Multi-connected storage bag for storing single-sampling platelet samples

Abstract

The multi-union storage bag comprises a plurality of small storage bags, a connecting pipe and a flow stopping clip, the small storage bags are made of special breathable materials for platelet storage and are provided with internal accommodating spaces and vacuum states, and the specification of the small storage bags is equal-ratio reduction of a clinical conventional platelet single-sampling storage bag. A small amount of platelets can be stored; the small storage bags are communicated through connecting pipes; and the flow stopping clamp can change the connecting pipe into a communicated or closed state. When the platelet storage bag is used, the connecting pipe of the multi-union storage bag is in heat seal connection with the connecting pipe of the clinical conventional single-sampling platelet storage bag by using a sterile pipe receiving machine, platelets are guided into the multi-union storage bag and are uniformly distributed into each small storage bag, and finally, the connecting pipe is fused by using a heat sealing machine to obtain a small number of platelet samples. The method can be directly used for platelet storage research subsequently. The blood platelet sampling device can effectively meet one-time multi-part sampling of single-sampling blood platelets, and is convenient for continuous and effective storage after sampling.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical auxiliary technology field, concretely relates to a kind of for storage apheresis platelet sampling multi-union storage bag. BACKGROUND

[0002] Platelets are anucleate cell fragments in blood, originating from megakaryocytes in bone marrow. They play a crucial role in the process of blood coagulation and hemostasis. Platelets are about 2-4 microns in diameter, round or oval in shape, and have high heterogeneity. The platelet membrane surface is rich in various receptors and adhesion molecules, which are involved in platelet adhesion, aggregation and activation. Platelets effectively maintain vascular integrity and prevent excessive blood loss through their unique physiological functions, such as adhering to damaged vascular endothelium, aggregating to form platelet thrombus, and releasing bioactive substances. In addition, platelets are also involved in pathological and physiological processes such as vascular repair, inflammatory response, and tumor metastasis. As an important component of blood, platelets play a crucial role in hemostasis, wound healing, inflammatory response, thrombus formation, and organ transplant rejection.

[0003] The industry standard in China specifies that the storage conditions for platelets are 20-24℃, with oscillatory storage and a 5-day time limit. Currently, single-donor platelets are used in clinical settings, with a typical treatment volume (bag) of approximately 250ml. These platelets are stored in specialized storage bags. Due to the influence of various factors on the in-vitro survival time of platelets, regular sampling for activity detection is required. Figure 8 The conventional single-donor platelet storage bag for clinical use has a bag body 01 made of breathable material, which can extend the storage time of platelets. A platelet sampling container 02 is connected to the bag body 01 for storing detection samples. However, the conventional platelet sampling container 02 is made of non-breathable ordinary material, and if the storage time is long, the activity of the stored samples inside the platelet sampling container 02 will decrease. At this time, the activity of the platelets extracted from the platelet sampling container 02 for activity detection cannot truly reflect the activity of the platelets stored in the bag body 01. Moreover, the conventional platelet sampling container 02 is an integral accessory container with the bag body 01, and can only be used for sampling and detecting one sample, which cannot meet the demand for multiple sampling and subsequent storage.

[0004] Therefore, how to design a storage bag that can achieve multiple sampling at one time and also allow for long-term storage, accurately reflect the activity of platelets during storage, and meet the demand for multiple sampling and subsequent storage of platelets in platelet storage research, is a technical problem that has not been solved in the prior art. UTILITY MODEL CONTENTS

[0005] Therefore, the technical problem to be solved by the utility model lies in overcoming the technical defects in the prior art that the conventional platelet sampling container is made of air impermeable plastic material, cannot truly reflect the platelet activity after being stored for a long time, and the container is an accessory container integrated with the bag body, can only be used for sampling detection once, and cannot meet the requirement of multiple sampling and subsequent storage, so as to provide a multi-connection storage bag for storing apheresis platelet sampling, which can realize multiple sampling at one time, can be further stored for a long time, can accurately reflect the activity of platelets in the storage process, and can meet the requirement of storing the apheresis platelets after multiple sampling in the platelet storage research.

[0006] Therefore, the utility model provides a multi-connection storage bag for storing apheresis platelet sampling, which comprises: a small storage bag, which has a plurality of plates, is made of air permeable material special for platelet storage, has an internal accommodating space, is in a vacuum state, and is suitable for storing platelets; a plurality of connecting pipes are arranged, which are used for connecting the plurality of small storage bags in series, and one connecting pipe is arranged on the small storage bag at the head end and / or tail end; the free end of the separately arranged connecting pipe can be connected to a conventional apheresis platelet storage bag for clinical use by heat sealing; the free end of the connecting pipe is in a closed state, which is used for maintaining the vacuum state in the small storage bag before heat sealing; a flow stop clamp is movably arranged at the free end of the connecting pipe, and moving the flow stop clamp can change the connecting pipe into a connected state or a closed state.

