Laboratory mouse brain three-dimensional positioning device

Abstract

The utility model provides a three-dimensional positioning device for the brain of an experimental mouse, which belongs to three-dimensional positioning devices for the brain of the experimental mouse and comprises a base, a fixed column and a limiting rod are arranged at one end of the base, a movable seat is movably connected onto the fixed column, and the movable seat is further movably connected with the limiting rod; the movable seat is arranged to be E-shaped, two end arms of the movable seat are movably connected with lug rods, and a spacer arm of the movable seat is movably connected with an incisor fixing rod; a clamping piece is hinged to the incisor fixing rod. The three-dimensional positioning device can be adjusted according to the skull size and the size of the laboratory mouse, and the fixing effect on the laboratory mouse is improved.

Description

Technical Field

[0001] This utility model belongs to the technical field of stereotactic positioning devices for laboratory rat brains, and specifically relates to a stereotactic positioning device for laboratory rat brains. Background Technology

[0002] A stereotaxic instrument, also known as a brain fixation device, uses a three-dimensional coordinate system defined by landmarks or other reference points outside the skull to determine the location of certain subcortical neural structures. This allows for targeted stimulation, destruction, drug injection, and potential guidance under non-direct visual exposure. Animal stereotaxic instruments are research equipment used in fields such as neuroanatomy, neurophysiology, neuropharmacology, and neurosurgery. They are used for targeted injection, stimulation, destruction, and potential guidance of neural structures, and are employed in the establishment of animal models of cerebral hemorrhage, Parkinson's disease, and epilepsy.

[0003] Currently, commonly used stereotaxic instruments for laboratory mice generally have incisor hooks and ear rods on both sides. The mouse's incisors are fixed to the incisor hooks, and the ear rods on both sides are aligned with the mouse's ear canals. The mouse's head is fixed using the three-point positioning principle. However, the height of the incisor hooks and ear rods in current stereotaxic instruments is generally fixed. When fixing laboratory mice of different sizes, there are problems such as inconvenience in operation and poor fixation effect. Utility Model Content

[0004] To address the aforementioned shortcomings in the existing technology, this utility model provides a stereotactic positioning device for the brain of laboratory mice. This stereotactic positioning device can be adjusted according to the size and volume of the laboratory mouse's skull, thereby improving the fixation effect on the laboratory mouse.

[0005] To achieve the above objectives, the technical solution adopted by this utility model to solve its technical problem is as follows:

[0006] A stereotactic device for the brain of an experimental mouse includes a base, a fixed column and a limiting rod at one end of the base, a movable seat movably connected to the fixed column, and the movable seat movably connected to the limiting rod.

[0007] The movable seat is shaped like a mountain. Ear rods are movably connected to the two end arms of the movable seat, and a tooth fixing rod is movably connected to the middle arm of the movable seat; a clamping element is hinged to the tooth fixing rod.

[0008] Furthermore, a rotating ring is fitted on the fixed column, and the rotating ring is threadedly connected to the fixed column; a U-shaped groove is provided on the upper side of the rotating ring (7), and a first roller is provided at the lower part of the movable seat, and the first roller is located in the U-shaped groove.

[0009] Furthermore, there are two limit rods, with a slide rail on the inner side of the limit rods, and a second roller on the movable seat, which is located inside the slide rail.

[0010] Further, the fixing column is arranged on the center line of the base, and the limiting rods are arranged on both sides of the center line of the base.

[0011] Further, the hollow groove and the screw rod are arranged on the interval arm of the movable seat, the screw rod is arranged on the upper part of the hollow groove and penetrates the movable seat, and the incisor fixing rod is arranged in the hollow groove.

[0012] Further, the free end of the end arm of the movable seat is provided with a fixing block, and the ear rod penetrates the fixing block and is threadedly connected with the fixing block.

[0013] Further, the clamping piece comprises an arc-shaped pressing plate and a connecting rod, the vertical rod is arranged on the incisor fixing rod, the connecting rod is hinged with the vertical rod, and the torsional spring is arranged on the hinge shaft.

[0014] Further, the pressing plate is provided with an air bag.

[0015] The utility model discloses the beneficial effect that:

[0016] The ear rod and the incisor fixing rod are arranged on the same movable seat in the positioning device, in use, the height can be kept relatively fixed, when fixing experimental mice of different sizes is needed, only the height of the movable seat needs to be adjusted, so that the ear rod and the incisor fixing rod can move upward or downward at the same time, the adjustment speed can be greatly improved, and the convenience of use is improved.

[0017] The incisor fixing rod in the device can move forward or back and forth relative to the movable seat, and the ear rod can also move inward or outward, the size of the skull of the experimental mouse can be adjusted, the fixing effect on the experimental mouse is improved, and the harm to the experimental mouse is reduced.

