Liquid injection structure for gene synthesizer

Abstract

The utility model relates to a liquid beating structure for a gene synthesizer, and belongs to the field of gene synthesizers, the liquid beating structure comprises an electromagnetic valve plate and a liquid beating plate, the electromagnetic valve plate and the liquid beating plate are both mounted in the synthesizer, the electromagnetic valve plate is provided with a plurality of medium diaphragm valves and liquid beating pipes, the liquid beating pipes are communicated with the medium diaphragm valves, and the liquid beating plate is provided with liquid beating needles communicated with the liquid beating pipes. The multiple medium diaphragm valves can convey reagents into the liquid injection pipe at the same time, and the reagents are output through the liquid injection needle, so that liquid injection can be carried out on a high-flux synthesizer.

Description

TECHNICAL FIELD

[0001] The application relates to the field of gene synthesizers, in particular to a liquid injection structure for a gene synthesizer. BACKGROUND

[0002] A gene synthesizer is an automated instrument designed to synthesize oligonucleotides that are structurally similar to DNA or RNA, generally applied to solid-phase synthesis, one nucleotide is added to the growing oligonucleotide chain each time, and the same chemical reaction is used for each nucleotide to react with the corresponding purine or pyrimidine base derivative, and the chemical reaction and operation details vary with different instruments.

[0003] After the synthesis carrier is pre-installed in each hole of a conventional multi-hole synthesis plate, the synthesis plate is placed in the instrument and synthesis is performed, and the corresponding reagent is added to each hole, and a liquid injection needle is generally used to inject liquid into the hole, and when the liquid injection is performed on a high-throughput synthesizer, the liquid injection time is long, and the synthesis efficiency is low. CONTENT OF THE INVENTION

[0004] In order to improve the above problems, the application provides a liquid injection structure for a gene synthesizer.

[0005] The application provides a liquid injection structure for a gene synthesizer, which adopts the following technical scheme:

[0006] A liquid injection structure for a gene synthesizer comprises an electromagnetic valve plate and a liquid injection plate, the electromagnetic valve plate and the liquid injection plate are both installed in a synthesizer, a plurality of medium diaphragm valves and liquid injection pipes are arranged on the electromagnetic valve plate, the liquid injection pipes and the medium diaphragm valves are in communication, and a liquid injection needle in communication with the liquid injection pipes is arranged on the liquid injection plate.

[0007] Through the above technical scheme, the electromagnetic valve plate can provide installation positions for the medium diaphragm valves and the liquid injection pipes, the liquid injection plate can provide installation positions for the liquid injection needles, the plurality of medium diaphragm valves can simultaneously deliver reagents into the liquid injection pipes and output through the liquid injection needles, so as to inject liquid into a high-throughput synthesizer, shorten the liquid injection time, and improve the synthesis efficiency.

[0008] Preferably, the electromagnetic valve plate is provided with an inlet pipe, a water inlet channel is formed in the electromagnetic valve plate, the inlet pipe and the water inlet channel are in communication, a plurality of water inlet branches are formed on the water inlet channel, and the water inlet branches and the medium diaphragm valves are in communication.

[0009] Through the above technical scheme, the reagents enter the water inlet channel through the inlet pipe and enter the plurality of medium diaphragm valves through the water inlet branches, so that the medium diaphragm valves can deliver the reagents into the liquid injection pipes.

[0010] Preferably, a first sleeve pipe is sleeved on the liquid injection pipe, a first installation groove is formed on the electromagnetic valve plate, one end of the first sleeve pipe is embedded in the first installation groove, a first limiting block is embedded on one end of the first sleeve pipe, a liquid outlet needle is arranged in the first limiting block, one end of the liquid outlet needle is communicated with the medium diaphragm valve, and the other end of the liquid outlet needle is communicated with the liquid injection pipe.

[0011] By adopting the above technical scheme, the first limiting block can limit the liquid outlet needle, the first sleeve pipe can limit the first limiting block and the liquid injection pipe, and the first installation groove can limit the first sleeve pipe, so that the liquid injection pipe and the liquid outlet needle are limited, and installation of the liquid injection pipe and the liquid outlet needle is facilitated.

[0012] Preferably, a counterbore is formed on the electromagnetic valve plate, and a first bolt is arranged on the electromagnetic valve plate.

