Cryopreservation box

Abstract

The utility model discloses a cryopreservation box which comprises a box body, and a plurality of through grooves are formed in the side wall of the box body. A plurality of containing grooves used for containing cryopreservation bags are formed in the box body, and each containing groove comprises a first opposite angle, a second opposite angle and a long edge, wherein the first opposite angles and the second opposite angles are located on the diagonal lines of the containing grooves, and the long edges are adjacent to the first opposite angles or the second opposite angles. The accommodating groove is divided into a first grabbing space and a second grabbing space by taking the diagonal line as a boundary; the cryopreservation bag is placed along the diagonal line of the containing groove when being placed in the containing groove; the containing groove is divided into the first grabbing space and the second grabbing space with the diagonal line as the boundary, the index finger and the thumb of an operator stretch into the first grabbing space and the second grabbing space respectively, then the cryopreservation bag in the containing groove can be taken out, and operation is convenient and fast.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of cryopreservation technology, specifically relates to a cryopreservation box. BACKGROUND

[0002] In the field of biomedical research, clinical diagnosis and biological sample library, the preservation of biological samples is crucial, one of the containers for preserving biological samples is a cryopreservation bag, which is a sealed bag for storing biological samples such as blood, cells and tissues, usually biological samples are loaded into the cryopreservation bag, then the cryopreservation bag is loaded into the cryopreservation box, and the cryopreservation box is placed in a low-temperature environment for preservation to maintain the activity and stability of the biological samples.

[0003] The cryopreservation box is generally provided with a plurality of rectangular grids, and the cryopreservation bag is placed parallel to the long side of the grid; when the operator takes out the cryopreservation bag, he needs to wear heavy gloves for operation under low-temperature conditions, and the operator will be hindered when grabbing the cryopreservation bag, the operation is not flexible, it is difficult to take out the cryopreservation bag, and the working efficiency is affected. UTILITY MODEL CONTENTS

[0004] In order to overcome the shortcomings of the prior art, the utility model provides a cryopreservation box convenient for taking and placing cryopreservation bags.

[0005] The utility model solves the technical problems by adopting the following technical scheme:

[0006] A cryopreservation box, comprising a box body, a plurality of through grooves are arranged on the side wall of the box body; a plurality of accommodating grooves for placing cryopreservation bags are arranged in the box body, the accommodating groove comprises a first diagonal and a second diagonal located on the diagonal line of the accommodating groove, and a long side of the accommodating groove adjacent to the first diagonal or the second diagonal;

[0007] The accommodating groove is divided into a first grabbing space and a second grabbing space by the diagonal line.

[0008] The length of the diagonal line of the accommodating groove is d, the length of the long side of the accommodating groove is D, and the width of the cryopreservation bag is L.

[0009] d, D and L satisfy the relationship: d >= L > D.

[0010] The shape of the accommodating groove is a parallelogram.

[0011] The cryopreservation box further comprises a box cover arranged opposite to the box body, and a plurality of through holes are arranged on the box cover.

[0012] The bottom of the box body is provided with a plurality of flow guide holes.

[0013] The freezing box as claimed in any one of the preceding claims, wherein the box body comprises a left side wall and a right side wall arranged oppositely.

[0014] The through slot comprises a left through slot arranged on the left side wall of the box body and a right through slot arranged on the right side wall of the box body.

[0015] The freezing box as claimed in any one of the preceding claims, wherein one side edge of the box cover is hinged to one side edge of the box body.

[0016] The freezing box as claimed in any one of the preceding claims, wherein the box body is provided with a partition rack, and the accommodating slot is arranged in the partition rack; and a plurality of partition through holes are arranged on the side wall of the partition rack.

[0017] The freezing box as claimed in any one of the preceding claims, wherein the partition rack has a gap with the inner wall of the box body, and a linkage partition lifting mechanism is arranged between the partition rack and the box cover, and the partition lifting mechanism is used for lifting the partition rack together.

[0018] The freezing box as claimed in any one of the preceding claims, wherein a label slot is arranged on the outer surface of the freezing box.

[0019] The freezing box has the following beneficial effects:

[0020] The first gripping space and the second gripping space are arranged in the accommodating slot for placing the freezing bag, the index finger and the thumb of the operator wearing gloves are respectively inserted into the first gripping space and the second gripping space, and the freezing bag in the accommodating slot can be taken out, so that the operation is convenient and fast. BRIEF DESCRIPTION OF DRAWINGS

[0021] The freezing box will be further described below in combination with the drawings and embodiments.

