch pipe 830, and a second branch pipe 840. The first branch pipe 830 is provided on the circumferential outer wall of the hollow diversion sphere 810. The other end of the first branch pipe 830 is installed on the inner wall of the vessel body 300. The interior of the first branch pipe 830 is connected to the interior of the hollow diversion sphere 810. There are six first branch pipes 830, and the six first branch pipes 830 are arranged in a ring array. The gas flowing into the hollow diversion sphere 810 will be diverted into the first branch pipe 830 and the second branch pipe 840.

[0038] A second branch pipe 840 is provided at the bottom center of the hollow flow splitting sphere 810. The interior of the second branch pipe 840 is connected to the interior of the hollow flow splitting sphere 810, and the other end of the second branch pipe 840 extends into the discharge pipe 310. The discharge pipe 310 is located at the bottom center of the vessel body 300, and a solenoid valve is provided on the discharge pipe 310. A third exhaust pipe 820 is provided on the circumferential outer wall of both the first branch pipe 830 and the second branch pipe 840, and a one-way valve is provided on the third exhaust pipe 820. The one-way valve is provided to prevent the solution from entering the hollow flow splitting sphere 810 from the third exhaust pipe 820.

[0039] A feeding pipe 210 is provided on one side of the top of the lid 200. A first exhaust pipe 220 and a first vent pipe 230 are respectively provided on both sides of the outer circumferential wall of the lid 200. Solenoid valves are provided on the feeding pipe 210, the first exhaust pipe 220 and the first vent pipe 230.

[0040] A liquid filling pipe 430 and a second exhaust pipe 440 are respectively provided on the upper sides of the outer wall of the outer shell 400. A drain pipe 420 is provided on both sides of the bottom of the outer shell 400. The interiors of the drain pipe 420, the liquid filling pipe 430 and the second exhaust pipe 440 are all connected to the cavity 450. A solenoid valve is provided on the drain pipe 420, the liquid filling pipe 430 and the second exhaust pipe 440. Four support columns 410 are provided on the outer wall of the outer shell 400, and the four support columns 410 are distributed in a ring array.

[0041] An air inlet pipe 610 and a second air outlet pipe 630 are respectively provided at the center of the top and bottom of the housing 600. The other end of the air inlet pipe 610 is connected to the first connecting pipe 500 through a pipe joint, and the other end of the first connecting pipe 500 is connected to the first air outlet pipe 230 through a pipe joint. The other end of the second air outlet pipe 630 is connected to the second connecting pipe 700 through a pipe joint, and the other end of the second connecting pipe 700 extends through the outer walls of the outer shell 400 and the vessel body 300 to the interior of the vessel body 300 and is connected to the hollow diverting sphere 810.

[0042] Working principle: When in use, connect the external power supply and start the device. The operator adds the desonide manufacturing raw materials into the vessel 300 through the feeding pipe 210. The geared motor 110 starts, driving the stirring paddle 130 on the outer wall of the rotating shaft 120 to rotate. The rotating paddle 130 stirs and mixes the desonide manufacturing raw materials inside the vessel 300. The reaction of the desonide manufacturing raw materials generates a certain amount of gas. The induced draft fan 620 starts, drawing in the gas from inside the vessel 300 and transporting it to the gas distribution assembly 800. The gas in the gas distribution assembly 800 flows through the first branch pipe 83... The gas is discharged from the third exhaust pipe 820 on the second branch pipe 840. When the gas is discharged from the third exhaust pipe 820, it will form bubbles and flow upward in the solution in the vessel body 300, increasing the fluidity of the solution. This effectively improves the mixing effect of the dextromethorphan raw material in the reaction process, allowing the dextromethorphan raw material to react fully. When the gas is discharged from the third exhaust pipe 820 on the second branch pipe 840, the gas will flow upward in the discharge pipe 310, increasing the fluidity of the solution in the discharge pipe 310, thus avoiding the situation where the dextromethorphan raw material in the discharge pipe 310 does not react fully.

[0043] The above description is merely a preferred embodiment of this utility model and is not intended to limit the invention. For those skilled in the art, various modifications and variations can be made to this invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this invention should be included within the protection scope of this invention.