[0013] By adopting the above technical scheme, when the electromagnetic valve plate needs to be installed, the operator can move the electromagnetic valve plate to a suitable position of the synthesizer, and then screw in the first bolt, so that the first bolt can limit the electromagnetic valve plate, thereby achieving installation of the electromagnetic valve plate.

[0014] Preferably, a second sleeve pipe is sleeved on one end of the liquid injection pipe close to the liquid injection plate, a second installation groove is formed on the liquid injection plate, one end of the second sleeve pipe is embedded in the second installation groove, a second limiting block is embedded on one end of the second sleeve pipe, the liquid injection needle is arranged in the second limiting block, and one end of the liquid injection needle extends out of the liquid injection plate.

[0015] By adopting the above technical scheme, the second limiting block can limit the liquid injection needle, the second sleeve pipe can limit the second limiting block, and the second installation groove can limit the second sleeve pipe, so that the liquid injection needle is limited, and positioning and installation of the liquid injection needle are facilitated.

[0016] Preferably, a second bolt is arranged on the liquid injection plate, and the second bolt is threadedly connected with the liquid injection plate.

[0017] By adopting the above technical scheme, when the liquid injection plate needs to be installed, the operator can move the liquid injection plate to a suitable position of the synthesizer, and then screw in the second bolt, so that the second bolt can limit the liquid injection plate, thereby achieving installation of the liquid injection plate.

[0018] Preferably, a handle is detachably connected to the liquid injection plate.

[0019] By adopting the above technical scheme, the handle can facilitate the operator to move the liquid injection plate, and facilitate the operator to apply force to the liquid injection plate.

[0020] Preferably, a connecting bolt is arranged on the liquid injection plate, and the connecting bolt is threadedly connected through the liquid injection plate and the handle.

[0021] By adopting the technical scheme, when the handle needs to be installed, the operator can move the handle to a suitable position of the liquid injection plate, and then screw in the connecting bolt, which can position the handle, thereby realizing installation of the handle.

[0022] To sum up, the present application has at least one of the following beneficial technical effects:

[0023] 1. By arranging the medium diaphragm valve, the liquid injection pipe and the liquid injection needle, the electromagnetic valve plate can provide installation positions for the medium diaphragm valve and the liquid injection pipe, the liquid injection plate can provide an installation position for the liquid injection needle, and multiple medium diaphragm valves can simultaneously deliver reagents into the liquid injection pipe and output through the liquid injection needle, so as to inject liquid for a high-throughput synthesis instrument, thereby shortening the liquid adding time and improving the synthesis efficiency.

[0024] 2. By arranging the first sleeve, the first installation slot, the first limiting block and the liquid outlet needle, the first limiting block can position the liquid outlet needle, the first sleeve can position the first limiting block and the liquid injection pipe, and the first installation slot can position the first sleeve, thereby positioning the liquid injection pipe and the liquid outlet needle, and facilitating installation of the liquid injection pipe and the liquid outlet needle. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 is a schematic diagram of the overall structure of the electromagnetic valve plate in the embodiment of the present application.

[0026] Figure 2 is a schematic diagram of the overall structure of the electromagnetic valve plate in the embodiment of the present application.

[0027] Figure 3 is a schematic diagram of the overall structure of the first sleeve, the first limiting block and the liquid outlet needle in the embodiment of the present application.

[0028] Figure 4 is a schematic diagram of the overall structure of the liquid injection plate in the embodiment of the present application.

[0029] Figure 5 is a schematic diagram of the overall structure of the second sleeve and the second limiting block in the embodiment of the present application.

[0030] Reference signs: 1, electromagnetic valve plate; 11, water inlet channel; 12, water inlet branch; 13, first installation slot; 14, counterbore; 141, first bolt; 2, liquid injection plate; 21, second installation slot; 22, second bolt; 23, handle; 231, connecting bolt; 3, medium diaphragm valve; 4, liquid injection pipe; 41, first sleeve; 411, first limiting block; 412, liquid outlet needle; 42, second sleeve; 421, second limiting block; 5, liquid injection needle; 6, liquid inlet pipe. DETAILED DESCRIPTION

[0031] To make the inventive objectives, features, and advantages of this application more apparent and understandable, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0032] The following is in conjunction with the appendix Figures 1-5 This application will be described in further detail.

