Sample mixing device for sample injector
By repeatedly aspirating in the clean section and cooperating with the drive unit, the problem of poor mixing effect of the original solution after dilution by the injector was solved, achieving efficient mixing and low impurity introduction, thus improving the accuracy of detection.
Patent Information
- Application Number
- CN202422976690.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-04
- Publication Date
- 2025-11-25
- Estimated Expiration
- 2034-12-04
AI Technical Summary
Existing injectors have poor mixing effects when mixing diluted stock solutions, which easily introduces impurities and affects the accuracy and repeatability of test data.
By combining a mixing tube with the pump body and a multi-way valve, the diluted stock solution is repeatedly aspirated through the clean section, and the movement of the drive unit is combined to achieve efficient mixing of reagents and reduce the introduction of impurities.
It improves the mixing effect, reduces the risk of impurity contamination, and enhances the accuracy and repeatability of test results.
Smart Images
Figure CN223597343U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to sample introduction equipment technical field, concretely is a sample homogenizing device for sampler. BACKGROUND
[0002] Sampler is a device used to introduce samples into analytical instruments or processing systems. It has a wide range of applications in laboratory analysis, chemical production, pharmaceuticals, environmental monitoring and other fields. Among them, the standard liquid prepared by diluting the stock solution with the sampler has a great influence on the calibration instrument or the accuracy of the analysis results. In practice, the structure of the sampler is precise, and the operation space is small. The existing technology usually adopts the bubble method to mix the standard liquid prepared by diluting the stock solution, that is, air or other gas is injected into the diluted stock solution to make the diluted stock solution roll to prepare the standard liquid, and the size of the air bubble needs to be controlled to avoid too large or too small air bubbles, which has a certain operation difficulty, especially in the case of small amount of diluted stock solution. In addition, the air or other gas introduced has the risk of introducing impurities into the stock solution, which is not conducive to improving the accuracy and repeatability of the test data. SUMMARY
[0003] The utility model discloses a kind of sample homogenizing device for sampler, it solves the technical problem that mixing uniformity effect is poor in the mixing uniformity of existing sampler using bubble method, with the technical effect that structure is reasonable, mixing uniformity effect is good, operation space is small, can greatly reduce the risk of mixing impurity and be conducive to improving the accuracy of detection result. The technical scheme used is as follows:
[0004] A kind of sample homogenizing device for sampler, including sample bottle, sample mixing pipe, pump body and multi-way valve, the sample bottle is used to contain reagent to be mixed, the first end of the sample mixing pipe is open, for extracting reagent or air, the second end of the sample mixing pipe is connected with pump body by multi-way valve, when the first end of the sample mixing pipe extracts air, the air can expel residual reagent in the sample mixing pipe to the second end of the sample mixing pipe, to form clean section, when under the action of the pump body, when the clean section is repeatedly pumped reagent to be mixed, reagent can be mixed.
[0005] On the basis of the above technical solution, it further includes a driving unit for driving the sample mixing pipe to move up and down, left and right, or forward and backward.
[0006] On the basis of the above technical solution, the first end of the sample mixing pipe includes a sampling needle, and the tip of the sampling needle includes a sharp portion for piercing a rubber stopper on the sample bottle.
[0007] On the basis of the above technical solution, a scale value is provided on the sample mixing pipe to identify the length of the clean section.
[0008] On the basis of the above technical scheme, the pump body comprises a syringe pump, and the syringe pump and the multi-way valve are electrically connected with an external controller respectively.
[0009] On the basis of the above technical scheme, when repeatedly sucking the reagent to be mixed under the action of the pump body in the clean section, the number of times of repeated suction is 3-6.
[0010] On the basis of the above technical scheme, the mixing device is provided with a shell, and a filter is arranged at an inlet of the shell in communication with external air.
[0011] Beneficial effects
[0012] The utility model discloses a reasonable structure, before mixing operation, through the first end quantitative extraction of air of sample mixing pipe, air flow is fast in the sample mixing pipe flow, promote the reagent in the sample mixing pipe residual to flow to the second end of sample mixing pipe, like this can form clean section in the first end of sample mixing pipe close, and then when the next operation is carried out in the sample mixing pipe, reduce the cross degree between reagent, be favorable to more accurate control reagent's concentration or sample amount.
[0013] When carrying out mixing operation, the dilution liquid is repeatedly sucked in the clean section, so that the liquid can be more vigorously stirred, which is beneficial to improve the mixing effect of the mixed standard liquid, and avoids the operation difficulty of controlling the size of the bubbles in the bubbling method. In addition, in the foregoing mixing operation, the reagent to be mixed always seals the air in the sample mixing pipe, that is, the reagent to be mixed contacts with the air in the cross-sectional area of the sample mixing pipe. Compared with the bubbling method, the contact degree of the mixed liquid and the air is greatly reduced, which is beneficial to reduce the risk of mixing impurities.
