Cervical cancer screening kit

Abstract

The utility model discloses a cervical cancer screening kit, which relates to the technical field of cervical cancer screening kits, and comprises a placing box, a bottom plate is arranged in the placing box, a fixing mechanism is arranged on the surface of the bottom plate, a limiting mechanism is arranged on the surface of the bottom plate, the limiting mechanism comprises a limiting column, and the limiting column is fixedly connected to the surface of the bottom plate. The surfaces of the limiting columns are slidably connected with limiting plates. By twisting the rotating block, the rotating block drives the rotating bolt to rotate, the rotating bolt drives the limiting plate to ascend and descend, and the limiting plate is limited through the limiting column when ascending and descending, so that the limiting plate stably and linearly ascends and descends, and the height of the limiting plate is adjusted according to the length of a test tube; the detection test tubes are placed in the fixing holes, and the test tubes are fixed through the limiting blocks and the rubber blocks, so that the detection test tubes can be flexibly and stably fixed in the kit, and the test tubes are prevented from being damaged in the transportation process of the kit.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of cervical cancer screening kit, specifically relates to a cervical cancer screening kit. BACKGROUND

[0002] After the infection (such as HPV16) of high-risk human papillomavirus (HR-HPVs) to cells, HPV16E6 / E7 regulated DNA methylation modification leads to malignant transformation of cells into cervical cancer. The molecular mechanism of gene selective transcription expression HR-HPVs DNA / RNA methylation targeted regulation of the occurrence and development of cervical cancer is clarified, and the protective effect of DNA / RNA methylation and demethylation targeted intervention and inhibitor intervention HPV16E6 / E7 protein activity on malignant transformation of cervical cells is clarified through gene intervention strategy;

[0003] At the cellular level, the system studies that HPV16E6 / E7 can cause malignant transformation of cells through DNA methylation modification, constructs and identifies the immortalized cell line by the way of lentivirus infection of HPV16E6 / E7, and the molecular mechanism of causing HPV16E6 / E7 through lentivirus infection.

[0004] The recombinant plasmid LV5-HPV16E6 / E7 is constructed, the cell cycle and apoptosis are interfered through E6 / p53-E7 / pRB path, leading to unregulated proliferation of cells and instability of chromosomes. The unlimited proliferation of cells is a necessary stage for the malignant transformation of cells;

[0005] At the level of epigenetics, the methylation and expression level changes of six target genes (SPARC, TFPI2, RRAD, SFRP1, MT1G and NMES1) caused by HPV16E6 / E7 are detected, the targeted intervention is carried out, the regulation effect and mechanism of HPV16E6 / E7 DNA methylation in the occurrence and development of cervical cancer are systematically studied, and the protective effect of HPV16E6 / E7 protein on malignant transformation of cervical cells is clarified through gene intervention strategy research DNA / RNA methylation and demethylation targeted intervention and inhibitor intervention HPV16E6 / E7 protein activity, and the interaction between each key molecule in the axial path is clarified. It is one of important mechanisms that HPV16E6 / E7 protein causes malignant transformation of cells through epigenetic path. The protective effect of HPV16E6 / E7 protein on malignant transformation of cervical cells is clarified through gene intervention strategy research DNA / RNA methylation and demethylation targeted intervention and inhibitor intervention HPV16E6 / E7 protein activity, and the interaction between each key molecule in the axial path is clarified. It is one of important mechanisms that HPV16E6 / E7 protein causes malignant transformation of cells through epigenetic path.

[0006] In the population study, using whole genome DNA / RNA sequencing, cervical cancer cell lines (SiHa, CaSki) are subjected to whole genome DNA sequence, whole genome DNA and RNA methylation sequencing, to explore the target regulation and development related to cervical cancer Single nucleotide variation, insertion and deletion, copy number variation and structural variation and other comprehensive mutation information, through data analysis, screening and finding the purpose gene that plays different functions in the process of cell immortalization and finally tumor cell formation, and then finding the pathogenic mutation and developing effective treatment drugs to provide guidance for clinical medication.

[0007] The currently announced number CN215795215U discloses a cervical cancer screening kit, which comprises a box body, a flip cover and a lamp groove. The top of the box body is movably connected with the flip cover. The inner side of the flip cover is fixedly connected with the lamp groove in the middle part. The inner left side of the box body is fixedly connected with a reagent storage part. The reagent storage part can store reagents. The bottom of the nesting block has a movable shaft, so that the nesting block can rotate, thereby improving the convenience of the device. The compression spring in the movable mechanism can be compressed, that is, the groove and the protrusion in the middle part of the rolling wheel are embedded together and fixed, which plays a role in fixing the position. The bottom of the vertical plate has a protrusion to avoid collision between the reagent and the box body, thereby improving the activity of the device. The hooks in the convenient stacking mechanism can be hung into the holes, that is, each reagent box can be connected together during stacking, which increases the stability of the reagent box during stacking, thereby improving the practicability of the device.