[0022] Figure 1 is a state schematic view of the freezing box filled with freezing bags (with the cover opened);

[0023] Figure 2 is one of the state schematic views of the freezing box (with the cover opened);

[0024] Figure 3 is Figure 2 the freezing box in the top view (with the cover opened);

[0025] Figure 4 is the second state schematic view of the freezing box (with the cover closed);

[0026] Figure 5 is the third state schematic view of the freezing box (with the cover opened);

[0027] Figure 6 is the structural schematic view of the freezing box omitting the partition rack (with the cover opened);

[0028] Figure 7 is the shape schematic view of the through slot;

[0029] Reference signs are as follows:

[0030] 1-box body; 11-through slot; 12-left side wall; 121-left through slot; 13-right side wall; 131-right through slot; 14-dividing plate; 2-receiving groove; 21-first diagonal; 22-second diagonal; 23-receiving groove long side; 24-first grabbing space; 25-second grabbing space; 3-box cover; 31-through hole; 32-rotation shaft; 4-cryogenic bag. DETAILED DESCRIPTION

[0031] The concept, specific structure and technical effects of the present application will be described clearly and completely in combination with the embodiments and drawings, so as to fully understand the purpose, features and effects of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all the embodiments, and other embodiments obtained by those skilled in the art without creative labor based on the embodiments of the present application are within the scope of protection of the present application. In addition, all the connection / connection relationships involved in the patent do not mean that the components are directly connected, but that a better connection structure can be composed by adding or reducing connection auxiliary components according to the specific implementation situation. The various technical features in the present application can be interactively combined without mutual contradiction and conflict.

[0032] The multi-connected cryogenic bag has a plurality of liquid storage chambers connected to each other. After the biological sample is loaded therein, each liquid storage chamber is divided into a plurality of cryogenic bags with single chambers by a heat sealing module. The present embodiment provides a cryogenic box for storing the cryogenic bag.

[0033] Reference Figures 1 to 3 A cryogenic box includes a box body 1, a plurality of through slots 11 are arranged on the side wall of the box body 1; a plurality of receiving grooves 2 for placing cryogenic bags 4 are arranged in the box body 1, the receiving grooves 2 include first diagonals 21 and second diagonals 22 on the diagonal lines of the receiving grooves 2, and a receiving groove long side 23 adjacent to the first diagonal 21 or the second diagonal 22.

[0034] The receiving grooves 2 are divided into first grabbing spaces 24 and second grabbing spaces 25 by the diagonal lines.

[0035] When the cryogenic bag 4 is taken out, after opening the liquid nitrogen tank for storing the cryogenic box, the operator's index finger and thumb are respectively inserted into the first grabbing space 24 and the second grabbing space 25, so that the cryogenic bag 4 in the receiving groove can be taken out, which is convenient and fast; and when the cryogenic box is placed in a liquid nitrogen low-temperature environment (such as a cryogenic tank), the density of liquid nitrogen is lower than that of air, liquid nitrogen first enters the box body 1 from the through slot 11, and quickly and directly contacts the cryogenic bag 4, so that the cryogenic bag 4 can be frozen faster.

[0036] As an example, the length of the diagonal of the accommodating groove 2 is d, the length of the long side 23 of the accommodating groove is D, and the width of the cryopreservation bag 4 is L; d, D, and L satisfy the relationship: d≥L>D.

[0037] When the condition d=L is met, the cryopreservation bag 4 is placed along the diagonal of the accommodating groove, and the two long sides on both sides of the cryopreservation bag 4 are respectively clamped on the first diagonal 21 and the second diagonal 22, so that the cryopreservation bag 4 does not shake when the cryopreservation box is moved; when the condition d≥L>D is met, the cryopreservation bag 4 has a certain amount of swing before and after the diagonal of the accommodating groove, but the condition that the cryopreservation bag is attached to the long side 23 of the accommodating groove does not occur; and the design of the above-mentioned accommodating groove 2 also helps to fix the cryopreservation bag 4 in the accommodating groove 2, so as to avoid the cryopreservation bag 4 in the cryopreservation box from swinging greatly when the cryopreservation box is moved.

[0038] For example, when the width of the cryopreservation bag 4 is equal to the length of the long side 23 of the accommodating groove, after the cryopreservation bag 4 is placed in the accommodating groove 2, the cryopreservation bag 4 will be against one side of the inner wall of the accommodating groove 2; in order to form a space for grabbing the cryopreservation bag 4, the cryopreservation bag 4 needs to be pushed away from the inner wall of the accommodating groove 2, and the gloves worn by the operator are very thick, which affects the perception of the fingers to the edge of the cryopreservation bag 4, making it more difficult to find the correct gripping point, but the cryopreservation box in the embodiment does not have this problem.