[0007] As a preferred scheme, the small storage bag is made of polyvinyl chloride plasticized with butyryl tri-n-hexyl citrate, which is air permeable and transparent.

[0008] As a preferred scheme, the free end of the connecting pipe is in an open state; an interface structure is fixedly arranged at the free end of the connecting pipe, and the connecting pipe can be connected to the conventional apheresis platelet storage bag for clinical use through the interface structure.

[0009] As a preferred scheme, the interface structure is a connecting section with internal threads, which can be connected to the bag body connector of the conventional apheresis platelet storage bag for clinical use through thread connection; or, the interface structure is a connecting section with external threads, which can be connected to the bag body connector of the conventional apheresis platelet storage bag for clinical use through thread connection; or, the interface structure is a puncture needle, which can be connected to the diaphragm connector of the conventional apheresis platelet storage bag for clinical use through plug-in connection.

[0010] As a preferred solution, the flow stopper includes: a circular through hole, which is provided through one side of the flow stopper, has an inner diameter greater than an outer diameter of the connecting pipe, and keeps the connecting pipe in a communication state when the connecting pipe is located inside the circular through hole; and a long strip through hole, which is provided through another side of the flow stopper, has one end communicated with the circular through hole and the other end communicated with the outside, and keeps the connecting pipe in a closed state when the connecting pipe is located inside the long strip through hole.

[0011] As a preferred solution, the flow stopper is provided in a plurality of numbers and is installed on each of the connecting pipes, and is used for keeping the platelets in each of the small storage bags independently stored when the small storage bags are used for guiding the platelets.

[0012] As a preferred solution, the small storage bags are provided in five numbers and have a size and a specification which are proportionally reduced from a conventional platelet storage bag used in a clinic.

[0013] As a preferred solution, the small storage bags include a first bag body and a second bag body, and the first bag body and the second bag body are connected through heat sealing and adhesion.

[0014] As a preferred solution, a sealing edge is further provided and is formed on an outer side of a connection position of the first bag body and the second bag body.

[0015] The technical solution provided by the utility model has the following advantages:

[0016] 1. The utility model discloses a multi-connected storage bag for storing plateletpheresis samples, which comprises small storage bags, connecting pipes and flow stoppers, wherein the small storage bags are provided in a plurality of numbers, are made of a breathable material special for platelet storage, have internal accommodating spaces, are in a vacuum state, and are suitable for storing a small amount of platelets; the connecting pipes are provided in a plurality of numbers, are used for connecting the small storage bags in series, and are individually arranged on the small storage bags at a head end and / or a tail end; free ends of the individually arranged connecting pipes can be heat sealed and connected with a conventional platelet storage bag used in a clinic; the free ends of the connecting pipes are in a closed state, which is used for keeping the small storage bags in a vacuum state before heat sealing and connection; and the flow stoppers are movably arranged at the free ends of the connecting pipes, and moving the flow stoppers can change the connecting pipes into a communication state or a closed state.

[0017] When the multi-connected storage bag for storing apheresis platelet sampling is used, firstly, the stop flow clamp is used to keep the connecting pipe in a closed state, then the sterile pipe connecting machine is used to heat seal connect the free end of the connecting pipe of the multi-connected storage bag with the connecting pipe of the conventional apheresis platelet storage bag for clinical use, then the stop flow clamp is moved to adjust the connecting pipe to a communicating state, since the inside of the multi-connected storage bag keeps a vacuum state, the platelets can be automatically guided to the inside of the multi-connected storage bag, then the platelets are uniformly distributed into each small storage bag by manually extruding each small storage bag, finally, the heat sealing machine is used to fuse and break the connecting pipe between the multi-connected storage bag and the conventional apheresis platelet storage bag for clinical use, a small amount of multiple platelet samples are obtained, which can be directly used for platelet storage research in the future. When sampling and detecting, firstly, the sterile heat sealing machine is used to fuse and break the connecting pipe to separate the small storage bag, then the syringe is used to extract the platelets in the separated small storage bag for activity detection. The multi-connected storage bag for storing apheresis platelet sampling can effectively prolong the storage time of the sampling sample, ensure the accuracy of the sampling detection result, and truly reflect the activity of the platelets in different stages of storage.