[0008] In order to solve the problem of the cervical cancer screening kit in the above technical scheme, the prior art uses a reagent storage part that can store reagents, and the bottom of the nesting block has a movable shaft, so that the nesting block can rotate, thereby improving the convenience of the device. However, the test tube cannot be stably fixed, which may cause damage to the test tube during transportation. Practical new type content

[0009] The purpose of the present application is to provide a cervical cancer screening kit to solve the problems in the above background art.

[0010] To solve the above technical problems, the technical scheme adopted by the present application is:

[0011] A cervical cancer screening kit comprises a placing box, a bottom plate is installed inside the placing box, a fixing mechanism is installed on the surface of the bottom plate, and a limiting mechanism is installed on the surface of the bottom plate.

[0012] The limiting mechanism comprises a limiting column, the limiting column is fixedly connected to the surface of the bottom plate, a limiting plate is slidably connected to the surface of the limiting column, and positioning holes are formed in the two sides of the limiting plate.

[0013] The fixing mechanism comprises a base fixedly connected to the surface of the bottom plate, and a convex ring fixedly connected to the surface of the base.

[0014] The further improvement of the utility model technical scheme lies in that: the surface of the limiting plate is provided with a fixing hole, the surface of the fixing hole is fixedly connected with a limiting block, and the surface of the limiting block is fixedly connected with a rubber block.

[0015] The further improvement of the utility model technical scheme lies in that: the surface of the positioning hole is threadedly connected with a rotating bolt, the rotating block is twisted, the rotating block drives the rotating bolt to rotate, and the rotating bolt drives the limiting plate to move up and down.

[0016] The further improvement of the utility model technical scheme lies in that: the top of the rotating bolt is fixedly connected with a rotating block, and the limiting column is used for limiting, so that the limiting plate stably moves up and down in a straight line.

[0017] The further improvement of the utility model technical scheme lies in that: the top of the base is provided with a mounting hole, and the mounting hole is internally provided with a clamping seat; the clamping seat is annularly protruded, and the inner diameter of the clamping seat is 0.9cm.

[0018] The further improvement of the utility model technical scheme lies in that: the surface of the mounting hole is clamped with a clamping ring, and the surface of the clamping ring is fixedly connected with a fixed cover; the test tube is inserted into the middle of the fixed cover made of soft rubber material, and the bottom of the test tube is clamped on the clamping seat in the base.

[0019] The further improvement of the utility model technical scheme lies in that: the clamping seat is annularly protruded, the inner diameter of the clamping seat is 0.6-1.2cm, the bottom of the base is outwardly extended to form a convex ring, so as to further increase the stability of the base.

[0020] Due to the adoption of the above technical scheme, the utility model has the following technical progress compared with the prior art:

[0021] 1、The utility model provides a cervical cancer screening kit, twists the rotating block, the rotating block drives the rotating bolt to rotate, the rotating bolt drives the limiting plate to move up and down, the limiting plate is limited by the limiting column when moving up and down, so that the limiting plate stably moves up and down in a straight line, so that the height of the limiting plate is adjusted according to the length of the test tube, the test tube is placed in the fixed hole, the test tube is fixed by the limiting block and the rubber block, so that the test tube can be flexibly and stably fixed in the kit, and the test tube is prevented from being damaged in the transportation of the kit.

[0022] 2, the utility model provides a kind of cervical cancer screening kit, the bottom of base extends to form convex ring outward, to further increase the stability of base, the diameter of base is 5.4cm, high is 5cm, clamping seat is circular ring protrusion, the inner diameter of clamping seat is 0.9cm, the inner diameter of mounting hole is 5cm, test tube is inserted from the middle part of the fixed cover of soft rubber material, and the bottom of test tube is clamped on the clamping seat inside base, so that test tube is upright fixed, the structure of fixed mechanism is simple so that overall light and easy to operate, improve the efficiency of test tube placement fixed. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is overall structure schematic diagram of the utility model;

[0024] Figure 2 It is structure schematic diagram of the utility model limiting mechanism;

[0025] Figure 3 It is structure schematic diagram of the utility model limiting plate;

[0026] Figure 4 It is structure schematic diagram of the utility model fixed mechanism.

