Automatic sampling device of medicine dissolution instrument

Abstract

The utility model relates to the field of drug dissolution rate detection, in particular to an automatic sampling device of a drug dissolution instrument, which comprises a lower dissolution instrument and an upper dissolution instrument, one end of the lower dissolution instrument is fixedly connected with an electric telescopic rod I for driving the upper dissolution instrument to lift, and the inner wall of the lower dissolution instrument is fixedly connected with a drug dissolution cavity for dissolving out drugs. A transmission mechanism for driving the sampling tube to rotate is mounted on the surface of the sampling tube, a sampling mechanism for conveniently sampling a sample liquid is mounted on the inner wall of the sampling tube, an air hole is formed in one end of the surface of the sampling tube, and a sampling head is fixedly connected to one end of the sampling tube; a plurality of sampling holes are formed in the surface of the sampling head, stirring blades are fixedly connected to one end of the surface of the sampling head, and a liquid outlet mechanism is installed at one end of the sampling pipe. The automatic sampling device of the medicine dissolution instrument stirs sample liquid, prevents medicine in the sample liquid from precipitating, and improves the detection accuracy of the sample liquid.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of drug dissolution detection, especially to a drug dissolution tester automatic sampling device. BACKGROUND

[0002] The drug dissolution tester, also known as a drug dissolution tester, is an experimental equipment for determining the dissolution rate and dissolution behavior of drugs under specific conditions. The drug dissolution tester analyzes the release of drugs from drug preparations over time by simulating the environmental conditions in the human digestive tract. It uses in-vitro simulation technology to set specific experimental conditions (such as temperature and stirring speed) and places drug preparations in appropriate solution media for dissolution and release, thereby evaluating the release performance of the drug.

[0003] Drug dissolution testing by drug dissolution tester is an important part of pharmaceutical experiments. The dissolution of drugs in the dissolution cup of the dissolution tester changes over time. To ensure the reproducibility of dissolution testing, the drug solution in the dissolution cup of the dissolution tester needs to be sampled and tested at different time intervals.

[0004] According to the Chinese patent authorization announcement number CN221899162U, a kind of drug dissolution tester automatic sampling device, including lower dissolution tester, main electric push rod being arranged at one side of lower dissolution tester And the upper dissolution tester being arranged at one end of main electric push rod, the bottom of the upper dissolution tester is provided with sampling assembly, one side of the sampling assembly is provided with pretreatment component;The pretreatment component includes filtrate cylinder, the one end of the flow guide pipe is connected with sampling assembly, detachable filter structure is arranged in the filtrate cylinder, liquid inlet pipe is arranged on the outside of the filtrate cylinder, one end of the liquid inlet pipe is connected with the sample storage tube in sampling assembly.The utility model can automatically collect drug dissolution sample liquid, and the collection process can discard a certain volume of initial filtrate according to the needs to realize online filtering, which greatly guarantees the accuracy and consistency of the operation time between samples during dissolution process;Online filtering function can filter and remove insoluble excipients in dissolution liquid in time, avoid excipient adsorption and reduce filter membrane adsorption.

[0005] However, when the above-mentioned device is sampling, the sample liquid in the lower dissolution tester is static for a long time, and the drug in the sample liquid precipitates, which causes deviation in the accuracy of detection after sampling. Utility model content

[0006] The utility model aims to provide a kind of drug dissolution tester automatic sampling device, the device has the advantages of stirring sample liquid, preventing drug precipitation in sample liquid and improving the accuracy of sample liquid detection.

[0007] The utility model discloses a medicine dissolution instrument automatic sampling device, including lower dissolution instrument and upper dissolution instrument, and one end of lower dissolution instrument is fixedly connected with drive upper dissolution instrument lift telescopic electric rod no.

[0008] Further, the upper dissolution instrument is fixedly connected with a handle on the surface for conveniently taking the device.

[0009] Further, the transmission mechanism comprises a motor fixedly connected on the surface of the upper dissolution instrument, the motor output shaft is fixedly connected with a gear, the gear surface is engaged with a gear ring, and the gear ring inner wall is fixedly connected on the surface of the sampling tube.

[0010] Further, the sampling mechanism comprises a telescopic electric rod no. 2 fixedly connected on the inner wall of the sampling tube, and the telescopic electric rod no. 2 output shaft is fixedly connected with a piston, and the piston is slidably connected on the inner wall of the sampling tube.

[0011] Further, the sampling tube and the sampling head connection place are fixedly connected with a one-way valve for preventing sample liquid backflow.