[0018] The clamping piece is arranged on the incisor fixing rod in the device, after the incisors of the experimental mouse are fixed, the head of the experimental mouse can be extruded and fixed through the clamping piece, the fixing effect on the head of the experimental mouse is further improved, the clamping piece is convenient to operate, the operation efficiency can be improved, and the air bag arranged on the clamping piece can reduce the influence and harm to the experimental mouse. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is a left view of the experimental mouse brain stereotaxic device.

[0020] Figure 2 It is a plan view of the experimental mouse brain stereotaxic device.

[0021] Figure 3 It is a plan view of the fixing column and the rotating ring of the experimental mouse brain stereotaxic device.

[0022] Figure 4 It is an enlarged schematic view of A.

[0023] Figure 5 Structure diagram of the movable seat, the pressing plate and the air bag;

[0024] Reference numerals: 1, base; 2, fixed column; 3, limiting rod; 4, movable seat; 5, ear rod; 6, incisor fixed rod; 7, rotating ring; 8, concave-shaped sliding groove; 9, first roller; 10, slide; 11, second roller; 12, screw rod; 13, pressing plate; 14, connecting rod; 15, vertical rod; 16, air bag. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical scheme and advantages of the present application clearer, the present application will be further described in detail below with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application, that is, the described embodiments are only some embodiments of the present application, but not all embodiments.

[0026] Therefore, the detailed description of the embodiments of the present application provided below is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of the present application.

[0027] It should be noted that the relationship terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between the entities or operations. Moreover, the terms "include", "contain" or any other variants thereof are intended to cover non-exclusive inclusion, so that the process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such process, method, article or device. Without more limitations, the element defined by the statement "including a" does not exclude the presence of another identical element in the process, method, article or device including the element.

[0028] The features and performances of the present application will be further described in detail below with embodiments and drawings.

[0029] An experimental mouse brain stereotaxic device, such as Figures 1-5As shown, including the base 1, the base 1 one end is provided with fixed column 2 and limiting rod 3, fixed column 2 and limiting rod 3 with base 1 fixed connection or integrated, fixed column 2 on the movable connection has movable seat 4, movable seat 4 is also with limiting rod 3 movable connection, movable seat 4 can be relative to fixed column 2 and limiting rod 3 up and down movement, limiting rod 3 for keeping the direction of movable seat 4, so that it can only move up and down, but not rotate; optimally, fixed column 2 is set on the center line of base 1, limiting rod 3 is set on both sides of the center line of base 1. The fixed column 2 and limiting rod 3 are provided with the middle part of the base 1, which is convenient for fixing operation of the experimental mouse;

[0030] Optimally, fixed column 2 is provided with a rotating ring 7, the outer surface of fixed column 2 is provided with external threads, the inner side of rotating ring 7 is provided with internal threads, rotating ring 7 is threadedly connected with fixed column 2, rotating ring 7 can be moved up and down on fixed column 2 by rotating rotating ring 7; the upper side of rotating ring 7 is provided with a concave-shaped sliding groove 8, the lower part of movable seat 4 is provided with a first roller 9, the first roller 9 is arranged in the concave-shaped sliding groove 8, when rotating ring 7 rotates, the first roller 9 rotates relative to rotating ring 7, and under the fixed action of limiting rod 3, the position of movable seat 4 is relatively fixed, and movable seat 4 does not rotate with rotating ring 7;

[0031] Optimally, limiting rod 3 is provided with two, the inner side of limiting rod 3 is provided with a slide 10, the upper part of movable seat 4 is provided with a second roller 11, the second roller 11 is arranged in the slide 10; under the action of limiting rod 3, rotating ring 7 can drive movable seat 4 to move up and down, the slide 10 is arranged on limiting rod 3, the second roller 11 is arranged on the place where movable seat 4 contacts with limiting rod 3, the rolling action of second roller 11 can improve the smoothness and stability of movable seat 4 moving up and down, and improve the use effect of the device.

[0032] Movable seat 4 is provided with a mountain-shaped, two end arms of movable seat 4 are movably connected with ear rods 5, optimally, the free end of the end arm of movable seat 4 is provided with a fixed block, ear rods 5 penetrate through the fixed block and are threadedly connected with the fixed block, in use, by rotating ear rods 5, ear rods 5 can move relative to the fixed block, so as to adjust the length of ear rods 5;

[0033] The interarm of movable seat 4 is movably connected with incisor fixing rod 6; optimally, the interarm of movable seat 4 is provided with a hollow groove and a screw rod 12, the screw rod 12 penetrates through movable seat 4 and is arranged on the upper part of the hollow groove, the incisor fixing rod 6 is arranged in the hollow groove, in use, according to the required length, the screw rod 12 can be rotated upward, then the incisor fixing rod 6 is moved forward or backward, when the position is appropriate, the screw rod 12 is reversely rotated again, so as to compress and fix the incisor fixing rod 6 through the screw rod 12;

[0034] The door tooth fixing rod 6 is hinged with a clamping part; preferably, the clamping part comprises an arc-shaped pressing plate 13 and a connecting rod 14, the door tooth fixing rod 6 is provided with a vertical rod 15, the connecting rod 14 is hinged with the vertical rod 15, and a torsional spring is arranged on the hinge shaft; the arrangement of the torsional spring can keep the position of the connecting rod 14 fixed; in use, only one end of the connecting rod 14 needs to be pressed to make one end of the connecting rod 14 provided with the pressing plate 13 open, so as to facilitate the placement of the head of the experimental mouse under the pressing plate 13 for pressing and fixing, and convenient operation.