[0018] 2. The multi-connected storage bag for storing apheresis platelet sampling of the utility model, the small storage bag is made of butyryl citric acid tri-n-hexyl ester plasticized polyvinyl chloride material, which is breathable and transparent. The butyryl citric acid tri-n-hexyl ester plasticized polyvinyl chloride material has high oxygen permeability and the same material as the conventional apheresis platelet storage bag for clinical use, which ensures that the state of the platelet sample preserved in the small storage bag is the same as that of the platelet preserved in the conventional apheresis platelet storage bag for clinical use, so that the detection result can correctly reflect the state of the platelets in the conventional apheresis platelet storage bag for clinical use. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical scheme in the prior art or the specific embodiment of the utility model, the drawings used in the description of the prior art or the specific embodiment are briefly introduced as follows.

[0020] Figure 1 is the overall structure schematic view of the multi-connected storage bag for storing apheresis platelet sampling of the utility model.

[0021] Figure 2 is Figure 1 the structure enlarged schematic view of part A in the figure.

[0022] Figure 3 is Figure 1 the structure enlarged schematic view of part B in the figure.

[0023] Figure 4 is Figure 1 the structure schematic view of the stop flow clamp.

[0024] Figure 5 is a structural diagram of an interface structure with an internal thread.

[0025] Figure 6 is a structural diagram of an interface structure with an external thread.

[0026] Figure 7 is a structural diagram of an interface structure with a puncture needle.

[0027] Figure 8 is a schematic diagram of a conventional clinical routine apheresis platelet storage bag.

[0028] Figure 9 is a schematic diagram of a conventional puncture needle.

[0029] Figure 10 is a schematic diagram of a conventional sterile tube connection machine.

[0030] Figure 11 is a schematic diagram of a conventional sterile heat sealing machine.

[0031] Reference signs: 01, bag body; 02, platelet sampling container; 03, bag body connector; 1, small storage bag; 11, first bag body; 12, second bag body; 13, sealing edge; 2, connecting tube; 3, flow stopper; 31, circular through hole; 32, long strip through hole; 4, interface structure. DETAILED DESCRIPTION

[0032] In order for those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the embodiments obtained by those skilled in the art without creative labor should fall within the scope of protection of the present application.

[0033] It should be noted that the terms "first", "second", and the like in the claims and the specification of the present application are used to distinguish similar objects, and are not intended to describe a specific order or sequence. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion, for example, a process, method, system, product or device that includes a series of steps or units is not limited to only those steps or units clearly listed, but can also include other steps or units that are not clearly listed or inherent to the process, method, product or device.

[0034] In this application, the terms "upper," "lower," "left," "right," "front," "rear," "top," "bottom," "inner," "outer," "middle," "vertical," "horizontal," "lateral," and "longitudinal" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for better description of this application and its embodiments, and are not intended to limit the indicated device, element, or component to having a specific orientation, or to be constructed and operated in a specific orientation. Furthermore, some of the above terms may be used to indicate other meanings besides orientation or positional relationship; for example, the term "upper" may also be used in some cases to indicate a certain dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in this application according to the specific circumstances. In addition, the term "multiple" should mean two or more. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other.

[0035] The present application will now be described in detail with reference to the accompanying drawings and embodiments. Example

[0036] This embodiment provides a multi-unit storage bag for storing apheresis platelet samples, such as... Figures 1-3 As shown, it includes: a storage bag 1, a connecting tube 2, and a flow-stopping clamp 3; wherein there are several small storage bags 1, which are made of breathable material specifically for platelet storage, have an internal space, are in a vacuum state, and are suitable for storing a small amount of platelets; there are several connecting tubes 2, which are used to connect several of the small storage bags 1 in series, and one is set on the first and / or the last of the small storage bags 1; the free end of the individually set connecting tube 2 can be heat-sealed to a conventional clinical apheresis platelet storage bag; the free end of the connecting tube 2 is in a closed state, which is used to maintain the vacuum state inside the small storage bag 1 before heat sealing; the flow-stopping clamp 3 is movably installed on the free end of the connecting tube 2, and moving the flow-stopping clamp 3 can change the connecting tube 2 to a connected or closed state.