[0012] Further, the liquid outlet mechanism comprises a liquid outlet ring rotatably connected on one end of the sampling tube, the sampling tube one end is provided with a connecting hole connected with the inner wall of the liquid outlet ring, the liquid outlet ring one side is fixedly connected with a liquid outlet pipe, the liquid outlet pipe is fixedly connected on the surface of the upper dissolution instrument, and the liquid outlet pipe one end is fixedly connected with an output valve.

[0013] The utility model discloses a working principle and use principle lie in: the sample liquid and medicine are placed in the medicine dissolution cavity of lower dissolution appearance, need to sample liquid to take out, start electric telescopic link no. 1, make electric telescopic link no. 1 drive upper dissolution appearance to move down, make sampling head reach the medicine dissolution cavity in lower dissolution appearance, start motor, make motor drive gear rotation, make gear drive gear ring rotation, make gear ring drive sampling tube rotation, make sampling tube drive sampling head and stirring vane rotation, sample liquid and medicine in the medicine dissolution cavity are stirred, start electric telescopic link no. 2, make electric telescopic link no. 2 drive piston to slide in the inner wall of sampling tube, make sample liquid through the multiple sampling holes of sampling head surface and be taken in sampling tube, prevent sample liquid backflow through check valve, then complete sampling, when discharging, start electric telescopic link no. 2, make electric telescopic link no. 2 drive piston to slide in the inner wall of sampling tube, because check valve makes sample liquid not flow from sampling head, start output valve, make output valve drive sample liquid to reach the liquid outlet ring, simultaneously discharge through liquid outlet pipe, conveniently sample liquid is stirred when sample liquid is taken out, prevent the medicine in sample liquid and deposit, improve the accuracy of sample liquid detection.

[0014] Compared with the prior art, the utility model has the advantages that: the sample liquid and medicine are placed in the medicine dissolution cavity of lower dissolution appearance, need to sample liquid to take out, start electric telescopic link no. 1, make electric telescopic link no. 1 drive upper dissolution appearance to move down, make sampling head reach the medicine dissolution cavity in lower dissolution appearance, start transmission mechanism, make transmission mechanism drive sampling tube rotation, make sampling tube drive sampling head and stirring vane rotation, sample liquid and medicine in the medicine dissolution cavity are stirred, then start sampling mechanism, through the multiple sampling holes of sampling head surface, sample liquid is extracted to sampling tube, complete sampling, and sample liquid is discharged for detection through liquid outlet mechanism, conveniently sample liquid is stirred when sample liquid is taken out, prevent the medicine in sample liquid and deposit, improve the accuracy of sample liquid detection.

[0015] Compared with the prior art, the utility model has the advantages that: the sample liquid and medicine are placed in the medicine dissolution cavity of lower dissolution appearance, need to sample liquid to take out, start electric telescopic link no. 1, make electric telescopic link no. 1 drive upper dissolution appearance to move down, make sampling head reach the medicine dissolution cavity in lower dissolution appearance, start transmission mechanism, make transmission mechanism drive sampling tube rotation, make sampling tube drive sampling head and stirring vane rotation, sample liquid and medicine in the medicine dissolution cavity are stirred, then start sampling mechanism, through the multiple sampling holes of sampling head surface, sample liquid is extracted to sampling tube, complete sampling, and sample liquid is discharged for detection through liquid outlet mechanism, conveniently sample liquid is stirred when sample liquid is taken out, prevent the medicine in sample liquid and deposit, improve the accuracy of sample liquid detection.

[0016] Compared with the prior art, the utility model has the advantages that: the sample liquid and medicine are placed in the medicine dissolution cavity of lower dissolution appearance, need to sample liquid to take out, start electric telescopic link no. 1, make electric telescopic link no. 1 drive upper dissolution appearance to move down, make sampling head reach the medicine dissolution cavity in lower dissolution appearance, start transmission mechanism, make transmission mechanism drive sampling tube rotation, make sampling tube drive sampling head and stirring vane rotation, sample liquid and medicine in the medicine dissolution cavity are stirred, then start sampling mechanism, through the multiple sampling holes of sampling head surface, sample liquid is extracted to sampling tube, complete sampling, and sample liquid is discharged for detection through liquid outlet mechanism, conveniently sample liquid is stirred when sample liquid is taken out, prevent the medicine in sample liquid and deposit, improve the accuracy of sample liquid detection. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 It is whole structure schematic diagram of the utility model a kind of medicine dissolution appearance automatic sampling device;