[0039] With reference to Figure 7 , as an example, the shape of the accommodating groove 2 can be rectangular, rhombic, octagonal, hexagonal, square, irregular polygon, etc.

[0040] In one embodiment, the shape of the accommodating groove 2 is a parallelogram.

[0041] With reference to Figures 1 to 2 , Figures 4 to 6 In one embodiment, the box cover 3 is further provided opposite to the box body 1, and a plurality of through holes 31 are arranged on the box cover 3. The through holes 31 can be used for the cooling gas to enter the box body 1, so as to quickly cool the cryopreservation bags in the box body 1.

[0042] Specifically, the through holes 31 are arranged on the top of the box cover 3, and liquid nitrogen can enter the box body 1 under the action of gravity, so as to quickly cool the cryopreservation bags 4.

[0043] Specifically, a plurality of flow guide holes (not shown in the figure) are arranged on the bottom of the box body 1; in the embodiment, the flow guide holes have two functions, one is to form a convection with the through holes 31 on the box body 1, so that the cold flow such as liquid nitrogen flows from top to bottom or from bottom to top, so that each cryopreservation bag 4 in the box body 1 is uniformly cooled, and the other function is to flow out of the cryopreservation box under the action of gravity during the thawing process of the cryopreservation box.

[0044] The relative positions of the through hole 31 and the flow guide hole can be correspondingly arranged or staggered.

[0045] More specifically, the flow guide hole can be provided with a guide groove or a guide inclined plane, so that the water flow in the box body 1 flows to the flow guide hole to flow out of the box body 1 from the bottom.

[0046] In one embodiment, the box body 1 includes a left side wall 12 and a right side wall 13 arranged oppositely.

[0047] The through slot 11 includes a left through slot 121 arranged on the left side wall 12 of the box body 1 and a right through slot 131 arranged on the right side wall 13 of the box body 1. The left through slot 121 and the right through slot 131 form a counterflow structure, further expanding the number of channels for liquid nitrogen to enter the box body 1, and liquid nitrogen can flow out of the right through slot 131 / left through slot 121 after entering the box body 1 from the left through slot 121 / right through slot 131, realizing the counterflow of liquid nitrogen in the box body 1, so that each cryopreservation bag 4 in the box body 1 is uniformly cooled.

[0048] Specifically, the through slot 11 is in the shape of a long strip, and the long side of the through slot 11 is parallel to the height of the box body 1. The shape of the through slot 11 further expands the area for liquid nitrogen to enter the box body 1, increasing the flow rate.

[0049] In one embodiment, the height of the box body 1 is greater than the height of the cryopreservation bag 4. This ensures that the cryopreservation bag 4 is completely located in the box body 1, and the box body 1 can protect the cryopreservation bag 4 from being squeezed, thereby protecting the cryopreservation bag 4.

[0050] Specifically, one side of the box cover 3 is hinged to one side of the box body 1. That is, the cryopreservation box is designed as a flip cover, which is convenient to open; closing the box cover 3 on the box body 1 can protect the cryopreservation bag 4 in the box body 1, ensuring that the cryopreservation bag 4 is not squeezed or collided in the cryopreservation box, thereby reducing the risk of breakage of the cryopreservation bag 4.

[0051] As an example, a hinge shaft 32 is arranged between the box cover 3 and the box body 1, one end of the hinge shaft 32 is embedded in the box body 1, and the other end is rotatably connected to the box cover 3.

[0052] In one embodiment, a partition rack 14 is arranged in the box body 1, and the accommodation groove 2 is arranged in the partition rack 14. A plurality of partition through holes (not shown in the figure) are arranged on the side wall of the partition rack 14. The arrangement of the partition through holes helps the liquid nitrogen to quickly enter the accommodation groove 2, further improving the freezing speed of the cryopreservation bag 4.

[0053] Specifically, the partition frame 14 has a gap with the inner wall of the box body 1, and a partition lifting mechanism linked with the box cover 3 is arranged in the box body 1, and the partition lifting mechanism is used for lifting the partition frame 14 together. When the box cover 3 is opened, the partition frame 14 is lifted on the side close to the gap through the linkage of the partition lifting mechanism, so that the containing groove 2 is inclined to the operator (refer to Figure 5 ), and the operator can easily take and place the cryopreservation bag 4 and observe whether the cryopreservation bag 4 is placed in each containing groove 2.