[0027] In the drawing: 1, placement box;2, bottom plate;3, fixed mechanism;30, convex ring;31, base;32, mounting hole;33, clamping ring;34, fixed cover;35, clamping seat;4, limiting mechanism;40, limiting plate;41, positioning hole;42, fixed hole;43, limit block;44, rubber block;45, rotating block;46, rotating bolt;47, limit column. DETAILED DESCRIPTION

[0028] The utility model is further explained in detail in connection with example below:

[0029] Example 1

[0030] As Figures 1-4 Indicated, the utility model provides a kind of cervical cancer screening kit, including placement box 1, the inside installation of placement box 1 is equipped with bottom plate 2, the surface of bottom plate 2 is equipped with fixed mechanism 3, the surface of bottom plate 2 is equipped with limiting mechanism 4, limiting mechanism 4 includes limit column 47, limit column 47 is fixedly connected on the surface of bottom plate 2, the surface of limit column 47 is slidably connected with limiting plate 40, the both sides of limiting plate 40 are equipped with positioning hole 41, the surface of limiting plate 40 is equipped with fixed hole 42, the surface of fixed hole 42 is fixedly connected with limit block 43, the surface of limit block 43 is fixedly connected with rubber block 44, the surface of positioning hole 41 is threadedly connected with rotating bolt 46, the top of rotating bolt 46 is fixedly connected with rotating block 45;

[0031] Specifically, the twist rotating block 45, rotating block 45 drive rotating bolt 46 rotation, rotating bolt 46 drive limiting plate 40 to move up and down, limiting plate 40 in the up and down movement, through the limiting post 47 limiting, so that the limiting plate 40 stable linear lifting, so as to adjust the height of the limiting plate 40 according to the length of the test tube, the test tube is placed in the fixed hole 42, through the limiting block 43 and rubber block 44 to consolidate the fixed test tube.

[0032] Embodiment 2

[0033] As Figures 1-4 The utility model provides a technical scheme on the basis of embodiment 1: preferably, fixed mechanism 3 includes base 31, base 31 fixedly connected at the surface of bottom plate 2, the surface of base 31 is connected with convex ring 30, the top of base 31 is equipped with mounting hole 32, the inside installation of mounting hole 32 is installed with clamping seat 35, the surface of mounting hole 32 is connected with snap ring 33, the surface of snap ring 33 is fixedly connected with fixed cover 34;

[0034] Specifically, the bottom of base 31 extends outward to form convex ring 30, to further increase the stability of base 31, the diameter of base 31 is 5.4cm, and the height is 5cm, clamping seat 35 is circular annular protrusion, the inner diameter of clamping seat 35 is 0.9cm, the inner diameter of mounting hole 32 is 5cm, the test tube is inserted from the middle of fixed cover 34 of soft rubber material, and the bottom of the test tube is clamped on the clamping seat 35 in the inside of base 31, so that the test tube is upright fixed.

[0035] The above general description of the utility model is made in detail, but on the basis of the utility model, some modifications or improvements can be made, which is obvious to the general technical personnel in the technical field. Therefore, the modification or improvement without departing from the spirit of the utility model idea is within the protection scope of the utility model.

Claims

1. A kit for cervical cancer screening comprising a housing (1), characterized in that: The inside of the placing box (1) is internally mounted with a bottom plate (2), the surface of the bottom plate (2) is mounted with a fixing mechanism (3), and the surface of the bottom plate (2) is mounted with a limiting mechanism (4); The limiting mechanism (4) comprises a limiting column (47) fixedly connected to the surface of the bottom plate (2), the surface of the limiting column (47) is slidably connected with a limiting plate (40), and both sides of the limiting plate (40) are provided with positioning holes (41); The fixing mechanism (3) comprises a base (31) fixedly connected to the surface of the bottom plate (2), and the surface of the base (31) is fixedly connected with a convex ring (30).

2. The cervical cancer screening kit according to claim 1, characterized in that: The surface of the limiting plate (40) is provided with a fixing hole (42), the surface of the fixing hole (42) is fixedly connected with a limiting block (43), and the surface of the limiting block (43) is fixedly connected with a rubber block (44).

3. The cervical cancer screening kit according to claim 2, wherein: The surface of the positioning hole (41) is threadedly connected with a rotating bolt (46).

4. The cervical cancer screening kit according to claim 3, wherein: The top of the rotating bolt (46) is fixedly connected with a rotating block (45).

5. The cervical cancer screening kit as claimed in claim 1, wherein: The top of the base (31) is provided with a mounting hole (32), and the inside of the mounting hole (32) is mounted with a clamping seat (35).

6. The cervical cancer screening kit according to claim 5, wherein: The surface of the mounting hole (32) is clamped with a clamping ring (33), and the surface of the clamping ring (33) is fixedly connected with a fixing cover (34).

7. The cervical cancer screening kit according to claim 5, wherein: The clamping seat (35) is a circular annular protrusion, and the inner diameter of the clamping seat (35) is 0.6-1.2 cm.

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