[0035] Preferably, the pressing plate 13 is provided with an air bag 16, which has a certain buffering effect and can reduce the hard extrusion on the experimental mouse.

[0036] The use process of the device is as follows: according to the size of the experimental mouse, the height of the movable seat 4 is adjusted by manually rotating the rotating ring 7, so that the experimental mouse is not in a suspended state after being fixed, which is convenient for the experiment; when the rotating ring 7 is rotated, the movable seat 4 is kept relatively fixed under the action of the limiting rod 3, the first roller 9 below the movable seat 4 rotates relative to the rotating ring 7, and when the rotating ring 7 moves up and down, the movable seat 4 is driven to move, the slide 10 is arranged on the limiting rod 3, and the second roller 11 is arranged on the movable seat 4, which can improve the smoothness of the sliding of the movable seat 4;

[0037] When the position of the movable seat 4 is appropriate, the teeth of the experimental mouse are placed in the clamping groove of the door tooth fixing rod 6, and then the mouth bone of the experimental mouse is extruded and fixed by the pressing plate 13; then the ear rod 5 is rotated, and the head bone of the experimental mouse is fixed by the two ear rods 5, thereby achieving the purpose of fixing the experimental mouse.

[0038] When the position of the door tooth fixing rod 6 is not appropriate, the screw rod 12 can be rotated to reduce the extrusion on the door tooth fixing rod 6, and then the door tooth fixing rod 6 is pushed inward or pulled outward to the appropriate position, and the screw rod 12 is tightened to realize the locking and fixing of the door tooth fixing rod 6, so that the position between the door tooth fixing rod 6 and the ear rod 5 is suitable for the placement of the head of the experimental mouse.

Claims

1. A stereotactic device for the brain of laboratory mice, characterized in that, Includes a base (1), one end of which is provided with a fixed column (2) and a limiting rod (3), and a movable seat (4) is movably connected to the fixed column (2), and the movable seat (4) is also movably connected to the limiting rod (3); The movable seat (4) is configured in the shape of a mountain. Ear rods (5) are movably connected to the two end arms of the movable seat (4), and a tooth fixing rod (6) is movably connected to the middle arm of the movable seat (4). A clamping member is hinged on the tooth fixing rod (6).

2. The stereotactic device for the brain of experimental mice as described in claim 1, characterized in that, A rotating ring (7) is fitted on the fixed column (2), and the rotating ring (7) is threadedly connected to the fixed column (2); a U-shaped groove (8) is provided on the upper side of the rotating ring (7), and a first roller (9) is provided on the lower part of the movable seat (4), and the first roller (9) is located in the U-shaped groove (8).

3. The stereotactic device for the brain of experimental mice as described in claim 1, characterized in that, Two limiting rods (3) are provided. A slide rail (10) is provided on the inner side of the limiting rod (3). A second roller (11) is provided on the movable seat (4). The second roller (11) is located in the slide rail (10).

4. The stereotactic device for the brain of experimental mice as described in claim 3, characterized in that, The fixing column (2) is located on the center line of the base (1), and the limiting rod (3) is located on both sides of the center line of the base (1).

5. The stereotactic device for the brain of experimental mice as described in claim 1, characterized in that, The movable seat (4) has a hollow groove and a screw (12) on its interarm. The screw (12) passes through the movable seat (4) and is located in the upper part of the hollow groove. The incisor fixing rod (6) is located in the hollow groove.

6. The stereotactic device for the brain of experimental mice as described in claim 1, characterized in that, The free end of the end arm of the movable seat (4) is provided with a fixing block, and the ear rod (5) passes through the fixing block and is threadedly connected to the fixing block.

7. The stereotactic device for the brain of experimental mice as described in claim 1, characterized in that, The clamping component includes an arc-shaped pressure plate (13) and a connecting rod (14). A vertical rod (15) is provided on the tooth fixing rod (6). The connecting rod (14) is hinged to the vertical rod (15), and a torsion spring is provided on the hinge shaft.

8. The stereotactic device for the brain of experimental mice as described in claim 7, characterized in that, An airbag (16) is provided on the pressure plate (13).

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