[0033] This application discloses a liquid dispensing structure for a gene synthesizer, such as... Figure 1 As shown, the system includes multiple solenoid valve plates 1, which are installed inside the synthesizer. Each solenoid valve plate 1 has a countersunk hole 14 and a first bolt 141. When installing the solenoid valve plate 1, the operator can move it to a suitable position within the synthesizer and then screw in the first bolt 141. The first bolt 141 limits the movement of the solenoid valve plate 1, fixing it relatively to the synthesizer, thus achieving the installation of the solenoid valve plate 1.

[0034] like Figure 1 and 2 As shown, the solenoid valve plate 1 is equipped with an inlet pipe 6, and an inlet channel 11 is opened inside the solenoid valve plate 1. The inlet pipe 6 and the inlet channel 11 are connected, and multiple inlet branches 12 are opened on the inlet channel 11. Multiple media diaphragm valves 3 are installed on the solenoid valve plate 1, and the inlet branches 12 are connected to the media diaphragm valves 3. The reagent enters the inlet channel 11 through the inlet pipe 6, then flows into the inlet branch 12, and then enters the multiple media diaphragm valves 3 through the inlet branch 12, facilitating the delivery of the reagent by the media diaphragm valves 3.

[0035] like Figure 1 and 3As shown, the electromagnetic valve plate 1 is provided with a plurality of liquid injection pipes 4, the first sleeve pipe 41 is sleeved on one end of the liquid injection pipe 4 close to the electromagnetic valve plate 1, the first installation groove 13 is formed on the electromagnetic valve plate 1, and one end of the first sleeve pipe 41 is embedded in the first installation groove 13. The first limiting block 411 is embedded on one end of the first sleeve pipe 41 embedded in the first installation groove 13, the liquid outlet needle 412 is fixedly penetrated in the first limiting block 411, one end of the liquid outlet needle 412 communicates with the medium diaphragm valve 3, and the other end communicates with the liquid injection pipe 4. The first limiting block 411 can limit the liquid outlet needle 412, the first sleeve pipe 41 can limit the first limiting block 411 and the liquid injection pipe 4, the first installation groove 13 can limit the first sleeve pipe 41, thereby limiting the liquid injection pipe 4 and the liquid outlet needle 412, and the installation of the liquid injection pipe 4 and the liquid outlet needle 412 is realized. After the reagent is delivered into the medium diaphragm valve 3, the reagent can be delivered into the liquid injection pipe 4 through the medium diaphragm valve 3, so as to facilitate the liquid injection work.

[0036] As shown in Figure 4 and 5 , it also includes a liquid injection plate 2, the liquid injection plate 2 is installed in the synthesizer, the liquid injection plate 2 is provided with a second bolt 22, and the second bolt 22 is threadedly connected with the liquid injection plate 2. When it is necessary to install the liquid injection plate 2, the operator can move the liquid injection plate 2 to a suitable position of the synthesizer, and then screw in the second bolt 22, the second bolt 22 can limit the liquid injection plate 2, so that the liquid injection plate 2 is relatively fixed with the synthesizer, thereby realizing the installation of the liquid injection plate 2. The handle 23 is detachably connected to the liquid injection plate 2, the liquid injection plate 2 is provided with a connecting bolt 231, and the connecting bolt 231 is threadedly connected through the liquid injection plate 2 and the handle 23. The operator can move the handle 23 to a suitable position of the liquid injection plate 2, and then screw in the connecting bolt 231, the connecting bolt 231 can limit the handle 23, thereby realizing the installation of the handle 23, and the handle 23 can facilitate the operator to apply force to the liquid injection plate 2, thereby realizing the movement of the liquid injection plate 2.

[0037] As shown in Figure 4 and 5 , the second sleeve pipe 42 is sleeved on one end of the liquid injection pipe 4 close to the liquid injection plate 2, the second installation groove 21 is formed on the liquid injection plate 2, and one end of the second sleeve pipe 42 is embedded in the second installation groove 21. The second limiting block 421 is embedded on one end of the second sleeve pipe 42 embedded in the second installation groove 21, the liquid injection needle 5 is communicated with one end of the liquid injection pipe 4 away from the electromagnetic valve plate 1, the liquid injection needle 5 is penetrated in the second limiting block 421, and one end of the liquid injection needle 5 away from the liquid injection pipe 4 extends out of the liquid injection plate 2. The second limiting block 421 can limit the liquid injection needle 5, the second sleeve pipe 42 can limit the second limiting block 421, the second installation groove 21 can limit the second sleeve pipe 42, thereby limiting the liquid injection needle 5, and realizing the positioning installation of the liquid injection needle 5. The reagent can be delivered into the liquid injection needle 5 through the liquid injection pipe 4, and the liquid injection needle 5 can output the reagent onto the synthesis plate, so as to inject the synthesizer.