[0018] Figure 2 It is sectional structure schematic diagram of the utility model a kind of medicine dissolution appearance automatic sampling device;

[0019] Figure 3The utility model discloses a sectional plane A place of the enlarged structure schematic diagram of automatic sampling device of medicine dissolution tester,

[0020] Figure 4 The utility model discloses a sectional plane A place of the enlarged structure schematic diagram of automatic sampling device of medicine dissolution tester,

[0021] The utility model discloses a sectional plane A place of the enlarged structure schematic diagram of automatic sampling device of medicine dissolution tester, Specific embodiments

[0022] In order to make the technical means, creative features, purposes and effects of the embodiments of the application easy to understand, the embodiments of the application will be further described below in conjunction with the drawings and specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the embodiments of the application and do not limit the embodiments of the application.

[0023] The specific embodiments of the application are as follows, Figures 1-4 The utility model discloses a sectional plane A place of the enlarged structure schematic diagram of automatic sampling device of medicine dissolution tester,

[0024] The sample liquid and the medicine are placed in the medicine dissolution cavity 3 in the lower dissolution instrument 1. When the sample liquid needs to be taken out, the electric telescopic rod one 4 is started to drive the upper dissolution instrument 2 to move downwards, so that the sampling head 7 reaches the medicine dissolution cavity 3 in the lower dissolution instrument 1. The transmission mechanism is started to drive the sampling tube 6 to rotate, so that the sampling tube 6 drives the sampling head 7 and the stirring blade 8 to rotate. The sample liquid and the medicine in the medicine dissolution cavity 3 are stirred. Then the sampling mechanism is started. The sample liquid is extracted into the sampling tube 6 through the plurality of sampling holes 9 formed on the surface of the sampling head 7. The sampling is completed. The sample liquid is discharged through the liquid outlet mechanism for detection. The sample liquid is stirred when it is taken out to prevent the medicine in the sample liquid from precipitating, thereby improving the accuracy of sample liquid detection.

[0025] The lower dissolution instrument 1 and the upper dissolution instrument 2 are consistent with the structure in the automatic sampling device of the medicine dissolution instrument disclosed in Chinese Patent No. CN221899162U, which is prior art.

[0026] As shown in Figures 1-4 , the transmission mechanism includes a motor 10 fixedly connected to the surface of the upper dissolution instrument 2. The output shaft of the motor 10 is fixedly connected with a gear 11. The surface of the gear 11 is engaged with a gear ring 12. The inner wall of the gear ring 12 is fixedly connected to the surface of the sampling tube 6. The sampling mechanism includes an electric telescopic rod two 13 fixedly connected to the inner wall of the sampling tube 6. The output shaft of the electric telescopic rod two 13 is fixedly connected with a piston 14. The piston 14 is slidingly connected to the inner wall of the sampling tube 6. A one-way valve 15 for preventing backflow of the sample liquid is fixedly connected to the connection between the sampling tube 6 and the sampling head 7. The direction of the one-way valve 15 is from the sampling head 7 to the sampling tube 6.

[0027] Through the above technical solution, the motor 10 is started to drive the gear 11 to rotate, drive the gear ring 12 to rotate, drive the sampling tube 6 to rotate, drive the sampling head 7 and the stirring blade 8 to rotate, and stir the sample liquid and the medicine in the medicine dissolution cavity 3. The electric telescopic rod two 13 is started to drive the piston 14 to slide in the inner wall of the sampling tube 6. The sample liquid is sucked into the sampling tube 6 through the plurality of sampling holes 9 formed on the surface of the sampling head 7. The backflow of the sample liquid is prevented through the one-way valve 15. Then the sampling is completed.

[0028] As shown in Figures 1-4 , the liquid outlet mechanism includes a liquid outlet ring 16 rotatably connected to one end of the sampling tube 6. The one end of the sampling tube 6 is provided with a connecting hole 19 connected with the inner wall of the liquid outlet ring 16. The liquid outlet ring 16 is fixedly connected with a liquid outlet pipe 17 on one side. The liquid outlet pipe 17 is fixedly connected to the surface of the upper dissolution instrument 2. The one end of the liquid outlet pipe 17 is fixedly connected with an output valve 18.

[0029] Through the above technical scheme, the electric telescopic rod two 13 is started, the electric telescopic rod two 13 drives the piston 14 to slide in the inner wall of the sampling pipe 6, because the one-way valve 15 makes the sample liquid not flow out from the sampling head 7, the output valve 18 is started, the output valve 18 drives the sample liquid to reach the liquid outlet ring 16, and is discharged through the liquid outlet pipe 17, and the sampling pipe 6 rotates while rotating above the liquid outlet ring 16.