[0037] When the multi-connection storage bag for storing apheresis platelet sample of the embodiment is used, first, the stop clamp 3 is used to keep the connecting pipe 2 in a closed state, then a sterile pipe connecting machine is used to heat and connect the connecting pipe 2 of the multi-connection storage bag with the connecting pipe 2 of a conventional apheresis platelet storage bag for clinical use, after that, the connecting pipe 2 is adjusted to a communicating state, since the inside of the multi-connection storage bag is kept in a vacuum state, platelets can be automatically guided to the inside of the multi-connection storage bag, then the platelets are evenly distributed into each small storage bag 1 by manually squeezing each small storage bag 1, finally, a heat sealing machine is used to melt and break the connecting pipe 2 between the multi-connection storage bag and the conventional apheresis platelet storage bag for clinical use, a small amount of platelet samples in multiple portions are obtained, which can be directly used for platelet storage research subsequently; when the sample is detected, first, a sterile heat sealing machine is used to melt and break the connecting pipe 2 to separate the small storage bag 1, then a syringe is used to extract platelets in the separated small storage bag 1 for activity detection. The multi-connection storage bag for storing apheresis platelet sample of the embodiment can effectively prolong the storage time of the sampling sample, ensure the accuracy of the sampling detection result, and thus truly reflect the activity of the platelets; in addition, the multi-connection storage bag can effectively meet the requirement of one-time multiple sampling of apheresis platelets, and is convenient for the requirement of effective storage after sampling.

[0038] The small storage bag 1 is made of butyryl citric acid tri-n-hexyl ester plasticized polyvinyl chloride material, which is breathable and transparent. The butyryl citric acid tri-n-hexyl ester plasticized polyvinyl chloride material has high oxygen permeability, and has the same material as the conventional apheresis platelet storage bag for clinical use, which ensures that the state of the platelet sample stored in the small storage bag 1 is the same as the state of the platelet stored in the conventional apheresis platelet storage bag for clinical use, so that the detection result can correctly represent the state of the platelet in the conventional apheresis platelet storage bag for clinical use.

[0039] As a variant design scheme, the free end of the connecting pipe 2 is in an open state; further comprising an interface structure 4 fixedly arranged at the free end of the connecting pipe 2, the connecting pipe 2 can communicate with the conventional apheresis platelet storage bag for clinical use through the interface structure 4. The interface structure 4 provides multiple methods for connecting with the conventional apheresis platelet storage bag for clinical use.

[0040] As shown in Figure 5 , the interface structure 4 is a connecting section with internal threads, which can be connected with the bag body connector of the conventional apheresis platelet storage bag for clinical use through threads. As a variant, as shown in Figure 6 , the interface structure 4 is a connecting section with external threads, which can be connected with the bag body connector of the conventional apheresis platelet storage bag for clinical use through threads. As another variant, as shown in Figure 7 , the interface structure 4 is a puncture needle, which can be connected with the diaphragm connector of the conventional apheresis platelet storage bag for clinical use through plug-in connection.

[0041] As shown in Figure 4 The flow-stopping clamp 3 includes a round hole 31 and a long hole 32. The round hole 31 is formed through one side of the flow-stopping clamp 3, and has an inner diameter greater than the outer diameter of the connecting tube 2. When the connecting tube 2 is located in the round hole 31, the connecting tube 2 remains in a communication state. The long hole 32 is formed through the other side of the flow-stopping clamp 3, and has one end connected to the round hole 31 and the other end connected to the outside. When the connecting tube 2 is located in the long hole 32, the connecting tube 2 remains in a closed state.

[0042] The flow-stopping clamp 3 is provided on each connecting tube 2, and is used to store the platelets in each small storage bag 1 independently when the platelets are guided by the small storage bag 1.

[0043] In this embodiment, five small storage bags 1 are provided, and the size of each small storage bag 1 is reduced in proportion to the size of a conventional platelet storage bag used in a clinic. The size of each small storage bag 1 is reduced in proportion to the size of a conventional platelet storage bag used in a clinic, and the platelets are stored independently in each small storage bag 1. The storage state of each small storage bag 1 is the same as that of a conventional platelet storage bag used in a clinic, so that the detection result can correctly reflect the state of the platelets in the conventional platelet storage bag used in a clinic.

[0044] The small storage bag 1 includes a first bag body 11 and a second bag body 12, and the first bag body 11 and the second bag body 12 are connected by heat sealing.

[0045] The small storage bag 1 further includes a sealing edge 13 formed on the outer side of the connection between the first bag body 11 and the second bag body 12, which can effectively prevent leakage and ensure the safety of long-term storage.