[0038] The implementation principle of the liquid punching structure for the gene synthesizer according to the embodiment of the application is as follows:

[0039] The operator moves the electromagnetic valve plate 1 to a suitable position of the synthesizer, and installs the electromagnetic valve plate 1 through the first bolt 141. The operator moves the liquid punching plate 2 to a suitable position of the synthesizer, and installs the liquid punching plate 2 through the second bolt 22. The reagent is transported to the water inlet channel 11 through the liquid inlet pipe 6 under the action of the medium diaphragm valve 3, transported to the plurality of medium diaphragm valves 3 through the water inlet branch 12, then transported to the liquid outlet needle 412, and finally flows out through the liquid punching needle 5, thereby realizing the liquid punching work.

[0040] The above are the preferred embodiments of the application, and are not intended to limit the protection scope of the application. Therefore, any equivalent changes made according to the structure, shape, principle of the application should be covered within the protection scope of the application.

Claims

1. A liquid punching structure for a gene synthesizer, characterized in that: Including electromagnetic valve plate (1) and liquid injection plate (2), the electromagnetic valve plate (1) and liquid injection plate (2) are installed in the synthesizer, a plurality of medium diaphragm valves (3) and liquid injection pipes (4) are arranged on the electromagnetic valve plate (1), the liquid injection pipe (4) is communicated with the medium diaphragm valve (3), and the liquid injection needle (5) communicated with the liquid injection pipe (4) is arranged on the liquid injection plate (2).

2. The liquid punching structure for a gene synthesizer according to claim 1, characterized in that: The electromagnetic valve plate (1) is provided with a liquid inlet pipe (6), the electromagnetic valve plate (1) is provided with a water inlet channel (11), the liquid inlet pipe (6) is communicated with the water inlet channel (11), and a plurality of water inlet branches (12) are arranged on the water inlet channel (11) and communicated with the medium diaphragm valve (3).

3. The liquid punching structure for a gene synthesizer according to claim 1, characterized in that: The liquid injection pipe (4) is provided with a first sleeve pipe (41), the electromagnetic valve plate (1) is provided with a first mounting groove (13), one end of the first sleeve pipe (41) is embedded into the first mounting groove (13), one end of the first sleeve pipe (41) is provided with a first limiting block (411), the first limiting block (411) is provided with a liquid outlet needle (412), one end of the liquid outlet needle (412) is communicated with the medium diaphragm valve (3), and the other end is communicated with the liquid injection pipe (4).

4. The liquid punching structure for a gene synthesizer according to claim 1, characterized in that: The electromagnetic valve plate (1) is provided with a counterbore (14), and the electromagnetic valve plate (1) is provided with a first bolt (141), and the counterbore (14) is screwed into the first bolt (141).

5. The liquid punching structure for a gene synthesizer according to claim 1, characterized in that: The liquid injection pipe (4) is provided with a second sleeve pipe (42) close to the liquid injection plate (2), the liquid injection plate (2) is provided with a second mounting groove (21), one end of the second sleeve pipe (42) is embedded into the second mounting groove (21), one end of the second sleeve pipe (42) is provided with a second limiting block (421), the liquid injection needle (5) is arranged in the second limiting block (421), and one end of the liquid injection needle (5) away from the liquid injection pipe (4) extends out of the liquid injection plate (2).

6. The liquid punching structure for a gene synthesizer according to claim 1, wherein: The liquid injection plate (2) is provided with a second bolt (22), and the second bolt (22) is screwed with the liquid injection plate (2).

7. The liquid punching structure for a gene synthesizer according to claim 1, wherein: The liquid injection plate (2) is detachably connected with a handle (23). 8.The liquid punching structure for a gene synthesizer according to claim 7, wherein: The liquid injection plate (2) is provided with a connecting bolt (231), and the connecting bolt (231) is screwed through the liquid injection plate (2) and the handle (23).

Images