[0014] The present application has simple structure, small operation space, and can effectively solve the mixing problem in a narrow space, better meet the use demand, avoid introducing impurities, and improve the detection accuracy. BRIEF DESCRIPTION OF DRAWINGS
[0015] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiment or the prior art description. Obviously, the drawings in the following description are only one embodiment of the present application, and for those skilled in the art, other embodiments can be obtained from the provided drawings without creating labor.
[0016] Figure 1 : structure diagram of air expelling residual liquid in sample mixing pipe to the second end of sample mixing pipe
[0017] Figure 2 : state diagram of sample mixing pipe repeatedly sucking mixed liquid Figure 1 ;
[0018] Figure 3 : state of repeated suction and mixing of liquid in a mixing tube Figure 2 ; DETAILED DESCRIPTION
[0019] The following description and drawings are illustrative of specific embodiments of the present document and are not intended to limit the generality of the present document. Parts and features of some embodiments can be included in, or alternative to, parts and features of other embodiments. The scope of the embodiments of the present document includes the full scope of the claims and all available equivalents of the claims. In this document, the terms "first", "second", etc. are used to distinguish one element from another, and do not require or imply any actual relationship or order between the elements. In fact, the first element could be named the second element and vice versa without changing the meaning of direct description. Also, the terms "include", "contain" or any other variants thereof are intended to cover non-exclusive inclusion, so that a structure, device or apparatus including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such structure, device or apparatus. Without more limitations, the element defined by the phrase "including a" does not exclude the presence of additional identical elements in the structure, device or apparatus including the element. In this document, various embodiments are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between various embodiments can be referred to each other.
[0020] In this document, the terms "longitudinal", "transverse", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate the orientation or positional relationship shown in the drawings, and are only used for the convenience of description and simplification of the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present invention. In the description of this document, unless otherwise specified and limited, the terms "mount", "connect", "connection" should be interpreted broadly, for example, it can be a mechanical connection or an electrical connection, it can be a communication between two elements inside, it can be a direct connection, or an indirect connection through an intermediate medium. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.
[0021] In this document, unless otherwise specified, the term "a plurality of" means two or more.
[0022] In this document, the character " / " represents an "or" relationship between the objects before and after it. For example, A / B means A or B.
[0023] In this article, the term "and / or" describes an association between objects, indicating that three relationships can exist. For example, A and / or B means: A or B, or A and B.
[0024] like Figures 1-3 The sample mixing device for a sample injector shown includes a sample vial 200, a mixing tube 100, a pump body, and a multi-way valve.
[0025] The sample vial 200 is used to hold the reagent to be mixed. In this embodiment, the sample vial 200 is placed on the sample holder.
[0026] The first end of the mixing tube 100 includes a sampling needle made of metal, and the tip of the sampling needle includes a spike for piercing the rubber stopper on the sample vial 200. Figure 1 As shown, the spiked portion of the mixing tube 100 forms the first end, which is open for drawing reagents or air. In this embodiment, the reagent can be a stock solution or a mixture of a stock solution and a diluent; for ease of description, it is referred to as a reagent. The stock solution is an undiluted or untreated high-concentration solution, often used as the basis for preparing other solutions. The diluent is used to adjust the high-concentration stock solution to a suitable concentration for the experiment or analysis, to avoid instrument overload or analytical errors caused by excessively high concentrations.
[0027] The second end of the mixing tube 100 is connected to the pump body via a multi-way valve. The second end of the mixing tube 100 is connected to the pump body via a flexible tube, on which the multi-way valve is located. The multi-way valve is existing technology and can be selected by those skilled in the art according to their needs; further details are omitted here. The pump body includes a syringe pump, which can be selected by those skilled in the art according to their needs. Both the syringe pump and the multi-way valve are electrically connected to an external controller for convenient automated control.
[0028] In addition, the mixing device is equipped with a housing, and a filter is installed at the inlet of the housing that communicates with the outside air to filter out impurities in the air, which helps to reduce the impurities mixed into the mixture and thus improve the accuracy of the test results.
[0029] like Figure 1 As shown, when a fixed amount of air is drawn from the first end of the mixing tube 100, the air can displace the residual reagent inside the mixing tube 100 to the second end of the mixing tube 100. This residual reagent can be a cleaning solution, a diluent, or a mixture of a diluent and the original solution; for ease of description, it is uniformly referred to as residual reagent. Under the pressure difference between the inside and outside of the mixing tube 100, a clean section is formed. When the reagent is repeatedly drawn from the clean section under the action of the pump body, the reagent can be mixed evenly, such as... Figure 2 and 3 As shown; in this embodiment, the number of repeated suctions is 3 to 6.
[0030] The suction force of the pump body is changed adaptively during the repeated suction. In addition, the length of the clean section extending in the mixing tube 100 is elastically changed during the suction. When the suction force of the pump body gradually increases, the length of the clean section extends and is filled with the mixed liquid. When the suction force of the pump body gradually decreases, the length of the clean section decreases, and the liquid level of the mixed liquid filled therein decreases.