Claims

1. A reaction apparatus for the preparation of dextromethorphan, comprising a vessel body (300), characterized in that: The top of the vessel body (300) is fitted with a vessel lid (200), and the vessel lid (200) is provided with a mixing component (100) for stirring and mixing the desonide raw material. The outer wall of the vessel body (300) is provided with an outer shell (400). A cavity (450) for holding liquid is provided between the inner wall of the outer shell (400) and the outer wall of the vessel body (300). An electric heating plate (460) for heating the liquid in the cavity (450) is provided below the inner wall of the outer shell (400). A gas diversion component (800) for diverting gas is provided below the interior of the vessel body (300). The upper side of one side of the outer wall of the vessel body (300) is connected to the box body (600) by a connecting rod. An induced draft fan (620) is provided inside the box body (600).

2. The reaction apparatus for preparing dextromethorphan according to claim 1, characterized in that: The mixing component (100) is composed of a geared motor (110), a rotating shaft (120) and a stirring paddle (130). The geared motor (110) is installed at the top of the vessel cover (200). The output shaft of the geared motor (110) extends through the sealed bearing at the center of the top of the vessel cover (200) to the inside of the vessel cover (200) and is connected to the rotating shaft (120) via a coupling. The stirring paddle (130) is installed below the outer wall of the rotating shaft (120) and is located inside the vessel body (300).

3. The reaction apparatus for preparing dextromethorphan according to claim 1, characterized in that: The gas splitting assembly (800) is composed of a hollow splitting sphere (810), a third exhaust pipe (820), a first branch pipe (830), and a second branch pipe (840). The first branch pipe (830) is provided on the circumferential outer wall of the hollow splitting sphere (810). The other end of the first branch pipe (830) is installed on the inner wall of the vessel body (300). The interior of the first branch pipe (830) is connected to the interior of the hollow splitting sphere (810). There are six first branch pipes (830), and the six first branch pipes (830) are arranged in a ring array.

4. The reaction apparatus for preparing dextromethorphan according to claim 3, characterized in that: The hollow flow divider sphere (810) has a second branch pipe (840) at its bottom center position. The interior of the second branch pipe (840) is connected to the interior of the hollow flow divider sphere (810), and the other end of the second branch pipe (840) extends into the discharge pipe (310). The discharge pipe (310) is located at the bottom center position of the vessel body (300), and a solenoid valve is provided on the discharge pipe (310). A third exhaust pipe (820) is provided on the circumferential outer wall of both the first branch pipe (830) and the second branch pipe (840), and a one-way valve is provided on the third exhaust pipe (820).

5. The reaction apparatus for preparing dexoned according to claim 1, characterized in that: A feeding pipe (210) is provided on one side of the top of the lid (200). A first exhaust pipe (220) and a first vent pipe (230) are respectively provided on both sides of the outer wall of the lid (200). A solenoid valve is provided on the feeding pipe (210), the first exhaust pipe (220) and the first vent pipe (230).

6. The reaction apparatus for the preparation of dextromethorphan according to claim 1, characterized in that: The outer casing (400) has a liquid filling pipe (430) and a second exhaust pipe (440) respectively installed on the upper sides of the outer walls of the outer casing (400). The bottom of the outer casing (400) has a drain pipe (420) installed on both sides. The interior of the drain pipe (420), the liquid filling pipe (430), and the second exhaust pipe (440) are all connected to the cavity (450). The drain pipe (420), the liquid filling pipe (430), and the second exhaust pipe (440) are all equipped with solenoid valves. The outer casing (400) has four support columns (410) installed on its outer walls. The four support columns (410) are arranged in a ring array.

7. The reaction apparatus for preparing dextromethorphan according to claim 1, characterized in that: An air inlet pipe (610) and a second air outlet pipe (630) are respectively provided at the center of the top and bottom of the box body (600). The other end of the air inlet pipe (610) is connected to the first connecting pipe (500) through a pipe joint, and the other end of the first connecting pipe (500) is connected to the first air outlet pipe (230) through a pipe joint. The other end of the second air outlet pipe (630) is connected to the second connecting pipe (700) through a pipe joint, and the other end of the second connecting pipe (700) extends through the outer wall of the outer shell (400) and the vessel body (300) to the interior of the vessel body (300) and is connected to the hollow diversion sphere (810).

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