[0030] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and are not limited thereto; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand; it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A pharmaceutical dissolution apparatus automatic sampling device comprising a lower dissolution apparatus (1) and an upper dissolution apparatus (2), characterized in that: The lower dissolution tester (1) is fixedly connected with an electric telescopic rod I (4) driving the lifting of the upper dissolution tester (2), and the output shaft of the electric telescopic rod I (4) is fixedly connected with one end of the upper dissolution tester (2); the inner wall of the lower dissolution tester (1) is fixedly connected with a drug dissolution cavity (3) for dissolving drugs; the surface of the upper dissolution tester (2) is rotatably connected with a sampling tube (6) convenient to rotate; the surface of the sampling tube (6) is provided with a transmission mechanism driving the rotation of the sampling tube (6); the inner wall of the sampling tube (6) is provided with a sampling mechanism convenient to sample sample liquid; one end of the surface of the sampling tube (6) is provided with an air hole; one end of the sampling tube (6) is fixedly connected with a sampling head (7); the surface of the sampling head (7) is provided with a plurality of sampling holes (9); one end of the surface of the sampling head (7) is fixedly connected with a stirring blade (8); and one end of the sampling tube (6) is provided with a liquid outlet mechanism.

2. The apparatus according to claim 1, wherein: The surface of the upper dissolution tester (2) is fixedly connected with a handle (5) convenient to take the device.

3. The apparatus according to claim 1 or 2, wherein: The transmission mechanism comprises a motor (10) fixedly connected with the surface of the upper dissolution tester (2); the output shaft of the motor (10) is fixedly connected with a gear (11); and the surface of the gear (11) is engaged with a gear ring (12) fixedly connected with the surface of the sampling tube (6).

4. The apparatus according to claim 1 or 2, wherein: The sampling mechanism comprises an electric telescopic rod II (13) fixedly connected with the inner wall of the sampling tube (6); the output shaft of the electric telescopic rod II (13) is fixedly connected with a piston (14) slidably connected with the inner wall of the sampling tube (6).

5. The apparatus according to claim 3, wherein: The sampling mechanism comprises an electric telescopic rod II (13) fixedly connected with the inner wall of the sampling tube (6); the output shaft of the electric telescopic rod II (13) is fixedly connected with a piston (14) slidably connected with the inner wall of the sampling tube (6).

6. The apparatus of claim 4, wherein: A one-way valve (15) for preventing the backflow of sample liquid is fixedly connected with the connection between the sampling tube (6) and the sampling head (7).

7. The apparatus of claim 5, wherein: A one-way valve (15) for preventing the backflow of sample liquid is fixedly connected with the connection between the sampling tube (6) and the sampling head (7).

8. The apparatus of claim 1, 2, 5, 6, or 7, wherein: The liquid outlet mechanism comprises a liquid outlet ring (16) rotatably connected with one end of the sampling tube (6); one end of the sampling tube (6) is provided with a connecting hole (19) connected with the inner wall of the liquid outlet ring (16); the liquid outlet ring (16) is fixedly connected with a liquid outlet tube (17) on one side; the liquid outlet tube (17) is fixedly connected with the surface of the upper dissolution tester (2); and the liquid outlet tube (17) is fixedly connected with an output valve (18) on one end.

9. The apparatus according to claim 3, wherein: The liquid outlet mechanism comprises a liquid outlet ring (16) rotatably connected with one end of the sampling tube (6); one end of the sampling tube (6) is provided with a connecting hole (19) connected with the inner wall of the liquid outlet ring (16); the liquid outlet ring (16) is fixedly connected with a liquid outlet tube (17) on one side; the liquid outlet tube (17) is fixedly connected with the surface of the upper dissolution tester (2); and the liquid outlet tube (17) is fixedly connected with an output valve (18) on one end.

10. The apparatus of claim 4, wherein: The liquid outlet mechanism comprises a liquid outlet ring (16) rotatably connected with one end of the sampling tube (6); one end of the sampling tube (6) is provided with a connecting hole (19) connected with the inner wall of the liquid outlet ring (16); the liquid outlet ring (16) is fixedly connected with a liquid outlet tube (17) on one side; the liquid outlet tube (17) is fixedly connected with the surface of the upper dissolution tester (2); and the liquid outlet tube (17) is fixedly connected with an output valve (18) on one end.

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