[0031] The mixing tube 100 is provided with a scale value (not shown) for identifying the length of the clean section, so as to facilitate identification of the amount of air sucked into the mixing tube 100.
[0032] The driving unit is also included, which is used to drive the up-and-down, left-and-right or front-and-back displacement of the mixing tube 100. Specifically, the driving unit includes a first driving assembly, a second driving assembly and a third driving assembly, wherein the first driving assembly is used to drive the front-and-back displacement of the sampling needle, the second driving assembly is used to drive the left-and-right displacement of the sampling needle, and the third driving assembly is used to drive the up-and-down displacement of the sampling needle. The driving unit is a prior art, which will not be described here.
[0033] Working process
[0034] Taking one mixing operation as an example
[0035] A. The mixing tube 100 is cleaned by a cleaning liquid. In this embodiment, the cleaning liquid is pure water. The method and device for cleaning the sampling needle by the cleaning liquid are prior arts, which will not be described here.
[0036] B. The driving unit drives the displacement of the sampling needle, so that the sampling needle pierces downwardly a sample bottle storing a stock solution. Then, under the action of the pump body, the sampling needle sucks the stock solution at the first end and injects the stock solution into a sample bottle 200 containing a mixed liquid.
[0037] C. Then, the multi-way valve is switched. Under the action of the pump body, a dilution liquid flows through the mixing tube 100 and is injected into the sample bottle 200 from the first end of the mixing tube 100 to form a reagent to be mixed. In this embodiment, the dilution liquid is pure water. In this process, the dilution liquid flushes the inner wall surface of the sampling needle, so that most of the stock solution adhering to the inner wall surface enters the sample bottle 200.
[0038] D. Then, the driving unit drives the mixing tube 100 to separate from the sample bottle, so that the first end of the mixing tube 100 is in contact with air. The multi-way valve is switched. Under the action of the pump body, a constant amount of air is sucked through the first end of the mixing tube 100, and the air expels the dilution liquid or the mixed liquid of the dilution liquid and the stock solution remaining in the mixing tube 100 to the second end of the mixing tube 100 to form a clean section.
[0039] E. After that, the driving unit drives the mixing tube 100 to extend into the sample bottle below the liquid level of the mixture of the diluent and the stock solution to be mixed, that is, the first end of the mixing tube 100 is in contact with the reagent in the sample bottle, the multi-way valve is switched, and the mixture to be mixed is repeatedly pumped in the clean section under the action of the pump body to mix the mixture, as shown in Figure 2 and 3 The mixing effect is good.
[0040] In other embodiments of the present application, in order to avoid the residual cleaning liquid in the mixing tube 100 from mixing into the stock solution, after the cleaning liquid cleans the mixing tube 100, the driving unit drives the mixing tube 100 to displace, so that the first end of the mixing tube 100 is in contact with the air, and then the multi-way valve is switched, and a certain amount of air is extracted through the first end of the mixing tube 100 under the action of the pump body, and the air expels the cleaning liquid in the mixing tube to the second end of the mixing tube, which is conducive to further improving the concentration accuracy of the standard solution prepared by the stock solution and the diluent.
[0041] The present application has been described above by way of example, but the present application is not limited to the above specific embodiments, and any modification or modification based on the present application falls within the scope of the present application.
Claims
1. A sample homogenizing device for a sample injector, characterized by, The mixing device comprises a sample bottle (200), a mixing tube (100), a pump body and a multi-way valve, the sample bottle (200) is used for containing a reagent to be mixed, the first end of the mixing tube (100) is open and used for extracting the reagent or air, and the second end of the mixing tube (100) is connected with the pump body through the multi-way valve; when the first end of the mixing tube (100) extracts the air, the air can expel the residual reagent in the mixing tube (100) to the second end of the mixing tube (100) to form a clean section, and the reagent to be mixed can be mixed when the clean section is repeatedly pumped under the action of the pump body.
2. The sample homogenizer device for a sample injector according to claim 1, wherein The device further comprises a driving unit, which is used for driving the mixing tube (100) to move up and down, left and right or forward and backward.
3. The sample homogenizer device for a sample injector according to claim 1 or 2, characterized in that, The first end of the mixing tube (100) comprises a sampling needle, and the end of the sampling needle comprises a sharp part, which is used for piercing a rubber plug on the sample bottle (200).
4. The sample homogenizer for a sampler according to claim 3, wherein The mixing tube (100) is provided with a scale value, which is used for identifying the length of the clean section.
5. The sample homogenizer for a sampler according to claim 3, wherein The pump body comprises a syringe pump, and the syringe pump and the multi-way valve are respectively electrically connected with an external controller.
6. The sample homogenizer device for a sampler according to claim 4 or 5, characterized in that The mixing device is provided with a shell, and the shell is provided with a filter at an inlet communicating with the outside air.