[0046] In this embodiment, the puncture needle is a puncture needle of an existing infusion device, the sterile connection machine is an SCDIIB sterile connection machine produced by Terumo, and the sterile heat sealing machine is a three-dimensional medical heat sealing machine produced by Shanghai Aboly Automation Co., Ltd. For details, please refer to Figures 9-11

[0047] The multi-connected storage bag for storing plateletpheresis samples in this embodiment is used as follows:

[0048] ​First, the connecting pipe 2 is kept in the closed state by using the flow stop clamp 3, then according to the type of the bag connecting piece 03 of the clinical conventional platelet collection bag, the corresponding connecting mode is selected, such as heat sealing connection, threaded connection or plug-in connection, the small storage bag 1 is connected with the clinical conventional platelet collection bag, then the connecting pipe 2 is adjusted to the connected state by adjusting the flow stop clamp 3, since the small storage bag 1 always keeps the vacuum state, the platelets can be automatically guided to the inside of the multi-union storage bag, then the platelets are uniformly distributed in each small storage bag 1 by manually extruding each small storage bag 1, finally the connecting pipe 2 between the multi-union storage bag and the clinical conventional platelet collection bag is fused and cut off by using the heat sealing machine, a small amount of multi-portion platelet samples are obtained, which can be directly used for platelet storage research; when sampling and detecting, first, the connecting pipe 2 is fused and cut off by using the sterile heat sealing machine, so as to separate the small storage bag 1, then the platelets in the separated small storage bag 1 are extracted by using the syringe for activity detection.

[0049] Obviously, the above embodiments are only examples for clearly illustrating, but not limitation to the embodiments. Other different forms of changes or variations can be made on the basis of the above description for those skilled in the art. All the embodiments do not need to be exhausted, and the obvious changes or variations derived therefrom are still within the protection scope of the technical scheme.

Claims

1. A multi-unit storage bag for storing apheresis platelet samples, characterized in that, The utility model relates to a kind of platelet storage bag, including: Small storage bag (1) has several, for platelet storage special breathable material, with internal containing space, for vacuum state, suitable for storing platelet; Connecting pipe (2) has several, for several described small storage bag (1) is connected in series, and separately set one on the small storage bag (1) of head and / or tail end;The free end of separately set described connecting pipe (2) can be connected with the heat of routine single platelet storage bag for clinical use;The free end of described connecting pipe (2) is closed state, for keeping the vacuum state in the small storage bag (1) before heat connection; Flow stop clamp (3) is movably installed in the free end of described connecting pipe (2), and moving described flow stop clamp (3) can change described connecting pipe (2) to communication or closed state.

2. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 1, wherein: Described small storage bag (1) is made of butyryl citric acid tri-n-hexyl ester plasticized polyvinyl chloride material, breathable and transparent.

3. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 1, wherein: The free end of described connecting pipe (2) is open state;Still include interface structure (4), fixedly set in the free end of described connecting pipe (2), and described connecting pipe (2) can be communicated with the routine single platelet storage bag for clinical use by described interface structure (4).

4. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 3, wherein: Described interface structure (4) is the connecting section with internal thread, can be connected with the bag body connector of routine single platelet storage bag for clinical use by thread; Or, described interface structure (4) is the connecting section with external thread, can be connected with the bag body connector of routine single platelet storage bag for clinical use by thread; Or, described interface structure (4) is puncture needle, can be connected with the diaphragm connector of routine single platelet storage bag for clinical use by plug-in connection.

5. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 1, wherein, Described flow stop clamp (3) includes: Circular through-hole (31) is set in one side inside described flow stop clamp (3), and the inner diameter is greater than the outer diameter of described connecting pipe (2), and described connecting pipe (2) is located in the inside of described circular through-hole (31) and keeps communication state; Long strip through-hole (32) is set in the other side inside described flow stop clamp (3), and one end is communicated with described circular through-hole (31), and the other end is communicated with outside, and described connecting pipe (2) is located in the inside of described long strip through-hole (32) and keeps closed state.

6. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 5, wherein: Described flow stop clamp (3) is several, is installed on each described connecting pipe (2), for when the small storage bag (1) is guided to flow platelet, keeps the platelet in each described small storage bag (1) independent storage.

7. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 1, wherein: Described small storage bag (1) is provided with five, and size specification is the equal proportion reduction of routine single platelet storage bag for clinical use.

8. The multi-pak storage bag for storing apheresis platelet collection according to claim 1, wherein: Described small storage bag (1) includes first bag body (11) and second bag body (12), and described first bag body (11) and described second bag body (12) are connected by heat bonding.

9. The multi-pak storage bag for use in storing apheresis platelet collection according to claim 8, wherein: Still include sealing edge (13), is formed on the outside of the connecting place of described first bag body (11) and described second bag body (12).

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