[0054] More specifically, the bottom plate is fixedly connected with the bottom of the partition frame 14, the cryopreservation bag 4 is placed on the bottom plate, and the partition lifting mechanism can lift the partition frame 14 and the bottom plate (not shown in the figure) together; preferably, the bottom plate is provided with a bottom plate through hole (not shown in the figure), and the bottom plate through hole has the same effect as the flow guide hole, which will not be repeated here.

[0055] As an example, the partition lifting mechanism can be a flexible belt (not shown in the figure), one end of the flexible belt is fixedly connected with one side of the bottom plate / partition frame 14, and the other end is fixedly connected with the inner wall of the box cover 3. When the box cover 3 is opened, the flexible belt changes from bending to straightening, and with the turning of the box cover 3, the bottom plate and one side of the partition frame 14 are lifted.

[0056] As an example, referring to Figure 6 , the partition lifting mechanism can be a lifting boss 33; the lifting boss 33 is arranged on the inner wall of the box cover 3 and located on the circumferential side of the box cover 3, the partition frame 14 has a gap with the inner wall of the box body 1, when the box cover 3 is closed on the box body 1, the lifting boss 33 is located in the gap; when the box cover is opened, one end of the lifting boss 33 abuts against the partition frame 14, and the box cover 3 is continuously turned, under the action of the friction between the lifting boss 33 and the partition frame 14, the bottom plate and the partition frame 14 are lifted together with the box cover 3, and the bottom plate and the partition frame 14 are lifted.

[0057] In an embodiment, a label slot is arranged on the outer surface of the cryopreservation box. The label slot can be used for placing a label, and the label can be used for recording the bagging time of the cryopreservation bag 4, biological sample information and other data, so as to facilitate the operator to identify and avoid sampling errors.

[0058] The above is a specific description of the preferred embodiment of the utility model, but the utility model creation is not limited to the above-mentioned embodiments, and those skilled in the art can make various equivalent modifications or replacements without departing from the spirit of the utility model, and these equivalent modifications or replacements are all included in the scope defined by the claims of the present application.

Claims

1. A cryopreservation box, characterized in that: The box includes a box body (1), and the side wall of the box body (1) is provided with a plurality of through grooves (11); the box body (1) is provided with a plurality of receiving slots (2) for placing cryopreservation bags (4), and the receiving slots (2) include a first diagonal (21) and a second diagonal (22) located on the diagonal line of the receiving slot (2), and a long side (23) of the receiving slot adjacent to the first diagonal (21) or the second diagonal (22); The receiving slot (2) is divided into a first gripping space (24) and a second gripping space (25) by the diagonal.

2. The cryopreservation box as described in claim 1, characterized in that: The length of the diagonal of the receiving groove (2) is d, the length of the long side (23) of the receiving groove is D, and the width of the cryopreservation bag (4) is L; d, D, and L satisfy the relationship: d ≥ L > D.

3. The cryopreservation box as described in claim 1, characterized in that: The shape of the receiving groove (2) is a parallelogram.

4. The cryopreservation box as described in claim 1, characterized in that: It also includes a box cover (3) disposed opposite to the box body (1), and the box cover (3) is provided with a plurality of through holes (31).

5. The cryopreservation box as described in claim 1 or 4, characterized in that: The bottom of the box (1) is provided with several flow guide holes.

6. The cryopreservation box as described in claim 5, characterized in that: The box body (1) includes a left side wall (12) and a right side wall (13) arranged opposite to each other; The through groove (11) includes a left through groove (121) provided on the left side wall (12) of the box body (1) and a right through groove (131) provided on the right side wall (13) of the box body (1).

7. The cryopreservation box as described in claim 4, characterized in that: One side of the lid (3) is hinged to one side of the body (1).

8. The cryopreservation box as described in claim 1, characterized in that: The box body (1) is provided with a partition frame (14), and the receiving groove (2) is provided in the partition frame (14); the side wall of the partition frame (14) is provided with a number of partition through holes.

9. The cryopreservation box as described in claim 7, characterized in that: The box body (1) is provided with a partition frame (14), the partition frame (14) has a gap with the inner wall of the box body (1), and a linkage partition lifting mechanism is provided between the partition frame (14) and the box cover (3), the partition lifting mechanism is used to lift the partition frame (14) together.

10. The cryopreservation box as described in claim 1, characterized in that: The outer surface of the cryopreservation box is provided with a label slot.

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